DE69903708D1 - 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate - Google Patents

2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate

Info

Publication number
DE69903708D1
DE69903708D1 DE69903708T DE69903708T DE69903708D1 DE 69903708 D1 DE69903708 D1 DE 69903708D1 DE 69903708 T DE69903708 T DE 69903708T DE 69903708 T DE69903708 T DE 69903708T DE 69903708 D1 DE69903708 D1 DE 69903708D1
Authority
DE
Germany
Prior art keywords
purin
tetrahydro
diol derivatives
diol
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69903708T
Other languages
English (en)
Other versions
DE69903708T2 (de
Inventor
Chuen Chan
Peter Cousins
Brian Cox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9802066.2A external-priority patent/GB9802066D0/en
Priority claimed from GBGB9813528.8A external-priority patent/GB9813528D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE69903708D1 publication Critical patent/DE69903708D1/de
Application granted granted Critical
Publication of DE69903708T2 publication Critical patent/DE69903708T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69903708T 1998-01-31 1999-01-29 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate Expired - Lifetime DE69903708T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9802066.2A GB9802066D0 (en) 1998-01-31 1998-01-31 Chemical compounds
GBGB9813528.8A GB9813528D0 (en) 1998-06-23 1998-06-23 Chemical compounds
PCT/EP1999/000503 WO1999038877A2 (en) 1998-01-31 1999-01-29 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES

Publications (2)

Publication Number Publication Date
DE69903708D1 true DE69903708D1 (de) 2002-12-05
DE69903708T2 DE69903708T2 (de) 2003-07-03

Family

ID=26313042

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903708T Expired - Lifetime DE69903708T2 (de) 1998-01-31 1999-01-29 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate

Country Status (39)

Country Link
US (1) US6762170B1 (de)
EP (1) EP1051425B1 (de)
JP (1) JP2002501928A (de)
KR (1) KR20010034473A (de)
CN (1) CN1289338A (de)
AP (1) AP2000001875A0 (de)
AR (1) AR014508A1 (de)
AT (1) ATE226957T1 (de)
AU (1) AU757183B2 (de)
BG (1) BG63783B1 (de)
BR (1) BR9907270A (de)
CA (1) CA2318278A1 (de)
CO (1) CO4980872A1 (de)
DE (1) DE69903708T2 (de)
DK (1) DK1051425T3 (de)
EA (1) EA003194B1 (de)
EE (1) EE200000441A (de)
ES (1) ES2186330T3 (de)
GE (1) GEP20022839B (de)
HK (1) HK1030611A1 (de)
HR (1) HRP20000511A2 (de)
HU (1) HUP0101305A3 (de)
ID (1) ID26326A (de)
IL (1) IL137042A0 (de)
IS (1) IS5550A (de)
MA (1) MA26601A1 (de)
NO (1) NO20003867D0 (de)
NZ (1) NZ505452A (de)
OA (1) OA11447A (de)
PE (1) PE20000280A1 (de)
PL (1) PL342670A1 (de)
PT (1) PT1051425E (de)
SI (1) SI1051425T1 (de)
SK (1) SK11192000A3 (de)
SV (1) SV1999000009A (de)
TR (1) TR200002218T2 (de)
TW (1) TW434250B (de)
WO (1) WO1999038877A2 (de)
YU (1) YU44900A (de)

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US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
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Also Published As

Publication number Publication date
NO20003867L (no) 2000-07-28
SI1051425T1 (en) 2003-04-30
IS5550A (is) 2000-06-27
AP2000001875A0 (en) 2000-09-30
CA2318278A1 (en) 1999-08-05
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EA200000723A1 (ru) 2001-04-23
WO1999038877A3 (en) 1999-09-30
DK1051425T3 (da) 2003-03-03
BR9907270A (pt) 2000-10-24
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PL342670A1 (en) 2001-07-02
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