DK1341753T3 - Cyclohexyl (alkyl) -propanolaminer, deres fremstilling, og farmaceutiske sammensætninger, der indeholder dem - Google Patents

Cyclohexyl (alkyl) -propanolaminer, deres fremstilling, og farmaceutiske sammensætninger, der indeholder dem

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Publication number
DK1341753T3
DK1341753T3 DK01998533T DK01998533T DK1341753T3 DK 1341753 T3 DK1341753 T3 DK 1341753T3 DK 01998533 T DK01998533 T DK 01998533T DK 01998533 T DK01998533 T DK 01998533T DK 1341753 T3 DK1341753 T3 DK 1341753T3
Authority
DK
Denmark
Prior art keywords
propanolamines
cyclohexyl
alkyl
preparation
pharmaceutical compositions
Prior art date
Application number
DK01998533T
Other languages
Danish (da)
English (en)
Inventor
Philippe R Bovy
Roberto Cecchi
Gilles Courtemanche
Ambrogio Oliva
Nunzia Viviani
Tiziano Croci
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of DK1341753T3 publication Critical patent/DK1341753T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/16Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DK01998533T 2000-11-30 2001-11-30 Cyclohexyl (alkyl) -propanolaminer, deres fremstilling, og farmaceutiske sammensætninger, der indeholder dem DK1341753T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0015477A FR2817257B1 (fr) 2000-11-30 2000-11-30 Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
PCT/FR2001/003784 WO2002044139A1 (fr) 2000-11-30 2001-11-30 Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant

Publications (1)

Publication Number Publication Date
DK1341753T3 true DK1341753T3 (da) 2008-01-14

Family

ID=8857054

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01998533T DK1341753T3 (da) 2000-11-30 2001-11-30 Cyclohexyl (alkyl) -propanolaminer, deres fremstilling, og farmaceutiske sammensætninger, der indeholder dem

Country Status (25)

Country Link
US (3) US7388031B2 (es)
EP (1) EP1341753B1 (es)
JP (1) JP4024149B2 (es)
CN (2) CN1935787A (es)
AR (1) AR031438A1 (es)
AT (1) ATE374177T1 (es)
AU (2) AU2207902A (es)
BR (1) BR0115768A (es)
CA (1) CA2429267C (es)
CY (1) CY1106997T1 (es)
CZ (1) CZ305140B6 (es)
DE (1) DE60130676T2 (es)
DK (1) DK1341753T3 (es)
ES (1) ES2290201T3 (es)
FR (1) FR2817257B1 (es)
HK (1) HK1055945A1 (es)
HU (1) HU229583B1 (es)
ME (1) MEP23308A (es)
MX (1) MXPA03004884A (es)
PL (1) PL206695B1 (es)
PT (1) PT1341753E (es)
RS (1) RS51571B (es)
SI (1) SI1341753T1 (es)
SK (1) SK287551B6 (es)
WO (1) WO2002044139A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2817257B1 (fr) * 2000-11-30 2009-03-20 Sanofi Synthelabo Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
FR2840304B1 (fr) * 2002-05-29 2007-05-18 Sanofi Synthelabo Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique
FR2840301B1 (fr) * 2002-05-29 2007-03-23 Sanofi Synthelabo Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique
EP2011490A1 (en) * 2007-07-05 2009-01-07 Sanofi-Aventis Beta adrenergic receptor ligand derivatives for modulating apoptosis
FR2935141B1 (fr) * 2008-08-21 2010-10-08 Sanofi Aventis Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate
AU2009308708B2 (en) * 2008-10-31 2015-11-19 Medivation Technologies, Inc. Azepino [4, 5-b] indoles and methods of use
CN116143575B (zh) * 2023-04-21 2023-06-30 研峰(天津)科学技术应用研究有限公司 昆虫信息素原料3-环己基-1-丙炔合成方法

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US4004028A (en) * 1975-08-06 1977-01-18 Smithkline Corporation Phenoxypropanolamines
CA1336911C (en) * 1988-06-03 1995-09-05 David Taiwai Wong Serotonin antagonists
US5258379A (en) 1990-05-04 1993-11-02 Eli Lilly And Company Method of inhibiting gastric acid secretion with n-arylpiperazines
US5096908A (en) 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
US5158956A (en) 1990-05-04 1992-10-27 Eli Lilly And Company Method of inhibiting gastric acid secretion with benzodioxanes
US5340838A (en) 1990-05-04 1994-08-23 Eli Lilly And Company Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AP9300589A0 (en) 1992-11-18 1994-01-31 Smithkline Beecham Corp Novel 17a and 17b substituted acyl-3-carboxy 3,5-diene steroidal compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-a-reductase.
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
IL110857A0 (en) 1993-09-09 1994-11-28 Lilly Co Eli Cessation of tobacco use
CA2134038C (en) 1994-06-16 1997-06-03 David Taiwai Wong Potentiation of drug response
EP0714663A3 (en) 1994-11-28 1997-01-15 Lilly Co Eli Potentiation of drug responses by serotonin 1A receptor antagonists
US5776959A (en) 1995-06-05 1998-07-07 Washington University Anticonvulsant and anxiolytic lactam and thiolactam derivatives
IL123677A0 (en) * 1995-09-21 1998-10-30 Lilly Co Eli Selective beta3 adrenergic agonists
EP0792649A1 (en) 1996-02-29 1997-09-03 Eli Lilly And Company Treatment of sleep disorders
US5958429A (en) 1996-08-16 1999-09-28 Eli Lilly And Company Potentiation of serotonin response
FR2755439B1 (fr) 1996-11-05 1998-12-24 Virbac Sa Derives aryloxypropanolamines, leur procede de preparation et leurs applications
US20020019440A1 (en) 1996-11-05 2002-02-14 Virbac Sa Aryloxypropanolamine derivatives, method of preparation and applications thereof
FR2758460B1 (fr) * 1997-01-21 1999-12-31 Sanofi Sa Utilisation des agonistes des recepteurs beta-3 adrenergiques pour la preparation de medicaments cicatrisants
US5776969A (en) 1997-02-27 1998-07-07 Eli Lilly And Company Treatment of sleep disorders
FR2780057B1 (fr) * 1998-06-18 2002-09-13 Sanofi Sa Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
JP2000086603A (ja) 1998-07-15 2000-03-28 Yoshitomi Pharmaceut Ind Ltd 桂皮酸アミド誘導体および3―フェニルプロピオン酸アミド誘導体
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FR2817257B1 (fr) 2000-11-30 2009-03-20 Sanofi Synthelabo Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
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FR2840301B1 (fr) 2002-05-29 2007-03-23 Sanofi Synthelabo Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique
FR2840304B1 (fr) * 2002-05-29 2007-05-18 Sanofi Synthelabo Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique
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Also Published As

Publication number Publication date
WO2002044139A1 (fr) 2002-06-06
US7419974B2 (en) 2008-09-02
YU41703A (sh) 2006-05-25
CN1478074A (zh) 2004-02-25
US7388031B2 (en) 2008-06-17
CA2429267C (fr) 2010-09-28
SI1341753T1 (sl) 2007-12-31
ES2290201T3 (es) 2008-02-16
CN1283622C (zh) 2006-11-08
US20040053916A1 (en) 2004-03-18
AU2207902A (en) 2002-06-11
HU229583B1 (en) 2014-02-28
HUP0400565A2 (hu) 2004-06-28
AU2002222079B2 (en) 2006-12-14
HUP0400565A3 (en) 2004-08-30
CY1106997T1 (el) 2012-01-25
FR2817257B1 (fr) 2009-03-20
JP4024149B2 (ja) 2007-12-19
AR031438A1 (es) 2003-09-24
FR2817257A1 (fr) 2002-05-31
JP2004514708A (ja) 2004-05-20
BR0115768A (pt) 2003-12-30
US20070015745A1 (en) 2007-01-18
EP1341753B1 (fr) 2007-09-26
PL364746A1 (en) 2004-12-13
PT1341753E (pt) 2007-11-13
ATE374177T1 (de) 2007-10-15
DE60130676D1 (de) 2007-11-08
CN1935787A (zh) 2007-03-28
US7718646B2 (en) 2010-05-18
RS51571B (en) 2011-08-31
US20080261949A1 (en) 2008-10-23
SK6522003A3 (en) 2003-11-04
MXPA03004884A (es) 2004-05-04
CA2429267A1 (fr) 2002-06-06
PL206695B1 (pl) 2010-09-30
SK287551B6 (sk) 2011-01-04
DE60130676T2 (de) 2008-07-17
MEP23308A (en) 2010-06-10
EP1341753A1 (fr) 2003-09-10
CZ20031499A3 (cs) 2003-08-13
CZ305140B6 (cs) 2015-05-20
HK1055945A1 (en) 2004-01-30

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