ES8301998A1 - Un procedimiento para la produccion de nuevas cefalosporinas. - Google Patents
Un procedimiento para la produccion de nuevas cefalosporinas.Info
- Publication number
- ES8301998A1 ES8301998A1 ES505760A ES505760A ES8301998A1 ES 8301998 A1 ES8301998 A1 ES 8301998A1 ES 505760 A ES505760 A ES 505760A ES 505760 A ES505760 A ES 505760A ES 8301998 A1 ES8301998 A1 ES 8301998A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- substituted
- attached
- carbon
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE CEFALOSPORINAS Y DE SUS SALES, DE FORMULA (I), EN LA QUE R ES HIDROGENO O GRUPO PROTECTOR DE CARBOXILO; R ES HIDROGENO O HALOGENO; R ES HIDROGENO O AMINO; B ES HIDROGENO O ALCOXI INFERIOR; Y R Y A PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE ACILACION ENTRE UN COMPUESTO DE FORMULA (II), O UNA SAL DEL MISMO, CON UN COMPUESTO DE FORMULA (III) O UN DERIVADO REACTIVO, EN LAS QUE R PUEDEN SER UNO DE VARIOS RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA ENTRE -50<025>C Y 40<025>C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIALES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55132253A JPS5758689A (en) | 1980-09-25 | 1980-09-25 | Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids |
JP55158184A JPS5782393A (en) | 1980-11-12 | 1980-11-12 | 7-amino-3-(2-(1,2,3,4-tetrazolyl)methyl)cephem-4-carboxylic acid |
JP55175263A JPS6052755B2 (ja) | 1980-12-13 | 1980-12-13 | 新規セファロスポリン類 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8301998A1 true ES8301998A1 (es) | 1983-01-01 |
ES505760A0 ES505760A0 (es) | 1983-01-01 |
Family
ID=27316463
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES505760A Granted ES505760A0 (es) | 1980-09-25 | 1981-09-24 | Un procedimiento para la produccion de nuevas cefalosporinas. |
ES514670A Granted ES514670A0 (es) | 1980-09-25 | 1982-08-02 | Un procedimiento para la produccion de nuevas cefalosporinas. |
ES514669A Granted ES514669A0 (es) | 1980-09-25 | 1982-08-02 | Un procedimiento para la produccion de nuevas cefalosporinas. |
ES514671A Expired ES8306157A1 (es) | 1980-09-25 | 1982-08-02 | Un procedimiento para la produccion de un acido 7-(amino sustituido o no sustituido)-3-metil sustituido-a3-cefem-4-carboxilico. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514670A Granted ES514670A0 (es) | 1980-09-25 | 1982-08-02 | Un procedimiento para la produccion de nuevas cefalosporinas. |
ES514669A Granted ES514669A0 (es) | 1980-09-25 | 1982-08-02 | Un procedimiento para la produccion de nuevas cefalosporinas. |
ES514671A Expired ES8306157A1 (es) | 1980-09-25 | 1982-08-02 | Un procedimiento para la produccion de un acido 7-(amino sustituido o no sustituido)-3-metil sustituido-a3-cefem-4-carboxilico. |
Country Status (27)
Country | Link |
---|---|
US (4) | US4489072A (es) |
KR (1) | KR860000932B1 (es) |
AR (1) | AR240645A1 (es) |
AT (4) | AT375082B (es) |
AU (3) | AU550330B2 (es) |
CA (2) | CA1204735A (es) |
CH (4) | CH652129A5 (es) |
DD (2) | DD202436A5 (es) |
DE (5) | DE3152934C2 (es) |
DK (1) | DK163877C (es) |
EG (1) | EG17373A (es) |
ES (4) | ES505760A0 (es) |
FI (2) | FI75575C (es) |
FR (2) | FR2509310B1 (es) |
GB (3) | GB2089339B (es) |
HU (1) | HU185850B (es) |
IN (4) | IN155375B (es) |
IT (1) | IT1172201B (es) |
LU (1) | LU83650A1 (es) |
MX (1) | MX155025A (es) |
NL (1) | NL8104386A (es) |
NO (1) | NO161117C (es) |
NZ (1) | NZ198350A (es) |
PH (5) | PH18072A (es) |
PT (1) | PT73727B (es) |
RO (4) | RO86825B (es) |
SE (5) | SE453090B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703046A (en) * | 1978-09-08 | 1987-10-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and processes for preparation thereof |
NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
EP0061234A3 (en) * | 1981-03-05 | 1983-11-16 | Beecham Group Plc | Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them |
US4576938A (en) * | 1981-12-08 | 1986-03-18 | Tanabe Seiyaku Co., Ltd. | Cephalosporin compound and process for preparing the same |
US4618606A (en) * | 1982-11-17 | 1986-10-21 | Toyama Chemical Co., Ltd. | Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins |
DK521883A (da) * | 1982-11-17 | 1984-05-18 | Toyama Chemical Co Ltd | Cephalosporinderivater, fremgangsmaade til fremstilling heraf og fremgangsmaade til fremstilling af mellemprodukter herfor |
JPS6064986A (ja) * | 1983-09-20 | 1985-04-13 | Toyama Chem Co Ltd | セファロスポリン類の製造法 |
JPS60190783A (ja) * | 1983-12-21 | 1985-09-28 | Sumitomo Seiyaku Kk | セフエム系化合物 |
GB8406231D0 (en) * | 1984-03-09 | 1984-04-11 | Fujisawa Pharmaceutical Co | Cephem compounds |
GB2161476B (en) * | 1984-05-25 | 1988-01-27 | Toyama Chemical Co Ltd | 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins |
AT397086B (de) * | 1984-05-25 | 1994-01-25 | Toyama Chemical Co Ltd | Verfahren zur herstellung von neuen 2-(2-aminothiazol-4-4yl)-2-(syn)-alkoxyimino- acetamiden |
FI851934L (fi) * | 1984-05-30 | 1985-12-01 | Ici Plc | Kefalosporinderivat. |
DE3539901A1 (de) * | 1985-11-11 | 1987-05-14 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
JPH064643B2 (ja) * | 1985-12-20 | 1994-01-19 | ファイザー製薬株式会社 | セフアロスポリン化合物 |
US4692517A (en) * | 1986-03-20 | 1987-09-08 | American Home Products Corporation | C-3' acylaminooxy-7-[(2-aminothiazol-4-yl)-α-(substituted-oximino)acetyl]cephalosporin derivatives |
EP0265185A3 (en) * | 1986-10-21 | 1990-03-28 | Beecham Group Plc | Cephalosporins, processes for their preparation and pharmaceutical compositions containing them |
ZA877987B (en) * | 1986-11-12 | 1988-08-31 | Ici Pharma | Antibiotic compounds |
DE3750673T2 (de) * | 1986-11-21 | 1995-03-16 | Ici Pharma | Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate. |
EP0269298B1 (en) * | 1986-11-21 | 1994-10-19 | Ici Pharma | Cephalosporins, process for their preparation and pharmaceutical compositions |
US4847373A (en) * | 1987-02-26 | 1989-07-11 | Bristol-Myers Company | Production of 3-allyl- and 3-butenyl-3-cephems |
US5232918A (en) * | 1987-07-23 | 1993-08-03 | Imperial Chemical Industries Plc | Cephalosporin derivatives |
GB8816519D0 (en) * | 1987-07-23 | 1988-08-17 | Ici Plc | Antibiotic compounds |
GB8811056D0 (en) * | 1988-05-10 | 1988-06-15 | Ici Plc | Antibiotic compounds |
JPH0699443B2 (ja) * | 1989-09-29 | 1994-12-07 | ファイザー製薬株式会社 | セファロスポリン化合物 |
US6800756B2 (en) * | 2002-05-03 | 2004-10-05 | Orchid Chemicals And Pharmaceuticals, Ltd. | Method for the preparation of ceftiofur sodium and its intermediates |
DE602004028111D1 (de) * | 2003-04-16 | 2010-08-26 | Sandoz Ag | Verfahren zur herstellung von cefepim |
US7847093B2 (en) * | 2003-04-16 | 2010-12-07 | Sandoz Ag | Processes for the preparations of cefepime |
JP2007530589A (ja) * | 2004-03-26 | 2007-11-01 | アンフォラ ディスカバリー コーポレーション | 特定のトリアゾールを基礎とする化合物、組成物、およびそれらの使用 |
US8198434B2 (en) | 2008-05-07 | 2012-06-12 | Idexx Laboratories, Inc. | Process for preparing cefsulodin sodium |
CA2828114A1 (en) * | 2010-02-26 | 2011-09-01 | Gary Igor DMITRIENKO | Cephalosporin derivatives useful as .beta.-lactamase inhibitors and compositions and methods of use thereof |
CN102351886B (zh) * | 2011-09-07 | 2013-10-16 | 山东罗欣药业股份有限公司 | 头孢特仑新戊酯晶体、其制备方法及含有该晶体的组合物片剂 |
SG11201600108PA (en) | 2013-07-17 | 2016-02-26 | Otsuka Pharma Co Ltd | Cyanotriazole compounds |
CN106046026B (zh) * | 2016-06-30 | 2018-07-06 | 济南康和医药科技有限公司 | 一种头孢特仑新戊酯的制备方法 |
CN112645842B (zh) * | 2020-12-25 | 2022-08-19 | 复旦大学 | 一种氰乙酸叔丁酯的连续流制备方法 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB912541A (en) * | 1958-03-17 | 1962-12-12 | Nat Res Dev | Cephalosporin c compounds |
DE1795484U (de) | 1959-04-21 | 1959-09-10 | Richard Langer | Quertraeger fuer laengsdraehte zum abstuetzen von pflanzen, insbesondere weinreben. |
GB1032641A (en) | 1962-02-16 | 1966-06-15 | Edward Penley Abraham | Cephalosporins |
GB1057883A (en) * | 1962-07-11 | 1967-02-08 | Glaxo Lab Ltd | Improvements in or relating to antibiotics |
US3226384A (en) | 1963-01-25 | 1965-12-28 | Nat Res Dev | Cephalosporin ca derivatives |
BE634644A (es) * | 1963-07-10 | |||
US3821206A (en) * | 1966-12-15 | 1974-06-28 | Glaxo Lab Ltd | Cephalosporins having a polyazole substituent |
GB1211694A (en) | 1966-12-15 | 1970-11-11 | Glaxo Lab Ltd | Derivatives of 7-aminocephalosporanic acid |
DE2132883A1 (de) * | 1970-07-08 | 1972-01-13 | Ciba Geigy Ag | Cephemverbindungen |
US3932465A (en) * | 1970-07-08 | 1976-01-13 | Ciba-Geigy Corporation | 3-R-methyl-7-amino-ceph-em-4-carboxylic acid compounds |
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
US4343937A (en) * | 1971-06-02 | 1982-08-10 | Merck & Co., Inc. | 3-Substituted-7-methoxy-7-amino-3-cephem-4-carboxylic acids |
SU589918A3 (ru) * | 1971-07-14 | 1978-01-25 | Мерк Энд Ко Инк (Фирма) | Способ получени сложного эфира 3-замещенной метил-7-ациломидо-7-метокси-2-цефем -4- карбоноаой кислоты |
JPS5653557B2 (es) * | 1973-10-15 | 1981-12-19 | ||
CH605997A5 (es) * | 1974-08-30 | 1978-10-13 | Ciba Geigy Ag | |
SE432254B (sv) * | 1975-02-04 | 1984-03-26 | Fujisawa Pharmaceutical Co | Analogiforfarande for framstellning av 3-substituerade 7-(alfa,alfa-disubstituerade acetamido)-3-cefem-4-karboxylsyror |
GB1547165A (en) * | 1975-08-15 | 1979-06-06 | Beecham Group Ltd | 3-carbamoylbenzyl and 3-(carbamoylpyridylmethyl)-cephems |
GB1575803A (en) * | 1976-03-09 | 1980-10-01 | Fujisawa Pharmaceutical Co | 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof |
US4165430A (en) * | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
JPS5946237B2 (ja) * | 1976-04-02 | 1984-11-10 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
DE2760484C2 (es) * | 1976-04-14 | 1992-12-03 | Takeda Chemical Industries, Ltd., Osaka, Jp | |
GB1565941A (en) | 1977-02-08 | 1980-04-23 | Toyama Chemical Co Ltd | Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids |
ES467601A1 (es) * | 1977-03-12 | 1979-06-16 | Hoechst Ag | Procedimiento para la preparacion de derivados de cefem. |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
US4148997A (en) * | 1977-11-07 | 1979-04-10 | Yeda Research And Development Co., Ltd. | 7-[Sulfomethyl)phenyl]acetamidocephalosporin derivatives |
AR229883A1 (es) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato |
DE2822861A1 (de) * | 1978-05-26 | 1979-11-29 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
JPS6027677B2 (ja) | 1978-07-06 | 1985-06-29 | 富山化学工業株式会社 | 7−置換又は非置換アミノ−3−置換チオメチルセフエムカルボン酸類の新規製造法 |
NZ191937A (en) | 1978-10-27 | 1982-09-07 | Glaxo Group Ltd | Cephalosporin anti-biotics with a 3-alkyl-1,2,3-triazolium-1-ylmethyl group at the 3-position |
NZ192127A (en) * | 1978-11-15 | 1982-12-21 | Glaxo Group Ltd | Cephalosporin antibiotics |
AT367766B (de) * | 1979-02-23 | 1982-07-26 | Glaxo Group Ltd | Verfahren zur herstellung von neuen cephalosporin-antibiotika |
JPS55139387A (en) | 1979-04-19 | 1980-10-31 | Yamanouchi Pharmaceut Co Ltd | Novel synthetic method of 7-amino-3-heterocyclic thiomethyl-delta3-carboxylic acids |
JPS55153790A (en) | 1979-05-17 | 1980-11-29 | Yamanouchi Pharmaceut Co Ltd | Preparation of 7-amino-3-heterocyclic thiomethyl-delta3- cephem-4-carboxylic acid |
FR2461713A1 (fr) * | 1979-07-19 | 1981-02-06 | Roussel Uclaf | Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
EP0061234A3 (en) * | 1981-03-05 | 1983-11-16 | Beecham Group Plc | Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them |
EP0074611B1 (en) * | 1981-09-10 | 1987-07-22 | Takeda Chemical Industries, Ltd. | Method for production of cephalosporin compounds |
JPS6064986A (ja) * | 1983-09-20 | 1985-04-13 | Toyama Chem Co Ltd | セファロスポリン類の製造法 |
GB2161476B (en) * | 1984-05-25 | 1988-01-27 | Toyama Chemical Co Ltd | 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins |
CA1293719C (en) * | 1986-09-22 | 1991-12-31 | Takao Takaya | Cephem compounds and processes for preparation thereof |
-
1981
- 1981-09-14 NZ NZ198350A patent/NZ198350A/en unknown
- 1981-09-16 CA CA000386066A patent/CA1204735A/en not_active Expired
- 1981-09-16 PH PH26215A patent/PH18072A/en unknown
- 1981-09-16 GB GB8128011A patent/GB2089339B/en not_active Expired
- 1981-09-17 AU AU75438/81A patent/AU550330B2/en not_active Expired
- 1981-09-19 IN IN1045/CAL/81A patent/IN155375B/en unknown
- 1981-09-23 DE DE3152934A patent/DE3152934C2/de not_active Expired - Lifetime
- 1981-09-23 DE DE3152931A patent/DE3152931C2/de not_active Expired
- 1981-09-23 DE DE3152935A patent/DE3152935C2/de not_active Expired - Lifetime
- 1981-09-23 NL NL8104386A patent/NL8104386A/xx not_active Application Discontinuation
- 1981-09-23 DE DE3152932A patent/DE3152932C2/de not_active Expired - Lifetime
- 1981-09-23 US US06/304,912 patent/US4489072A/en not_active Expired - Lifetime
- 1981-09-23 IT IT49348/81A patent/IT1172201B/it active
- 1981-09-23 DE DE19813137854 patent/DE3137854A1/de active Granted
- 1981-09-24 PT PT73727A patent/PT73727B/pt unknown
- 1981-09-24 NO NO813252A patent/NO161117C/no unknown
- 1981-09-24 DK DK421881A patent/DK163877C/da active
- 1981-09-24 AT AT0410981A patent/AT375082B/de not_active IP Right Cessation
- 1981-09-24 SE SE8105658A patent/SE453090B/sv not_active IP Right Cessation
- 1981-09-24 MX MX7609A patent/MX155025A/es unknown
- 1981-09-24 ES ES505760A patent/ES505760A0/es active Granted
- 1981-09-24 HU HU812759A patent/HU185850B/hu unknown
- 1981-09-24 FI FI812980A patent/FI75575C/fi not_active IP Right Cessation
- 1981-09-24 LU LU83650A patent/LU83650A1/fr unknown
- 1981-09-25 DD DD81233599A patent/DD202436A5/de unknown
- 1981-09-25 CH CH6202/81A patent/CH652129A5/de not_active IP Right Cessation
- 1981-09-25 CH CH4519/84A patent/CH651837A5/de not_active IP Right Cessation
- 1981-09-25 RO RO112113A patent/RO86825B/ro unknown
- 1981-09-25 CH CH4520/84A patent/CH652130A5/de not_active IP Right Cessation
- 1981-09-25 DD DD81247292A patent/DD208351A5/de unknown
- 1981-09-25 RO RO112111A patent/RO86823B/ro unknown
- 1981-09-25 RO RO81105405A patent/RO82689A/ro unknown
- 1981-09-25 FR FR8118156A patent/FR2509310B1/fr not_active Expired
- 1981-09-25 CH CH4521/84A patent/CH652128A5/de not_active IP Right Cessation
- 1981-09-25 RO RO112112A patent/RO86824B/ro unknown
- 1981-09-26 EG EG543/81A patent/EG17373A/xx active
-
1982
- 1982-08-02 ES ES514670A patent/ES514670A0/es active Granted
- 1982-08-02 ES ES514669A patent/ES514669A0/es active Granted
- 1982-08-02 ES ES514671A patent/ES8306157A1/es not_active Expired
- 1982-09-22 FR FR8215992A patent/FR2511377B1/fr not_active Expired
-
1983
- 1983-01-07 AR AR29180883A patent/AR240645A1/es active
- 1983-02-18 AT AT0055683A patent/AT378193B/de not_active IP Right Cessation
- 1983-02-18 AT AT0055483A patent/AT378961B/de not_active IP Right Cessation
- 1983-02-18 AT AT0055583A patent/AT378962B/de not_active IP Right Cessation
- 1983-06-17 PH PH29076A patent/PH19147A/en unknown
- 1983-06-17 PH PH29075A patent/PH19251A/en unknown
- 1983-06-17 PH PH29078A patent/PH18484A/en unknown
- 1983-06-17 PH PH29077A patent/PH20221A/en unknown
- 1983-09-01 CA CA000435930A patent/CA1200541A/en not_active Expired
-
1984
- 1984-01-27 GB GB08402249A patent/GB2135304B/en not_active Expired
- 1984-01-27 GB GB08402250A patent/GB2136420B/en not_active Expired
- 1984-08-29 IN IN603/CAL/84A patent/IN159126B/en unknown
- 1984-08-29 IN IN601/CAL/84A patent/IN158589B/en unknown
- 1984-08-29 IN IN602/CAL/84A patent/IN158590B/en unknown
- 1984-09-26 US US06/654,681 patent/US4673738A/en not_active Expired - Lifetime
-
1985
- 1985-11-13 AU AU49862/85A patent/AU558649B2/en not_active Expired
- 1985-11-13 AU AU49861/85A patent/AU568033B2/en not_active Expired
-
1986
- 1986-01-16 SE SE8600193A patent/SE468479B/sv not_active IP Right Cessation
- 1986-01-16 SE SE8600194A patent/SE468476B/sv not_active IP Right Cessation
- 1986-01-16 SE SE8600195A patent/SE468477B/sv not_active IP Right Cessation
- 1986-01-16 SE SE8600192A patent/SE468478B/sv not_active IP Right Cessation
- 1986-03-29 KR KR1019860002383A patent/KR860000932B1/ko not_active IP Right Cessation
-
1987
- 1987-01-15 FI FI870153A patent/FI80041C/fi not_active IP Right Cessation
- 1987-03-06 US US07/022,433 patent/US4879381A/en not_active Expired - Lifetime
-
1991
- 1991-05-24 US US07/707,221 patent/US5144027A/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8301998A1 (es) | Un procedimiento para la produccion de nuevas cefalosporinas. | |
AU552147B2 (en) | Quinoline derivatives | |
EP0144986A3 (en) | Indole-3-carboxamide derivatives | |
IE832654L (en) | ß-LACTAM COMPOUNDS | |
ES8505691A1 (es) | Un procedimiento para preparar derivados de cefem | |
ES2001773A6 (es) | Un procedimiento para preparar un compuesto de cefalosporina | |
AU556922B2 (en) | Pyridobenzodiazepinone derivatives | |
ES462012A1 (es) | Un procedimiento para preparar derivados de cefalosporinas. | |
ES8407052A1 (es) | Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas | |
IE820238L (en) | Carbapenem derivatives | |
ES8307821A1 (es) | "procedimiento para la preparacion de nuevas cefalosporinas". | |
ES8607321A1 (es) | Un procedimiento de produccion de una cefalosporina | |
ES436173A1 (es) | Procedimiento para la preparacion de hidrazinocefalospori- nas. | |
IE45116L (en) | Preparation of 3-methylene-cephalosporins. | |
ES8301484A1 (es) | Procedimiento para la obtencion de compuestos de aminohidro-xifenilo | |
ES8506012A1 (es) | Procedimiento para la preparacion de derivados de acridanona | |
ES8105325A1 (es) | Un procedimiento para la preparacion de una composicion far-maceutica de derivados del acido penicilanico. | |
ES8404359A1 (es) | Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulanico. | |
GB916204A (en) | Penicillins | |
JPS57136587A (en) | Preparation of cephalosporin derivative | |
JPS57102893A (en) | Cephalosporin derivative |