EA201990851A1 - NEW CARBANUCLEOSIDE ANALOGUES REPLACED BY MONOCYCLIC AND BICYCLIC RING SYSTEM FOR USE AS PRMT5 INHIBITORS - Google Patents

NEW CARBANUCLEOSIDE ANALOGUES REPLACED BY MONOCYCLIC AND BICYCLIC RING SYSTEM FOR USE AS PRMT5 INHIBITORS

Info

Publication number
EA201990851A1
EA201990851A1 EA201990851A EA201990851A EA201990851A1 EA 201990851 A1 EA201990851 A1 EA 201990851A1 EA 201990851 A EA201990851 A EA 201990851A EA 201990851 A EA201990851 A EA 201990851A EA 201990851 A1 EA201990851 A1 EA 201990851A1
Authority
EA
Eurasian Patent Office
Prior art keywords
monocyclic
ring system
bicyclic ring
new
prmt5 inhibitors
Prior art date
Application number
EA201990851A
Other languages
Russian (ru)
Inventor
Тонгфей Ву
Дирк Бремер
Лейс Беке
Ан Буккс
Гастон Станислас Марселла Дилс
Эдвард Чарльз Лосон
Ливен Мерпул
Винет Панде
Маркус Корнелис Бернардус Катарина Параде
Вим Берт Грит Схепенс
Вэймэй Сунь
Йоханнес Вильхельмус Йохн Ф. Тюринг
Марсель Вьейевуа
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201990851A1 publication Critical patent/EA201990851A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым аналогам карбануклеозида, замещенным моноциклической и бициклической кольцевой системой, формулы (I)где переменные имеют значения, определенные в формуле изобретения. Соединения согласно настоящему изобретению являются пригодными в качестве ингибиторов PRMT5. Кроме того, настоящее изобретение относится к фармацевтическим композициям, содержащим указанные соединения в качестве активного ингредиента, а также к применению указанных соединений в качестве лекарственного препарата.The present invention relates to new analogues of carbanucleoside substituted by a monocyclic and bicyclic ring system, formula (I) where the variables have the meanings defined in the claims. The compounds of the present invention are useful as PRMT5 inhibitors. In addition, the present invention relates to pharmaceutical compositions containing said compounds as an active ingredient, and also to the use of said compounds as a medicine.

EA201990851A 2017-02-24 2017-10-02 NEW CARBANUCLEOSIDE ANALOGUES REPLACED BY MONOCYCLIC AND BICYCLIC RING SYSTEM FOR USE AS PRMT5 INHIBITORS EA201990851A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17157785 2017-02-24
PCT/EP2017/074983 WO2018065365A1 (en) 2016-10-03 2017-10-02 Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors

Publications (1)

Publication Number Publication Date
EA201990851A1 true EA201990851A1 (en) 2019-09-30

Family

ID=58158964

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990851A EA201990851A1 (en) 2017-02-24 2017-10-02 NEW CARBANUCLEOSIDE ANALOGUES REPLACED BY MONOCYCLIC AND BICYCLIC RING SYSTEM FOR USE AS PRMT5 INHIBITORS

Country Status (2)

Country Link
EA (1) EA201990851A1 (en)
WO (1) WO2018065365A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI730980B (en) 2015-08-26 2021-06-21 比利時商健生藥品公司 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors
MA43671A (en) 2016-03-10 2018-11-28 Janssen Pharmaceutica Nv ANALOGUES OF SUBSTITUTED NUCLEOSIDES FOR USE AS PRMT5 INHIBITORS
UA124074C2 (en) 2016-10-03 2021-07-14 Янссен Фармацевтика Нв Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors
UA127679C2 (en) 2017-02-27 2023-11-29 Янссен Фармацевтика Нв Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor
KR20200036922A (en) 2017-08-09 2020-04-07 프렐루드 테라퓨틱스, 인코포레이티드 Selective inhibitor of protein arginine methyltransferase 5 (PRMT5)
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KR20200096265A (en) * 2017-12-05 2020-08-11 앤젝스 파마수티컬, 인크. Heterocyclic compounds as PRMT5 inhibitors
CN111479817B (en) 2017-12-08 2023-03-21 詹森药业有限公司 Spirobicyclic analogs
ES2927860T3 (en) * 2017-12-13 2022-11-11 Lupin Ltd Substituted Bicyclic Heterocyclic Compounds as PRMT5 Inhibitors
BR112020018636A2 (en) * 2018-03-14 2020-12-29 Prelude Therapeutics, Incorporated SELECTIVE ARGININE METHYLTRANSPHERASE 5 (PRMT5) INHIBITORS
US10711007B2 (en) 2018-03-14 2020-07-14 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
WO2020033288A1 (en) * 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3833669A4 (en) * 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. Prmt5 inhibitors
GB201819621D0 (en) 2018-11-30 2019-01-16 Sumitomo Chemical Co Photoactive compound
JP2022521818A (en) * 2019-03-25 2022-04-12 カリフォルニア インスティチュート オブ テクノロジー PRMT5 inhibitor and its use
MX2021011606A (en) * 2019-04-02 2021-12-10 Aligos Therapeutics Inc Compounds targeting prmt5.
KR20220004068A (en) * 2019-04-03 2022-01-11 미토키닌, 인크. Compositions for the treatment of neurodegenerative and mitochondrial diseases and methods of using the same
JP2022534998A (en) * 2019-05-30 2022-08-04 エンジェクス ファーマシューティカル インコーポレイテッド Heterocyclic compounds as PRMT5 inhibitors
TW202112375A (en) 2019-06-06 2021-04-01 比利時商健生藥品公司 Methods of treating cancer using prmt5 inhibitors
DK3980417T3 (en) 2019-06-10 2023-12-18 Lupin Ltd PRMT5-Inhibitorer
IL288741B1 (en) 2019-06-12 2024-11-01 Janssen Pharmaceutica Nv Novel spirobicyclic intermediates
CN115298179A (en) * 2019-10-21 2022-11-04 埃克森特治疗公司 METTL3 modulators
GEP20247638B (en) * 2019-10-22 2024-07-10 Lupin Ltd Pharmaceutical combination of prmt5 inhibitors
EP4069698A1 (en) 2019-12-03 2022-10-12 Lupin Limited Substituted nucleoside analogs as prmt5 inhibitors
WO2021202480A1 (en) * 2020-04-01 2021-10-07 Aligos Therapeutics, Inc. Compounds targeting prmt5
US20240101589A1 (en) * 2020-10-08 2024-03-28 Strom Therapeutics Limited Inhibitors of mettl3

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UA118315C2 (en) 2015-02-24 2018-12-26 Пфайзер Інк. Substituted nucleoside derivatives useful as anticancer agents
TWI730980B (en) 2015-08-26 2021-06-21 比利時商健生藥品公司 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors

Also Published As

Publication number Publication date
WO2018065365A1 (en) 2018-04-12

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