DK2925782T3 - Anti-cd47-antistoffer og fremgangsmåder til anvendelse deraf - Google Patents
Anti-cd47-antistoffer og fremgangsmåder til anvendelse deraf Download PDFInfo
- Publication number
- DK2925782T3 DK2925782T3 DK13849989.2T DK13849989T DK2925782T3 DK 2925782 T3 DK2925782 T3 DK 2925782T3 DK 13849989 T DK13849989 T DK 13849989T DK 2925782 T3 DK2925782 T3 DK 2925782T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibodies
- procedures
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261732452P | 2012-12-03 | 2012-12-03 | |
| US201361816788P | 2013-04-28 | 2013-04-28 | |
| US201361863106P | 2013-08-07 | 2013-08-07 | |
| US201361881523P | 2013-09-24 | 2013-09-24 | |
| US201361898710P | 2013-11-01 | 2013-11-01 | |
| PCT/IB2013/003164 WO2014087248A2 (en) | 2012-12-03 | 2013-12-03 | Anti-cd47 antibodies and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2925782T3 true DK2925782T3 (da) | 2020-04-06 |
Family
ID=50588748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13849989.2T DK2925782T3 (da) | 2012-12-03 | 2013-12-03 | Anti-cd47-antistoffer og fremgangsmåder til anvendelse deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11059910B2 (da) |
| EP (2) | EP3725807A1 (da) |
| JP (4) | JP6392770B2 (da) |
| CN (2) | CN110183534A (da) |
| AU (2) | AU2013353763B2 (da) |
| CA (2) | CA2892585C (da) |
| DK (1) | DK2925782T3 (da) |
| ES (1) | ES2784631T3 (da) |
| PT (1) | PT2925782T (da) |
| RU (2) | RU2693078C2 (da) |
| WO (1) | WO2014087248A2 (da) |
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| WO2014087248A2 (en) * | 2012-12-03 | 2014-06-12 | Novimmune S.A. | Anti-cd47 antibodies and methods of use thereof |
| US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
| WO2014093678A2 (en) | 2012-12-12 | 2014-06-19 | Frazier William A | Therapeutic cd47 antibodies |
| EP3188758B1 (en) * | 2014-08-08 | 2023-10-04 | The Board of Trustees of the Leland Stanford Junior University | Sirp alpha-antibody fusion proteins |
| CA2964173A1 (en) * | 2014-10-10 | 2016-04-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to eliminate cancer stem cells by targeting cd47 |
| US10035855B2 (en) * | 2015-03-04 | 2018-07-31 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind CD47 |
| CA3184363C (en) * | 2015-04-21 | 2024-01-02 | Isolation Bio Inc. | High resolution systems, kits, apparatus, and methods for high throughput microbiology applications |
| BR112018005322A2 (pt) * | 2015-09-18 | 2018-12-11 | Arch Oncology, Inc. | anticorpo monoclonal ou seu fragmento de ligação a antígenos, composição farmacêutica, anticorpo monoclonal ou seu fragmento de ligação a antígenos para uso, método de tratamento de lesão de isquemia-reperfusão, método de tratamento de câncer em um paciente humano, método de avaliação da expressão de cd47 em células tumorais e/ou imunes usando um anticorpo monoclonal ou seu fragmento de ligação a antígenos |
| EP3156417A1 (en) * | 2015-10-13 | 2017-04-19 | Affimed GmbH | Multivalent fv antibodies |
| EP3386545A4 (en) | 2015-12-11 | 2019-06-05 | The Board of Trustees of the Leland Stanford Junior University | ANTICANCER TREATMENT WITH DOUBLE TARGETING OF CD47 AND R-EGF |
| US10927173B2 (en) * | 2016-01-11 | 2021-02-23 | Forty Seven, Inc. | Humanized, mouse or chimeric anti-CD47 monoclonal antibodies |
| WO2017127707A1 (en) * | 2016-01-21 | 2017-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of cancer with combinations of immunoregulatory agents |
| CN106084052B (zh) * | 2016-06-17 | 2019-12-27 | 长春金赛药业股份有限公司 | 抗cd47单克隆抗体及其应用 |
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| US11352425B2 (en) | 2016-11-08 | 2022-06-07 | Absos, Llc | Anti-CD47 antibodies |
| KR102247704B1 (ko) | 2016-11-18 | 2021-05-03 | 북경한미약품 유한공사 | 항 pd-1/항 her2 천연항체 구조 형태의 헤테로다이머 계의 이중특이성 항체 및 그 제조방법 |
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| KR102646468B1 (ko) | 2017-08-02 | 2024-03-11 | 페인스 테라퓨틱스 인코포레이티드 | 항-cd47 항체 및 이의 용도 |
| CN111201031B (zh) * | 2017-08-25 | 2024-11-01 | 诺夫免疫股份有限公司 | 抗CD47 x抗间皮素抗体及其使用方法 |
| CN109422811A (zh) | 2017-08-29 | 2019-03-05 | 信达生物制药(苏州)有限公司 | 抗cd47抗体及其用途 |
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-
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| RU2693078C2 (ru) | 2019-07-01 |
| EP2925782B1 (en) | 2020-01-22 |
| PT2925782T (pt) | 2020-04-22 |
| US20180355065A1 (en) | 2018-12-13 |
| US11840553B2 (en) | 2023-12-12 |
| JP2019023187A (ja) | 2019-02-14 |
| US20180291115A1 (en) | 2018-10-11 |
| JP2022177319A (ja) | 2022-11-30 |
| JP2015536351A (ja) | 2015-12-21 |
| WO2014087248A2 (en) | 2014-06-12 |
| CA2892585C (en) | 2022-07-05 |
| US20140303354A1 (en) | 2014-10-09 |
| CN105121467A (zh) | 2015-12-02 |
| US11059910B2 (en) | 2021-07-13 |
| AU2018220150A1 (en) | 2018-09-13 |
| JP2020183451A (ja) | 2020-11-12 |
| AU2013353763A1 (en) | 2015-06-11 |
| CN110183534A (zh) | 2019-08-30 |
| RU2015126533A (ru) | 2017-01-12 |
| CN105121467B (zh) | 2019-07-05 |
| JP7563916B2 (ja) | 2024-10-08 |
| CA3155275A1 (en) | 2014-06-12 |
| EP2925782A2 (en) | 2015-10-07 |
| EP3725807A1 (en) | 2020-10-21 |
| AU2018220150B2 (en) | 2021-02-25 |
| JP6392770B2 (ja) | 2018-09-19 |
| ES2784631T3 (es) | 2020-09-29 |
| WO2014087248A3 (en) | 2014-11-06 |
| RU2019118257A (ru) | 2019-06-24 |
| CA2892585A1 (en) | 2014-06-12 |
| US20180291116A1 (en) | 2018-10-11 |
| AU2013353763B2 (en) | 2018-09-13 |
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