EP0189391A2 - Blood sample tube - Google Patents

Blood sample tube Download PDF

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Publication number
EP0189391A2
EP0189391A2 EP86890008A EP86890008A EP0189391A2 EP 0189391 A2 EP0189391 A2 EP 0189391A2 EP 86890008 A EP86890008 A EP 86890008A EP 86890008 A EP86890008 A EP 86890008A EP 0189391 A2 EP0189391 A2 EP 0189391A2
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EP
European Patent Office
Prior art keywords
tube
closure element
cap
sealing membrane
open end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86890008A
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German (de)
French (fr)
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EP0189391A3 (en
Inventor
Franz Konrad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CA Greiner and Soehne GmbH
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CA Greiner and Soehne GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by CA Greiner and Soehne GmbH filed Critical CA Greiner and Soehne GmbH
Publication of EP0189391A2 publication Critical patent/EP0189391A2/en
Publication of EP0189391A3 publication Critical patent/EP0189391A3/en
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the invention relates to a sealed, evacuable blood sample tube for a blood collection device with a hollow cylindrical holder, which has a double-ended hollow needle at one end and in the other, open end of which the blood sample tube can be inserted to such an extent that one needle end pierces the seal.
  • the tube is closed at its open end by a cap having a double jacket, which encloses the open end of the tube from the inside and outside, is press-fitted therein and carries a closure element which is made of a flat, preferably constant wall thickness film, e.g. consists of aluminum, which is provided on its side facing the inside of the tube with a continuous heat-sealable layer, the closure element additionally having a sealing membrane made of rubber-elastic material, e.g. Silicone rubber, is provided.
  • a tube for a vacuum blood collection system is known from DE-OS 2908817.
  • the closure element there forms a screw-on cap which has an opening, the edge of which presses a membrane forming the seal from a material which can be pierced by one end of the needle, sealingly against the open end of the blood test tube.
  • threads have to be made at its opening and at its closure cap, and furthermore, when the cap is screwed on, a careful sealing of the membrane between the cap and the end of the tube must be made.
  • Access to the sample taken with such a tube ultimately requires unscrewing the cap again, which is cumbersome and time consuming; in addition, it cannot be determined on the tube whether an unwanted opening has been carried out.
  • a flange is provided in the cap on which the closure element is fixed by means of the heat-sealable layer, the sealing membrane being outside the closure element but still inside the cap.
  • the object of the invention is to eliminate the drawbacks in the tubes of the latter types and to create a closure element which is easy to manufacture and handle.
  • this object is achieved in that the closure element closes the cap at its upper end by means of the heat-sealable layer and that the sealing membrane is arranged within the closure element.
  • the cap has a closed bottom part. In this way, the bottom part can support the desired press fit of the cap on the tube.
  • Another feature of the invention provides that a sleeve is arranged within the inner cap shell, which receives the sealing membrane. This training enables a substantial reduction in the volume of the sealing membrane consisting of expensive material.
  • a final feature of the invention is that on the inside of the inner jacket or sleeve protrusions, e.g. V-ribs are arranged, which engage in the sealing membrane.
  • This inner jacket 4 is provided on the inside, approximately halfway up, with a base part 5, which gives the cap or its inner jacket 4 increased rigidity and additionally increases the tightness of the tube.
  • the cap 1 carries on its upper side a closure 6 which is formed in the form of a circuit board from an aluminum foil 8 provided with a heat seal layer 7 and having a constant wall thickness. Such films are known per se. A 0.3 mm thick aluminum foil is expediently used.
  • the closure 6 is heat-sealed on the web part 3 of the cap 1 by means of the layer 7.
  • sealing pad 9 as a membrane, which consists of a rubber-elastic material, preferably silicone rubber and is arranged in the illustrated embodiment within a sleeve 10, which extends from the base part 5 upwards, etc. at a distance from the inner jacket 4.
  • a sleeve 10 which extends from the base part 5 upwards, etc. at a distance from the inner jacket 4.
  • the inside of the sleeve 10 is provided with protrusions in the form of V-ribs 11.
  • This sealing pad 9 has the property that when you pierce one end of the double-ended needle of the hollow cylindrical holder and pull the needle out again after the blood is drawn, it closes completely.
  • the tube 12 to be closed for example made of glass, is inserted with its open end 13 between the outer jacket 2 and the inner jacket 4, with an interference fit between these parts.
  • the outside of the outside jacket 2 can, as shown, be provided with grooves 14.
  • the interior of the tube 12 is under vacuum; this can be generated after the seal 6 has been heat-sealed and the sealing pad 9 has been applied.
  • the tube 12 e.g. also consist of plastic instead of glass. It is also possible to produce the closure 6 with a plastic film 8 instead of a metal film.
  • the bottom part 5 can also be designed in the form of a circular ring, that is to say have a central opening which, for example, has the same diameter as the inner diameter of the sleeve 10.
  • the sleeve 10 can also be omitted at all, so that the sealing pad 9 extends to the inner wall of the inner shell 4; in this case, the V-ribs 11 are formed on this inner wall.
  • the shape of these protrusions can also be different from that of continuous V-ribs, e.g. as individually spaced pyramids, hemispheres or the like.
  • the tube designed according to the invention can be used not only for taking blood, but also for taking other body fluids and also for similar purposes.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Dieses mit einer Dichtung verschlossene, evakuierbare Blutprobenröhrchen dient für ein Blutabnahmegerät mit einem hohlzylindrischen Halter, der an einem Ende eine doppelendige Hohlnadel aufweist und in dessen anderes, offenes Ende das Blutprobenröhrchen soweit einschiebbar ist, dass das eine Nadelende die Dichtung durchstösst. Das Röhrchen ist an seinem offenen Ende durch eine einen Doppelmantel aufweisende Kappe verschlossen, die das offene Ende des Röhrchens von innen und aussen umfasst, mittels Presssitz in diesem gelagert ist und ein Verschlusselement trägt, das aus einer ebenen, vorzugsweise gleichbleibende Wandstärke aufweisenden Folie, z.B. aus Aluminium besteht, die an ihrer dem Röhrcheninneren zugewandten Seite mit einer durchgehenden heisssiegelbaren Schicht versehen ist. Dabei ist das Verschlusselement zusätzlich mit einer Dichtungsmembran aus gummielastischem Werkstoff, z.B. Silikonkautschuk, versehen. Zwecks besonders einfacher Herstellung und Handhabung ist vorgesehen, dass das Verschlusselement (6) mittels der heisssiegelbaren Schicht (7) die Kappe (1) an ihrem oberen Ende abschliesst und dass innerhalb des Verschlusselementes (6) die Dichtungsmembran (9) angeordnet ist.This evacuable blood sample tube, which is closed with a seal, is used for a blood collection device with a hollow cylindrical holder which has a double-ended hollow needle at one end and in the other, open end of which the blood sample tube can be inserted to such an extent that one needle end pierces the seal. The tube is closed at its open end by a cap having a double jacket, which covers the open end of the tube from the inside and outside, is press-fitted therein and carries a closure element which is made of a flat, preferably constant wall thickness film, e.g. consists of aluminum, which is provided on its side facing the inside of the tube with a continuous heat-sealable layer. The closure element is additionally provided with a sealing membrane made of rubber-elastic material, e.g. Silicone rubber, provided. For the purpose of particularly simple manufacture and handling, it is provided that the closure element (6) closes the cap (1) at its upper end by means of the heat-sealable layer (7) and that the sealing membrane (9) is arranged within the closure element (6).

Description

Die Erfindung bezieht sich auf ein mit einer Dichtung verschlossenes, evakuierbares Blutprobenröhrchen für ein Blutabnahmegerät mit einem hohlzylindrischen Halter, der an einem Ende eine doppelendige Hohlnadel aufweist und in dessen anderes, offenes Ende das Blutprobenröhrchen soweit einschiebbar ist, daß das eine Nadelende die Dichtung durchstößt, wobei das Röhrchen an seinem offenen Ende durch eine einen Doppelmantel aufweisende Kappe verschlossen ist, die das offene Ende des Röhrchens von innen und außen umfaßt, mittels Preßsitz in diesem gelagert ist und ein Verschlußelement trägt, das aus einer ebenen, vorzugsweise gleichbleibende Wandstärke aufweisenden Folie, z.B. aus Aluminium besteht, die an ihrer dem Röhrcheninneren zugewandten Seite mit einer durchgehenden heißsiegelbaren Schicht versehen ist, wobei das Verschlußelement zusätzlich mit einer Dichtungsmembran aus gummielastischem Werkstoff, z.B. Silikonkautschuk, versehen ist.The invention relates to a sealed, evacuable blood sample tube for a blood collection device with a hollow cylindrical holder, which has a double-ended hollow needle at one end and in the other, open end of which the blood sample tube can be inserted to such an extent that one needle end pierces the seal. wherein the tube is closed at its open end by a cap having a double jacket, which encloses the open end of the tube from the inside and outside, is press-fitted therein and carries a closure element which is made of a flat, preferably constant wall thickness film, e.g. consists of aluminum, which is provided on its side facing the inside of the tube with a continuous heat-sealable layer, the closure element additionally having a sealing membrane made of rubber-elastic material, e.g. Silicone rubber, is provided.

Ein Röhrchen für ein Vakuum-Blutentnahmesystem ist aus der DE-OS 2908817 bekannt. Das Verschlußelement bildet dort eine aufschraubbare Kappe, die eine Öffnung aufweist, deren Rand eine die Dichtung bildende Membrane aus einem Material, das vom einen Ende der Nadel durchstechbar ist, an das offene Ende des Blutprobenröhrchens abdichtend andrückt. Bei diesem Röhrchen müssen also an seiner Öffnung und an seiner Verschlußkappe Gewinde hergestellt werden, und ferner muß beim Aufschrauben der Kappe eine sorgfältige Dichtung der Membrane zwischen der Kappe und dem Röhrchenende hergestellt werden. Der Zugang zu der mit einem solchen Röhrchen entnommenen Probe erfordert letztlich wieder das Abschrauben der Kappe, was umständlich und zeitraubend ist; außerdem kann am Röhrchen nicht festgestellt werden, ob ein ungewolltes Öffnen vorgenommen ist. Außerdem hat sich herausgestellt, daß bei längerer Lagerung dieser Röhrchen, insbes. wenn sie aus mikroporösem Kunststoff bestehen, das Vakuum nicht mehr oder nur mehr ungenügend vorhanden ist.A tube for a vacuum blood collection system is known from DE-OS 2908817. The closure element there forms a screw-on cap which has an opening, the edge of which presses a membrane forming the seal from a material which can be pierced by one end of the needle, sealingly against the open end of the blood test tube. With this tube, therefore, threads have to be made at its opening and at its closure cap, and furthermore, when the cap is screwed on, a careful sealing of the membrane between the cap and the end of the tube must be made. Access to the sample taken with such a tube ultimately requires unscrewing the cap again, which is cumbersome and time consuming; in addition, it cannot be determined on the tube whether an unwanted opening has been carried out. In addition, it has been found that when these tubes are stored for a long time, especially if they are made of microporous plastic, the vacuum is no longer or only insufficiently present.

Bei einem eigenen älteren Vorschlag der eingangs genannten Art ist in der Kappe ein Flansch vorgesehen, an dem das Verschlußelement mittels der heißsiegelbaren Schicht festgelegt ist, wobei die Dichtungsmembran außerhalb des Verschlußelementes, aber noch innerhalb der Kappe liegt.In a separate older proposal of the type mentioned, a flange is provided in the cap on which the closure element is fixed by means of the heat-sealable layer, the sealing membrane being outside the closure element but still inside the cap.

Wiewohl sich dieses Röhrchen bezüglich seiner Dichtheit und Handhabung ausgezeichnet bewährt hat, weist es produktionstechnische Schwierigkeiten auf, was den Einbau und die Lagerung der Dichtungsmembran und des Verschluß-- elementes betrifft.Although this tube has proven itself with regard to its tightness and handling, it has production-technical difficulties with regard to the installation and storage of the sealing membrane and the closure element.

Von diesem bekannten Stand der Technik ausgehend, stellt sich die Erfindung die Aufgabe, die Übelstände bei den Röhrchen der letztgenannten Arten zu beseitigen und dabei ein Verschlußelement zu schaffen, das leicht herzustellen und handzuhaben ist.Starting from this known prior art, the object of the invention is to eliminate the drawbacks in the tubes of the latter types and to create a closure element which is easy to manufacture and handle.

Die Lösung dieser Aufgabe besteht gemäß der Erfindung darin, daß das Verschlußelement mittels der heißsiegelbaren Schicht die Kappe an ihrem oberen Ende abschließt und daß innerhalb des Verschlußelementes die Dichtungsmembran angeordnet ist. Diese Ausbildung ermöglicht eine einfache Verstellung des Röhrchens, unter sicherer Abdichtung, sodaß damit Vakuumverluste vermieden werden.According to the invention, this object is achieved in that the closure element closes the cap at its upper end by means of the heat-sealable layer and that the sealing membrane is arranged within the closure element. This design allows easy adjustment of the tube, with a secure seal, so that vacuum losses are avoided.

Ein weiteres Merkmal der Erfindung ist, daß die Kappe einen geschlossenen Bodenteil aufweist. In dieser Weise vermag der Bodenteil den gewünschten Preßsitz der Kappe am Röhrchen zu unterstützen.Another feature of the invention is that the cap has a closed bottom part. In this way, the bottom part can support the desired press fit of the cap on the tube.

Ein anderes Merkmal der Erfindung sieht vor, daß innerhalb des inneren Kappenmantels eine Hülse angeordnet ist, welche die Dichtungsmembran aufnimmt. Diese Ausbildung ermöglicht eine wesentliche Verminderung des Volumens der aus teurem Werkstoff bestehenden Dichtungsmembran.Another feature of the invention provides that a sleeve is arranged within the inner cap shell, which receives the sealing membrane. This training enables a substantial reduction in the volume of the sealing membrane consisting of expensive material.

Ein letztes Merkmal der Erfindung ist, daß an der Innenseite des Innenmantels oder der Hülse Vorragungen, z.B. Keilrippen angeordnet sind, welche in die Dichtungsmembran eingreifen.A final feature of the invention is that on the inside of the inner jacket or sleeve protrusions, e.g. V-ribs are arranged, which engage in the sealing membrane.

Damit wird eine zusätzliche Lagesicherung der Dichtungsmembran bewirkt.This provides an additional securing of the position of the sealing membrane.

Weitere Einzelheiten der Erfindung ergeben sich aus der folgenden Beschreibung eines Ausführungsbeispieles anhand der Zeichnung, in der

  • Fig. 1 eine den Verschluß tragende Kappe im ver- tikalschnitt und
  • Fig. 2 diese Kappe in ähnlicher Weise, aufgesteckt auf ein Blutprobenröhrchen, jedoch zur Hälfte in Seitenansicht, darstellen.
Further details of the invention will become apparent from the following description of an embodiment with reference to the drawing, in which
  • 1 shows a cap carrying the closure in vertical section and
  • Fig. 2 represent this cap in a similar manner, attached to a blood test tube, but half in side view.

Die aus spritzgießbarem Kunststoff, z.B. Polyäthylen, bestehende Kappe 1, hier in zylindrischer Form, weist, wie aus Fig. 1 hervorgeht, einen äußeren Mantel 2, eine Stirnwand 3 und einen inneren Mantel 4 auf. Dieser innere Mantel 4 ist innen, etwa in halber Höhe, mit einem Bodenteil 5 versehen, welcher der Kappe bzw. deren Innenmantel 4 eine erhöhte Steifigkeit verleiht und zusätzlich die Dichtheit des Röhrchens erhöht. Die Kappe 1 trägt an ihrer Oberseite einen Verschluß 6, der in Form einer Platine aus einer mit einer Heißsiegelschicht 7 versehenen, gleichbleibende Wandstärke aufweisenden Aluminiumfolie 8 ausgebildet ist. Solche Folien sind an sich bekannt. Zweckmäßig wird eine 0,3 mm starke Aluminiumfolie verwendet. Die Heißsiegelung des Verschlusses 6 erfolgt am St-egteil 3 der Kappe 1 mittels der Schicht 7.The made of injection moldable plastic, e.g. Polyethylene, existing cap 1, here in a cylindrical shape, has, as shown in FIG. 1, an outer jacket 2, an end wall 3 and an inner jacket 4. This inner jacket 4 is provided on the inside, approximately halfway up, with a base part 5, which gives the cap or its inner jacket 4 increased rigidity and additionally increases the tightness of the tube. The cap 1 carries on its upper side a closure 6 which is formed in the form of a circuit board from an aluminum foil 8 provided with a heat seal layer 7 and having a constant wall thickness. Such films are known per se. A 0.3 mm thick aluminum foil is expediently used. The closure 6 is heat-sealed on the web part 3 of the cap 1 by means of the layer 7.

Unterhalb des Verschlußelementes 6 ist ferner ein etwa 1,5 - 3 mm starkes Dichtungspolster 9 als Membran vorgesehen, das aus einem gummielastischen Werkstoff, vorzugsweise Silìkonkautschukbesteht und bei dem dargestellten Ausführungsbeispiel innerhalb einer Hülse 10 angeordnet ist, die sich vom Bodenteil 5 nach oben erstreckt, u.zw. im Abstand vom Innenmantel 4. Zur Lagesicherung des Dichtungspolsters 9 ist die Innenseite der Hülse 10 mit Vorragungen in Form von Keilrippen 11 versehen. Dieses Dichtungspolster 9 hat die Eigenschaft, daß es sich, wenn man das eine Ende der doppelendigen Nadel des hohlzylindrischen Halters hindurchsticht und die Nadel nach der Blutabnahme wieder herauszieht, wieder ganz schließt.Below the closure element 6 there is also an approximately 1.5-3 mm thick sealing pad 9 as a membrane, which consists of a rubber-elastic material, preferably silicone rubber and is arranged in the illustrated embodiment within a sleeve 10, which extends from the base part 5 upwards, etc. at a distance from the inner jacket 4. To secure the position of the sealing pad 9, the inside of the sleeve 10 is provided with protrusions in the form of V-ribs 11. This sealing pad 9 has the property that when you pierce one end of the double-ended needle of the hollow cylindrical holder and pull the needle out again after the blood is drawn, it closes completely.

Wie aus Fig. 2 erkenntlich, ist das zu verschließende Röhrchen 12, z.B. aus Glas , mit seinem offenen Ende 13 zwischen den äußeren Mantel 2 und den inneren Mantel 4 eingeschoben, unter Herstellung eines Preßsitzes zwischen diesen Teilen. Die Außenseite des Außenmantels 2 kann, wie dargestellt, mit Riefen 14 versehen sein.As can be seen from Fig. 2, the tube 12 to be closed, for example made of glass, is inserted with its open end 13 between the outer jacket 2 and the inner jacket 4, with an interference fit between these parts. The outside of the outside jacket 2 can, as shown, be provided with grooves 14.

Der Innenraum des Röhrchens 12 steht unter Vakuum; dieses kann nach dem Heißsiegeln des Verschlusses 6 und dem Aufbringen des Dichtungspolsters 9 erzeugt werden.The interior of the tube 12 is under vacuum; this can be generated after the seal 6 has been heat-sealed and the sealing pad 9 has been applied.

Die Handhabung und Wirkungsweise dieses Röhrchens bezüglich der Blutabnahme ist wie in der genannten DE-OS 2908817 beschrieben.The handling and mode of operation of this tube with regard to blood collection is as described in the aforementioned DE-OS 2908817.

An dem beschriebenen Ausführungsbeispiel können Abänderungen vorgenommen werden. So kann das Röhrchen 12, z.B. auch aus Kunststoff statt aus Glas bestehen. Es ist ferner möglich, den Verschluß 6 auch mit einer Kunststoffolie 8 statt einer Metallfolie herzustlelen.Modifications can be made to the exemplary embodiment described. So the tube 12, e.g. also consist of plastic instead of glass. It is also possible to produce the closure 6 with a plastic film 8 instead of a metal film.

Der Bodenteil 5 kann auch in Kreisringform ausgebildet sein, also eine zentrische Öffnung aufweisen, die z.B.denselben Durchmesser wie der Innendurchmesser der Hülse 10 aufweist. Die Hülse 10 kann aber auch überhaupt weggelassen werden, sodaß das Dichtungspolster 9 bis zur Innenwand des inneren Mantels 4 reicht; diesfalls werden sinngemäß die Keilrippen 11 an dieser Innenwand ausgebildet. Die Form dieser Vorragungen kann auch eine andere als die von durchgehenden Keilrippen sein, z.B. als einzeln beabstandete Pyramiden, Halbkugeln od.dgl.The bottom part 5 can also be designed in the form of a circular ring, that is to say have a central opening which, for example, has the same diameter as the inner diameter of the sleeve 10. The sleeve 10 can also be omitted at all, so that the sealing pad 9 extends to the inner wall of the inner shell 4; in this case, the V-ribs 11 are formed on this inner wall. The shape of these protrusions can also be different from that of continuous V-ribs, e.g. as individually spaced pyramids, hemispheres or the like.

Das erfindungsgemäß ausgebildete Röhrchen kann nicht nur zur Blutentnahme, sondern auch zur Entnahme von anderen Körperflüssigkeiten und auch für dazu ähnliche Zwecke eingesetzt werden.The tube designed according to the invention can be used not only for taking blood, but also for taking other body fluids and also for similar purposes.

Claims (4)

1. Mit einer Dichtung verschlossenes, evakuierbares Blutprobenröhrchen für ein Blutabnahmegerät mit einem hohlzylindrischen Halter, der an einem Ende eine doppelendige Hohlnadel aufweist und in dessen anderes, offenes Ende das Blutprobenröhrchen soweit einschiebbar ist, daß das eine Nadelende die Dichtung durchstößt, wobei das Röhrchen an seinem offenen Ende durch eine einen Doppelmantel aufweisende Kappe verschlossen ist, die das offene Ende des Röhrchens von innen und außen umfaßt, mittels Preßsitz in diesem gelagert ist und ein Verschlußelement trägt, das aus einer ebenen, vorzugsweise gleichbleibende Wandstärke aufweisenden Folie, z.B. aus Aluminium besteht, die an ihrer dem Röhrcheninneren zugewandten Seite mit einer durchgehenden heißsiegelbaren Schicht versehen ist, wobei das Verschlußelement zusätzlich mit einer Dichtungsmembran aus gummielastischem Werkstoff, z.B. Silikonkautschuk,versehen ist, dadurch gekennzeichnet, daß das Verschlußelement (6) mittels der heißsiegelbaren Schicht (7) die Kappe (1) an ihrem oberen Ende abschließt und daß innerhalb des Verschlußelementes (6) die Dichtungsmembran (9) angeordnet ist.1. Closed with a seal, evacuable blood sample tube for a blood collection device with a hollow cylindrical holder, which has a double-ended hollow needle at one end and in the other, open end of the blood sample tube can be inserted so far that one end of the needle pierces the seal, the tube on its open end is closed by a cap having a double jacket, which encloses the open end of the tube from the inside and outside, is mounted therein by means of a press fit and carries a closure element which is made of a flat, preferably constant film thickness, for example consists of aluminum, which is provided on its side facing the inside of the tube with a continuous heat-sealable layer, the closure element additionally having a sealing membrane made of rubber-elastic material, e.g. Silicone rubber is provided, characterized in that the closure element (6) closes the cap (1) at its upper end by means of the heat-sealable layer (7) and in that the sealing membrane (9) is arranged within the closure element (6). 2. Röhrchen nach Anspruch 1, dadurch gekennzeichnet, daß die Kappe (1) einen geschlossenen Bodenteil (5) aufweist.2. Tube according to claim 1, characterized in that the cap (1) has a closed bottom part (5). 3. Röhrchen nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß innerhalb des inneren Kappenmantels (4) eine Hülse (10) angeordnet ist, welche die Dichtungsmembran (9) aufnimmt.3. Tube according to claim 1 or 2, characterized in that a sleeve (10) is arranged within the inner cap shell (4), which receives the sealing membrane (9). 4. Röhrchen nach Anspruch 1, 2 oder 3, dadurch gekennzeichnet, daß an der Innenseite des Innenmantels (4) oder der Hülse (10) Vorragungen, z.B. Keilrippen (ll)angeordnet sind, welche in die Dichtungsmembran (9) eingreifen.4. Tube according to claim 1, 2 or 3, characterized in that on the inside of the inner jacket (4) or the sleeve (10) protrusions, e.g. V-ribs (11) are arranged which engage in the sealing membrane (9).
EP86890008A 1985-01-24 1986-01-20 Blood sample tube Withdrawn EP0189391A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT186/85 1985-01-24
AT0018685A AT380392B (en) 1985-01-24 1985-01-24 BLOOD SAMPLING!

Publications (2)

Publication Number Publication Date
EP0189391A2 true EP0189391A2 (en) 1986-07-30
EP0189391A3 EP0189391A3 (en) 1989-05-10

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Application Number Title Priority Date Filing Date
EP86890008A Withdrawn EP0189391A3 (en) 1985-01-24 1986-01-20 Blood sample tube

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US (1) US4664274A (en)
EP (1) EP0189391A3 (en)
JP (1) JPS61170437A (en)
AT (1) AT380392B (en)
AU (1) AU573418B2 (en)
ZA (1) ZA86233B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
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US5358641A (en) * 1989-10-27 1994-10-25 Helena Laboratories Corporation Column analyzer system and improved chromatograph column for use in the system
US7097057B2 (en) 1999-12-23 2006-08-29 Helvoet Pharma Belgium N.V. Closure device for a vacuum sample collector
CN102847572A (en) * 2012-09-26 2013-01-02 无锡耐思生物科技有限公司 Microcentrifuge tube structure

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
EP0189391A3 (en) 1989-05-10
AU573418B2 (en) 1988-06-09
AT380392B (en) 1986-05-12
US4664274A (en) 1987-05-12
ZA86233B (en) 1986-09-24
ATA18685A (en) 1985-10-15
AU5262186A (en) 1986-07-31
JPS61170437A (en) 1986-08-01

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