ES2152563T3 - Procedimiento para preparar derivados de dihidroxipirimidina. - Google Patents

Procedimiento para preparar derivados de dihidroxipirimidina.

Info

Publication number
ES2152563T3
ES2152563T3 ES96930988T ES96930988T ES2152563T3 ES 2152563 T3 ES2152563 T3 ES 2152563T3 ES 96930988 T ES96930988 T ES 96930988T ES 96930988 T ES96930988 T ES 96930988T ES 2152563 T3 ES2152563 T3 ES 2152563T3
Authority
ES
Spain
Prior art keywords
dihydroxipirimidine
procedure
prepare derivatives
general formula
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96930988T
Other languages
English (en)
Inventor
Beat Schmidt
Andreas Kiener
John Mcgarrity
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2152563T3 publication Critical patent/ES2152563T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCESO PARA LA FABRICACION DE DERIVADOS DIHIDROXIPIRIMIDINICOS DE FORMULA GENERICA (I), EN DONDE R 1 Y R 2 SON IGUALES O DISTINTOS Y SIGNIFICAN UN ATOMO DE HIDROGENO, UN GRUPO C 1 - C 4 - ALQUILO O UN G RUPO ARILO. EN UNA PRIMERA FASE DEL PROCESO SE TRANSFORMA UN COMPUESTO EN FORMA DE SUSTRATO DE FORMULA GENERICA (II), EN DONDE R 2 TIENE EL SIGNIFICADO MENCIONADO Y R 3 ES - CN O COOR 4 , EN DONDE R 4 ES UN GRUPO C 1 - C 4 ALQUILO, MEDIANTE MICROORGANISMOS DE LA ESPECIE RHODOCOCCUS EN UN DERIVADO DEL ACIDO MALONICO DE FORMULA GENERICA (III), EN DONDE R 2 TIENE EL SIGNIFICADO MENCIONADO Y R 5 ES UN GRUPO C 1 - C 4 - ALCOXI O - NH 2 , Y A CONTINUACION SE CICLA ESTE EN UNA SEGUNDA FASE CON UNA AMIDA DE ACIDO CARBONICO DE FORMULA GENERICA (IV), EN DONDE R 1 TIENE EL SIGNIFICADO MENCIONADO, EN PRESENCIA DE UNA BASE PARA FORMAR EL PRODUCTO FINAL DE FORMULA (I).
ES96930988T 1995-08-31 1996-08-30 Procedimiento para preparar derivados de dihidroxipirimidina. Expired - Lifetime ES2152563T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH247495 1995-08-31

Publications (1)

Publication Number Publication Date
ES2152563T3 true ES2152563T3 (es) 2001-02-01

Family

ID=4234620

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96930988T Expired - Lifetime ES2152563T3 (es) 1995-08-31 1996-08-30 Procedimiento para preparar derivados de dihidroxipirimidina.

Country Status (11)

Country Link
US (1) US6248571B1 (es)
EP (1) EP0852580B1 (es)
JP (1) JP2000507911A (es)
AT (1) ATE197150T1 (es)
AU (1) AU6985796A (es)
CA (1) CA2227949A1 (es)
DE (1) DE59606057D1 (es)
DK (1) DK0852580T3 (es)
ES (1) ES2152563T3 (es)
PT (1) PT852580E (es)
WO (1) WO1997008152A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10140269A1 (de) 2001-08-16 2003-02-27 Degussa Verfahren zur Herstellung von 4,6-Dihydroxypyrimidin
ES2278079T3 (es) * 2001-10-31 2007-08-01 Alcon, Inc. Proteinas morfogenicas oseas (bmp), receptores de bmp y proteinas de union a bmp y su utilizacion en el diagnostico y en el tratamiento del glaucoma.
US20030143601A1 (en) * 2001-11-16 2003-07-31 Hansen Thomas R. Methods and compositions for the detection of bovine pregnancy which utilize members of the 1-8 family of interferon inducible genes
PT1599468E (pt) 2003-01-14 2008-01-14 Arena Pharm Inc Derivados de arilo e heteroarilo 1,2,3.-trissubstituídos comomoduladores do metabolismo, e profilaxia e tratamento dedesordens relacionadas tais como diabetes e hiperglicemia
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
US7854756B2 (en) * 2004-01-22 2010-12-21 Boston Scientific Scimed, Inc. Medical devices
BR112013008100A2 (pt) 2010-09-22 2016-08-09 Arena Pharm Inc "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
CN102442954B (zh) * 2011-09-06 2014-01-08 淄博万昌科技股份有限公司 利用丙烯腈副产氢氰酸制备4，6-二羟基嘧啶的方法
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CN108349891B (zh) 2015-06-22 2022-04-05 艾尼纳制药公司 用于s1p1受体相关病症的化合物的结晶l-精氨酸盐
WO2020136130A1 (de) * 2018-12-28 2020-07-02 Saltigo Gmbh Verbessertes verfahren zur herstellung von 4,6-dihydroxypyrimidin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3306900A (en) * 1964-02-21 1967-02-28 Kyowa Hakko Kogyo Kk Method for producing 4,6-dihydroxy-pyrimidine
FR1424940A (fr) * 1964-02-21 1966-01-14 Kyowa Hakko Kogyo Kk Procédé de production de la 4, 6-dihydroxypyrimidine
JPH06256278A (ja) * 1993-03-03 1994-09-13 Nissan Chem Ind Ltd 光学活性α−カルバモイルアルカン酸誘導体およびその製法
JPH0799983A (ja) * 1993-10-05 1995-04-18 Nippon Kayaku Co Ltd 微生物によるｐ−ニトロベンジルアルコールマロン酸モノエステルの製造方法

Also Published As

Publication number Publication date
PT852580E (pt) 2001-02-28
WO1997008152A1 (de) 1997-03-06
US6248571B1 (en) 2001-06-19
CA2227949A1 (en) 1997-03-06
EP0852580A1 (de) 1998-07-15
JP2000507911A (ja) 2000-06-27
DK0852580T3 (da) 2000-11-20
EP0852580B1 (de) 2000-10-25
AU6985796A (en) 1997-03-19
DE59606057D1 (de) 2000-11-30
ATE197150T1 (de) 2000-11-15

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