EA201890806A1 - Ингибитор рецептора p2x7 - Google Patents

Ингибитор рецептора p2x7

Info

Publication number
EA201890806A1
EA201890806A1 EA201890806A EA201890806A EA201890806A1 EA 201890806 A1 EA201890806 A1 EA 201890806A1 EA 201890806 A EA201890806 A EA 201890806A EA 201890806 A EA201890806 A EA 201890806A EA 201890806 A1 EA201890806 A1 EA 201890806A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptor inhibitor
morpholinoethyl
pyrimidin
carboxamide
thiazole
Prior art date
Application number
EA201890806A
Other languages
English (en)
Inventor
Джон Пол Килбурн
Аллен Т. Хоппер
Мартин Джухл
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA201890806A1 publication Critical patent/EA201890806A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение предусматривает (S)-N-(2-(4-хлорфенил)-2-морфолиноэтил)-2-(пиримидин-2-ил)-4-(трифторметил)тиазол-5-карбоксамид в качестве ингибитора P2X7, его применение в качестве лекарственного препарата и подходящий протокол синтеза энантиомеров для получения (S)-N-(2-(4-хлорфенил)-2-морфолиноэтил)-2-(пиримидин-2-ил)-4-(трифторметил)тиазол-5-карбоксамида.
EA201890806A 2015-11-02 2016-11-01 Ингибитор рецептора p2x7 EA201890806A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201500678 2015-11-02
PCT/EP2016/076285 WO2017076825A1 (en) 2015-11-02 2016-11-01 Inhibitor of the p2x7 receptor

Publications (1)

Publication Number Publication Date
EA201890806A1 true EA201890806A1 (ru) 2018-10-31

Family

ID=57241072

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890806A EA201890806A1 (ru) 2015-11-02 2016-11-01 Ингибитор рецептора p2x7

Country Status (16)

Country Link
US (1) US20180319786A1 (ru)
EP (1) EP3371180A1 (ru)
JP (1) JP2018532751A (ru)
CN (1) CN108137571A (ru)
AR (1) AR106542A1 (ru)
AU (1) AU2016348487A1 (ru)
BR (1) BR112017014117A2 (ru)
CA (1) CA3001766A1 (ru)
EA (1) EA201890806A1 (ru)
IL (1) IL258573A (ru)
MX (1) MX2018005251A (ru)
PH (1) PH12018500898A1 (ru)
RU (1) RU2018114986A (ru)
SG (1) SG11201803477VA (ru)
TW (1) TW201722432A (ru)
WO (1) WO2017076825A1 (ru)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150118197A (ko) 2007-07-19 2015-10-21 하. 룬트벡 아크티에 셀스카브 5-원 헤테로시클릭 아미드 및 관련 화합물

Also Published As

Publication number Publication date
CN108137571A (zh) 2018-06-08
CA3001766A1 (en) 2017-05-11
RU2018114986A (ru) 2019-12-05
JP2018532751A (ja) 2018-11-08
US20180319786A1 (en) 2018-11-08
WO2017076825A1 (en) 2017-05-11
AR106542A1 (es) 2018-01-24
EP3371180A1 (en) 2018-09-12
AU2016348487A1 (en) 2018-05-10
PH12018500898A1 (en) 2018-10-29
BR112017014117A2 (pt) 2018-03-06
MX2018005251A (es) 2018-08-01
IL258573A (en) 2018-05-31
TW201722432A (zh) 2017-07-01
SG11201803477VA (en) 2018-05-30

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