ES8304571A1 - "procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas". - Google Patents

"procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas".

Info

Publication number
ES8304571A1
ES8304571A1 ES512846A ES512846A ES8304571A1 ES 8304571 A1 ES8304571 A1 ES 8304571A1 ES 512846 A ES512846 A ES 512846A ES 512846 A ES512846 A ES 512846A ES 8304571 A1 ES8304571 A1 ES 8304571A1
Authority
ES
Spain
Prior art keywords
tetrahydropyrazolo
diazepin
pyrido
ones
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512846A
Other languages
English (en)
Other versions
ES512846A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8304571A1 publication Critical patent/ES8304571A1/es
Publication of ES512846A0 publication Critical patent/ES512846A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1,4,9,10-TETRAHIDRO-PIRAZOLO 4,3-E PIRIDO 3,2-B 1,4 DIAZEPIN- 10-ONAS, DE FORMULA (I) EN LA QUE R ES HIDROGENO O ALCOHILO C <- ; R ES ALCOHILO C <- ; R ES HIDROGENO O ALCOHILO C <- ; Y R ES HIDROGENO O ALCOHILO C <- . CONSISTE EN LA REACCION DE CICLIZACION DE UN N-(2-HALOGENO-3-PIRIDINIL)-4-AMINO-1H-PIRAZOL-5-CARBOXAMIDA, DE FORMULA (II), EN LA QUE R -R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y HAL ES UN ATOMO DE HALOGENO. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE, EVENTUALMENTE EN PRESENCIA DE UN ACIDO MINERAL, COMO CATALIZADOR, A UNA TEMPERATURA ENTRE 80 C Y 200 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO ANALGESICO, ANTIFLOGISTICO Y ANTIPIRETICO.
ES512846A 1981-06-06 1982-06-04 "procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas". Granted ES512846A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813122670 DE3122670A1 (de) 1981-06-06 1981-06-06 "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"

Publications (2)

Publication Number Publication Date
ES8304571A1 true ES8304571A1 (es) 1983-03-01
ES512846A0 ES512846A0 (es) 1983-03-01

Family

ID=6134176

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512846A Granted ES512846A0 (es) 1981-06-06 1982-06-04 "procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas".

Country Status (27)

Country Link
US (1) US4381303A (es)
EP (1) EP0066774B1 (es)
JP (1) JPS57212182A (es)
KR (1) KR880001719B1 (es)
AR (1) AR229124A1 (es)
AT (1) ATE10744T1 (es)
AU (1) AU552765B2 (es)
CA (1) CA1167440A (es)
CS (1) CS226743B2 (es)
DD (1) DD202574A5 (es)
DE (2) DE3122670A1 (es)
DK (1) DK253382A (es)
ES (1) ES512846A0 (es)
FI (1) FI71560C (es)
GB (1) GB2117755B (es)
GR (1) GR76438B (es)
HU (1) HU186067B (es)
IE (1) IE53067B1 (es)
IL (1) IL65977A (es)
NO (1) NO158063C (es)
NZ (1) NZ200859A (es)
PH (1) PH17719A (es)
PL (1) PL135845B1 (es)
PT (1) PT75016B (es)
SU (1) SU1103795A3 (es)
YU (1) YU118282A (es)
ZA (1) ZA823919B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3643666A1 (de) * 1986-12-20 1988-06-30 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4749788A (en) * 1987-04-13 1988-06-07 A. H. Robins Company, Incorporated Process for the preparation of aryl-pyrido(1,4) benzodiazepines
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
EP0410148B1 (en) * 1989-06-28 1994-04-06 Boehringer Ingelheim Pharmaceuticals Inc. Novel 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and thiones and their use in the prevention or treatment of AIDS
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
ES2137113B1 (es) 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450694A (en) * 1966-02-23 1969-06-17 Abbott Lab Substituted benzoxazepines and benzothiazepines
DE2707269A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
NO802326L (no) * 1979-08-03 1981-02-04 Byk Gulden Lomberg Chem Fab Fremgangsmaate ved fremstilling av substituerte tetraazatricyklen

Also Published As

Publication number Publication date
KR840000543A (ko) 1984-02-25
US4381303A (en) 1983-04-26
JPS57212182A (en) 1982-12-27
ZA823919B (en) 1984-02-29
AR229124A1 (es) 1983-06-15
PL236742A1 (en) 1984-03-26
GB2117755B (en) 1985-01-30
HU186067B (en) 1985-05-28
YU118282A (en) 1986-04-30
GB2117755A (en) 1983-10-19
IL65977A (en) 1984-12-31
DK253382A (da) 1982-12-07
NO821882L (no) 1982-12-07
IE821350L (en) 1982-12-06
FI821992A0 (fi) 1982-06-04
PT75016B (de) 1985-05-17
IE53067B1 (en) 1988-05-25
NO158063B (no) 1988-03-28
PL135845B1 (en) 1985-12-31
DD202574A5 (de) 1983-09-21
DE3261530D1 (en) 1985-01-24
CS226743B2 (en) 1984-04-16
KR880001719B1 (ko) 1988-09-08
AU8460582A (en) 1982-12-16
ES512846A0 (es) 1983-03-01
FI71560B (fi) 1986-10-10
DE3122670A1 (de) 1982-12-23
FI71560C (fi) 1987-01-19
SU1103795A3 (ru) 1984-07-15
NO158063C (no) 1988-07-06
EP0066774B1 (de) 1984-12-12
PH17719A (en) 1984-11-21
CA1167440A (en) 1984-05-15
GR76438B (es) 1984-08-10
NZ200859A (en) 1985-08-16
ATE10744T1 (de) 1984-12-15
IL65977A0 (en) 1982-09-30
EP0066774A1 (de) 1982-12-15
PT75016A (de) 1982-07-01
AU552765B2 (en) 1986-06-19

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