GB1430684A - Prolonged release lozenges - Google Patents

Prolonged release lozenges

Info

Publication number
GB1430684A
GB1430684A GB2973173A GB2973173A GB1430684A GB 1430684 A GB1430684 A GB 1430684A GB 2973173 A GB2973173 A GB 2973173A GB 2973173 A GB2973173 A GB 2973173A GB 1430684 A GB1430684 A GB 1430684A
Authority
GB
United Kingdom
Prior art keywords
active ingredient
methyl cellulose
june
humidity
prolonged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2973173A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1430684A publication Critical patent/GB1430684A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1430684 Prolonged release lozenge H LOWEY 22 June 1973 [26 June 1972] 29731/73 Heading A5B A shaped and compressed pharmaceutical composition comprises a pharmaceutically active ingredient incorporated in a carrier material which is hydroxypropyl methyl cellulose or a mixture of hydroxypropyl methyl cellulose and sodium carboxy methyl cellulose, the carrier material having been humidity- and heat-treated at a temperature between 110 and 120‹F at a humidity of 85 to 90% for a minimum of 24 hours and the carrier and pharmaceutically active ingredient having been compressed into shape at a pressure of from 7 to 13 kg/sq. inch, the composition having a longlasting slow disintegration rate to give a prolonged and regular release pattern. The active ingredient may be gastric mucin, aluminium hydroxide, magnesium trisilicate, nitroglycerin. amyl nitrite, ascorbic acid, chlorpheniramine maleate, benzocaine, phenolphthalein and dextrose, or mixtures thereof.
GB2973173A 1972-06-26 1973-06-22 Prolonged release lozenges Expired GB1430684A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26645272A 1972-06-26 1972-06-26

Publications (1)

Publication Number Publication Date
GB1430684A true GB1430684A (en) 1976-03-31

Family

ID=23014648

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2973173A Expired GB1430684A (en) 1972-06-26 1973-06-22 Prolonged release lozenges

Country Status (8)

Country Link
JP (1) JPS4954519A (en)
BR (1) BR7304698D0 (en)
CA (1) CA1018456A (en)
DE (1) DE2332484C2 (en)
DK (1) DK146434C (en)
FR (1) FR2190409B1 (en)
GB (1) GB1430684A (en)
NL (1) NL183808C (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133284A (en) * 1983-01-07 1984-07-25 English Grains Limited Resilient pharmaceutical unit for treating mouth ulcers
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
US4775535A (en) * 1986-04-04 1988-10-04 Hans Lowey Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics
US4855143A (en) * 1986-04-04 1989-08-08 Hans Lowey Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics
US5316773A (en) * 1990-07-19 1994-05-31 Otsuka Pharmaceutical Co., Ltd. Particulate preparation containing a flourracil derivative and hydroxypropylmethyl-cellulose
US5948437A (en) * 1996-05-23 1999-09-07 Zeneca Limited Pharmaceutical compositions using thiazepine
WO2004028507A1 (en) * 2002-09-24 2004-04-08 Akzo Nobel N.V. Method to improve pharmaceutical tablets having a matrix of cellulose ether
US8298581B2 (en) 2003-03-26 2012-10-30 Egalet A/S Matrix compositions for controlled delivery of drug substances
US8609143B2 (en) 2001-09-21 2013-12-17 Egalet Ltd. Morphine polymer release system
US8617605B2 (en) 2001-09-21 2013-12-31 Egalet Ltd. Polymer release system
US8877241B2 (en) 2003-03-26 2014-11-04 Egalet Ltd. Morphine controlled release system
US9005660B2 (en) 2009-02-06 2015-04-14 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
US9023394B2 (en) 2009-06-24 2015-05-05 Egalet Ltd. Formulations and methods for the controlled release of active drug substances
US9044402B2 (en) 2012-07-06 2015-06-02 Egalet Ltd. Abuse-deterrent pharmaceutical compositions for controlled release
US9642809B2 (en) 2007-06-04 2017-05-09 Egalet Ltd. Controlled release pharmaceutical compositions for prolonged effect

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43437B (en) * 1976-05-05 1989-08-31 Lowey Hans Process for obtaining tablets containing an active component with long lasting effect
FR2455459A1 (en) * 1979-05-02 1980-11-28 Sertog Carboxy:methylcellulose matrix for slow release of volatile cpd. - contains tri:ethanolamine, stearin and an alcohol e.g. cetyl is esp. useful for perfumes, insect repellents eczema treatment etc.
US4226849A (en) 1979-06-14 1980-10-07 Forest Laboratories Inc. Sustained release therapeutic compositions
US4357469A (en) 1979-06-14 1982-11-02 Forest Laboratories, Inc. Carrier base material for prolonged release therapeutic compositions
US4259314A (en) 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
CH652025A5 (en) * 1981-09-14 1985-10-31 Hoffmann La Roche Pharmaceutical preparation.
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
JPH0729927B2 (en) * 1983-04-09 1995-04-05 日研化学株式会社 Theophylline sustained release formulation
JPH0662404B2 (en) * 1983-06-14 1994-08-17 シンテックス・ファーマシユーテイカルズ・インターナシヨナル・リミテツド Controlled-release naproxen and naproxen sodium tablets
JPH07112934A (en) * 1993-10-15 1995-05-02 Taiyo Yakuhin Kogyo Kk Sustained release preparation of pentoxyphylline and its production
DK0746310T3 (en) * 1994-02-23 1999-08-02 Bm Res As Controlled release preparation
JP4533531B2 (en) 1998-04-03 2010-09-01 ビーエム リサーチ エイ／エス Controlled release composition
EP1562552A1 (en) 2002-11-08 2005-08-17 Egalet A/S Controlled release carvedilol compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171691A (en) * 1967-02-24 1969-11-26 Forest Laboratories Lond-Acting Oral Carrier
GB1279214A (en) * 1970-01-22 1972-06-28 Forest Laboratories Long-acting oral carrier

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133284A (en) * 1983-01-07 1984-07-25 English Grains Limited Resilient pharmaceutical unit for treating mouth ulcers
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
US4775535A (en) * 1986-04-04 1988-10-04 Hans Lowey Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics
US4855143A (en) * 1986-04-04 1989-08-08 Hans Lowey Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics
US5316773A (en) * 1990-07-19 1994-05-31 Otsuka Pharmaceutical Co., Ltd. Particulate preparation containing a flourracil derivative and hydroxypropylmethyl-cellulose
US5948437A (en) * 1996-05-23 1999-09-07 Zeneca Limited Pharmaceutical compositions using thiazepine
US8808745B2 (en) 2001-09-21 2014-08-19 Egalet Ltd. Morphine polymer release system
US9694080B2 (en) 2001-09-21 2017-07-04 Egalet Ltd. Polymer release system
US8609143B2 (en) 2001-09-21 2013-12-17 Egalet Ltd. Morphine polymer release system
US8617605B2 (en) 2001-09-21 2013-12-31 Egalet Ltd. Polymer release system
US9707179B2 (en) 2001-09-21 2017-07-18 Egalet Ltd. Opioid polymer release system
WO2004028507A1 (en) * 2002-09-24 2004-04-08 Akzo Nobel N.V. Method to improve pharmaceutical tablets having a matrix of cellulose ether
US9375428B2 (en) 2003-03-26 2016-06-28 Egalet Ltd. Morphine controlled release system
US8298581B2 (en) 2003-03-26 2012-10-30 Egalet A/S Matrix compositions for controlled delivery of drug substances
US8877241B2 (en) 2003-03-26 2014-11-04 Egalet Ltd. Morphine controlled release system
US9884029B2 (en) 2003-03-26 2018-02-06 Egalet Ltd. Morphine controlled release system
US9642809B2 (en) 2007-06-04 2017-05-09 Egalet Ltd. Controlled release pharmaceutical compositions for prolonged effect
US9358295B2 (en) 2009-02-06 2016-06-07 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
US9005660B2 (en) 2009-02-06 2015-04-14 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
US9023394B2 (en) 2009-06-24 2015-05-05 Egalet Ltd. Formulations and methods for the controlled release of active drug substances
US9044402B2 (en) 2012-07-06 2015-06-02 Egalet Ltd. Abuse-deterrent pharmaceutical compositions for controlled release
US9549899B2 (en) 2012-07-06 2017-01-24 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release

Also Published As

Publication number Publication date
DE2332484C2 (en) 1984-11-15
BR7304698D0 (en) 1974-09-24
DK146434B (en) 1983-10-10
JPS4954519A (en) 1974-05-27
CA1018456A (en) 1977-10-04
FR2190409B1 (en) 1977-04-15
DK146434C (en) 1984-03-19
FR2190409A1 (en) 1974-02-01
NL183808C (en) 1989-02-01
NL7308859A (en) 1973-12-28
NL183808B (en) 1988-09-01
DE2332484A1 (en) 1974-01-10

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years

Effective date: 19930621