DK151623C - Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf

Info

Publication number
DK151623C
DK151623C DK178379A DK178379A DK151623C DK 151623 C DK151623 C DK 151623C DK 178379 A DK178379 A DK 178379A DK 178379 A DK178379 A DK 178379A DK 151623 C DK151623 C DK 151623C
Authority
DK
Denmark
Prior art keywords
analogue
preparation
acid addition
addition salts
acceptable acid
Prior art date
Application number
DK178379A
Other languages
Danish (da)
English (en)
Other versions
DK151623B (da
DK178379A (da
Inventor
Shingo Matsumura
Hiroshi Enomoto
Yoshiaki Aoyagi
Yoshiaki Yoshikuni
Kohei Kura
Masahiro Yagi
Ichiro Shirahase
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP53053603A external-priority patent/JPS5943947B2/ja
Priority claimed from JP8260678A external-priority patent/JPS5943948B2/ja
Priority claimed from JP12066178A external-priority patent/JPS5943949B2/ja
Priority claimed from JP571479A external-priority patent/JPS6026387B2/ja
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of DK178379A publication Critical patent/DK178379A/da
Publication of DK151623B publication Critical patent/DK151623B/da
Application granted granted Critical
Publication of DK151623C publication Critical patent/DK151623C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK178379A 1978-05-03 1979-05-01 Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf DK151623C (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP5360378 1978-05-03
JP53053603A JPS5943947B2 (ja) 1978-05-03 1978-05-03 Ｎ−置換モラノリン誘導体
JP8260678 1978-07-06
JP8260678A JPS5943948B2 (ja) 1978-07-06 1978-07-06 置換モラノリン誘導体
JP12066178A JPS5943949B2 (ja) 1978-09-29 1978-09-29 モラノリンのｎ−置換誘導体
JP12066178 1978-09-29
JP571479 1979-01-20
JP571479A JPS6026387B2 (ja) 1979-01-20 1979-01-20 シンナミルモラノリン誘導体

Publications (3)

Publication Number Publication Date
DK178379A DK178379A (da) 1979-11-04
DK151623B DK151623B (da) 1987-12-21
DK151623C true DK151623C (da) 1988-07-18

Family

ID=27454348

Family Applications (1)

Application Number Title Priority Date Filing Date
DK178379A DK151623C (da) 1978-05-03 1979-05-01 Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (9)

Country Link
US (1) US4533668A (sv)
CH (1) CH642629A5 (sv)
DE (1) DE2915037C3 (sv)
DK (1) DK151623C (sv)
FR (1) FR2424910A1 (sv)
GB (1) GB2020278B (sv)
IT (1) IT1116820B (sv)
NL (1) NL175820C (sv)
SE (4) SE436874B (sv)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2925943A1 (de) * 1979-06-27 1981-01-29 Bayer Ag 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
JP2504000B2 (ja) * 1986-09-02 1996-06-05 日本新薬株式会社 グルコシルモラノリン誘導体
JPS6461459A (en) * 1987-08-28 1989-03-08 Nippon Shinyaku Co Ltd Moranoline derivative
US5192772A (en) * 1987-12-09 1993-03-09 Nippon Shinyaku Co. Ltd. Therapeutic agents
GB8827701D0 (en) * 1987-12-09 1988-12-29 Nippon Shinyaku Co Ltd Thrombolytic &c compositions
US4985445A (en) * 1988-02-12 1991-01-15 Meiji Seika Kaisha, Ltd. Cancer cell metastasis inhibitors and novel compounds
EP0350012A3 (en) * 1988-07-08 1990-09-05 Meiji Seika Kaisha Ltd. Antiviral composition
DK0566557T3 (da) * 1992-04-01 1996-11-04 Searle & Co 2- og 3-amino- og azidoderivater af 1,5- iminosukkere som antivirale forbindelser
US5206251A (en) * 1992-04-01 1993-04-27 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5216168A (en) * 1992-04-01 1993-06-01 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5331096A (en) * 1992-04-01 1994-07-19 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5268482A (en) * 1992-04-01 1993-12-07 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
US6291657B1 (en) 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5399567A (en) * 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
PT1030839E (pt) 1997-11-10 2004-05-31 Searle & Co Utilizacao de iminoacucares para tratar a resistencia a multifarmacos
ES2272054T3 (es) 1998-02-12 2007-04-16 United Therapeutics Corporation Uso de compuestos de n-sustituido-1,5-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
ES2311921T3 (es) * 1999-02-12 2009-02-16 United Therapeutics Corporation N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
US6515028B1 (en) 1999-02-12 2003-02-04 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
US20050119310A1 (en) * 2000-02-14 2005-06-02 Mueller Richard A. Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
BRPI0517701A8 (pt) * 2004-11-10 2018-01-23 Genzyme Corp métodos de tratamento de diabetes mellitus
AT502145B1 (de) * 2005-03-24 2012-01-15 Univ Graz Tech Glycosidase-hemmendes iminoalditol
ES2546181T3 (es) 2006-05-09 2015-09-21 Genzyme Corporation Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos
US8975280B2 (en) * 2006-05-24 2015-03-10 The Chancellor, Masters And Scholars Of The University Of Oxford Deoxynojirimycin and D-arabinitol analogs and methods of using
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
EP2594563B1 (en) 2007-05-31 2018-07-18 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
MX337396B (es) * 2007-10-05 2016-03-02 Genzyme Corp Metodo para el tratamiento de enfermedades del riñon poliquisticas con derivados de ceramica.
CA2731685A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
WO2010039256A1 (en) 2008-10-03 2010-04-08 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
WO2017192599A1 (en) 2016-05-02 2017-11-09 Florida State University Research Foundation, Inc. Treatment of zika virus infections using alpha-glucosidase inhibitors
EP4106752A4 (en) 2020-02-21 2024-03-20 Florida State University Research Foundation, Inc. TREATMENT OF HUMAN CORONAVIRUS INFECTIONS USING ALPHA-GLUCOSIDASE-GLYCOPROTEIN PROCESSING INHIBITORS
WO2021224865A1 (en) * 2020-05-07 2021-11-11 Alectos Therapeutics Inc. Non-lysosomal glucosylceramidase inhibitors and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5282710A (en) * 1975-12-29 1977-07-11 Nippon Shinyaku Co Ltd Extraction of effective drug component from mulberry
DE2735316C3 (de) * 1977-08-05 1981-01-29 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von nadeiförmigen, ferrimagnetischen Eisenoxiden

Also Published As

Publication number Publication date
US4533668A (en) 1985-08-06
DE2915037A1 (de) 1979-11-08
DK151623B (da) 1987-12-21
SE8402549L (sv) 1984-05-11
SE451015B (sv) 1987-08-24
IT7948904A0 (it) 1979-05-02
GB2020278A (en) 1979-11-14
FR2424910B1 (sv) 1981-12-11
SE8402551L (sv) 1984-05-11
DE2915037B2 (de) 1981-01-29
IT1116820B (it) 1986-02-10
SE8402549D0 (sv) 1984-05-11
SE8402551D0 (sv) 1984-05-11
NL7903421A (nl) 1979-11-06
FR2424910A1 (fr) 1979-11-30
SE8402550L (sv) 1984-05-11
DE2915037C3 (de) 1981-11-05
SE8402550D0 (sv) 1984-05-11
NL175820B (nl) 1984-08-01
SE451016B (sv) 1987-08-24
SE7903817L (sv) 1979-11-04
NL175820C (nl) 1985-01-02
DK178379A (da) 1979-11-04
SE436874B (sv) 1985-01-28
SE451017B (sv) 1987-08-24
CH642629A5 (de) 1984-04-30
GB2020278B (en) 1983-02-23

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