EA004049B1
(ru)
*
|
1998-11-10 |
2003-12-25 |
Янссен Фармацевтика Н.В. |
Пиримидины, ингибирующие репликацию вич
|
GB9914258D0
(en)
*
|
1999-06-18 |
1999-08-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
DE19945982A1
(de)
*
|
1999-09-24 |
2001-03-29 |
Knoll Ag |
Geschwindigkeitsbestimmte Partikel
|
EE04991B1
(et)
*
|
1999-09-24 |
2008-04-15 |
Janssen Pharmaceutica N.V. |
Osake, ravimvorm, nende valmistamismeetodid, osakeste kasutamine ning farmatseutiline pakend
|
AU770600B2
(en)
|
1999-10-07 |
2004-02-26 |
Amgen, Inc. |
Triazine kinase inhibitors
|
US20030004174A9
(en)
|
2000-02-17 |
2003-01-02 |
Armistead David M. |
Kinase inhibitors
|
JP5230050B2
(ja)
*
|
2000-05-08 |
2013-07-10 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
Hiv複製阻害剤
|
CA2407754C
(fr)
*
|
2000-05-08 |
2009-09-15 |
Janssen Pharmaceutica N.V. |
Promedicaments a base de pyrimidines inhibant la replication du vih
|
AU2002227379A1
(en)
*
|
2000-11-01 |
2002-05-15 |
Snapnames.Com, Inc. |
Registry-integrated internet domain name acquisition system
|
US6958211B2
(en)
|
2001-08-08 |
2005-10-25 |
Tibotech Bvba |
Methods of assessing HIV integrase inhibitor therapy
|
US8101629B2
(en)
|
2001-08-13 |
2012-01-24 |
Janssen Pharmaceutica N.V. |
Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
|
JO3429B1
(ar)
|
2001-08-13 |
2019-10-20 |
Janssen Pharmaceutica Nv |
مشتقات برميدينات مثبطة فيروس الايدز
|
US7638522B2
(en)
|
2001-08-13 |
2009-12-29 |
Janssen Pharmaceutica N.V. |
Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
|
US6939874B2
(en)
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
US7115617B2
(en)
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
EP2332924A1
(fr)
|
2001-10-17 |
2011-06-15 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Derivés pyrimidine, agent pharmaceutique contenant ces composés, utilisation et procédé de fabrication de ces composés
|
EP1453516A2
(fr)
|
2001-10-17 |
2004-09-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Nouvelles pyrimidines substituees, procede permettant de les produire et leur utilisation comme medicament
|
WO2003037891A1
(fr)
|
2001-11-01 |
2003-05-08 |
Janssen Pharmaceutica N.V. |
Heteroaryl amines utiles comme inhibiteurs de glycogene synthase kinase 3beta (inhibiteurs de gsk3)
|
CN1582277A
(zh)
|
2001-11-01 |
2005-02-16 |
詹森药业有限公司 |
用作糖原合酶激酶3β抑制剂的酰胺衍生物
|
SE0104140D0
(sv)
|
2001-12-07 |
2001-12-07 |
Astrazeneca Ab |
Novel Compounds
|
TWI329105B
(en)
*
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
JP4725945B2
(ja)
|
2002-03-13 |
2011-07-13 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体
|
ATE424395T1
(de)
|
2002-03-13 |
2009-03-15 |
Janssen Pharmaceutica Nv |
Aminoderivate als histone-deacetylase-inhibitoren
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
KR20040111466A
(ko)
*
|
2002-05-03 |
2004-12-31 |
얀센 파마슈티카 엔.브이. |
폴리머성 마이크로에멀젼
|
AR039540A1
(es)
*
|
2002-05-13 |
2005-02-23 |
Tibotec Pharm Ltd |
Compuestos microbicidas con contenido de pirimidina o triazina
|
TW200409629A
(en)
|
2002-06-27 |
2004-06-16 |
Bristol Myers Squibb Co |
2,4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors
|
US7517886B2
(en)
|
2002-07-29 |
2009-04-14 |
Rigel Pharmaceuticals, Inc. |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
|
CN102225902B
(zh)
|
2002-08-09 |
2013-04-24 |
詹森药业有限公司 |
制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
|
DK1551372T3
(en)
|
2002-09-20 |
2018-07-23 |
Alpharma Pharmaceuticals Llc |
SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES
|
RS20050363A
(en)
*
|
2002-11-28 |
2007-11-15 |
Schering Aktiengesellschaft, |
Chk-,pdk-and akt-inhibitory pyrimidines,their production an use as pharmaceutical agents
|
PT1599468E
(pt)
|
2003-01-14 |
2008-01-14 |
Arena Pharm Inc |
Derivados de arilo e heteroarilo 1,2,3.-trissubstituídos comomoduladores do metabolismo, e profilaxia e tratamento dedesordens relacionadas tais como diabetes e hiperglicemia
|
CN102503903A
(zh)
*
|
2003-02-07 |
2012-06-20 |
詹森药业有限公司 |
抑制hiv的1,2,4-三嗪
|
US20070021449A1
(en)
|
2003-02-07 |
2007-01-25 |
Jan Heeres |
Pyrimidine derivatives for the prevention of hiv infection
|
CL2004000303A1
(es)
*
|
2003-02-20 |
2005-04-08 |
Tibotec Pharm Ltd |
Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
|
EP1597251B1
(fr)
*
|
2003-02-20 |
2009-06-10 |
SmithKline Beecham Corporation |
Composes de pyrimidine
|
BRPI0412734A
(pt)
|
2003-07-17 |
2006-09-26 |
Tibotec Pharm Ltd |
processo para preparação de partìculas que contêm um antiviral
|
DK1656372T3
(da)
|
2003-07-30 |
2013-07-01 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme
|
ATE500254T1
(de)
*
|
2003-09-25 |
2011-03-15 |
Janssen Pharmaceutica Nv |
Die replikation von hiv hemmende purinderivate
|
WO2005086061A2
(fr)
|
2004-03-02 |
2005-09-15 |
Virco Bvba |
Estimations de releves cliniques
|
EP1598343A1
(fr)
*
|
2004-05-19 |
2005-11-23 |
Boehringer Ingelheim International GmbH |
Dérivés de 2-arylaminopyrimidines comme des inhibiteurs de PLK
|
MX2007001120A
(es)
|
2004-07-28 |
2007-03-15 |
Janssen Pharmaceutica Nv |
Derivados de indolil alquil sustituidos como nuevos inhibidores de la histona desacetilasa.
|
WO2006015985A1
(fr)
|
2004-08-10 |
2006-02-16 |
Janssen Pharmaceutica N.V. |
Dérivés de 1,2,4-triazin-6-one inhibiteurs du vih
|
RU2403244C2
(ru)
|
2004-09-30 |
2010-11-10 |
Тиботек Фармасьютикалз Лтд. |
Вич-ингибирующие 5-карбо- или гетероциклические замещенные пиримидины
|
TW200626574A
(en)
|
2004-09-30 |
2006-08-01 |
Tibotec Pharm Ltd |
HIV inhibiting 5-heterocyclyl pyrimidines
|
CN101027288B
(zh)
*
|
2004-09-30 |
2013-04-17 |
泰博特克药品有限公司 |
抑制hiv的5-取代嘧啶
|
BRPI0517272A
(pt)
|
2004-10-29 |
2008-10-07 |
Tibotec Pharm Ltd |
derivados de pirimidina bicìclicos de inibição de hiv
|
WO2006052373A2
(fr)
*
|
2004-11-08 |
2006-05-18 |
Boehringer Ingelheim International Gmbh |
Methode de traitement d'infection vih par coadministration de tipranavir et etravirine
|
SI1814878T1
(sl)
|
2004-11-24 |
2012-06-29 |
Rigel Pharmaceuticals Inc |
Spojine spiro-2,4-pirimidindiamina in njihova uporaba
|
PL1856135T3
(pl)
|
2005-01-19 |
2010-05-31 |
Rigel Pharmaceuticals Inc |
Proleki związków 2,4-pirymidynodiaminy i ich zastosowanie
|
US20090124644A1
(en)
*
|
2005-01-27 |
2009-05-14 |
Janssen Pharmaceutica N.V. |
Hiv inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives
|
DE602006001515D1
(de)
|
2005-02-16 |
2008-07-31 |
Astrazeneca Ab |
Chemische verbindungen
|
AU2006215599B2
(en)
*
|
2005-02-18 |
2012-09-27 |
Janssen Sciences Ireland Uc |
HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives
|
ATE473212T1
(de)
*
|
2005-03-04 |
2010-07-15 |
Tibotec Pharm Ltd |
Hiv-inhibierende 2-(4-cyanophenyl)-6- hydroxylaminopyrimidine
|
MX2007014328A
(es)
|
2005-05-16 |
2008-02-12 |
Astrazeneca Ab |
Compuestos quimicos.
|
US8101752B2
(en)
*
|
2005-05-26 |
2012-01-24 |
Tibotec Pharmaceuticals Ltd. |
Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile
|
JP5225079B2
(ja)
|
2005-06-08 |
2013-07-03 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
Jak経路の阻害のための組成物および方法
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
EP1945208A4
(fr)
*
|
2005-10-06 |
2011-08-03 |
Univ Massachusetts |
Composition et synthese de nouveaux reactifs pour inhiber la replication du vih
|
TW200800963A
(en)
|
2005-10-28 |
2008-01-01 |
Astrazeneca Ab |
Chemical compounds
|
WO2007082874A1
(fr)
|
2006-01-19 |
2007-07-26 |
Janssen Pharmaceutica N.V. |
Dérivés de pyridine et de pyrimidine en tant qu'inhibiteurs d'histone désacétylase
|
AU2007206950B2
(en)
|
2006-01-19 |
2012-02-02 |
Janssen Pharmaceutica N.V. |
Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
|
SI1981874T1
(sl)
|
2006-01-19 |
2009-10-31 |
Janssen Pharmaceutica Nv |
Aminofenilni derivati kot novi inhibitorji histon deacetilaze
|
CA2642229C
(fr)
|
2006-02-24 |
2015-05-12 |
Rigel Pharmaceuticals, Inc. |
Compositions et methodes destinees a l'inhibition de la voie jak
|
CA2645958C
(fr)
*
|
2006-03-30 |
2014-11-04 |
Tibotec Pharmaceuticals Ltd. |
Pyrimidines a substitution 5-amido inhibant le vih
|
US8163745B2
(en)
|
2006-03-30 |
2012-04-24 |
Tibotec Pharmaceuticals Ltd. |
HIV inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines
|
PE20120006A1
(es)
|
2006-05-15 |
2012-02-02 |
Boehringer Ingelheim Int |
Compuestos derivados de pirimidina como inhibidores de la quinasa aurora
|
US20090197903A1
(en)
*
|
2006-06-06 |
2009-08-06 |
Tibotec Pharmaceuticals Ltd. |
Process for preparing spray dried formulation of tmc125
|
US8158156B2
(en)
|
2006-06-19 |
2012-04-17 |
Alpharma Pharmaceuticals, Llc |
Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist
|
EP2073797A2
(fr)
*
|
2006-10-11 |
2009-07-01 |
Alpharma, Inc. |
Compositions pharmaceutiques
|
WO2008068299A2
(fr)
|
2006-12-06 |
2008-06-12 |
Tibotec Pharmaceuticals Ltd. |
Sel de bromhydrate d'un composé anti-vih
|
EP2114902B1
(fr)
*
|
2006-12-29 |
2014-09-17 |
Janssen R&D Ireland |
Pymiridines substituées en 5,6, inhibitrices du vih
|
US9006243B2
(en)
|
2006-12-29 |
2015-04-14 |
Janssen R&D Ireland |
HIV inhibiting 6-substituted pyrimidines
|
UA99459C2
(en)
|
2007-05-04 |
2012-08-27 |
Астразенека Аб |
9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
|
US8410124B2
(en)
|
2007-10-18 |
2013-04-02 |
Concert Pharmaceuticals Inc. |
Deuterated etravirine
|
US8623418B2
(en)
|
2007-12-17 |
2014-01-07 |
Alpharma Pharmaceuticals Llc |
Pharmaceutical composition
|
EP2224805A4
(fr)
*
|
2007-12-17 |
2013-10-16 |
Alpharma Pharmaceuticals Llc |
Composition pharmaceutique
|
US20100151014A1
(en)
*
|
2008-12-16 |
2010-06-17 |
Alpharma Pharmaceuticals, Llc |
Pharmaceutical composition
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
EA029131B1
(ru)
|
2008-05-21 |
2018-02-28 |
Ариад Фармасьютикалз, Инк. |
Фосфорсодержащие производные в качестве ингибиторов киназы
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
SG10201510696RA
(en)
|
2008-06-27 |
2016-01-28 |
Celgene Avilomics Res Inc |
Heteroaryl compounds and uses thereof
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
TW201016676A
(en)
*
|
2008-10-03 |
2010-05-01 |
Astrazeneca Ab |
Heterocyclic derivatives and methods of use thereof
|
US20110071158A1
(en)
*
|
2009-03-18 |
2011-03-24 |
Boehringer Ingelheim International Gmbh |
New compounds
|
JP5748737B2
(ja)
|
2009-03-30 |
2015-07-15 |
ヤンセン・アールアンドデイ・アイルランド |
エトラビリンとニコチンアミドの共結晶
|
CA2760794C
(fr)
|
2009-05-05 |
2017-07-25 |
Dana Farber Cancer Institute |
Inhibiteurs d'egfr et procedes de traitement de troubles
|
WO2010131118A2
(fr)
*
|
2009-05-12 |
2010-11-18 |
Pliva Hrvatska D.O.O. |
Formes polymorphes d'étravirine et leurs procédés de préparation
|
US20110196156A1
(en)
|
2009-06-22 |
2011-08-11 |
Mukund Keshav Gurjar |
Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor
|
US8153790B2
(en)
|
2009-07-27 |
2012-04-10 |
Krizmanic Irena |
Process for the preparation and purification of etravirine and intermediates thereof
|
GR1007010B
(el)
|
2009-10-08 |
2010-10-07 |
Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), |
Ινσουλινοειδη πεπτιδια
|
AU2011260323A1
(en)
|
2010-06-04 |
2012-11-15 |
F. Hoffmann-La Roche Ag |
Aminopyrimidine derivatives as LRRK2 modulators
|
WO2012001695A1
(fr)
|
2010-06-28 |
2012-01-05 |
Hetero Research Foundation |
Procédé de préparation d'intermédiaire de l'étravirine et de polymorphes de l'étravirine
|
BR112013003388A2
(pt)
|
2010-08-10 |
2016-07-12 |
Celgene Avilomics Res Inc |
sal de besilato de um inibidor de btk
|
BR112013008100A2
(pt)
|
2010-09-22 |
2016-08-09 |
Arena Pharm Inc |
"moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
|
JP5956999B2
(ja)
|
2010-11-01 |
2016-07-27 |
セルジーン アヴィロミクス リサーチ, インコーポレイテッド |
ヘテロアリール化合物およびその使用
|
MY181898A
(en)
|
2010-11-01 |
2021-01-12 |
Celgene Car Llc |
Heterocyclic compounds and uses thereof
|
JP5957003B2
(ja)
|
2010-11-10 |
2016-07-27 |
セルジーン アヴィロミクス リサーチ, インコーポレイテッド |
変異体選択的egfr阻害剤およびその使用
|
LT3124483T
(lt)
|
2010-11-10 |
2019-09-25 |
Genentech, Inc. |
Pirazolo aminopirimidino dariniai, kaip lrrk2 moduliatoriai
|
ES2655525T3
(es)
|
2011-04-26 |
2018-02-20 |
Mylan Laboratories Ltd. |
Proceso novedoso para la preparación de Etravirina
|
EP2704572B1
(fr)
|
2011-05-04 |
2015-12-30 |
Ariad Pharmaceuticals, Inc. |
Composés permettant d'inhiber la prolifération cellulaire dans les cancers induits par l'egfr
|
WO2012170647A1
(fr)
*
|
2011-06-09 |
2012-12-13 |
Assia Chemical Industriew Ltd. |
Procédé pour la préparation d'étravirine et intermédiaires dans la synthèse de celle-ci
|
FI3392252T3
(fi)
|
2011-08-23 |
2024-01-08 |
Libertas Bio Inc |
Pyrimidopyridazinoniyhdisteet ja niiden käyttö
|
US20130123498A1
(en)
|
2011-10-19 |
2013-05-16 |
Maja Sepelj MAJER |
Process for the preparation of etravirine and intermediates in the synthesis thereof
|
TW201325593A
(zh)
|
2011-10-28 |
2013-07-01 |
Celgene Avilomics Res Inc |
治療布魯頓(bruton’s)酪胺酸激酶疾病或病症之方法
|
WO2013109354A2
(fr)
*
|
2011-12-07 |
2013-07-25 |
Texas Southern University |
Formulations d'étravirine et leurs utilisations
|
KR102090453B1
(ko)
|
2012-03-15 |
2020-03-19 |
셀젠 카르 엘엘씨 |
상피 성장 인자 수용체 키나제 억제제의 염
|
MY169233A
(en)
|
2012-03-15 |
2019-03-19 |
Celgene Car Llc |
Solid forms of an epidermal growth factor receptor kinase inhibitor
|
US20150166591A1
(en)
|
2012-05-05 |
2015-06-18 |
Ariad Pharmaceuticals, Inc. |
Methods and compositions for raf kinase mediated diseases
|
WO2014068588A2
(fr)
*
|
2012-10-29 |
2014-05-08 |
Biophore India Pharmaceuticals Pvt. Ltd. |
Procédé de synthèse d'étravirine et ses intermédiaires
|
WO2014072419A1
(fr)
|
2012-11-08 |
2014-05-15 |
Universiteit Antwerpen |
Nouveaux composés anti-vih
|
US9375411B2
(en)
|
2012-12-21 |
2016-06-28 |
Verlyx Pharma Inc. |
Uses and methods for the treatment of liver diseases or conditions
|
WO2014100748A1
(fr)
|
2012-12-21 |
2014-06-26 |
Celgene Avilomics Research, Inc. |
Composés hétéroarylés et leurs utilisations
|
US9145387B2
(en)
|
2013-02-08 |
2015-09-29 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
DK3179858T3
(da)
|
2014-08-13 |
2019-07-22 |
Celgene Car Llc |
Forme og sammensætninger af en ERK-inhibitor
|
AU2016205361C1
(en)
|
2015-01-06 |
2021-04-08 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
CN104926829A
(zh)
*
|
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