EA202092849A1 - Моноспецифические и мультиспецифические антитела к tmeff2 и их применение - Google Patents

Моноспецифические и мультиспецифические антитела к tmeff2 и их применение

Info

Publication number
EA202092849A1
EA202092849A1 EA202092849A EA202092849A EA202092849A1 EA 202092849 A1 EA202092849 A1 EA 202092849A1 EA 202092849 A EA202092849 A EA 202092849A EA 202092849 A EA202092849 A EA 202092849A EA 202092849 A1 EA202092849 A1 EA 202092849A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tmeff2
monospecific
application
multispecific antibodies
antibodies
Prior art date
Application number
EA202092849A
Other languages
English (en)
Inventor
Филип Купер
Робин Эрнст
Раджкумар Ганезан
Коллин Кейн
Майкл Расселл
Санджайа Сингх
Сатядеви Венкатарамани
Шэн-Дзюн У
Original Assignee
Янссен Байотек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Байотек, Инк. filed Critical Янссен Байотек, Инк.
Publication of EA202092849A1 publication Critical patent/EA202092849A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Предложенное в настоящем изобретении описание относится к моноспецифическим и мультиспецифическим антителам к TMEFF2 и способам получения и применения описанных антител.
EA202092849A 2018-05-24 2019-05-21 Моноспецифические и мультиспецифические антитела к tmeff2 и их применение EA202092849A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862675957P 2018-05-24 2018-05-24
PCT/IB2019/054184 WO2019224713A2 (en) 2018-05-24 2019-05-21 Monospecific and multispecific anti-tmeff2 antibodies and there uses

Publications (1)

Publication Number Publication Date
EA202092849A1 true EA202092849A1 (ru) 2021-03-16

Family

ID=67211771

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092849A EA202092849A1 (ru) 2018-05-24 2019-05-21 Моноспецифические и мультиспецифические антитела к tmeff2 и их применение

Country Status (25)

Country Link
US (1) US11866499B2 (ru)
EP (1) EP3802607A2 (ru)
JP (2) JP2021524255A (ru)
KR (1) KR20210011999A (ru)
CN (1) CN112703203A (ru)
AR (1) AR115419A1 (ru)
AU (1) AU2019274652A1 (ru)
BR (1) BR112020023416A2 (ru)
CA (1) CA3101304A1 (ru)
CL (1) CL2020003032A1 (ru)
CO (1) CO2020014515A2 (ru)
CR (1) CR20200564A (ru)
EA (1) EA202092849A1 (ru)
EC (1) ECSP20075234A (ru)
IL (1) IL278862A (ru)
JO (1) JOP20200295A1 (ru)
MA (1) MA52772A (ru)
MX (1) MX2020012589A (ru)
NI (1) NI202000087A (ru)
PE (1) PE20210634A1 (ru)
PH (1) PH12020551948A1 (ru)
SG (1) SG11202011268VA (ru)
TW (1) TW202003584A (ru)
UY (1) UY38243A (ru)
WO (1) WO2019224713A2 (ru)

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WO2022081516A1 (en) 2020-10-13 2022-04-21 Janssen Biotech, Inc. Bioengineered t cell mediated immunity, materials and other methods for modulating cluster of differentiation iv &/or viii
AU2023223455A1 (en) 2022-02-23 2024-08-29 Janssen Biotech, Inc. Anti-cd28 x anti-psma antibodies
WO2024052831A1 (en) * 2022-09-09 2024-03-14 Janssen Biotech, Inc. Method of treating cancer with an anti tmeff2xcd3 bispecific antibody

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Also Published As

Publication number Publication date
EP3802607A2 (en) 2021-04-14
WO2019224713A3 (en) 2020-01-02
UY38243A (es) 2019-11-29
CN112703203A (zh) 2021-04-23
AU2019274652A1 (en) 2020-11-26
KR20210011999A (ko) 2021-02-02
CL2020003032A1 (es) 2021-04-16
NI202000087A (es) 2021-03-23
WO2019224713A2 (en) 2019-11-28
US11866499B2 (en) 2024-01-09
AR115419A1 (es) 2021-01-13
TW202003584A (zh) 2020-01-16
PE20210634A1 (es) 2021-03-23
MX2020012589A (es) 2021-01-29
CO2020014515A2 (es) 2020-12-10
SG11202011268VA (en) 2020-12-30
JOP20200295A1 (ar) 2020-11-22
MA52772A (fr) 2021-04-14
US20190359711A1 (en) 2019-11-28
PH12020551948A1 (en) 2021-08-16
CA3101304A1 (en) 2019-11-28
JP2021524255A (ja) 2021-09-13
CR20200564A (es) 2021-06-21
JP2024105476A (ja) 2024-08-06
BR112020023416A2 (pt) 2021-02-17
IL278862A (en) 2021-01-31
ECSP20075234A (es) 2020-12-31

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