DE69623497D1 - 1-methylcarbapenem-derivate - Google Patents

1-methylcarbapenem-derivate

Info

Publication number
DE69623497D1
DE69623497D1 DE69623497T DE69623497T DE69623497D1 DE 69623497 D1 DE69623497 D1 DE 69623497D1 DE 69623497 T DE69623497 T DE 69623497T DE 69623497 T DE69623497 T DE 69623497T DE 69623497 D1 DE69623497 D1 DE 69623497D1
Authority
DE
Germany
Prior art keywords
substituted
ylcarbonyl
hydroxy
ethyl
methylcarbapenem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69623497T
Other languages
English (en)
Other versions
DE69623497T2 (de
Inventor
Isao Kawamoto
Limited Shimoji
Katsuya Ishikawa
Katsuhiko Kojima
Hiroshi Yasuda
Satoshi Ohya
Yukio Utsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of DE69623497D1 publication Critical patent/DE69623497D1/de
Application granted granted Critical
Publication of DE69623497T2 publication Critical patent/DE69623497T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69623497T 1995-12-21 1996-12-20 1-methylcarbapenem-derivate Expired - Lifetime DE69623497T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33313595 1995-12-21
JP30894096 1996-11-20
PCT/JP1996/003726 WO1997023483A1 (en) 1995-12-21 1996-12-20 1-methylcarbapenem derivatives

Publications (2)

Publication Number Publication Date
DE69623497D1 true DE69623497D1 (de) 2002-10-10
DE69623497T2 DE69623497T2 (de) 2003-05-28

Family

ID=26565749

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69623497T Expired - Lifetime DE69623497T2 (de) 1995-12-21 1996-12-20 1-methylcarbapenem-derivate

Country Status (18)

Country Link
US (1) US6090802A (de)
EP (1) EP0882728B1 (de)
KR (1) KR100386993B1 (de)
CN (1) CN1095843C (de)
AT (1) ATE223411T1 (de)
AU (1) AU711135B2 (de)
CA (1) CA2241092C (de)
CZ (1) CZ298246B6 (de)
DE (1) DE69623497T2 (de)
DK (1) DK0882728T3 (de)
ES (1) ES2181927T3 (de)
HK (1) HK1015766A1 (de)
HU (1) HUP9901376A3 (de)
MX (1) MX9805023A (de)
NO (1) NO310684B1 (de)
NZ (1) NZ324447A (de)
PT (1) PT882728E (de)
WO (1) WO1997023483A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ272099A3 (cs) 1997-02-07 1999-11-17 Kyoto Pharmaceutical Industries, Ltd. Karbapenémové sloučeniny, jejich použití a jejich meziprodukty
WO1999057121A1 (fr) 1998-05-01 1999-11-11 Kyoto Pharmaceutical Industries, Ltd. Derives de carbapenem, son utilisation et composes intermediaires a base de carbapenem
WO2000034282A1 (fr) * 1998-12-07 2000-06-15 Sankyo Company, Limited Derives de 1-methylcarbapenem
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
US6531594B2 (en) * 2000-08-24 2003-03-11 Mitsubishi Chemical Corporation Process for producing 1H-3-aminopyrrolidine and derivatives thereof
ATE315568T1 (de) * 2000-11-20 2006-02-15 Sankyo Co Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ
MXPA03010607A (es) * 2001-05-21 2004-04-02 Kyoto Pharma Ind Compuesto de carbapenem.
WO2003024928A2 (en) 2001-09-14 2003-03-27 Novo Nordisk A/S Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
CA2644316A1 (en) * 2003-08-25 2005-03-03 Sankyo Company Limited Crystal of 1-methyl carbapenem compound
CA2602097A1 (en) * 2005-03-22 2006-09-28 Daiichi Sankyo Company, Limited Process for producing carbapenem derivatives having 1-alkylpyrrolidine structure
US20080227768A1 (en) * 2005-05-13 2008-09-18 Makoto Michida Crystal of 1-Methylcarbapenem Compound
CN101918407B (zh) 2008-01-18 2014-02-26 默沙东公司 β-内酰胺酶抑制剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS62155279A (ja) * 1984-11-08 1987-07-10 Sumitomo Pharmaceut Co Ltd 新規なβ−ラクタム化合物
DE3579888D1 (de) * 1984-11-08 1990-10-31 Sumitomo Pharma Carbapenemverbindungen und deren herstellung.
JP3005045B2 (ja) * 1990-02-14 2000-01-31 住友製薬株式会社 新規なβ―ラクタム化合物及びその製造法
TW198034B (de) * 1990-03-27 1993-01-11 Manyu Seiyaku Kk
NO302475B1 (no) * 1991-06-04 1998-03-09 Sankyo Co 1-metylkarbapenemderivater og farmasöytisk preparat inneholdende disse
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
JP3048196B2 (ja) * 1991-06-20 2000-06-05 第一製薬株式会社 カルバペネム誘導体
CZ290002B6 (cs) * 1992-03-11 2002-05-15 Sankyo Company Limited Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek
JP3411589B2 (ja) * 1992-05-11 2003-06-03 第一製薬株式会社 カルバペネム誘導体
JP3344662B2 (ja) * 1992-09-14 2002-11-11 三共株式会社 カルバペネム−３−カルボン酸誘導体
JPH06199860A (ja) * 1992-09-16 1994-07-19 Sankyo Co Ltd カルバペネム誘導体
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
GB9320816D0 (en) * 1993-10-08 1993-12-01 Fujisawa Pharmaceutical Co Novel compounds
DK0900797T3 (da) * 1996-04-26 2002-09-09 Sankyo Co Et 1-methylcarbapenemderivat

Also Published As

Publication number Publication date
NO982873L (no) 1998-08-21
KR19990071960A (ko) 1999-09-27
NZ324447A (en) 1999-08-30
EP0882728B1 (de) 2002-09-04
CA2241092A1 (en) 1997-07-03
ATE223411T1 (de) 2002-09-15
DE69623497T2 (de) 2003-05-28
KR100386993B1 (ko) 2003-12-18
CN1209130A (zh) 1999-02-24
HUP9901376A2 (hu) 1999-08-30
EP0882728A4 (de) 1999-03-24
CN1095843C (zh) 2002-12-11
CZ298246B6 (cs) 2007-08-01
AU711135B2 (en) 1999-10-07
MX9805023A (es) 1998-11-30
DK0882728T3 (da) 2003-01-06
CZ191898A3 (cs) 1998-09-16
NO310684B1 (no) 2001-08-13
WO1997023483A1 (en) 1997-07-03
US6090802A (en) 2000-07-18
ES2181927T3 (es) 2003-03-01
AU1171897A (en) 1997-07-17
CA2241092C (en) 2004-04-27
PT882728E (pt) 2002-11-29
HUP9901376A3 (en) 2000-03-28
HK1015766A1 (en) 1999-10-22
EP0882728A1 (de) 1998-12-09
NO982873D0 (no) 1998-06-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition