ES508453A0 - Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina. - Google Patents

Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina.

Info

Publication number
ES508453A0
ES508453A0 ES508453A ES508453A ES508453A0 ES 508453 A0 ES508453 A0 ES 508453A0 ES 508453 A ES508453 A ES 508453A ES 508453 A ES508453 A ES 508453A ES 508453 A0 ES508453 A0 ES 508453A0
Authority
ES
Spain
Prior art keywords
amino
preparing
procedure
hydroxyquinazoline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES508453A
Other languages
English (en)
Other versions
ES8308314A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Publication of ES8308314A1 publication Critical patent/ES8308314A1/es
Publication of ES508453A0 publication Critical patent/ES508453A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES508453A 1979-12-19 1981-12-30 Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina. Granted ES508453A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7943715 1979-12-19
GB8006813 1980-02-28

Publications (2)

Publication Number Publication Date
ES8308314A1 ES8308314A1 (es) 1983-09-01
ES508453A0 true ES508453A0 (es) 1983-09-01

Family

ID=26273917

Family Applications (3)

Application Number Title Priority Date Filing Date
ES497884A Granted ES497884A0 (es) 1979-12-19 1980-12-18 Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina
ES508454A Expired ES8307762A1 (es) 1979-12-19 1981-12-30 Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina.
ES508453A Granted ES508453A0 (es) 1979-12-19 1981-12-30 Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES497884A Granted ES497884A0 (es) 1979-12-19 1980-12-18 Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina
ES508454A Expired ES8307762A1 (es) 1979-12-19 1981-12-30 Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina.

Country Status (17)

Country Link
US (2) US4447608A (es)
EP (1) EP0031237B1 (es)
AU (1) AU543237B2 (es)
CA (1) CA1184900A (es)
DE (1) DE3069468D1 (es)
DK (1) DK157019C (es)
ES (3) ES497884A0 (es)
FI (1) FI76791C (es)
GB (1) GB2065653B (es)
GR (1) GR72847B (es)
HU (1) HU193505B (es)
IE (1) IE51188B1 (es)
IL (1) IL61756A (es)
NO (1) NO154919C (es)
NZ (1) NZ195876A (es)
PT (1) PT72232B (es)
YU (1) YU321180A (es)

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US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
US5187167A (en) * 1986-03-27 1993-02-16 Imperial Chemical Industries Plc Pharmaceutical compositions comprising quinazolin-4-one derivatives
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4833145A (en) * 1986-06-30 1989-05-23 The Trustees Of Princeton University 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
US5223620A (en) * 1988-04-01 1993-06-29 Takeda Chemical Industries, Ltd. Pyrido[2,3-d]pyrimidine compounds useful as intermediates
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
EP0365763A1 (en) * 1988-09-30 1990-05-02 Agouron Pharmaceuticals, Inc. Antiproliferative cyclic compounds
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5252573A (en) * 1988-12-15 1993-10-12 Imperial Chemical Industries Plc Anti-tumor agents
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US5160727A (en) * 1990-02-13 1992-11-03 Warner-Lambert Company Tumor cell sensitization method using quinazolinedione derivatives
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
ZA913730B (en) * 1990-05-30 1992-02-26 Ici Plc Anti-tumor compounds
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
US5145854A (en) * 1991-11-27 1992-09-08 Nair Madhavan G 1-formyl-5,8,10-trideazafolates
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
CH684644A5 (de) * 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
US5821231A (en) * 1993-12-06 1998-10-13 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using same
CA2177840A1 (en) * 1993-12-06 1995-06-15 Thomas S. Arrhenius Cs-1 peptidomimetics, compositions and methods of using the same
WO1995015973A1 (en) * 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
US5770573A (en) * 1993-12-06 1998-06-23 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
US5593999A (en) * 1995-06-07 1997-01-14 Nair; Madhavan G. Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
AU5984296A (en) * 1995-06-07 1996-12-30 Sugen, Inc. Quinazolines and pharmaceutical compositions
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
AU5596998A (en) * 1996-12-11 1998-07-03 New York University Medical Center Pyk2 related products and methods
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US6388063B1 (en) * 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
EP1049786A2 (en) 1998-01-21 2000-11-08 Sugen, Inc. Human orthologues of wart
JP2002522009A (ja) 1998-04-14 2002-07-23 スージェン・インコーポレーテッド Ｓｔｅ−２０関連蛋白質キナーゼ
US6861442B1 (en) * 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
GB9904275D0 (en) 1999-02-24 1999-04-21 Cancer Res Campaign Tech Anti-cancer compounds
US6521607B1 (en) 1999-09-23 2003-02-18 Pharmacia Corporation (R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US6476057B1 (en) 1999-09-23 2002-11-05 G.D. Searle & Co. Use of substituted N, N-disubstituted cycloalkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity
US6677382B1 (en) 1999-09-23 2004-01-13 Pharmacia Corporation Substituted N,N-bis-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US6835546B1 (en) 1999-10-22 2004-12-28 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
CA2388865A1 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Novel g protein-coupled receptors
US6143776A (en) * 2000-02-02 2000-11-07 Sunesis Pharmaceuticals, Inc. Tosylproline analogs as thymidylate synthase inhibitors
US20030003451A1 (en) * 2000-02-23 2003-01-02 Gabriel Vogeli Novel G protein-coupled receptors
US20030027308A1 (en) * 2000-05-30 2003-02-06 Sugen Incorporated Novel human protein phosphatases identified from genomic sequencing
CA2321345A1 (fr) * 2000-10-02 2002-04-02 Abdelbast Guerfi Utilisation du graphite dans un composite pour reduire l'accumulation de glace
US20040157306A1 (en) * 2000-11-13 2004-08-12 Sugen Incorporated Mammalian protein phosphatases
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
DE60237902D1 (de) 2001-08-31 2010-11-18 Btg Int Ltd ANTIKREBS-CYCLOPENTAiG CHINAZOLINE-DERIVATE
ATE526028T1 (de) 2001-08-31 2011-10-15 Btg Int Ltd Verwendung von cyclopentaägüchinazoline-derivaten zur krebsbehandlung
WO2003042390A1 (en) * 2001-11-13 2003-05-22 Sugen, Inc. Mammalian protein phosphatases
US7537774B2 (en) * 2005-12-23 2009-05-26 Orion Therapeautics, Llc Therapeutic formulation
US20110008347A1 (en) * 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
DK2150514T3 (en) 2007-04-11 2019-02-18 Merck & Cie 18F-LABELED FOLATES
US8273617B2 (en) 2009-09-30 2012-09-25 Suvolta, Inc. Electronic devices and systems, and methods for making and using the same

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* Cited by examiner, † Cited by third party
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GB1021196A (en) * 1964-02-20 1966-03-02 Parke Davis & Co Novel amino acids and means for producing the same
US3471498A (en) * 1967-08-11 1969-10-07 Parke Davis & Co Certain n-p-((2,4-diamino-6-quinazolinyl)-methyl)benzoylamino acids

Also Published As

Publication number Publication date
DK157019C (da) 1990-03-26
IE51188B1 (en) 1986-10-29
AU543237B2 (en) 1985-04-04
ES8300716A1 (es) 1982-11-01
DK540080A (da) 1981-06-20
EP0031237A1 (en) 1981-07-01
ES508454A0 (es) 1983-08-01
FI76791C (fi) 1988-12-12
GB2065653B (en) 1983-03-09
NO154919B (no) 1986-10-06
US4447608A (en) 1984-05-08
IL61756A0 (en) 1981-01-30
GR72847B (es) 1983-12-07
HU193505B (en) 1987-10-28
NO803868L (no) 1981-06-22
FI803957L (fi) 1981-06-20
NO154919C (no) 1987-01-14
PT72232B (en) 1981-11-02
ES497884A0 (es) 1982-11-01
ES8307762A1 (es) 1983-08-01
EP0031237B1 (en) 1984-10-17
US4564616A (en) 1986-01-14
ES8308314A1 (es) 1983-09-01
PT72232A (en) 1981-01-01
NZ195876A (en) 1983-11-18
AU6549580A (en) 1981-06-25
CA1184900A (en) 1985-04-02
GB2065653A (en) 1981-07-01
DE3069468D1 (en) 1984-11-22
IL61756A (en) 1987-02-27
FI76791B (fi) 1988-08-31
DK157019B (da) 1989-10-30
YU321180A (en) 1983-06-30
IE802672L (en) 1981-06-19

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506