ES8700652A1 - Un metodo de preparar n-4-(3-aminopropil)-aminobutil-2,2-di-hidroxietanoamida - Google Patents

Un metodo de preparar n-4-(3-aminopropil)-aminobutil-2,2-di-hidroxietanoamida

Info

Publication number
ES8700652A1
ES8700652A1 ES540729A ES540729A ES8700652A1 ES 8700652 A1 ES8700652 A1 ES 8700652A1 ES 540729 A ES540729 A ES 540729A ES 540729 A ES540729 A ES 540729A ES 8700652 A1 ES8700652 A1 ES 8700652A1
Authority
ES
Spain
Prior art keywords
glyoxylylspermidine
related compounds
producing
production
spergualin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540729A
Other languages
English (en)
Other versions
ES540729A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takara Shuzo Co Ltd
Nippon Kayaku Co Ltd
Original Assignee
Takara Shuzo Co Ltd
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Shuzo Co Ltd, Nippon Kayaku Co Ltd filed Critical Takara Shuzo Co Ltd
Publication of ES540729A0 publication Critical patent/ES540729A0/es
Publication of ES8700652A1 publication Critical patent/ES8700652A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO PARA LA PREPARACION DE N-4-(3-AMINOPROPIL)-AMINOBUTIL-2,2-DIHIDROXIETANOAMIDA DE FORMULA (I). COMPRENDE LA ESCISION OXIDANTE SELECTIVA DEL ENLACE C-C DEL COMPUESTO DE FORMULA GENERAL (II), DONDE R1 ES UN GRUPO HIDROXILO O AMINO PERO NO LOS DOS AMINO A LA VEZ, Y R2 UN H, ALQUILO, CARBOXILO, ALCOXICARBONILO O CARBAMOILO. LA ESCISION SE LLEVA A CABO EN UN DISOLVENTE A UNA TEMPERATURA ENTRE 0J Y EL PUNTO DE EBULLICION DEL DISOLVENTE DURANTE UN TIEMPO ENTRE UNOS CUANTOS MINUTOS Y VARIOS DIAS. APLICABLE COMO PRODUCTO INTERMEDIO PARA LA SINTESIS DEL ANTICANCERIGENO ESPERGUALINA.
ES540729A 1984-02-29 1985-02-27 Un metodo de preparar n-4-(3-aminopropil)-aminobutil-2,2-di-hidroxietanoamida Expired ES8700652A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59036263A JPS60181056A (ja) 1984-02-29 1984-02-29 Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法

Publications (2)

Publication Number Publication Date
ES540729A0 ES540729A0 (es) 1986-10-16
ES8700652A1 true ES8700652A1 (es) 1986-10-16

Family

ID=12464879

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540729A Expired ES8700652A1 (es) 1984-02-29 1985-02-27 Un metodo de preparar n-4-(3-aminopropil)-aminobutil-2,2-di-hidroxietanoamida

Country Status (16)

Country Link
US (1) US4603015A (es)
JP (1) JPS60181056A (es)
KR (1) KR900001076B1 (es)
AR (1) AR240553A1 (es)
AU (1) AU564211B2 (es)
CA (1) CA1226004A (es)
CH (1) CH665635A5 (es)
CS (1) CS268666B2 (es)
DE (1) DE3506330A1 (es)
DK (1) DK168762B1 (es)
ES (1) ES8700652A1 (es)
FR (1) FR2563829B1 (es)
GB (1) GB2155013B (es)
HU (1) HU193738B (es)
IT (1) IT1208798B (es)
SE (1) SE469130B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576757A (en) * 1984-04-26 1986-03-18 Johnson & Johnson Baby Products Company Process for the preparation of monoacyl polyalkylene polyamines
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
EP0241797B1 (en) * 1986-04-04 1991-06-12 Microbial Chemistry Research Foundation Novel spergualin-related compounds and process for producing the same
US5002756A (en) * 1988-04-04 1991-03-26 Zaidanhojin Biseibutsu Kagakukenkyukai Method for relieving radiogenic or drug-induced side effects
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
RU2171811C2 (ru) * 1989-05-29 2001-08-10 Такара Сузо Ко., Лтд., (Jp), Ниппон Каяку Кабусики Кайся КРИСТАЛЛИЧЕСКИЙ ТРИГИДРОХЛОРИД ДЕОКСИСПЕРГУАЛИНА В β-ФОРМЕ, ОБЛАДАЮЩИЙ ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ И СПОСОБ ЕГО ПОЛУЧЕНИЯ
US5196453A (en) * 1989-05-29 1993-03-23 Takara Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
US5352387A (en) * 1992-11-25 1994-10-04 Lever Brothers Company Alkyl glyceramide surfactants and compositions comprising these surfactants
US5352386A (en) * 1992-11-25 1994-10-04 Lever Brothers Company Compositions free of boron comprising N-alkylerythronamides and N-alkylxylonamides as surfactants

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2904490A1 (de) * 1979-02-07 1980-08-21 Bayer Ag Verfahren zur herstellung von alpha -hydroxycarbonsaeureamiden
DE2944456C2 (de) * 1979-11-03 1982-04-01 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von N-α -Alkoxyalkyl-carbonsäureamiden
IT8248390A0 (it) * 1981-05-11 1982-05-11 Zaidan Hojin Biseidutsu Kagaku N-[4-(3-amminopropil)amminobutil]2,2-diidrossiotanammide come immuno -stimolante ed intermedio per laproduzione di sostanze carcinostati che, e procedimento per la sua preparazione
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5952263A (ja) * 1982-09-18 1984-03-26 Minolta Camera Co Ltd 静電潜像現像装置
US4448905A (en) * 1982-09-30 1984-05-15 Gaf Corporation Alcohol substituted amides as chain extenders for polyurethanes

Also Published As

Publication number Publication date
ES540729A0 (es) 1986-10-16
GB8505049D0 (en) 1985-03-27
JPH0350749B2 (es) 1991-08-02
SE8500845D0 (sv) 1985-02-21
CS268666B2 (en) 1990-04-11
AU3914485A (en) 1985-09-05
AU564211B2 (en) 1987-08-06
CS139285A2 (en) 1989-08-14
GB2155013A (en) 1985-09-18
AR240553A1 (es) 1990-05-31
DK168762B1 (da) 1994-06-06
FR2563829B1 (fr) 1988-10-14
JPS60181056A (ja) 1985-09-14
IT1208798B (it) 1989-07-10
DE3506330A1 (de) 1985-08-29
KR900001076B1 (ko) 1990-02-26
CH665635A5 (de) 1988-05-31
SE8500845L (sv) 1985-08-30
HUT36781A (en) 1985-10-28
US4603015A (en) 1986-07-29
GB2155013B (en) 1988-04-27
CA1226004A (en) 1987-08-25
DK86485A (da) 1985-08-30
SE469130B (sv) 1993-05-17
KR850006926A (ko) 1985-10-25
FR2563829A1 (fr) 1985-11-08
DE3506330C2 (es) 1989-10-26
IT8567205A0 (it) 1985-02-27
HU193738B (en) 1987-11-30
DK86485D0 (da) 1985-02-26

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20040705