FI973278A - Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet - Google Patents
Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet Download PDFInfo
- Publication number
- FI973278A FI973278A FI973278A FI973278A FI973278A FI 973278 A FI973278 A FI 973278A FI 973278 A FI973278 A FI 973278A FI 973278 A FI973278 A FI 973278A FI 973278 A FI973278 A FI 973278A
- Authority
- FI
- Finland
- Prior art keywords
- novel
- preparation
- pharmaceutical preparations
- preparations containing
- farnesyltransferase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9501489A FR2730491B1 (fr) | 1995-02-09 | 1995-02-09 | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR1996/000198 WO1996024611A1 (fr) | 1995-02-09 | 1996-02-07 | Inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI973278A0 FI973278A0 (fi) | 1997-08-08 |
| FI973278A true FI973278A (fi) | 1997-08-08 |
Family
ID=9475979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI973278A FI973278A (fi) | 1995-02-09 | 1997-08-08 | Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5856439A (fr) |
| EP (1) | EP0808328A1 (fr) |
| JP (1) | JPH10513467A (fr) |
| KR (1) | KR19980702048A (fr) |
| CN (1) | CN1173874A (fr) |
| AU (1) | AU4722796A (fr) |
| BR (1) | BR9607317A (fr) |
| CA (1) | CA2210955A1 (fr) |
| CZ (1) | CZ249897A3 (fr) |
| FI (1) | FI973278A (fr) |
| FR (1) | FR2730491B1 (fr) |
| NO (1) | NO973608D0 (fr) |
| PL (1) | PL321675A1 (fr) |
| SK (1) | SK108797A3 (fr) |
| TR (1) | TR199700727T1 (fr) |
| WO (1) | WO1996024611A1 (fr) |
| ZA (1) | ZA961072B (fr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2730491B1 (fr) * | 1995-02-09 | 1997-03-14 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
| EP1888050B1 (fr) | 2005-05-17 | 2012-03-21 | Merck Sharp & Dohme Ltd. | Acide cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl) cyclohexanepropanoique pour le traitement du cancer |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| CA2664113C (fr) | 2006-09-22 | 2013-05-28 | Merck & Co., Inc. | Utilisation de la platencine et de la platensimycine en tant qu'inhibiteurs de la synthese des acides gras pour traiter l'obesite, lediabete et le cancer |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| RS51780B (en) | 2007-01-10 | 2011-12-31 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. | INDASOLS SUBSTITUTED BY AMIDE AS INHIBITORS OF POLY (ADP-Ribose) POLYMERASES (PARP) |
| MX2009009304A (es) | 2007-03-01 | 2009-11-18 | Novartis Ag | Inhibidores de cinasa pim y metodos para su uso. |
| AU2008254425A1 (en) | 2007-05-21 | 2008-11-27 | Novartis Ag | CSF-1R inhibitors, compositions, and methods of use |
| EP3103791B1 (fr) | 2007-06-27 | 2018-01-31 | Merck Sharp & Dohme Corp. | Dérivés de 4-carboxybenzylamino utilisés comme inhibiteurs de l'histone désacétylase |
| US7932036B1 (en) | 2008-03-12 | 2011-04-26 | Veridex, Llc | Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase |
| US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
| WO2010144909A1 (fr) | 2009-06-12 | 2010-12-16 | Novartis Ag | Composés hétérocycliques fondus et leurs utilisations |
| KR101485645B1 (ko) | 2009-10-14 | 2015-01-22 | 머크 샤프 앤드 돔 코포레이션 | ｐ53 활성을 증가시키는 치환된 피페리딘 및 그의 용도 |
| EP2937345B1 (fr) | 2009-12-29 | 2018-03-21 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de la kinase raf de type ii |
| WO2011115725A2 (fr) | 2010-03-16 | 2011-09-22 | Dana-Farber Cancer Institute, Inc. | Composés d'indazole et leurs utilisations |
| US8999957B2 (en) | 2010-06-24 | 2015-04-07 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as ERK inhibitors |
| EP2598874B1 (fr) | 2010-07-28 | 2018-10-24 | Janssen Diagnostics, LLC | Procédés de détermination de réponse de la leucémie myéloïde aiguë à traitement par inhibiteurs de la farnésyltransférase |
| AU2011285909B2 (en) | 2010-08-02 | 2016-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
| WO2012024170A2 (fr) | 2010-08-17 | 2012-02-23 | Merck Sharp & Dohme Corp. | Inhibition médiée par des arn interférents de l'expression génique du virus de l'hépatite b (vhb) à l'aide de petits acides nucléiques interférents (pani) |
| US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
| EP2613782B1 (fr) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk |
| EP2615916B1 (fr) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk |
| ES2663009T3 (es) | 2010-10-29 | 2018-04-10 | Sirna Therapeutics, Inc. | Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic) |
| EP2654748B1 (fr) | 2010-12-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Dérivés d'indazole utiles en tant qu'inhibiteurs de erk |
| WO2012143879A1 (fr) | 2011-04-21 | 2012-10-26 | Piramal Healthcare Limited | Forme cristalline d'un sel d'un dérivé de morpholinosulfonylindole et son procédé de préparation |
| EP2770987B1 (fr) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Nouveaux composés qui sont des inhibiteurs d'erk |
| EP2822935B1 (fr) | 2011-11-17 | 2019-05-15 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de la kinase c-jun-terminale (jnk) |
| EP3919620A1 (fr) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Compositions d'acide nucléique interférent court (sina) |
| WO2014052563A2 (fr) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Nouveaux composés inhibiteurs de erk |
| US10112927B2 (en) | 2012-10-18 | 2018-10-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| WO2014063054A1 (fr) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinase moelle osseuse sur chromosome x (bmx) et leurs utilisations |
| US9758522B2 (en) | 2012-10-19 | 2017-09-12 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
| RS56680B1 (sr) | 2012-11-28 | 2018-03-30 | Merck Sharp & Dohme | Kompozicije i postupci za lečenje kancera |
| JP6387013B2 (ja) | 2012-12-20 | 2018-09-12 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｈｄｍ２阻害薬としての置換されたイミダゾピリジン類 |
| US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
| WO2015034925A1 (fr) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Polynucléotides circulaires |
| AU2014337122B2 (en) | 2013-10-18 | 2019-01-03 | Dana-Farber Cancer Institute, Inc. | Heteroaromatic compounds useful for the treatment of proliferative diseases |
| AU2014337044A1 (en) | 2013-10-18 | 2016-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
| US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
| WO2015164614A1 (fr) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de janus kinase et leurs utilisations |
| JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| US10870651B2 (en) | 2014-12-23 | 2020-12-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| JP6861166B2 (ja) | 2015-03-27 | 2021-04-21 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
| EP3307728A4 (fr) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | Thérapie d'association utilisant des inhibiteurs de transcription et des inhibiteurs de kinases |
| ES2741782T3 (es) | 2015-08-17 | 2020-02-12 | Kura Oncology Inc | Métodos para tratar pacientes con cáncer a partir de inhibidores de la farnesiltransferasa |
| WO2017044858A2 (fr) | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinases cycline-dépendantes |
| JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
| EP3525785A4 (fr) | 2016-10-12 | 2020-03-25 | Merck Sharp & Dohme Corp. | Inhibiteurs de kdm5 |
| SI3534885T1 (sl) | 2016-11-03 | 2021-08-31 | Kura Oncology, Inc. | Zaviralci farnezil-transferaze za uporabo pri zdravljenju raka |
| MX2019012233A (es) | 2017-04-13 | 2020-01-14 | Aduro Biotech Holdings Europe Bv | Anticuerpos anti-sirpa. |
| US11098059B2 (en) | 2017-11-08 | 2021-08-24 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| WO2019113269A1 (fr) | 2017-12-08 | 2019-06-13 | Kura Oncology, Inc. | Méthodes de traitement de patients cancéreux avec des inhibiteurs de la farnésyltransférase |
| WO2019148412A1 (fr) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anticorps bispécifiques anti-pd-1/lag3 |
| US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| EP3833668A4 (fr) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | Inhibiteurs de prmt5 |
| US20220143006A1 (en) | 2019-03-15 | 2022-05-12 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| WO2024180169A1 (fr) | 2023-03-02 | 2024-09-06 | Carcimun Biotech Gmbh | Moyens et procédés de diagnostic du cancer et/ou d'une maladie inflammatoire aiguë |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
| CA2044333A1 (fr) * | 1990-06-12 | 1991-12-13 | Jackson B. Gibbs | Agents chimiotherapeutiques |
| CA2072033A1 (fr) * | 1991-06-28 | 1992-12-29 | Jackson B. Gibbs | Inhibiteur de la farnesyl-proteine-transferase ne se rapportant pas a un substrat |
| CA2118985A1 (fr) * | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Inhibiteurs heterocycliques de la farnesyl proteine transferase |
| US5843941A (en) * | 1993-05-14 | 1998-12-01 | Genentech, Inc. | Ras farnesyl transferase inhibitors |
| US5439918A (en) * | 1994-03-14 | 1995-08-08 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| FR2730491B1 (fr) * | 1995-02-09 | 1997-03-14 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2730492B1 (fr) * | 1995-02-09 | 1997-03-14 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1995
- 1995-02-09 FR FR9501489A patent/FR2730491B1/fr not_active Expired - Fee Related
-
1996
- 1996-02-07 EP EP96903061A patent/EP0808328A1/fr not_active Ceased
- 1996-02-07 KR KR1019970705443A patent/KR19980702048A/ko not_active Application Discontinuation
- 1996-02-07 PL PL96321675A patent/PL321675A1/xx unknown
- 1996-02-07 US US08/875,752 patent/US5856439A/en not_active Expired - Fee Related
- 1996-02-07 AU AU47227/96A patent/AU4722796A/en not_active Abandoned
- 1996-02-07 WO PCT/FR1996/000198 patent/WO1996024611A1/fr not_active Application Discontinuation
- 1996-02-07 CN CN96191867A patent/CN1173874A/zh active Pending
- 1996-02-07 CZ CZ972498A patent/CZ249897A3/cs unknown
- 1996-02-07 BR BR9607317A patent/BR9607317A/pt not_active Application Discontinuation
- 1996-02-07 TR TR97/00727T patent/TR199700727T1/xx unknown
- 1996-02-07 JP JP8524037A patent/JPH10513467A/ja active Pending
- 1996-02-07 SK SK1087-97A patent/SK108797A3/sk unknown
- 1996-02-07 CA CA002210955A patent/CA2210955A1/fr not_active Abandoned
- 1996-02-09 ZA ZA961072A patent/ZA961072B/xx unknown
-
1997
- 1997-08-05 NO NO973608A patent/NO973608D0/no unknown
- 1997-08-08 FI FI973278A patent/FI973278A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US5856439A (en) | 1999-01-05 |
| AU4722796A (en) | 1996-08-27 |
| FI973278A0 (fi) | 1997-08-08 |
| CZ249897A3 (en) | 1997-11-12 |
| ZA961072B (en) | 1996-08-20 |
| FR2730491B1 (fr) | 1997-03-14 |
| KR19980702048A (ko) | 1998-07-15 |
| MX9706015A (es) | 1997-11-29 |
| BR9607317A (pt) | 1997-12-30 |
| SK108797A3 (en) | 1997-12-10 |
| TR199700727T1 (xx) | 1998-02-21 |
| CA2210955A1 (fr) | 1996-08-15 |
| CN1173874A (zh) | 1998-02-18 |
| WO1996024611A1 (fr) | 1996-08-15 |
| NO973608L (no) | 1997-08-05 |
| JPH10513467A (ja) | 1998-12-22 |
| PL321675A1 (en) | 1997-12-22 |
| EP0808328A1 (fr) | 1997-11-26 |
| FR2730491A1 (fr) | 1996-08-14 |
| NO973608D0 (no) | 1997-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |