DE68914515D1 - 4-amino-quinolines and naphthyridines, process for their preparation and their use as medicines. - Google Patents

4-amino-quinolines and naphthyridines, process for their preparation and their use as medicines.

Info

Publication number
DE68914515D1
DE68914515D1 DE68914515T DE68914515T DE68914515D1 DE 68914515 D1 DE68914515 D1 DE 68914515D1 DE 68914515 T DE68914515 T DE 68914515T DE 68914515 T DE68914515 T DE 68914515T DE 68914515 D1 DE68914515 D1 DE 68914515D1
Authority
DE
Germany
Prior art keywords
naphthyridines
quinolines
medicines
amino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68914515T
Other languages
German (de)
Other versions
DE68914515T2 (en
Inventor
Etienne Mendes
Jean-Claude Vernieres
Peter Eugene Keane
Andre Bachy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Elf Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8807498A external-priority patent/FR2632305B1/en
Priority claimed from FR8808025A external-priority patent/FR2632861B1/en
Application filed by Elf Sanofi SA filed Critical Elf Sanofi SA
Publication of DE68914515D1 publication Critical patent/DE68914515D1/en
Application granted granted Critical
Publication of DE68914515T2 publication Critical patent/DE68914515T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE68914515T 1988-06-06 1989-06-05 4-amino-quinolines and naphthyridines, process for their preparation and their use as medicines. Expired - Fee Related DE68914515T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8807498A FR2632305B1 (en) 1988-06-06 1988-06-06 AMINO-4 AROYL-3 QUINOLEINS AND NAPHTYRIDINES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
FR8808025A FR2632861B1 (en) 1988-06-15 1988-06-15 AMINO-4 CARBOXY-3 QUINOLEINS AND NAPHTYRIDINES DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS

Publications (2)

Publication Number Publication Date
DE68914515D1 true DE68914515D1 (en) 1994-05-19
DE68914515T2 DE68914515T2 (en) 1994-08-18

Family

ID=26226703

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68914515T Expired - Fee Related DE68914515T2 (en) 1988-06-06 1989-06-05 4-amino-quinolines and naphthyridines, process for their preparation and their use as medicines.

Country Status (12)

Country Link
US (1) US5026711A (en)
EP (1) EP0346208B1 (en)
JP (1) JP2766672B2 (en)
KR (1) KR910000731A (en)
AU (1) AU624825B2 (en)
CA (1) CA1337073C (en)
DE (1) DE68914515T2 (en)
DK (1) DK273689A (en)
ES (1) ES2063153T3 (en)
IE (1) IE63429B1 (en)
NZ (1) NZ229413A (en)
PT (1) PT90748B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211661A (en) * 1990-03-28 1992-08-03 Otsuka Pharmaceut Co Ltd Quinoline derivative and anti-ulcer agent containing the same
US5395399A (en) * 1993-06-14 1995-03-07 Sport Wrapz, Inc. Thermal wrap for a body member
DE4405712A1 (en) * 1994-02-23 1995-08-24 Basf Ag Substituted naphthyridines and their use
IL117659A (en) * 1995-04-13 2000-12-06 Dainippon Pharmaceutical Co Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same
KR0169813B1 (en) * 1995-07-12 1999-01-15 김종인 4-amino-3-acylnaphthyridine derivatives
US5998624A (en) * 1997-05-07 1999-12-07 Emory University Haloisoquinoline carboxamide
ZA9810490B (en) 1997-12-03 1999-05-20 Dainippon Pharmaceutical Co 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
WO1999058117A1 (en) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Use of compounds for reducing apoptosis
FR2778564B1 (en) * 1998-05-13 2001-07-13 Sanofi Sa USE OF COMPOUNDS REDUCING APOPTOSIS
EP1140107B1 (en) 1998-12-18 2006-07-19 Scios Inc. Agonists and antagonists of peripheral-type benzodiazepine receptors
US6380183B1 (en) 1998-12-18 2002-04-30 Scios, Inc. Treatment of diseases involving cyst formation
DE19960924C2 (en) * 1999-12-17 2002-08-01 Therapeutics Gmbh G.O.T. Amphiphilic polyamines, their uses
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
FR2862301B1 (en) * 2003-11-17 2007-12-21 Aventis Pharma Sa NEW PROCESS FOR THE PREPARATION OF 3-FLUORINATED QUINOLINES
SE0400284D0 (en) * 2004-02-10 2004-02-10 Astrazeneca Ab Novel compounds
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
MX365890B (en) * 2004-06-24 2019-06-19 Vertex Pharma Modulators of atp-binding cassette transporters.
AU2006331614A1 (en) * 2005-12-24 2007-07-05 Vertex Pharmaceuticals Incorporated Quinolin- 4 - one derivatives as modulators of ABC transporters
RS55940B1 (en) 2005-12-28 2017-09-29 Vertex Pharma Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
TW200829555A (en) * 2006-11-10 2008-07-16 Astrazeneca Ab Chemical compounds
CL2008000191A1 (en) * 2007-01-25 2008-08-22 Astrazeneca Ab COMPOUNDS DERIVED FROM 4-AMINO-CINNOTINA-3-CARBOXAMIDA; CSF-1R QUINASA INHIBITORS; YOUR PREPARATION PROCESS; AND ITS USE TO TREAT CANCER.
UY31812A (en) * 2008-05-07 2010-01-05 Astrazeneca Ab CINOLINE DERIVATIVES AS CSF-1 INHIBITORS
WO2010097410A1 (en) 2009-02-24 2010-09-02 Respiratorius Ab Novel bronchodilating diazaheteroaryls
SG174410A1 (en) 2009-03-20 2011-11-28 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
MX366983B (en) * 2012-01-19 2019-08-01 Oncotherapy Science Inc 1,5-naphthyridine derivatives and melk inhibitors containing the same.
RU2692779C2 (en) 2012-02-27 2019-06-27 Вертекс Фармасьютикалз Инкорпорейтед Pharmaceutical composition and introduction thereof
EP3204358B1 (en) 2014-10-07 2018-09-19 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324893A (en) * 1979-04-18 1982-04-13 American Home Products Corporation 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
FR2581382B1 (en) * 1985-05-06 1987-06-26 Sanofi Sa N- (QUINOLYL) GLYCINAMIDE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION AS PSYCHOTROPES
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
AU634561B2 (en) * 1989-07-27 1993-02-25 Eli Lilly And Company Naphthyridine derivatives
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives

Also Published As

Publication number Publication date
NZ229413A (en) 1990-11-27
CA1337073C (en) 1995-09-19
PT90748A (en) 1989-12-29
EP0346208A1 (en) 1989-12-13
IE63429B1 (en) 1995-04-19
JPH0232058A (en) 1990-02-01
AU624825B2 (en) 1992-06-25
JP2766672B2 (en) 1998-06-18
DK273689A (en) 1989-12-07
KR910000731A (en) 1991-01-30
PT90748B (en) 1994-10-31
ES2063153T3 (en) 1995-01-01
DE68914515T2 (en) 1994-08-18
EP0346208B1 (en) 1994-04-13
IE891797L (en) 1989-12-06
US5026711A (en) 1991-06-25
AU3603589A (en) 1989-12-07
DK273689D0 (en) 1989-06-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8339 Ceased/non-payment of the annual fee