DE60028040D1 - Annexin-proteine und auto-antikörper als serummarker für lungenkrebs und ösophaguskrebs - Google Patents

Annexin-proteine und auto-antikörper als serummarker für lungenkrebs und ösophaguskrebs

Info

Publication number
DE60028040D1
DE60028040D1 DE60028040T DE60028040T DE60028040D1 DE 60028040 D1 DE60028040 D1 DE 60028040D1 DE 60028040 T DE60028040 T DE 60028040T DE 60028040 T DE60028040 T DE 60028040T DE 60028040 D1 DE60028040 D1 DE 60028040D1
Authority
DE
Germany
Prior art keywords
cancer
oenophagus
auto
antibody
serum markers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60028040T
Other languages
English (en)
Other versions
DE60028040T2 (de
Inventor
M Hanash
David Misek
Robert Hinderer
David Beer
Franck Brichory
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Publication of DE60028040D1 publication Critical patent/DE60028040D1/de
Application granted granted Critical
Publication of DE60028040T2 publication Critical patent/DE60028040T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4718—Lipocortins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60028040T 1999-08-06 2000-08-04 Annexin-proteine und auto-antikörper als serummarker für lungenkrebs und ösophaguskrebs Expired - Lifetime DE60028040T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US370337 1989-06-22
US09/370,337 US6645465B2 (en) 1999-08-06 1999-08-06 Annexin proteins and autoantibodies as serum markers for cancer
PCT/US2000/021514 WO2001011372A1 (en) 1999-08-06 2000-08-04 Annexins and autoantibodies used as markers for cancer

Publications (2)

Publication Number Publication Date
DE60028040D1 true DE60028040D1 (de) 2006-06-22
DE60028040T2 DE60028040T2 (de) 2006-11-23

Family

ID=23459219

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60028040T Expired - Lifetime DE60028040T2 (de) 1999-08-06 2000-08-04 Annexin-proteine und auto-antikörper als serummarker für lungenkrebs und ösophaguskrebs
DE60041839T Expired - Lifetime DE60041839D1 (de) 1999-08-06 2000-08-04 Auto-Antikörper gegen Annexin-Proteine als Marker für Lungenkrebs

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60041839T Expired - Lifetime DE60041839D1 (de) 1999-08-06 2000-08-04 Auto-Antikörper gegen Annexin-Proteine als Marker für Lungenkrebs

Country Status (10)

Country Link
US (5) US6645465B2 (de)
EP (3) EP1200832B1 (de)
JP (1) JP4594575B2 (de)
AT (3) ATE529751T1 (de)
AU (1) AU780772B2 (de)
CA (1) CA2380398C (de)
DE (2) DE60028040T2 (de)
DK (2) DK1200832T3 (de)
ES (2) ES2320585T3 (de)
WO (1) WO2001011372A1 (de)

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GB9810040D0 (en) * 1998-05-11 1998-07-08 Univ Nottingham Blood borne tumour markers
GB9827228D0 (en) * 1998-12-10 1999-02-03 Univ Nottingham Cancer detection method and reagents
US6645465B2 (en) * 1999-08-06 2003-11-11 Michigan, University Of The Regents Annexin proteins and autoantibodies as serum markers for cancer
US20030232399A1 (en) * 2000-06-14 2003-12-18 Robertson John Forsyth Russell Cancer detection methods and reagents
WO2002008249A1 (fr) * 2000-07-21 2002-01-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Procede de purification de la proteine de liaison a l'ion calcium
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
EP1839670A3 (de) 2001-02-21 2009-11-11 Alavita Pharmaceuticals, Inc. Modifizierte Annexinproteine und deren Verwendung zur Thrombosetherapie
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
US7214498B2 (en) * 2001-03-23 2007-05-08 Benaroya Research Institute At Virginia Mason Tumor associated antigens and methods of using the same
WO2003025568A2 (de) * 2001-09-14 2003-03-27 Reinhard Zeidler Identifizierung von antigenen durch xenogene, allogene oder autologe antikörper-vermittelte präzipitation
WO2003064593A2 (en) * 2001-11-09 2003-08-07 Virginia Mason Research Center Antigen panels and methods of using the same
GB2395270B (en) * 2002-11-14 2006-08-16 Univ Nottingham Tumour marker proteins and uses thereof
US7700307B2 (en) 2003-03-08 2010-04-20 Auvation Limited Mitochondrial stress-70 protein markers for colorectal cancer
PL1720611T3 (pl) * 2004-02-16 2010-09-30 Proteosys Ag Marker diagnostyczny dla raka
EP1756572B1 (de) * 2004-05-13 2016-02-24 Centre National De La Recherche Scientifique (Cnrs) Vorrichtung zur bindung eines zielelements an ein köderelement sowie nachweisverfahren damit
US20060024757A1 (en) * 2004-07-30 2006-02-02 Robert Hussa Detection of oncofetal fibronectin for selection of concepti
RU2277242C2 (ru) * 2004-08-23 2006-05-27 Александр Владимирович Балюра Способ диагностики опухолей
JP4521575B2 (ja) * 2005-03-17 2010-08-11 国立大学法人 千葉大学 特発性肺線維症の検出マーカー、検出キット及び検出方法
EP1724585A1 (de) * 2005-05-21 2006-11-22 ProteoSys AG Annexin für Krebsrisikofeststellung
EP1724586A3 (de) * 2005-05-21 2007-07-04 ProteoSys AG Annexin für Krebsrisikomanagement
GB2426581A (en) * 2005-05-27 2006-11-29 Univ Nottingham Immunoassay methods
SI1889059T1 (sl) 2005-05-27 2009-12-31 Oncimmune Ltd Izboljšani imunotestni postopek
WO2006130525A2 (en) * 2005-05-31 2006-12-07 Sidney Kimmel Cancer Center Methods for immunotherapy of cancer
EP1929311B1 (de) * 2005-09-26 2010-03-31 Ulrich Loos Verfahren zum nachweis von autoimmunantikörpern gegen den tsh-rezeptor und neue tsh- rezeptorchimären
WO2007079284A2 (en) * 2005-11-10 2007-07-12 University Of Kentucky Lung cancer diagnostic assay
US9347945B2 (en) * 2005-12-22 2016-05-24 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
CN101490550A (zh) * 2006-07-08 2009-07-22 肯塔基大学研究基金会 肺癌诊断分析
CN101632020B (zh) * 2006-09-13 2013-11-27 昂西免疫有限公司 改进的免疫测定方法
US20080305512A1 (en) * 2006-10-26 2008-12-11 Mattingly Phillip G Assay for cardiac troponin autoantibodies
US7776605B2 (en) 2006-10-26 2010-08-17 Abbott Laboratories Assay for cardiac troponin autoantibodies
WO2008051762A2 (en) * 2006-10-26 2008-05-02 Abbott Laboratories Immunoassay of analytes in samples containing endogenous anti-analyte antibodies
US20090047689A1 (en) * 2007-06-20 2009-02-19 John Kolman Autoantigen biomarkers for early diagnosis of lung adenocarcinoma
GB0725239D0 (en) * 2007-12-24 2008-02-06 Oncimmune Ltd Calibrator for autoantibody assay
EP2277049A4 (de) * 2008-05-09 2012-05-30 Univ Duke Autoantikörper für den nachweis und die behandlung von krebs
US9581599B2 (en) 2010-06-28 2017-02-28 The Board Of Regents Of The University Of Texas System Diagnosis of benign and cancerous growths by measuring circulating tumor stem cells and serum AnnexinA2
US9555074B2 (en) 2010-10-08 2017-01-31 Regents Of The University Of Minnesota Annexin II compositions
KR20150010882A (ko) * 2013-07-19 2015-01-29 삼성전자주식회사 아넥신 Ａ2 결합단백질, ｐ53 단백질 및 ｐ18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물
AU2014324080B2 (en) * 2013-09-18 2020-07-23 Adelaide Research & Innovation Pty Ltd Autoantibody biomarkers of ovarian cancer
US10206986B2 (en) 2013-11-13 2019-02-19 Regents Of The University Of Minnesota Annexin II variant compositions and methods
CN104407151B (zh) * 2014-11-19 2016-06-08 汕头大学医学院 Kindlin-2，Myosin-9和Annexin II三蛋白联合预测食管鳞癌患者预后试剂盒
CN113721021B (zh) * 2021-09-16 2023-07-07 郑州大学 Prkcz自身抗体在食管鳞癌辅助诊断中的应用
CN116539885B (zh) * 2023-07-06 2023-09-29 上海秤信生物科技有限公司 用于乳腺癌早期检测的肿瘤自身抗原/抗体组合及应用

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JPH02496A (ja) * 1987-12-24 1990-01-05 Nippon Shinyaku Co Ltd モノクローナル抗体、製法、及び利用法
DE4012341A1 (de) * 1990-04-18 1991-10-24 Behringwerke Ag Monoklonale antikoerper gegen pp4, verfahren zu ihrer herstellung und ihre verwendung
DE4040306A1 (de) 1990-12-17 1992-06-25 Behringwerke Ag Verfahren zur bestimmung von antikoerpern gegen lipocortine
US5405749A (en) * 1991-12-06 1995-04-11 Polans; Arthur S. Method for identifying and purifying a cancer associated retinopathy autoantigen, and testing patient serum for the autoantibody to the autoantigen
JPH0772149A (ja) * 1993-06-30 1995-03-17 Nippon Shinyaku Co Ltd 肝癌又は肝硬変の診断薬及び診断法
JPH0772147A (ja) * 1993-07-02 1995-03-17 Noboru Kaneko 抗アネキシンｖ抗体並びに該抗体の製法及び利用
EP0651253A1 (de) * 1993-11-02 1995-05-03 Abbott Laboratories Immunoassay zum Nachweis menschlicher Autoantikörper
US5658877A (en) * 1995-05-18 1997-08-19 Wisconsin Alumni Research Foundation Method to treat endotoxin effects by administration of 33 kilodalton phospholipid binding protein
ATE266203T1 (de) 1997-06-26 2004-05-15 Univ Michigan Methode zur identifizierung von tumorantigenen mit autoantikörpern in serum
CA2274776C (en) * 1997-10-08 2008-11-25 Noboru Kaneko Method for analyzing annexin v in urine and use thereof
JP2003529318A (ja) * 1998-12-28 2003-10-07 プロ ダクト ヘルス インコーポレーティッド 乳管から材料を採取するための装置、方法、およびシステム
US6645465B2 (en) * 1999-08-06 2003-11-11 Michigan, University Of The Regents Annexin proteins and autoantibodies as serum markers for cancer

Also Published As

Publication number Publication date
EP2051079A2 (de) 2009-04-22
US20100330587A1 (en) 2010-12-30
EP2051079B1 (de) 2011-10-19
US7759081B2 (en) 2010-07-20
AU6526200A (en) 2001-03-05
CA2380398A1 (en) 2001-02-15
CA2380398C (en) 2017-01-31
US6645465B2 (en) 2003-11-11
WO2001011372A9 (en) 2002-04-11
ES2259609T3 (es) 2006-10-16
ATE529751T1 (de) 2011-11-15
JP2003535309A (ja) 2003-11-25
US20040048320A1 (en) 2004-03-11
US20070037227A1 (en) 2007-02-15
ATE326699T1 (de) 2006-06-15
ES2320585T3 (es) 2009-05-25
US7955602B2 (en) 2011-06-07
AU780772B2 (en) 2005-04-14
DE60028040T2 (de) 2006-11-23
DK1200832T3 (da) 2006-09-18
DE60041839D1 (de) 2009-04-30
EP1734368B1 (de) 2009-03-18
EP1734368A2 (de) 2006-12-20
ATE426167T1 (de) 2009-04-15
EP1200832B1 (de) 2006-05-17
EP1200832A1 (de) 2002-05-02
DK1734368T3 (da) 2009-06-02
JP4594575B2 (ja) 2010-12-08
EP2051079A3 (de) 2009-06-10
US20060275845A1 (en) 2006-12-07
WO2001011372A1 (en) 2001-02-15
EP1734368A3 (de) 2007-03-07
US20020168696A1 (en) 2002-11-14

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