FI109697B - Menetelmä uusien terapeuttisesti käyttökelpoisten fuusioituneiden bentsojohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten fuusioituneiden bentsojohdannaisten valmistamiseksi Download PDF

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Publication number
FI109697B
FI109697B FI952824A FI952824A FI109697B FI 109697 B FI109697 B FI 109697B FI 952824 A FI952824 A FI 952824A FI 952824 A FI952824 A FI 952824A FI 109697 B FI109697 B FI 109697B
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FI
Finland
Prior art keywords
formula
group
compound
phenyl
halogen
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Application number
FI952824A
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English (en)
Finnish (fi)
Swedish (sv)
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FI952824A (fi
FI952824A0 (fi
Inventor
Henrik Pedersen
Jens Perregaard
Ejner K Moltzen
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Lundbeck & Co As H
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Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of FI952824A publication Critical patent/FI952824A/fi
Publication of FI952824A0 publication Critical patent/FI952824A0/fi
Application granted granted Critical
Publication of FI109697B publication Critical patent/FI109697B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
FI952824A 1992-12-09 1995-06-08 Menetelmä uusien terapeuttisesti käyttökelpoisten fuusioituneiden bentsojohdannaisten valmistamiseksi FI109697B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK148392 1992-12-09
DK921483A DK148392D0 (da) 1992-12-09 1992-12-09 Heterocykliske forbindelser
DK9300414 1993-12-08
PCT/DK1993/000414 WO1994013659A1 (en) 1992-12-09 1993-12-08 Fused benzo compounds

Publications (3)

Publication Number Publication Date
FI952824A FI952824A (fi) 1995-06-08
FI952824A0 FI952824A0 (fi) 1995-06-08
FI109697B true FI109697B (fi) 2002-09-30

Family

ID=8105314

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952824A FI109697B (fi) 1992-12-09 1995-06-08 Menetelmä uusien terapeuttisesti käyttökelpoisten fuusioituneiden bentsojohdannaisten valmistamiseksi

Country Status (23)

Country Link
US (2) US5753661A (da)
EP (1) EP0673375B1 (da)
JP (1) JPH08504410A (da)
KR (1) KR100299624B1 (da)
AT (1) ATE176909T1 (da)
AU (1) AU675263B2 (da)
CA (1) CA2151378A1 (da)
CZ (1) CZ283143B6 (da)
DE (1) DE69323630T2 (da)
DK (2) DK148392D0 (da)
ES (1) ES2127912T3 (da)
FI (1) FI109697B (da)
GR (1) GR3030200T3 (da)
HU (1) HUT73632A (da)
IL (1) IL107923A (da)
MX (1) MX9307779A (da)
NO (1) NO311617B1 (da)
NZ (1) NZ258117A (da)
RU (1) RU2141959C1 (da)
SG (1) SG52722A1 (da)
SK (1) SK280779B6 (da)
WO (1) WO1994013659A1 (da)
ZA (1) ZA939203B (da)

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DE4333254A1 (de) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
ES2117934B1 (es) * 1994-07-29 1999-04-01 Esteve Labor Dr Tetrahidropiridinas (0 4-hidroxipiperidinas) alquilazoles.
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
FR2735127B1 (fr) * 1995-06-09 1997-08-22 Pf Medicament Nouvelles piperazines heteroaromatiques utiles comme medicaments.
SE9601110D0 (sv) * 1996-03-22 1996-03-22 Astra Ab Substituted 1,2,3,4-tetrahydronaphthalene derivatives
TR199801942T2 (xx) * 1996-03-29 2000-08-21 Duphar International Research B.V. Piperazin ve piperidin bile�ikleri.
FR2757161B1 (fr) * 1996-12-13 1999-03-12 Sanofi Sa Diphenylalkyl-tetrahydropyridines
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
US6077850A (en) 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
SE9900190D0 (sv) 1999-01-22 1999-01-22 Astra Ab New compounds
SE9702799D0 (sv) 1997-07-25 1997-07-25 Astra Ab New compounds
ATE253058T1 (de) 1997-09-02 2003-11-15 Duphar Int Res Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
US6436964B1 (en) 1998-06-30 2002-08-20 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems
EP1146045A1 (en) * 1998-06-30 2001-10-17 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems
UA71590C2 (en) * 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
AR022303A1 (es) 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
EP1196413A2 (en) * 1999-06-29 2002-04-17 Eli Lilly And Company Preparation of 7-substituted benzothiophenes
AR027134A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de indol.
FR2803298A1 (fr) * 1999-12-30 2001-07-06 Adir Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AR027133A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de heteroarilo, su preparacion y uso.
FR2804429B1 (fr) * 2000-01-31 2003-05-09 Adir Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2405758A1 (en) * 2000-05-12 2001-11-15 Solvay Pharmaceuticals B.V. Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders
DE10043659A1 (de) * 2000-09-05 2002-03-14 Merck Patent Gmbh Arylpiperazinderivate
US6743796B2 (en) 2001-05-07 2004-06-01 Wyeth Piperazinyl-isatins
EP1408976B3 (en) 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
NZ538713A (en) 2002-08-12 2007-01-26 Takeda Chemical Industries Ltd Fused benzene derivative and use
ES2297386T3 (es) 2003-03-03 2008-05-01 F. Hoffmann-La Roche Ag Tetrahidroisoquinolinas 2,5-sustituidas para uso como moduladores de 5-ht6.
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
US8389510B2 (en) * 2005-11-18 2013-03-05 Astrazeneca Ab Crystalline forms
EP2099459A4 (en) * 2006-12-20 2011-04-27 Astrazeneca Ab COMPOUNDS AND USES THEREOF
US8367676B2 (en) * 2009-06-30 2013-02-05 Astrazeneca Ab 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
WO2011069075A2 (en) 2009-12-04 2011-06-09 Grant Jon E Treating impulse control disorders with catechol-o- methyl-transferase inhibitors
CN106065018B (zh) * 2015-04-23 2020-04-21 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
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Also Published As

Publication number Publication date
MX9307779A (es) 1994-06-30
ZA939203B (en) 1994-08-08
DK148392D0 (da) 1992-12-09
HU9501668D0 (en) 1995-08-28
ATE176909T1 (de) 1999-03-15
CZ283143B6 (cs) 1998-01-14
ES2127912T3 (es) 1999-05-01
EP0673375A1 (en) 1995-09-27
NZ258117A (en) 1996-08-27
FI952824A (fi) 1995-06-08
RU95117096A (ru) 1997-06-10
WO1994013659A1 (en) 1994-06-23
IL107923A (en) 1999-08-17
AU5561894A (en) 1994-07-04
KR100299624B1 (ko) 2001-11-05
HUT73632A (en) 1996-08-28
SK76195A3 (en) 1995-11-08
DK0673375T3 (da) 1999-10-04
RU2141959C1 (ru) 1999-11-27
EP0673375B1 (en) 1999-02-24
NO311617B1 (no) 2001-12-17
CA2151378A1 (en) 1994-06-23
US6140331A (en) 2000-10-31
NO952275D0 (no) 1995-06-08
JPH08504410A (ja) 1996-05-14
NO952275L (no) 1995-08-03
IL107923A0 (en) 1994-04-12
CZ151795A3 (en) 1996-01-17
AU675263B2 (en) 1997-01-30
DE69323630T2 (de) 1999-10-14
KR950704294A (ko) 1995-11-17
FI952824A0 (fi) 1995-06-08
SK280779B6 (sk) 2000-07-11
SG52722A1 (en) 1998-09-28
DE69323630D1 (de) 1999-04-01
GR3030200T3 (en) 1999-08-31
US5753661A (en) 1998-05-19

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