DK0844241T3 - Inhibitor af narkotisk analgetisk afhængighed/resistensudvikling - Google Patents

Inhibitor af narkotisk analgetisk afhængighed/resistensudvikling

Info

Publication number
DK0844241T3
DK0844241T3 DK96926004T DK96926004T DK0844241T3 DK 0844241 T3 DK0844241 T3 DK 0844241T3 DK 96926004 T DK96926004 T DK 96926004T DK 96926004 T DK96926004 T DK 96926004T DK 0844241 T3 DK0844241 T3 DK 0844241T3
Authority
DK
Denmark
Prior art keywords
narcotic analgesic
inhibitor
resistance development
development
substituted
Prior art date
Application number
DK96926004T
Other languages
English (en)
Inventor
Tadashi Shiotani
Toshitaka Nabeshima
Mitsunobu Yoshii
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Application granted granted Critical
Publication of DK0844241T3 publication Critical patent/DK0844241T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4021-aryl substituted, e.g. piretanide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK96926004T 1995-08-07 1996-08-06 Inhibitor af narkotisk analgetisk afhængighed/resistensudvikling DK0844241T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20076395 1995-08-07
PCT/JP1996/002207 WO1997006139A1 (fr) 1995-08-07 1996-08-06 Inhibiteur de la dependance / de la resistance a l'egard des analgesiques narcotiques

Publications (1)

Publication Number Publication Date
DK0844241T3 true DK0844241T3 (da) 2003-05-12

Family

ID=16429771

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96926004T DK0844241T3 (da) 1995-08-07 1996-08-06 Inhibitor af narkotisk analgetisk afhængighed/resistensudvikling

Country Status (13)

Country Link
US (1) US6107330A (da)
EP (1) EP0844241B1 (da)
KR (1) KR19990036248A (da)
CN (1) CN1085979C (da)
AT (1) ATE231491T1 (da)
AU (1) AU6631396A (da)
CA (1) CA2228813A1 (da)
DE (1) DE69625913T2 (da)
DK (1) DK0844241T3 (da)
ES (1) ES2191763T3 (da)
NO (1) NO315078B1 (da)
TW (1) TW457087B (da)
WO (1) WO1997006139A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727482B2 (en) * 1996-10-01 2000-12-14 Daiichi Pharmaceutical Co., Ltd. Mitochondrial membrane stabilizer
AU8131198A (en) * 1997-07-15 1999-02-10 Daiichi Pharmaceutical Co., Ltd. Prophylactic or therapeutic agent for amnesia
US6890951B2 (en) 1998-08-05 2005-05-10 Brookhaven Science Associates Llc Treatment of addiction and addiction-related behavior
US20040077709A1 (en) * 1999-05-31 2004-04-22 Daiichi Pharmaceutical Co., Ltd. Neuronal death inhibitors
US6423739B1 (en) 2000-02-23 2002-07-23 Daiichi Pharmaceutical Co., Ltd. Method for aiding cerebral recovery following neurodegeneration
US6348489B1 (en) 2000-04-11 2002-02-19 Daiichi Pharmaceutical Co., Ltd. Method of treating traumatic brain injury and other neuronal disorders
CN1484527A (zh) * 2000-12-28 2004-03-24 ��һ��������ҩ��ʽ���� 神经性疼痛治疗和预防药
US7250422B2 (en) 2002-10-29 2007-07-31 Sungkyunkwan University Pharmaceutical composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine
US20060241144A1 (en) * 2005-04-20 2006-10-26 Albert Cha Method for treating apathy syndrome

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5198317A (en) * 1975-02-21 1976-08-30 22 okisopirorijin 11 iruasetamidochushaekinoseizoho
US4212878A (en) * 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
US4490167A (en) * 1979-08-06 1984-12-25 Ciba-Geigy Corporation Oxime derivatives of diphenyl ethers and their use in herbicidal compositions
BE893276A (fr) * 1981-06-01 1982-11-24 Sandoz Sa Nouvelle application therapeutique d'un derive de l'acetamide
IL91451A0 (en) * 1988-08-30 1990-04-29 Bristol Myers Co Pharmaceutical compositions comprising azapiron compounds and their use in the treatment of addiction
US5468749A (en) * 1988-08-30 1995-11-21 Gawin; Frank H. Method for treatment of substance addiction
US5185329A (en) * 1988-08-30 1993-02-09 Bristol-Myers Squibb Company Method for treatment of substance addiction
DE415693T1 (de) * 1989-08-28 1991-10-17 Arizona Technology Development Corp., Tucson, Ariz. Zusammensetzung und verfahren zur selektiven verstaerkung der opiat-wirkung und verminderung von opiat-toleranz und abhaengigkeit.
US5220018A (en) * 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
IL101514A (en) * 1991-04-10 1996-01-31 Merck & Co Inc History of benzodiazepines and anticoagulants containing cholecystokinin containing them
JPH0517421A (ja) * 1991-07-10 1993-01-26 Yamanouchi Pharmaceut Co Ltd N−置換アミド誘導体
CA2098663A1 (en) * 1992-06-19 1993-12-20 Shinji Kamihara Process for preparing pyrrolidinylacetamide derivative
US5461157A (en) * 1992-06-19 1995-10-24 Daiichi Pharmaceutical Co., Ltd. Process for preparing pyrrolidinylacetamide derivatives

Also Published As

Publication number Publication date
DE69625913T2 (de) 2003-11-27
KR19990036248A (ko) 1999-05-25
DE69625913D1 (de) 2003-02-27
WO1997006139A1 (fr) 1997-02-20
NO315078B1 (no) 2003-07-07
CA2228813A1 (en) 1997-02-20
ES2191763T3 (es) 2003-09-16
ATE231491T1 (de) 2003-02-15
EP0844241A1 (en) 1998-05-27
EP0844241B1 (en) 2003-01-22
EP0844241A4 (en) 1998-11-18
CN1198738A (zh) 1998-11-11
US6107330A (en) 2000-08-22
NO980531L (no) 1998-04-06
TW457087B (en) 2001-10-01
CN1085979C (zh) 2002-06-05
NO980531D0 (no) 1998-02-06
AU6631396A (en) 1997-03-05

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