FI771951A - Nya halosporinderivat - Google Patents

Nya halosporinderivat

Info

Publication number
FI771951A
FI771951A FI771951A FI771951A FI771951A FI 771951 A FI771951 A FI 771951A FI 771951 A FI771951 A FI 771951A FI 771951 A FI771951 A FI 771951A FI 771951 A FI771951 A FI 771951A
Authority
FI
Finland
Prior art keywords
halosporinderivat
nya
nya halosporinderivat
Prior art date
Application number
FI771951A
Other languages
English (en)
Other versions
FI67384B (fi
FI67384C (fi
Inventor
Mitsuo Numata
Isao Minamida
Susumu Tsushima
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FI771951A publication Critical patent/FI771951A/fi
Publication of FI67384B publication Critical patent/FI67384B/fi
Application granted granted Critical
Publication of FI67384C publication Critical patent/FI67384C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI771951A 1976-09-08 1977-06-22 Foerfarande foer framstaellning av farmaceutiskt anvaendbara 7-(2-(2-imino-4-tiazolin-4-yl)-2-hydroxiiminoacetamido)-3-cefem-4-karboxylsyraderivat FI67384C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10810176 1976-09-08
JP51108101A JPS6011713B2 (ja) 1976-09-08 1976-09-08 セフアロスポリン誘導体およびその製造法

Publications (3)

Publication Number Publication Date
FI771951A true FI771951A (fi) 1978-03-09
FI67384B FI67384B (fi) 1984-11-30
FI67384C FI67384C (fi) 1985-03-11

Family

ID=14475887

Family Applications (1)

Application Number Title Priority Date Filing Date
FI771951A FI67384C (fi) 1976-09-08 1977-06-22 Foerfarande foer framstaellning av farmaceutiskt anvaendbara 7-(2-(2-imino-4-tiazolin-4-yl)-2-hydroxiiminoacetamido)-3-cefem-4-karboxylsyraderivat

Country Status (22)

Country Link
US (1) US4264595A (fi)
JP (1) JPS6011713B2 (fi)
AT (1) AT352277B (fi)
AU (1) AU508551B2 (fi)
BE (1) BE856045A (fi)
CA (1) CA1316171C (fi)
CH (4) CH629813A5 (fi)
DE (3) DE2727753A1 (fi)
DK (2) DK159783C (fi)
ES (2) ES460124A1 (fi)
FI (1) FI67384C (fi)
FR (1) FR2408612A1 (fi)
GB (1) GB1587941A (fi)
GR (1) GR63635B (fi)
HU (1) HU182053B (fi)
MX (1) MX5198E (fi)
NL (1) NL189354C (fi)
NO (1) NO772170L (fi)
PH (2) PH15144A (fi)
PT (1) PT66735B (fi)
SE (1) SE464581B (fi)
ZA (1) ZA773775B (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071979A (en) * 1981-05-12 1991-12-10 Hoechst Aktiengesellschaft Cephalosporin derivatives

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5760345B2 (fi) * 1974-12-19 1982-12-18 Takeda Chemical Industries Ltd
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
US4963542A (en) * 1976-09-08 1990-10-16 Takeda Chemical Industries, Ltd. Cephalosporin derivatives
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US5089490A (en) * 1977-04-02 1992-02-18 Hoechst Aktiengesellschaft Cephem derivatives
FR2410655A1 (fr) 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4379922A (en) * 1978-09-12 1983-04-12 Fujisawa Pharmaceutical Co., Ltd. Cepham compounds
EP0048504B1 (en) * 1978-09-12 1988-08-17 Fujisawa Pharmaceutical Co., Ltd. Intermediate compounds for preparing cephem compounds; processes for their preparation and processes for preparing cephem compounds
DE2945248A1 (de) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel
HU184771B (en) * 1979-05-23 1984-10-29 Rhone Poulenc Ind Process for producing new 3-thiovinyl-cepheme-carboxylic acid derivatives
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS56125392A (en) * 1980-03-06 1981-10-01 Fujisawa Pharmaceut Co Ltd Cepham and cephem compound and preparation thereof
IT1141286B (it) * 1980-04-17 1986-10-01 Dob Far Spa Esteri delle desacetossi cefalosporine loro sali e procedimenti per il loro ottenimento
JPS5759894A (en) * 1980-09-30 1982-04-10 Sankyo Co Ltd Cephalosporin for oral administration
DK379581A (da) * 1980-10-06 1982-04-07 Hoffmann La Roche Fremgangsmaade til fremstilling af acylderivater
US4431642A (en) * 1980-12-01 1984-02-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0061234A3 (en) * 1981-03-05 1983-11-16 Beecham Group Plc Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
FR2508458A1 (fr) * 1981-06-29 1982-12-31 Sandoz Sa Nouveaux derives de l'acide cephalosporanique, leur preparation et leur application comme medicaments
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
US4396619A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
US4396620A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin quinolinium betaines
US4576938A (en) * 1981-12-08 1986-03-18 Tanabe Seiyaku Co., Ltd. Cephalosporin compound and process for preparing the same
GB8323034D0 (en) * 1983-08-26 1983-09-28 Fujisawo Pharmaceutical Co Ltd 7-substituted-3-vinyl-3-cephem compounds
US4761409A (en) * 1984-08-16 1988-08-02 Sumitomo Pharmaceuticals Company, Limited Cephem derivatives
CA1267647A (en) * 1984-12-27 1990-04-10 Ryosuke Ushijima Cephalosporin derivatives
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
NO862910L (no) * 1985-08-05 1987-02-06 Fujisawa Pharmaceutical Co Fremgangsmaate for fremstilling av 3,7-disubstituerte-3-cefemforbindelser.
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
JPS6417892A (en) * 1987-07-14 1989-01-20 Totoku Electric Iron coated composite material and production thereof
JPH01230547A (ja) * 1988-01-14 1989-09-14 Takeda Chem Ind Ltd ３−オキソ酪酸第三ブチルの製造法及びその用途
DE3804841A1 (de) * 1988-02-17 1989-08-31 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
EP0333082A3 (en) * 1988-03-15 1991-05-02 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
US5081116A (en) * 1989-04-12 1992-01-14 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin derivatives
DE3919259A1 (de) * 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
CA2054126A1 (en) * 1990-10-26 1992-04-27 Michiyuki Sendai Cephem compounds, their production and use
IL113744A (en) * 1990-11-09 1998-06-15 Eisai Co Ltd History of 3-tufts and their preparation
YU48484B (sh) * 1991-05-24 1998-09-18 Hoechst Aktiengesellschaft Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
ATE262533T1 (de) * 1991-09-07 2004-04-15 Aventis Pharma Gmbh Diastereomer des 3-cephem-4-carbonsäure-1-(- isopropoxycarbonyloxy)ethylesters und verfahren zu dessen herstellung
TW212181B (fi) * 1992-02-14 1993-09-01 Hoechst Ag
ES2117066T3 (es) * 1992-05-21 1998-08-01 Hoechst Ag Procedimiento para la disociacion de esteres profarmacos de cefalosporina para dar acido 7-amino-3-metoximetil-cef-3-em-4-carboxilico.
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
US8802387B2 (en) * 2008-04-30 2014-08-12 Nanyang Technological University Methods and compounds for detecting beta-lactamase activity
WO2010118361A1 (en) * 2009-04-09 2010-10-14 Sopharmia, Inc. Beta lactamase inhibitors
DK2968352T3 (da) 2013-03-12 2019-01-02 Gladius Pharmaceuticals Corp Derivatiserede 3-styryl-cephalosporiner

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024134A (en) * 1971-01-29 1977-05-17 Glaxo Laboratories Limited Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
US4024137A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
US4093803A (en) * 1971-05-14 1978-06-06 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
US4033950A (en) * 1971-05-14 1977-07-05 Glaxo Laboratories Limited 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US4091209A (en) * 1971-05-14 1978-05-23 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]cephalosporins having a 2-haloalkylcarbamoyloxymethyl group at the 3-position
JPS5119765A (en) * 1974-08-09 1976-02-17 Takeda Chemical Industries Ltd Aminochiazoorujudotaino seizoho
DK154939C (da) 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
FR2383188A2 (fr) * 1976-01-23 1978-10-06 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2361893A2 (fr) * 1976-01-23 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
FR2346014A1 (fr) * 1976-01-23 1977-10-28 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2361894A2 (fr) * 1976-01-23 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071979A (en) * 1981-05-12 1991-12-10 Hoechst Aktiengesellschaft Cephalosporin derivatives

Also Published As

Publication number Publication date
HU182053B (en) 1983-12-28
DK161081C (da) 1991-11-11
GB1587941A (en) 1981-04-15
CH634578A5 (de) 1983-02-15
BE856045A (fr) 1977-12-23
DK159783B (da) 1990-12-03
PT66735B (en) 1978-11-24
DK621189D0 (da) 1989-12-08
AT352277B (de) 1979-09-10
NL7707129A (nl) 1978-03-10
DE2727753C2 (fi) 1987-11-05
DK159783C (da) 1991-04-22
DE2760448C2 (fi) 1989-06-22
FR2408612A1 (fr) 1979-06-08
AU508551B2 (en) 1980-03-27
JPS6011713B2 (ja) 1985-03-27
DK161081B (da) 1991-05-27
DE2760271C2 (fi) 1988-08-18
DE2727753A1 (de) 1978-03-16
GR63635B (en) 1979-11-27
CH630386A5 (de) 1982-06-15
ES470782A1 (es) 1979-01-16
PT66735A (en) 1977-07-01
SE7707176L (sv) 1978-03-09
AU2627177A (en) 1979-01-04
CA1316171C (en) 1993-04-13
ZA773775B (en) 1978-05-30
FI67384B (fi) 1984-11-30
PH15144A (en) 1982-08-24
NL189354B (nl) 1992-10-16
NL189354C (nl) 1993-03-16
CH629813A5 (de) 1982-05-14
DK270377A (da) 1978-03-09
US4264595A (en) 1981-04-28
NO772170L (no) 1978-03-09
PH19543A (en) 1986-05-20
SE464581B (sv) 1991-05-13
FR2408612B1 (fi) 1982-10-15
ES460124A1 (es) 1978-10-01
FI67384C (fi) 1985-03-11
DK621189A (da) 1989-12-08
CH630923A5 (de) 1982-07-15
JPS5334794A (en) 1978-03-31
ATA442477A (de) 1979-02-15
MX5198E (es) 1983-04-25

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Owner name: TAKEDA CHEMICAL INDUSTRIES, LTD.