FR2158464B1 - - Google Patents

Info

Publication number
FR2158464B1
FR2158464B1 FR7238836A FR7238836A FR2158464B1 FR 2158464 B1 FR2158464 B1 FR 2158464B1 FR 7238836 A FR7238836 A FR 7238836A FR 7238836 A FR7238836 A FR 7238836A FR 2158464 B1 FR2158464 B1 FR 2158464B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7238836A
Other versions
FR2158464A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of FR2158464A1 publication Critical patent/FR2158464A1/fr
Application granted granted Critical
Publication of FR2158464B1 publication Critical patent/FR2158464B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7238836A 1971-11-03 1972-11-02 Expired FR2158464B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1811672A GB1356834A (en) 1971-11-03 1971-11-03 Indole derivatives
GB1811672 1972-04-19
GB3076772 1972-06-30

Publications (2)

Publication Number Publication Date
FR2158464A1 FR2158464A1 (fr) 1973-06-15
FR2158464B1 true FR2158464B1 (fr) 1976-07-02

Family

ID=27257588

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7238836A Expired FR2158464B1 (fr) 1971-11-03 1972-11-02

Country Status (17)

Country Link
US (1) US3884919A (fr)
JP (1) JPS4856667A (fr)
AR (3) AR198064A1 (fr)
BE (1) BE790679A (fr)
CA (1) CA983932A (fr)
CH (1) CH577499A5 (fr)
DD (1) DD105611A5 (fr)
DE (1) DE2253927A1 (fr)
EG (1) EG11358A (fr)
ES (2) ES408226A1 (fr)
FR (1) FR2158464B1 (fr)
GB (1) GB1356834A (fr)
HU (1) HU169711B (fr)
IE (1) IE37998B1 (fr)
IL (1) IL40521A (fr)
NL (1) NL7214807A (fr)
SE (1) SE384856B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022780A (en) * 1973-03-06 1977-05-10 Imperial Chemical Industries Limited Process for the manufacture of indole derivatives
FR2421900A1 (fr) * 1977-03-17 1979-11-02 Sauba Lab Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
US4316847A (en) * 1979-07-30 1982-02-23 Hoffmann-La Roche Inc. Pyrroles and pyrrolidines
US4459227A (en) * 1981-03-02 1984-07-10 Duke University Para-hydroxyphenylhydrazines as in situ precursors of iminoquinones and quinones
AU686843B2 (en) * 1994-02-23 1998-02-12 Pfizer Inc. 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents
US6252084B1 (en) * 1994-03-15 2001-06-26 Eli Lilly And Company 1H-indole-3-acetamide sPLA2 inhibitors
NZ506329A (en) * 1998-02-25 2004-01-30 Inst Genetics Llc Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
SE0200411D0 (sv) * 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200356D0 (sv) * 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0201635D0 (sv) * 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301009D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
ES2257616T3 (es) 2003-04-25 2006-08-01 Actimis Pharmaceuticals, Inc. Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2.
CA2524221A1 (fr) * 2003-04-30 2004-11-18 The Institutes For Pharmaceutical Discovery, Llc Heteroaryles substitues utilises en tant qu'inhibiteurs des proteine-tyrosine phosphatases
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) * 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
SE0303180D0 (sv) 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
RU2373208C2 (ru) 2004-01-31 2009-11-20 Актимис Фармасьютикалз, Инк. Производные имидазо[1,2-c]пиримидинилуксусной кислоты
GB0415320D0 (en) 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
JP5208510B2 (ja) 2004-11-23 2013-06-12 アストラゼネカ・アクチエボラーグ 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
EP1937632A1 (fr) 2005-10-06 2008-07-02 Astra Zeneca AB Nouveaux composes
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
CN102558021A (zh) 2006-05-26 2012-07-11 阿斯利康(瑞典)有限公司 联芳基或芳基-杂芳基取代的吲哚类化合物
US7999119B2 (en) 2006-07-22 2011-08-16 Oxagen Limited Compounds having CRTH2 antagonist activity
UA100983C2 (ru) 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
ATE547407T1 (de) 2007-09-25 2012-03-15 Actimis Pharmaceuticals Inc Alkylthiopyrimidine als crth2-antagonisten
TW200920373A (en) 2007-09-25 2009-05-16 Actimis Pharmaceuticals Inc 2-S-benzyl substituted pyrimidines as CRTH2 antagonists
MX2010007833A (es) 2008-01-18 2010-08-11 Oxagen Ltd Compuestos que tienen actividad antagonista de crth2.
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
US8168673B2 (en) 2008-01-22 2012-05-01 Oxagen Limited Compounds having CRTH2 antagonist activity
JP2011509990A (ja) 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
CA3114672A1 (fr) * 2018-10-05 2020-04-23 Vertex Pharmaceuticals Incorporated Modulateurs de l'alpha -1 antitrypsine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125443C (fr) * 1963-06-06
US3679692A (en) * 1969-10-01 1972-07-25 Mead Johnson & Co Iminomethylindolines

Also Published As

Publication number Publication date
BE790679A (fr) 1973-04-27
ES437311A1 (es) 1977-04-01
AR203627A1 (es) 1975-09-30
CH577499A5 (fr) 1976-07-15
ES408226A1 (es) 1976-02-01
SE384856B (sv) 1976-05-24
AR198064A1 (es) 1974-05-31
FR2158464A1 (fr) 1973-06-15
DD105611A5 (fr) 1974-05-05
GB1356834A (en) 1974-06-19
US3884919A (en) 1975-05-20
CA983932A (en) 1976-02-17
DE2253927A1 (de) 1973-05-10
HU169711B (fr) 1977-02-28
IL40521A (en) 1975-06-25
EG11358A (en) 1977-02-28
IE37998B1 (en) 1977-12-07
AR203626A1 (es) 1975-09-30
IE37998L (en) 1973-05-03
IL40521A0 (en) 1972-12-29
JPS4856667A (fr) 1973-08-09
NL7214807A (fr) 1973-05-07

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Legal Events

Date Code Title Description
ST Notification of lapse