EA200400223A1 - Новые производные 2h-пиридазин-3-она, фармацевтические композиции, содержащие эти производные, и способ получения активного ингредиента - Google Patents

Новые производные 2h-пиридазин-3-она, фармацевтические композиции, содержащие эти производные, и способ получения активного ингредиента

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Publication number
EA200400223A1
EA200400223A1 EA200400223A EA200400223A EA200400223A1 EA 200400223 A1 EA200400223 A1 EA 200400223A1 EA 200400223 A EA200400223 A EA 200400223A EA 200400223 A EA200400223 A EA 200400223A EA 200400223 A1 EA200400223 A1 EA 200400223A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
formula
new
pyridazin
active ingredient
Prior art date
Application number
EA200400223A
Other languages
English (en)
Other versions
EA006246B1 (ru
Inventor
Йожеф Баркоци
Петер Котаи Надь
Дьюла Шимиг
Дьёрди Леваи
Иштван Гачальи
Андраш Эдьед
Юдит Рацне Байногель
Каталин Паллаги
Эва Шмидт
Габор Сенаши
Анико Миклошне Ковач
Янош Вельман
Original Assignee
Эгиш Дьёдьсердьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Рт. filed Critical Эгиш Дьёдьсердьяр Рт.
Publication of EA200400223A1 publication Critical patent/EA200400223A1/ru
Publication of EA006246B1 publication Critical patent/EA006246B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение касается новых производных 2H-пиридазин-3-она формулы I, фармацевтических композиций, содержащих эти производные, и способа получения активного ингредиента. Новые соединения обладают нейролептическим эффектом и могут быть использованы в первую очередь для лечения шизофрении. В формуле I R означает атом водорода или C-алкильную группу, X и Y независимо представляют собой атом водорода, атом галогена или группу формулы II, при условии, что один из X и Y всегда представляет собой группу формулы II, а другой радикал представляет собой атом водорода или атом галогена, где n в формуле II имеет значение 1 или 2.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400223A 2001-07-26 2002-07-24 Производные 2h-пиридазин-3-она, фармацевтические композиции, содержащие эти производные, и способ получения активного ингредиента EA006246B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103063A HU225955B1 (en) 2001-07-26 2001-07-26 Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
PCT/HU2002/000072 WO2003010166A1 (en) 2001-07-26 2002-07-24 Novel 2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient

Publications (2)

Publication Number Publication Date
EA200400223A1 true EA200400223A1 (ru) 2004-12-30
EA006246B1 EA006246B1 (ru) 2005-10-27

Family

ID=89979562

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400223A EA006246B1 (ru) 2001-07-26 2002-07-24 Производные 2h-пиридазин-3-она, фармацевтические композиции, содержащие эти производные, и способ получения активного ингредиента

Country Status (28)

Country Link
US (1) US7098210B2 (ru)
EP (1) EP1417206B1 (ru)
JP (1) JP4249012B2 (ru)
KR (1) KR100909514B1 (ru)
CN (1) CN1247571C (ru)
AR (2) AR036248A1 (ru)
AT (1) ATE466859T1 (ru)
AU (1) AU2002321669B8 (ru)
BR (1) BR0211440A (ru)
CA (1) CA2453917C (ru)
CY (1) CY1110240T1 (ru)
CZ (1) CZ2004123A3 (ru)
DE (1) DE60236294D1 (ru)
DK (1) DK1417206T3 (ru)
EA (1) EA006246B1 (ru)
ES (1) ES2345541T3 (ru)
HK (1) HK1067626A1 (ru)
HU (1) HU225955B1 (ru)
MA (1) MA27867A1 (ru)
MX (1) MXPA04000814A (ru)
NO (1) NO326155B1 (ru)
NZ (1) NZ531154A (ru)
PL (1) PL206824B1 (ru)
PT (1) PT1417206E (ru)
SI (1) SI1417206T1 (ru)
SK (1) SK552004A3 (ru)
WO (1) WO2003010166A1 (ru)
ZA (1) ZA200400482B (ru)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227255B1 (en) * 2002-04-26 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Novel piperidine-alkyl-amino-pyridazine derivatives, pharmaceutical compositions containing the same and process for the preparation of the active ingredient
US7852298B2 (en) 2005-06-08 2010-12-14 Ignis Innovation Inc. Method and system for driving a light emitting device display
US9489891B2 (en) 2006-01-09 2016-11-08 Ignis Innovation Inc. Method and system for driving an active matrix display circuit
EP1971975B1 (en) 2006-01-09 2015-10-21 Ignis Innovation Inc. Method and system for driving an active matrix display circuit
US9269322B2 (en) 2006-01-09 2016-02-23 Ignis Innovation Inc. Method and system for driving an active matrix display circuit
HUP0600555A3 (en) * 2006-07-03 2008-10-28 Egis Gyogyszergyar Nyrt Use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]izoxazol-3-yl)piperidin-1-yl]ethylamino}2-methyl-3(2h)-piridazinon for the production of pharmaceutical compositions for influencing cognitive functions and causing neuroprotective effect
JP5466694B2 (ja) 2008-04-18 2014-04-09 イグニス・イノベーション・インコーポレイテッド 発光デバイス・ディスプレイのためのシステムおよび駆動方法
CA2637343A1 (en) 2008-07-29 2010-01-29 Ignis Innovation Inc. Improving the display source driver
US9370075B2 (en) 2008-12-09 2016-06-14 Ignis Innovation Inc. System and method for fast compensation programming of pixels in a display
US8633873B2 (en) 2009-11-12 2014-01-21 Ignis Innovation Inc. Stable fast programming scheme for displays
CA2687631A1 (en) 2009-12-06 2011-06-06 Ignis Innovation Inc Low power driving scheme for display applications
CA2696778A1 (en) 2010-03-17 2011-09-17 Ignis Innovation Inc. Lifetime, uniformity, parameter extraction methods
US9351368B2 (en) 2013-03-08 2016-05-24 Ignis Innovation Inc. Pixel circuits for AMOLED displays
US20140368491A1 (en) 2013-03-08 2014-12-18 Ignis Innovation Inc. Pixel circuits for amoled displays
US9886899B2 (en) 2011-05-17 2018-02-06 Ignis Innovation Inc. Pixel Circuits for AMOLED displays
JP2014522506A (ja) 2011-05-28 2014-09-04 イグニス・イノベイション・インコーポレーテッド ディスプレイのピクセルの速い補償プログラミングためのシステムと方法
US9747834B2 (en) 2012-05-11 2017-08-29 Ignis Innovation Inc. Pixel circuits including feedback capacitors and reset capacitors, and display systems therefore
US9786223B2 (en) 2012-12-11 2017-10-10 Ignis Innovation Inc. Pixel circuits for AMOLED displays
US9336717B2 (en) 2012-12-11 2016-05-10 Ignis Innovation Inc. Pixel circuits for AMOLED displays
WO2014124755A1 (de) 2013-02-18 2014-08-21 Jürgen Von Der Ohe Verfahren und vorrichtung zum kaltstrahlreinigen
CA2894717A1 (en) 2015-06-19 2016-12-19 Ignis Innovation Inc. Optoelectronic device characterization in array with shared sense line
US9721505B2 (en) 2013-03-08 2017-08-01 Ignis Innovation Inc. Pixel circuits for AMOLED displays
CA2873476A1 (en) 2014-12-08 2016-06-08 Ignis Innovation Inc. Smart-pixel display architecture
CA2886862A1 (en) 2015-04-01 2016-10-01 Ignis Innovation Inc. Adjusting display brightness for avoiding overheating and/or accelerated aging
US10657895B2 (en) 2015-07-24 2020-05-19 Ignis Innovation Inc. Pixels and reference circuits and timing techniques
US10373554B2 (en) 2015-07-24 2019-08-06 Ignis Innovation Inc. Pixels and reference circuits and timing techniques
CA2898282A1 (en) 2015-07-24 2017-01-24 Ignis Innovation Inc. Hybrid calibration of current sources for current biased voltage progra mmed (cbvp) displays
CA2908285A1 (en) 2015-10-14 2017-04-14 Ignis Innovation Inc. Driver with multiple color pixel structure

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
IL117646A (en) * 1995-04-12 2000-06-01 Ferrer Int 7-¬3-¬4-(6-fluoro-1,2-benzisoxazole-3-YL)piperidin-1-YL¾propoxy¾3-alkyl-chromen-4-ones their preparation their uses and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
DE60236294D1 (de) 2010-06-17
AR088808A2 (es) 2014-07-10
CA2453917C (en) 2009-06-23
ATE466859T1 (de) 2010-05-15
DK1417206T3 (da) 2010-08-16
EP1417206B1 (en) 2010-05-05
AR036248A1 (es) 2004-08-25
HU225955B1 (en) 2008-01-28
EP1417206A1 (en) 2004-05-12
PT1417206E (pt) 2010-07-29
MXPA04000814A (es) 2004-05-21
WO2003010166A1 (en) 2003-02-06
EA006246B1 (ru) 2005-10-27
CY1110240T1 (el) 2015-01-14
ES2345541T3 (es) 2010-09-27
KR100909514B1 (ko) 2009-07-27
HK1067626A1 (en) 2005-04-15
NZ531154A (en) 2005-09-30
KR20040030862A (ko) 2004-04-09
AU2002321669B2 (en) 2008-05-15
CN1545513A (zh) 2004-11-10
PL206824B1 (pl) 2010-09-30
JP4249012B2 (ja) 2009-04-02
NO20040268L (no) 2004-03-23
US7098210B2 (en) 2006-08-29
AU2002321669A2 (en) 2003-02-17
BR0211440A (pt) 2004-07-20
NO326155B1 (no) 2008-10-13
AU2002321669B8 (en) 2008-06-05
HUP0103063A2 (hu) 2003-02-28
HUP0103063A3 (en) 2005-06-28
SI1417206T1 (sl) 2010-09-30
MA27867A1 (fr) 2006-05-02
HU0103063D0 (en) 2001-10-28
ZA200400482B (en) 2005-05-25
US20040171619A1 (en) 2004-09-02
PL367447A1 (en) 2005-02-21
CZ2004123A3 (cs) 2004-05-12
CN1247571C (zh) 2006-03-29
CA2453917A1 (en) 2003-02-06
JP2004538293A (ja) 2004-12-24
SK552004A3 (en) 2004-08-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU