EA202190774A2 - Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения - Google Patents
Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их полученияInfo
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- EA202190774A2 EA202190774A2 EA202190774A EA202190774A EA202190774A2 EA 202190774 A2 EA202190774 A2 EA 202190774A2 EA 202190774 A EA202190774 A EA 202190774A EA 202190774 A EA202190774 A EA 202190774A EA 202190774 A2 EA202190774 A2 EA 202190774A2
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- -1 DICARBONIC ACID BISAMIDE DERIVATIVES Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 206010009208 Cirrhosis alcoholic Diseases 0.000 abstract 1
- 241000097929 Porphyria Species 0.000 abstract 1
- 208000010642 Porphyrias Diseases 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 208000010002 alcoholic liver cirrhosis Diseases 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 231100000572 poisoning Toxicity 0.000 abstract 1
- 230000000607 poisoning effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract
Настоящее изобретение относится к новым биологически активным соединениям, производным бисамидов дикарбоновых кислот общей формулы Iили их фармацевтически приемлемым солям, обладающим способностью к комплексообразованию или хелатированию ионов металлов, а также их применению в качестве средства для профилактики и/или лечения сердечно-сосудистых, вирусных, онкологических, нейродегенеративных, воспалительных заболеваний, диабета, геронтологических заболеваний, а также заболеваний, вызываемых токсинами микроорганизмов, а также алкоголизма, алкогольного цирроза печени, анемии, поздней порфирии, отравлений солями переходных металлов. Настоящее изобретение также относится к новым способам получения производных бисамидов дикарбоновых кислот общей формулы I.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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RU2013116822A RU2665688C2 (ru) | 2013-04-12 | 2013-04-12 | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
Publications (2)
Publication Number | Publication Date |
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EA202190774A2 true EA202190774A2 (ru) | 2021-07-30 |
EA202190774A3 EA202190774A3 (ru) | 2021-10-29 |
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Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
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EA202092453A EA202092453A3 (ru) | 2013-04-12 | 2014-04-10 | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
EA202190774A EA202190774A3 (ru) | 2013-04-12 | 2014-04-10 | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
EA202190775A EA202190775A1 (ru) | 2013-04-12 | 2014-04-10 | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
EA201992275A EA039440B1 (ru) | 2013-04-12 | 2014-04-10 | Производное бисамидов дикарбоновых кислот |
EA201501014A EA036961B1 (ru) | 2013-04-12 | 2014-04-10 | Производное бисамидов дикарбоновых кислот |
EA202092452A EA202092452A3 (ru) | 2013-04-12 | 2014-04-10 | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция, на их основе, способы их получения |
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EA201992275A EA039440B1 (ru) | 2013-04-12 | 2014-04-10 | Производное бисамидов дикарбоновых кислот |
EA201501014A EA036961B1 (ru) | 2013-04-12 | 2014-04-10 | Производное бисамидов дикарбоновых кислот |
EA202092452A EA202092452A3 (ru) | 2013-04-12 | 2014-04-10 | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция, на их основе, способы их получения |
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SI (1) | SI2985284T1 (ru) |
UA (1) | UA119748C2 (ru) |
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RU2665688C2 (ru) * | 2013-04-12 | 2018-09-04 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
BR122020010204B1 (pt) * | 2013-04-12 | 2022-03-03 | Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises" | Composto derivado de glutarimida, seu uso, composiçâo farmacêutica e método de de preparação |
RU2647438C2 (ru) * | 2015-05-27 | 2018-03-15 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Бисамидное производное дикарбоновой кислоты в качестве средства, стимулирующего регенерацию тканей и восстановление сниженных функций тканей |
RU2662559C1 (ru) * | 2017-10-27 | 2018-07-26 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Новый ингибитор глутаминилциклаз и его применение для лечения заболеваний легких и дыхательных путей |
RU2665633C1 (ru) * | 2017-05-26 | 2018-09-03 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Новый ингибитор глутаминилциклаз и его применение |
KR102714537B1 (ko) * | 2017-05-26 | 2024-10-11 | 엘티디 "발렌타-인텔렉트" | 신규한 글루타미닐 고리화효소 억제제 및 다양한 질환의 치료에서의 이의 용도 |
US11479532B2 (en) | 2017-06-23 | 2022-10-25 | University Of South Florida | 5-aminolevulinate synthase inhibitors and methods of use thereof |
RU2685277C1 (ru) * | 2018-05-24 | 2019-04-17 | Общество с ограниченной ответственностью "Фарминтерпрайсез Аллерджи" | Применение бисамидного производного малоновой кислоты для лечения аллергических и других заболеваний человека и животных |
RU2679636C1 (ru) * | 2018-10-29 | 2019-02-12 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Новый способ получения n,n'-бис[2-(1н-имидазол-4-ил)этил]малонамида |
RU2745265C2 (ru) * | 2019-09-12 | 2021-03-22 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Новые составы 2-(имидазол-4-ил)-этанамида пентандиовой-1,5 кислоты для лечения и профилактики вирусных заболеваний |
RU2746692C1 (ru) * | 2020-04-14 | 2021-04-19 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Новые составы 2-(имидазол-4-ил)-этанамида пентандиовой-1,5 кислоты для лечения и профилактики вирусных заболеваний |
WO2021049980A1 (ru) * | 2019-09-12 | 2021-03-18 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новые составы для лечения и профилактики вирусных заболеваний |
WO2023177328A1 (en) | 2022-03-17 | 2023-09-21 | Treamid Therapeutics Gmbh | Bisamide derivative of dicarboxylic acid for use in restoring the external respiratory function after coronavirus infection |
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JPS6169759A (ja) * | 1984-09-14 | 1986-04-10 | Agency Of Ind Science & Technol | タンパク質の架橋反応用修飾剤及びそれを用いる方法 |
JPS6344567A (ja) * | 1986-08-08 | 1988-02-25 | Shikoku Chem Corp | 新規なイミダゾール系ジアミド化合物、該化合物の合成方法および該化合物を有効成分とするポリエポキシ樹脂硬化剤 |
IL86131A0 (en) * | 1987-04-24 | 1988-11-15 | Boehringer Ingelheim Kg | Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
AU2001283740A1 (en) * | 2000-08-17 | 2002-02-25 | University Of British Columbia | Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours |
RU2287524C1 (ru) * | 2005-03-31 | 2006-11-20 | ООО "Фарминтерпрайсез" | Аспартильные производные гистамина, способ их получения, фармацевтическая композиция и их применение в качестве модуляторов активности ферментов антиоксидантной защиты |
RU2335495C2 (ru) * | 2005-06-15 | 2008-10-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств |
CN1919884A (zh) * | 2005-08-26 | 2007-02-28 | 建筑技术研究有限公司 | 基于氧化烯二醇烯基醚和不饱和二羧酸衍生物的共聚物 |
AU2006315467B2 (en) * | 2005-11-14 | 2013-02-07 | Curis, Inc. | Bisamide inhibitors of hedgehog signaling |
EP1884515A1 (en) * | 2006-07-31 | 2008-02-06 | Laboratorios del Dr. Esteve S.A. | Substituted indanyl sulfonamide compounds, their preparation and use as medicaments |
JP6079148B2 (ja) * | 2012-11-07 | 2017-02-15 | Jsr株式会社 | 液晶配向剤、液晶配向膜及び液晶表示素子 |
RU2665688C2 (ru) * | 2013-04-12 | 2018-09-04 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
JP6169759B1 (ja) * | 2016-07-11 | 2017-07-26 | 株式会社山寿セラミックス | 弾性表面波素子用基板及びその製造方法 |
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