ES288219A1 - Procedure for the preparation of compounds of 2-guanidinoalcohil-1,4-benzodioxano (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of compounds of 2-guanidinoalcohil-1,4-benzodioxano (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES288219A1
ES288219A1 ES288219A ES288219A ES288219A1 ES 288219 A1 ES288219 A1 ES 288219A1 ES 288219 A ES288219 A ES 288219A ES 288219 A ES288219 A ES 288219A ES 288219 A1 ES288219 A1 ES 288219A1
Authority
ES
Spain
Prior art keywords
compound
formula
salt
cho
lower alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES288219A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Pfizer Inc
Original Assignee
Pfizer Corp
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp, Pfizer Inc filed Critical Pfizer Corp
Publication of ES288219A1 publication Critical patent/ES288219A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A procedure for the preparation of compounds having the general formula ** (See formula) ** wherein each of R1 and R2 is a hydrogen, chlorine, bromine, iodine, lower alcohol or lower alkoxy, each of R3 and R4 is a hydrogen or a lower alcohol, each of R5 and R6 is a hydrogen, lower alcohol or lower acyl, or R5 and R6 taken together with the nitrogen atoms to which they are attached complete a heterocyclic ring, X is (-CH2-) n, -CH2NH-or -CH2-CH2-NH- in where n is an integer from one to six, and its acid addition salts, characterized by the reaction of a compound having the general formula ** (See formula) ** or an acid addition salt thereof wherein Compound II is a basic compound, wherein R1, R2, R3 and X are as defined above, Z is -NHR4, -OSO2R7 or -CHO where R4 is as defined above and R7 is an organic radical, X is (-CH2-) n when Z is -OSO2R7 or (-CH2-) n-1 when Z is -CHO; with a compound that has the formula ** (See formula) ** or acid addition salts thereof, where Y is -S-R8, ** (See formula) ** or -NHCN when Z is -NHR4; R8 is a lower alcohol and R9 and R10 are hydrogen or a lower alcohol, or Y is NHR4- when Z is -OSO2R7, or Y is NH2 when Z is -CHO, and, when Z is CHO, subsequently reducing the compound resulting hydrazone intermediate, the compound of formula II being a free base when the compound of formula III is a salt and Z is other than CHO, and the compound of formula III being a free base when the compound of formula II is a salt or with a compound having the formula NCY1 where Y1 is Br or NHR6, and, if Y1 is Br, then reacting the resulting product with an amine having the formula R6NH2 or its acid addition salt, being R6 as defined above, with compound II in which Z is -OSO2R7, if desired, first becoming the corresponding compound in which Z is -NHR4 by treatment with NH2R 4, or phthalimide and water, or with a metal azide, followed by reduction of the resulting organic azide; and, if desired, treating the salt of compound I with a base to obtain free basic compound I, or, if compound I is in its free base form, treating compound I with an acid to obtain the corresponding salt by addition of acid. (Machine-translation by Google Translate, not legally binding)
ES288219A 1962-05-22 1963-05-21 Procedure for the preparation of compounds of 2-guanidinoalcohil-1,4-benzodioxano (Machine-translation by Google Translate, not legally binding) Expired ES288219A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1967762 1962-05-22

Publications (1)

Publication Number Publication Date
ES288219A1 true ES288219A1 (en) 1963-11-01

Family

ID=10133350

Family Applications (1)

Application Number Title Priority Date Filing Date
ES288219A Expired ES288219A1 (en) 1962-05-22 1963-05-21 Procedure for the preparation of compounds of 2-guanidinoalcohil-1,4-benzodioxano (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
US (1) US3247221A (en)
AT (1) AT251599B (en)
BE (1) BE632701A (en)
BR (1) BR6349262D0 (en)
CH (1) CH446389A (en)
DE (1) DE1518088A1 (en)
DK (2) DK107354C (en)
ES (1) ES288219A1 (en)
FR (1) FR3085M (en)
GB (1) GB1030752A (en)
SE (1) SE310498B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004468A (en) * 1963-08-21 1965-09-15 Pfizer Ltd Chroman derivatives
US3496183A (en) * 1964-11-19 1970-02-17 Egyt Gyogyszervegyeszeti Gyar Beta-guanidino-ethyl-piperazine derivatives
FR1476752A (en) * 1966-02-28 1967-04-14 Lipha New heterocyclic guanidine derivatives and their preparation methods
GB1215152A (en) * 1967-04-11 1970-12-09 Science Union & Cie Biguanide derivatives and pharmaceutical preparations containing them
US3882147A (en) * 1969-06-09 1975-05-06 Merck & Co Inc 3-Hydroxy-3-(3,4-methylenedioxyphenylalkyl-3,4-dihydro-2H-1,5-benzodioxepin products
US3700691A (en) * 1969-06-09 1972-10-24 Frosst & Co Charles E 3,3-disubstituted-3,4-dihydrobenzodioxepins
US3746724A (en) * 1970-04-13 1973-07-17 Ciba Geigy Corp 3-guanidinoalkyl-thiophenes
US3907793A (en) * 1972-05-01 1975-09-23 Merck & Co Inc 3-Hydroxy-3-morpholino-loweralkyl-3,4-dihydro-2H-1,5-benzodioxepin products
US4039676A (en) * 1975-06-23 1977-08-02 Ciba-Geigy Corporation 2-piperidinoalkyl-1,4-benzodioxans
US4129655A (en) * 1976-04-26 1978-12-12 Ciba-Geigy Corporation Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans
US6162455A (en) * 1997-01-22 2000-12-19 American Cyanamid Company Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals
WO2009089053A1 (en) * 2008-01-11 2009-07-16 Nektar Therapeutics Al, Corporation Oligomer-guanidine class conjugates
CN105061392B (en) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 A kind of guanoxan sulfate synthetic method

Also Published As

Publication number Publication date
AT251599B (en) 1967-01-10
DE1518088A1 (en) 1969-11-27
DK107355C (en) 1967-05-22
DK107354C (en) 1967-05-22
GB1030752A (en)
FR3085M (en) 1965-01-25
US3247221A (en) 1966-04-19
CH446389A (en) 1967-11-15
BR6349262D0 (en) 1973-08-02
SE310498B (en) 1969-05-05
BE632701A (en)

Similar Documents

Publication Publication Date Title
ES288219A1 (en) Procedure for the preparation of compounds of 2-guanidinoalcohil-1,4-benzodioxano (Machine-translation by Google Translate, not legally binding)
ES394421A1 (en) Phenyl-imidazolylalkanyl derivatives
GB1144001A (en) Antimicrobial compositions
ES330164A1 (en) A procedure for preparing a triamide of a phosphorus acid. (Machine-translation by Google Translate, not legally binding)
ES450381A1 (en) Indaneacetic acid derivatives
ES335186A1 (en) Aryl n-(aryl)-alkanoimidates
ES319653A1 (en) A procedure for the preparation of imidazole derivatives. (Machine-translation by Google Translate, not legally binding)
ES297620A1 (en) Procedure for obtaining derivatives of phenoxyactic acid (Machine-translation by Google Translate, not legally binding)
ES393554A1 (en) Thiazole derivatives and a process for the manufacture thereof
ES325546A1 (en) Procedure for the preparation of new biologically active derivatives of fenantridone. (Machine-translation by Google Translate, not legally binding)
ES360859A1 (en) Procedure for the preparation of new derivatives of tiazepine. (Machine-translation by Google Translate, not legally binding)
ES306668A1 (en) Procedure for the preparation of 4-amino-antipirinic derivatives. (Machine-translation by Google Translate, not legally binding)
ES325147A1 (en) A procedure for the preparation of sulfonamides. (Machine-translation by Google Translate, not legally binding)
ES417337A2 (en) Derivatives of phenylaminopyridine
ES332176A1 (en) Procedure for the preparation of antibacterial agents (Machine-translation by Google Translate, not legally binding)
ES266946A1 (en) Procedure for obtaining new derivatives of 2,6-dialkilbenzoic acid (Machine-translation by Google Translate, not legally binding)
ES344394A1 (en) Procedure for the preparation of new N-substituted N-arilsulfonilures. (Machine-translation by Google Translate, not legally binding)
ES386652A1 (en) A procedure for preparation of 1,2,5-benzotriazepin carboxamides. (Machine-translation by Google Translate, not legally binding)
ES328203A1 (en) A procedure for preparing derivatives of dibenzocicloalcohilenilideno pirrolidina. (Machine-translation by Google Translate, not legally binding)
ES310642A2 (en) Procedure for the manufacture of new phenyl-ciclohexilalquilaminas and their salts. (Machine-translation by Google Translate, not legally binding)
ES384600A1 (en) Procedure for the preparation of new basic pirrol derivatives. (Machine-translation by Google Translate, not legally binding)
ES285615A1 (en) Procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)
ES371235A1 (en) Procedure for the preparation of new benzofuran derivatives. (Machine-translation by Google Translate, not legally binding)
ES355291A1 (en) Procedure for the preparation of new derivatives of sulfanilamide. (Machine-translation by Google Translate, not legally binding)
ES277937A1 (en) Procedure for the production of new pyrolrolidine compounds (Machine-translation by Google Translate, not legally binding)