EP1470237A4 - Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria - Google Patents

Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria

Info

Publication number: EP1470237A4
Authority: EP; European Patent Office
Prior art keywords: peptidoglycan; multifunctional; gram; monoclonal antibodies; antibodies directed
Prior art date: 2001-12-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP02806494A

Other languages

German (de)

French (fr)

Other versions

EP1470237A2 (en

Inventor

Richard F Schuman

John F Kokai-Kun

Simon Foster

Jeffrey R Stinson

Gerald W Fischer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Biosynexus Inc

Original Assignee

Biosynexus Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-21

Filing date

2002-12-23

Publication date

2006-02-01

2002-12-23 Application filed by Biosynexus Inc filed Critical Biosynexus Inc

2004-10-27 Publication of EP1470237A2 publication Critical patent/EP1470237A2/en

2006-02-01 Publication of EP1470237A4 publication Critical patent/EP1470237A4/en

Status Withdrawn legal-status Critical Current

Links

241000192125 Firmicutes Species 0.000 title 1
MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 title 1
108010013639 Peptidoglycan Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1296—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Listeria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

EP02806494A 2001-12-21 2002-12-23 Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria Withdrawn EP1470237A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US34180601P	2001-12-21	2001-12-21
US34344401P	2001-12-21	2001-12-21
US341806P		2001-12-21
US343444P		2001-12-21
PCT/US2002/041032 WO2003059259A2 (en)	2001-12-21	2002-12-23	Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria

Publications (2)

Publication Number	Publication Date
EP1470237A2 EP1470237A2 (en)	2004-10-27
EP1470237A4 true EP1470237A4 (en)	2006-02-01

Family

ID=26992674

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP02806494A Withdrawn EP1470237A4 (en)	2001-12-21	2002-12-23	Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria

Country Status (5)

Country	Link
EP (1)	EP1470237A4 (en)
JP (2)	JP2005524624A (en)
AU (2)	AU2002364740A1 (en)
CA (1)	CA2469714A1 (en)
WO (1)	WO2003059259A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ572775A (en) *	2006-06-06	2011-09-30	Crucell Holland Bv	Human binding molecules having killing activity against enterococci and staphylococcus aureus and uses thereof
JP5586952B2 (en)	2006-06-06	2014-09-10	クルセルホランドベーヴェー	Human binding molecules having killing activity against enterococci and methods of use thereof
CA2881717C (en) *	2006-06-06	2018-06-12	Cecilia Anna Wilhelmina Geuijen	Human binding molecules having killing activity against staphylococci and uses thereof
JP2008255084A (en) *	2007-04-04	2008-10-23	Isako Hashimoto	Anti-pollinosis agent or foodstuff
EP2291196A4 (en) *	2008-05-12	2012-05-30	Strox Biopharmaceuticals Llc	Staphylococcus aureus-specific antibody preparations
WO2010085590A1 (en) *	2009-01-23	2010-07-29	Biosynexus Incorporated	Opsonic and protective antibodies specific for lipoteichoic acid gram positive bacteria
EP2872535A1 (en)	2012-07-16	2015-05-20	Pfizer Inc.	Saccharides and uses thereof
JP6371758B2 (en) *	2013-03-12	2018-08-08	全薬工業株式会社	Anti-staphylococcal antibody, method for producing the same and use thereof
CN106749652A (en) *	2017-03-14	2017-05-31	天津喜诺生物医药有限公司	A kind of polyclonal antibody of aureus peptide glycan
US20210355429A1 (en) *	2018-10-25	2021-11-18	Nissui Pharmaceutical Co., Ltd.	Method for collecting microorganism cell

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4596769A (en) *	1984-03-05	1986-06-24	Temple University	Monoclonal antibodies to peptidoglycan and methods of preparing same
WO1998057994A2 (en) *	1997-06-16	1998-12-23	Henry M. Jackson Foundation For The Advancement Of Military Medicine	Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
WO2000056357A2 (en) *	1999-03-19	2000-09-28	Nabi	Staphylococcus antigen and vaccine
GB2356402A (en) *	2000-07-22	2001-05-23	Michael G Morgan	radiolabelled peptidoglycan antibodies

2002
- 2002-12-23 EP EP02806494A patent/EP1470237A4/en not_active Withdrawn
- 2002-12-23 CA CA002469714A patent/CA2469714A1/en not_active Abandoned
- 2002-12-23 WO PCT/US2002/041032 patent/WO2003059259A2/en active Application Filing
- 2002-12-23 JP JP2003559424A patent/JP2005524624A/en active Pending
- 2002-12-23 AU AU2002364740A patent/AU2002364740A1/en not_active Abandoned
2009
- 2009-08-17 AU AU2009210372A patent/AU2009210372B2/en not_active Ceased
- 2009-08-24 JP JP2009193403A patent/JP2010013454A/en not_active Withdrawn

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4596769A (en) *	1984-03-05	1986-06-24	Temple University	Monoclonal antibodies to peptidoglycan and methods of preparing same
WO1998057994A2 (en) *	1997-06-16	1998-12-23	Henry M. Jackson Foundation For The Advancement Of Military Medicine	Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
WO2000056357A2 (en) *	1999-03-19	2000-09-28	Nabi	Staphylococcus antigen and vaccine
GB2356402A (en) *	2000-07-22	2001-05-23	Michael G Morgan	radiolabelled peptidoglycan antibodies

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CLARK L A ET AL: "Opsonic activity of intravenous immunoglobulin preparations against Staphylococcus epidermidis.", JOURNAL OF CLINICAL PATHOLOGY AUG 1986 LNKD- PUBMED:3745476, vol. 39, no. 8, August 1986 (1986-08-01), pages 856 - 860, ISSN: 0021-9746 *
DRYLA AGNIESZKA ET AL: "Comparison of antibody repertoires against Staphylococcus aureus in healthy individuals and in acutely infected patients", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 12, no. 3, 1 March 2005 (2005-03-01), pages 387 - 398, XP009094535, ISSN: 1071-412X, DOI: 10.1128/CDLI.12.3.387-398.2005 *
DZIARSKI R: "Ontogenic development of proliferative and polyclonal antibody and autoantibody responses to staphylococcal peptidoglycan, protein A and cell walls in mice.", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. WINTER 1985, vol. 9, no. 1, January 1985 (1985-01-01), pages 119 - 130, XP002355350, ISSN: 0145-305X *
FROST A J ET AL: "THE EFFECT ON INFLAMMATION OF THE BOVINE MAMMARY GLAND OF VACCINATION WITH A CELL WALL EXTRACT OF STAPHYLOCOCCUS AUREUS", JOURNAL OF VETERINARY MEDICINE. SERIES B - ZENTRALBLATT FUER VETERINAERMEDIZIN. REINE B, PAUL PAREY, BERLIN, DE, vol. 35, no. 9, 1988, pages 687 - 694, XP000973782, ISSN: 0931-1793 *
HENCKAERTS ET AL: "Validation of a routine opsonophagocytosis assay to predict invasive pneumococcal disease efficacy of conjugate vaccine in children", VACCINE, ELSEVIER LTD, GB, vol. 25, no. 13, 13 March 2007 (2007-03-13), pages 2518 - 2527, XP005919810, ISSN: 0264-410X, DOI: 10.1016/J.VACCINE.2006.09.029 *
PETERSON P K ET AL: "The key role of peptidoglycan in the opsonization of Staphylococcus aureus.", THE JOURNAL OF CLINICAL INVESTIGATION. MAR 1978, vol. 61, no. 3, March 1978 (1978-03-01), pages 597 - 609, XP002355351, ISSN: 0021-9738 *
SEDER ROBERT A ET AL: "T-cell quality in memory and protection: implications for vaccine design", NATURE REVIEWS. IMMUNOLOGY, NATURE PUBLISHING GROUP, GB, vol. 8, no. 4, 1 April 2008 (2008-04-01), pages 247 - 258, XP009117658, ISSN: 1474-1733, DOI: 10.1038/NRI2274 *
WERGELAND H I ET AL: "Antibodies to staphylococcal peptidoglycan and its peptide epitopes, teichoic acid, and lipoteichoic acid in sera from blood donors and patients with staphylococcal infections.", JOURNAL OF CLINICAL MICROBIOLOGY. JUN 1989, vol. 27, no. 6, June 1989 (1989-06-01), pages 1286 - 1291, XP002355360, ISSN: 0095-1137 *

Also Published As

Publication number	Publication date
EP1470237A2 (en)	2004-10-27
WO2003059259A3 (en)	2004-06-17
CA2469714A1 (en)	2003-07-24
WO2003059259A2 (en)	2003-07-24
JP2005524624A (en)	2005-08-18
JP2010013454A (en)	2010-01-21
AU2009210372B2 (en)	2012-07-26
AU2002364740A1 (en)	2003-07-30
AU2009210372A1 (en)	2009-09-10

Legal Events

Date	Code	Title	Description
2004-09-10	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2004-10-27	17P	Request for examination filed	Effective date: 20040702
2004-10-27	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR
2004-10-27	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO
2005-03-02	RIN1	Information on inventor provided before grant (corrected)	Inventor name: FISCHER, GERALD, W. Inventor name: STINSON, JEFFREY, R. Inventor name: FOSTER, SIMON Inventor name: KOKAI-KUN, JOHN, F. Inventor name: SCHUMAN, RICHARD F.
2005-06-03	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1069852 Country of ref document: HK
2006-01-25	RIC1	Information provided on ipc code assigned before grant	Ipc: C07K 16/12 19950101ALN20051205BHEP Ipc: A61K 39/02 19850101ALI20051205BHEP Ipc: C12N 5/20 19900101ALI20051205BHEP Ipc: A61P 31/04 20000101ALI20051205BHEP Ipc: A61K 39/40 19850101AFI20051205BHEP
2006-02-01	A4	Supplementary search report drawn up and despatched	Effective date: 20051220
2010-02-24	17Q	First examination report despatched	Effective date: 20100122
2011-12-30	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2012-02-01	18D	Application deemed to be withdrawn	Effective date: 20110806
2012-08-03	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1069852 Country of ref document: HK

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