DK0889886T5 - Hidtil ukendte, i 6-stilling substituerede phenanthridiner - Google Patents

Hidtil ukendte, i 6-stilling substituerede phenanthridiner

Info

Publication number
DK0889886T5
DK0889886T5 DK97915422T DK97915422T DK0889886T5 DK 0889886 T5 DK0889886 T5 DK 0889886T5 DK 97915422 T DK97915422 T DK 97915422T DK 97915422 T DK97915422 T DK 97915422T DK 0889886 T5 DK0889886 T5 DK 0889886T5
Authority
DK
Denmark
Prior art keywords
novel
position substituted
phenanthridines
substituted phenanthridines
compounds
Prior art date
Application number
DK97915422T
Other languages
English (en)
Other versions
DK0889886T3 (da
Inventor
Hermann Amschler
Dieter Flockerzi
Armin Hatzelmann
Rolf Beume
Dietrich Haefner
Hans-Peter Kley
Beate Gutterer
Wolf-Ruediger Ulrich
Thomas Baer
Thomas Martin
Christian Schudt
Hildegard Boss
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996113091 external-priority patent/DE19613091A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of DK0889886T3 publication Critical patent/DK0889886T3/da
Application granted granted Critical
Publication of DK0889886T5 publication Critical patent/DK0889886T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
DK97915422T 1996-03-26 1997-03-24 Hidtil ukendte, i 6-stilling substituerede phenanthridiner DK0889886T5 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19611922 1996-03-26
EP96105038 1996-03-29
DE1996113091 DE19613091A1 (de) 1996-04-02 1996-04-02 6-Phenylphenanthridine
EP96105311 1996-04-03
PCT/EP1997/001487 WO1997035854A1 (de) 1996-03-26 1997-03-24 Neue in 6-position substituierte phenanthridine

Publications (2)

Publication Number Publication Date
DK0889886T3 DK0889886T3 (da) 2003-01-20
DK0889886T5 true DK0889886T5 (da) 2003-02-24

Family

ID=27438318

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97915422T DK0889886T5 (da) 1996-03-26 1997-03-24 Hidtil ukendte, i 6-stilling substituerede phenanthridiner

Country Status (12)

Country Link
EP (1) EP0889886B1 (da)
JP (1) JP4141501B2 (da)
AT (1) ATE224386T1 (da)
AU (1) AU718752B2 (da)
CA (1) CA2250569C (da)
CY (1) CY2431B1 (da)
DE (1) DE59708265D1 (da)
DK (1) DK0889886T5 (da)
ES (1) ES2184077T3 (da)
PT (1) PT889886E (da)
SI (1) SI0889886T1 (da)
WO (1) WO1997035854A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2189235T3 (es) * 1997-07-25 2003-07-01 Altana Pharma Ag 6-fenilfenantridinas sustituidas.
IL133824A (en) * 1997-07-25 2005-12-18 Altana Pharma Ag Tetrazole derivatives and medicaments containing the same
AR015966A1 (es) * 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
IT1296985B1 (it) 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
ATE294793T1 (de) * 1999-01-15 2005-05-15 Altana Pharma Ag Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
CA2359404A1 (en) * 1999-01-15 2000-07-20 Beate Gutterer Phenanthridine-n-oxides with pde-iv inhibiting activity
DE60024581T2 (de) * 1999-01-15 2006-08-10 Altana Pharma Ag 6-phenylphenanthridine mit pde-iv hemmender wirkung
PT1147088E (pt) * 1999-01-15 2006-05-31 Altana Pharma Ag 6-arilfenantridinas com actividade inibitoria da pde-iv
DE60033918D1 (de) * 1999-01-15 2007-04-26 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
DE60043318D1 (de) 1999-08-21 2010-01-14 Nycomed Gmbh Synergistische kombination von pumafentrine und salmeterol
AU782908B2 (en) * 2000-01-11 2005-09-08 Altana Pharma Ag Phenanthridine-N-oxides
AU2001269126A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Phenanthridine n-oxides
AU2001281965A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Novel 6-phenylphenanthridines
ES2236288T3 (es) 2000-07-14 2005-07-16 Altana Pharma Ag 6-heteroarilfenantridinas.
AU2001267589A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
EP1536798B1 (en) 2002-08-29 2007-02-07 ALTANA Pharma AG 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
CA2495827C (en) 2002-08-29 2012-05-08 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
EP1658271A1 (en) * 2003-07-31 2006-05-24 ALTANA Pharma AG Novel 6-phenylphenanthridines
WO2005012252A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenantridines
US7585872B2 (en) 2004-02-18 2009-09-08 Nycomed Gmbh Guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (PDE) 4 inhibitors
KR101152439B1 (ko) 2004-03-03 2012-07-06 니코메드 게엠베하 신규 히드록시-6-헤테로아릴페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도
WO2005084104A2 (en) * 2004-03-09 2005-09-15 Altana Pharma Ag Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
WO2005087744A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
WO2005085203A1 (en) * 2004-03-10 2005-09-15 Altana Pharma Ag Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
ES2342728T3 (es) 2005-02-01 2010-07-13 Nycomed Gmbh Nuevas 6-piridilfenantridinas.
DK1856093T3 (da) 2005-03-02 2010-03-15 Nycomed Gmbh (2R,4aR,10bR)-6-(2,6-dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol, HCI-salt
WO2006092417A1 (en) * 2005-03-02 2006-09-08 Nycomed Gmbh 6 -heteroaryl-1, 2, 3,4,4a, 1ob-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders
JP2009508815A (ja) * 2005-08-30 2009-03-05 アボット・ラボラトリーズ ジペプチジルペプチダーゼ−ｉｖ（ｄｐｐ−ｉｖ）の阻害薬としての医薬組成物
UY35543A (es) * 2013-04-30 2014-11-28 Bayer Cropscience Ag N-(fenilcicloalquil)carboxamidas y n-(fenilcicloalquil)tiocarboxamidas nematicidas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786031A (fr) * 1971-07-08 1973-01-08 Rhone Poulenc Sa Nouveaux derives de la phenanthridine, leur preparation et les compositions medicinales qui les contiennent
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof

Also Published As

Publication number Publication date
SI0889886T1 (en) 2003-02-28
CA2250569C (en) 2005-05-10
CA2250569A1 (en) 1997-10-02
JP4141501B2 (ja) 2008-08-27
AU718752B2 (en) 2000-04-20
AU2291097A (en) 1997-10-17
JP2000507256A (ja) 2000-06-13
ES2184077T3 (es) 2003-04-01
PT889886E (pt) 2003-02-28
EP0889886A1 (de) 1999-01-13
EP0889886B1 (de) 2002-09-18
DK0889886T3 (da) 2003-01-20
DE59708265D1 (de) 2002-10-24
CY2431B1 (en) 2004-11-12
ATE224386T1 (de) 2002-10-15
WO1997035854A1 (de) 1997-10-02

Similar Documents

Publication Publication Date Title
DK0889886T5 (da) Hidtil ukendte, i 6-stilling substituerede phenanthridiner
BR9707233A (pt) Fenantridinas
ES2189235T3 (es) 6-fenilfenantridinas sustituidas.
EE200000033A (et) Uudsed tetrasoolderivaadid
BR0007527A (pt) Fenilfenantridinas com atividade inibitória depde-iv
DE69918422D1 (de) Phthalazinone pde iii/iv hemmer
ID22042A (id) Benzonaftiridin sebagai pengobatan cabang tenggorokan
DE60020595D1 (de) 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
ATE294793T1 (de) Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
ATE281439T1 (de) 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
NZ331374A (en) Phenanthridine compounds and pharmaceutical compositions thereof
PL343848A1 (en) Novel benzimidazoles and benzoxazoles