DE60313021D1 - 4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung - Google Patents

4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung

Info

Publication number
DE60313021D1
DE60313021D1 DE60313021T DE60313021T DE60313021D1 DE 60313021 D1 DE60313021 D1 DE 60313021D1 DE 60313021 T DE60313021 T DE 60313021T DE 60313021 T DE60313021 T DE 60313021T DE 60313021 D1 DE60313021 D1 DE 60313021D1
Authority
DE
Germany
Prior art keywords
phenylpiperidindervate
tetrazolyl
pain treatment
pain
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60313021T
Other languages
English (en)
Other versions
DE60313021T2 (de
Inventor
Zhengming Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of DE60313021D1 publication Critical patent/DE60313021D1/de
Application granted granted Critical
Publication of DE60313021T2 publication Critical patent/DE60313021T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60313021T 2002-11-18 2003-11-17 4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung Expired - Lifetime DE60313021T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US42738102P 2002-11-18 2002-11-18
US427381P 2002-11-18
US46027803P 2003-04-03 2003-04-03
US460278P 2003-04-03
US48848803P 2003-07-17 2003-07-17
US488488P 2003-07-17
US714066P 2003-11-13
US10/714,066 US7202259B2 (en) 2002-11-18 2003-11-13 Therapeutic agents useful for treating pain
PCT/US2003/036742 WO2004046132A1 (en) 2002-11-18 2003-11-17 4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Publications (2)

Publication Number Publication Date
DE60313021D1 true DE60313021D1 (de) 2007-05-16
DE60313021T2 DE60313021T2 (de) 2007-12-13

Family

ID=32777221

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60322451T Expired - Lifetime DE60322451D1 (de) 2002-11-18 2003-11-17 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung
DE60313021T Expired - Lifetime DE60313021T2 (de) 2002-11-18 2003-11-17 4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60322451T Expired - Lifetime DE60322451D1 (de) 2002-11-18 2003-11-17 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung

Country Status (37)

Country Link
US (3) US7202259B2 (de)
EP (2) EP1562932B9 (de)
JP (2) JP4601429B2 (de)
KR (1) KR20050115221A (de)
CN (2) CN100567288C (de)
AP (1) AP2210A (de)
AR (1) AR047008A1 (de)
AT (2) ATE358674T1 (de)
AU (2) AU2003294313B2 (de)
BR (1) BR0316305A (de)
CA (1) CA2506242C (de)
CO (1) CO5690588A2 (de)
CR (2) CR7877A (de)
CY (2) CY1107682T1 (de)
DE (2) DE60322451D1 (de)
DK (2) DK1562932T3 (de)
EA (1) EA008621B1 (de)
EC (1) ECSP055840A (de)
ES (2) ES2285235T3 (de)
GE (1) GEP20084539B (de)
HK (1) HK1086829A1 (de)
IL (1) IL209352A0 (de)
IS (2) IS2720B (de)
MA (1) MA27565A1 (de)
ME (1) MEP48108A (de)
MX (1) MXPA05004669A (de)
MY (1) MY135647A (de)
NI (1) NI200500087A (de)
NO (1) NO20052894L (de)
NZ (2) NZ540068A (de)
OA (1) OA13010A (de)
PT (2) PT1562932E (de)
RS (1) RS51047B (de)
SG (1) SG165998A1 (de)
SI (2) SI1562932T1 (de)
TW (2) TW200819436A (de)
WO (1) WO2004046132A1 (de)

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TWI513697B (zh) 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
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WO2015097548A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
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WO2015099863A1 (en) 2013-12-27 2015-07-02 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
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Also Published As

Publication number Publication date
ECSP055840A (es) 2005-08-11
EP1803718B1 (de) 2008-07-23
MEP48108A (en) 2011-02-10
AU2003294313B2 (en) 2010-08-26
MY135647A (en) 2008-06-30
GEP20084539B (en) 2008-11-25
EA008621B1 (ru) 2007-06-29
US7202259B2 (en) 2007-04-10
NZ540068A (en) 2007-07-27
ES2285235T3 (es) 2007-11-16
EP1562932B9 (de) 2007-09-12
RS51047B (sr) 2010-10-31
HK1086829A1 (en) 2006-09-29
ATE402167T1 (de) 2008-08-15
EP1803718A1 (de) 2007-07-04
CA2506242C (en) 2011-07-05
MXPA05004669A (es) 2005-06-08
US20040152689A1 (en) 2004-08-05
CR7877A (es) 2005-11-30
SI1803718T1 (sl) 2008-12-31
EA200500726A1 (ru) 2005-10-27
CR11037A (es) 2009-10-29
JP4601429B2 (ja) 2010-12-22
BR0316305A (pt) 2005-09-27
CY1107682T1 (el) 2013-04-18
NI200500087A (es) 2007-07-24
NO20052894D0 (no) 2005-06-14
WO2004046132A1 (en) 2004-06-03
US8026254B2 (en) 2011-09-27
CN101648941A (zh) 2010-02-17
NO20052894L (no) 2005-06-14
SI1562932T1 (sl) 2007-08-31
ATE358674T1 (de) 2007-04-15
AP2210A (en) 2011-02-25
JP2010163452A (ja) 2010-07-29
AU2010246411A1 (en) 2010-12-16
CA2506242A1 (en) 2004-06-03
CN1711256A (zh) 2005-12-21
MA27565A1 (fr) 2005-10-03
KR20050115221A (ko) 2005-12-07
DE60322451D1 (de) 2008-09-04
JP2006525944A (ja) 2006-11-16
PT1562932E (pt) 2007-07-02
ES2312150T3 (es) 2009-02-16
TWI343917B (en) 2011-06-21
US20070179141A1 (en) 2007-08-02
PT1803718E (pt) 2008-09-26
TW200819436A (en) 2008-05-01
SG165998A1 (en) 2010-11-29
IL209352A0 (en) 2011-01-31
NZ572685A (en) 2010-06-25
CY1108422T1 (el) 2014-04-09
CN100567288C (zh) 2009-12-09
EP1562932B1 (de) 2007-04-04
DK1803718T3 (da) 2008-10-27
CO5690588A2 (es) 2006-10-31
AR047008A1 (es) 2006-01-04
RS20050375A (en) 2007-11-15
IS7812A (is) 2005-04-19
DK1562932T3 (da) 2007-08-13
IS8913A (is) 2010-07-21
IS2720B (is) 2011-02-15
OA13010A (en) 2006-11-10
US20100069437A1 (en) 2010-03-18
DE60313021T2 (de) 2007-12-13
US7687518B2 (en) 2010-03-30
TW200418828A (en) 2004-10-01
AP2005003297A0 (en) 2005-06-30
EP1562932A1 (de) 2005-08-17
AU2003294313A1 (en) 2004-06-15

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