DE2458164A1 - Verfahren zur herstellung von neuen heterocyclischen verbindungen - Google Patents

Verfahren zur herstellung von neuen heterocyclischen verbindungen

Info

Publication number
DE2458164A1
DE2458164A1 DE19742458164 DE2458164A DE2458164A1 DE 2458164 A1 DE2458164 A1 DE 2458164A1 DE 19742458164 DE19742458164 DE 19742458164 DE 2458164 A DE2458164 A DE 2458164A DE 2458164 A1 DE2458164 A1 DE 2458164A1
Authority
DE
Germany
Prior art keywords
formula
compounds
case
methylene chloride
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19742458164
Other languages
German (de)
English (en)
Other versions
DE2458164C2 (xx
Inventor
Paul Pfaeffli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1768973A external-priority patent/CH588488A5/de
Priority claimed from CH162174A external-priority patent/CH596207A5/de
Priority claimed from CH176574A external-priority patent/CH593283A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE2458164A1 publication Critical patent/DE2458164A1/de
Application granted granted Critical
Publication of DE2458164C2 publication Critical patent/DE2458164C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19742458164 1973-12-18 1974-12-09 Verfahren zur herstellung von neuen heterocyclischen verbindungen Granted DE2458164A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1768973A CH588488A5 (en) 1973-12-18 1973-12-18 Vincamine derivs for treating behaviour disorders - by ring closure of indoloquinolizine deriv
CH162174A CH596207A5 (en) 1974-02-06 1974-02-06 Vincamine derivs for treating behaviour disorders
CH176574A CH593283A5 (en) 1974-02-08 1974-02-08 Vincamine derivs for treating behaviour disorders - by ring closure of indoloquinolizine deriv

Publications (2)

Publication Number Publication Date
DE2458164A1 true DE2458164A1 (de) 1975-06-26
DE2458164C2 DE2458164C2 (xx) 1991-04-18

Family

ID=27173122

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742458164 Granted DE2458164A1 (de) 1973-12-18 1974-12-09 Verfahren zur herstellung von neuen heterocyclischen verbindungen

Country Status (16)

Country Link
JP (1) JPS5817474B2 (xx)
CA (1) CA1051899A (xx)
DD (1) DD116043A5 (xx)
DE (1) DE2458164A1 (xx)
DK (1) DK139358B (xx)
ES (3) ES432952A1 (xx)
FI (1) FI59096C (xx)
FR (1) FR2254342B1 (xx)
GB (1) GB1492579A (xx)
HK (1) HK53980A (xx)
IE (1) IE40791B1 (xx)
MY (1) MY8100186A (xx)
NL (1) NL7416237A (xx)
NO (1) NO744456L (xx)
PH (1) PH12927A (xx)
SE (1) SE422798B (xx)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5436297A (en) * 1977-07-27 1979-03-16 Richter Gedeon Vegyeszet Vincinic acid derivative and its preparation
DE2800063A1 (de) * 1978-01-02 1979-07-12 Sandoz Ag 10-bromvincamin, seine herstellung und verwendung
DE2928219A1 (de) * 1978-07-12 1980-01-24 Richter Gedeon Vegyeszet Optisch aktive oder racemische 10-brom-14-oxo-e-homoeburnanderivate, 1-alkyl-9-bromhexahydroindolochinoliziniumderivate, 1-alkyl-1-(2'-alkoxycarbonylaethyl)-9-brom-1,2,3,4,6,7,12,12b-octahydroindolo eckige klammer auf 2,3-a eckige klammer zu chinolizin- bzw. 1-alkyl-1 -(2'-carboxyaethyl)-9-brom-1,2,3,4,6,7, 12,12b-octahydroindolo eckige klammer auf 2,3-a eckige klammer zu chinolizinderivate und 5-bromtryptamin-2-carbonsaeurederivate, verfahren zur herstellung derselben und von optisch aktiven oder racemischen 10-bromvincaminsaeureesterderivaten und optisch aktive oder racemische 10-bromvincaminsaeureesterderivate sowie erstere oder letztere enthaltende arzneimittel
DE2928187A1 (de) * 1978-07-12 1980-01-24 Richter Gedeon Vegyeszet Optisch aktive oder racemische brom- 14-oxo-e-homoeburnanderivate, verfahren zur herstellung derselben und von optisch aktiven oder racemischen 11-bromvincaminsaeureesterderivaten und optisch aktive oder racemische 11-bromvincaminsaeureesterderivate sowie erstere oder letztere enthaltende arzneimittel
US4285949A (en) * 1978-12-11 1981-08-25 Omnichem Societe Anonyme Vincamine derivatives, their preparation and therapeutical use
US4343738A (en) * 1979-08-06 1982-08-10 Richter Gedeon Vegyeszeti Gyar Rt. Halogenated 15-hydroxy-E-homoeburane derivatives
DE3204588A1 (de) * 1981-02-11 1982-12-30 Richter Gedeon Vegyészeti Gyár R.T., 1103 Budapest Im ring a substituierte apovincaminol-verbindungen, ihre saeureadditionssalze und verfahren zu ihrer herstellung
AT389513B (de) * 1981-08-23 1989-12-27 Richter Gedeon Vegyeszet Verfahren zur herstellung von alkoxyapovincaminsaeureestern

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2396759A1 (fr) * 1977-07-06 1979-02-02 Omnium Chimique Sa Nouveaux composes heterocycliques, derives de la vincamine, leur preparation et leur application comme medicaments, notamment dans le domaine des insuffisances cardio-circulatoires, cerebro-vasculaires ou respiratoires
FR2423493A1 (fr) * 1977-10-19 1979-11-16 Omnium Chimique Sa Nouveaux composes heterocycliques derives de l'apo-vincamine, leur preparation et leur application comme medicaments, notamment dans le domaine des insuffisances cardio-circulatoires, cerebro-vasculaires et respiratoires
FR2407931A1 (fr) * 1977-11-02 1979-06-01 Synthelabo Derives de l'eburnamenine et leur application en therapeutique
JPS5493000A (en) * 1977-12-28 1979-07-23 Sandoz Ag Improvement of organic compound
HU177732B (en) * 1978-12-15 1981-12-28 Richter Gedeon Vegyeszet Process for producing 10-bromo-vincamine and acid additional salts thereof,and 10-bromo-14-epivincamine
HU180929B (en) * 1979-08-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing new bromo-vincamone derivatives
ES8604952A1 (es) * 1985-11-05 1986-03-16 Covex Sa Procedimiento para la preparacion de los compuestos 10-11 bromo-14,15-dihidro-14 b-hidroxi-(3x,16x)-eburnamenina-14- carboxilato de metilo
US4883876A (en) * 1987-09-07 1989-11-28 Taisho Pharmaceutical Co., Ltd. Acylated vincaminic acid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Bull. Soc. Chim. France, 1965, 2497 *
Tetrahedron 29, 1973, 1131 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5436297A (en) * 1977-07-27 1979-03-16 Richter Gedeon Vegyeszet Vincinic acid derivative and its preparation
DE2800063A1 (de) * 1978-01-02 1979-07-12 Sandoz Ag 10-bromvincamin, seine herstellung und verwendung
DE2928219A1 (de) * 1978-07-12 1980-01-24 Richter Gedeon Vegyeszet Optisch aktive oder racemische 10-brom-14-oxo-e-homoeburnanderivate, 1-alkyl-9-bromhexahydroindolochinoliziniumderivate, 1-alkyl-1-(2'-alkoxycarbonylaethyl)-9-brom-1,2,3,4,6,7,12,12b-octahydroindolo eckige klammer auf 2,3-a eckige klammer zu chinolizin- bzw. 1-alkyl-1 -(2'-carboxyaethyl)-9-brom-1,2,3,4,6,7, 12,12b-octahydroindolo eckige klammer auf 2,3-a eckige klammer zu chinolizinderivate und 5-bromtryptamin-2-carbonsaeurederivate, verfahren zur herstellung derselben und von optisch aktiven oder racemischen 10-bromvincaminsaeureesterderivaten und optisch aktive oder racemische 10-bromvincaminsaeureesterderivate sowie erstere oder letztere enthaltende arzneimittel
DE2928187A1 (de) * 1978-07-12 1980-01-24 Richter Gedeon Vegyeszet Optisch aktive oder racemische brom- 14-oxo-e-homoeburnanderivate, verfahren zur herstellung derselben und von optisch aktiven oder racemischen 11-bromvincaminsaeureesterderivaten und optisch aktive oder racemische 11-bromvincaminsaeureesterderivate sowie erstere oder letztere enthaltende arzneimittel
US4285949A (en) * 1978-12-11 1981-08-25 Omnichem Societe Anonyme Vincamine derivatives, their preparation and therapeutical use
US4343738A (en) * 1979-08-06 1982-08-10 Richter Gedeon Vegyeszeti Gyar Rt. Halogenated 15-hydroxy-E-homoeburane derivatives
DE3204588A1 (de) * 1981-02-11 1982-12-30 Richter Gedeon Vegyészeti Gyár R.T., 1103 Budapest Im ring a substituierte apovincaminol-verbindungen, ihre saeureadditionssalze und verfahren zu ihrer herstellung
AT389513B (de) * 1981-08-23 1989-12-27 Richter Gedeon Vegyeszet Verfahren zur herstellung von alkoxyapovincaminsaeureestern

Also Published As

Publication number Publication date
IE40791L (en) 1975-06-18
ES450740A1 (es) 1977-12-16
FR2254342A1 (xx) 1975-07-11
DK139358B (da) 1979-02-05
DE2458164C2 (xx) 1991-04-18
ES450741A1 (es) 1978-03-16
IE40791B1 (en) 1979-08-15
ES432952A1 (es) 1977-02-16
SE7415416L (xx) 1975-06-19
HK53980A (en) 1980-10-03
MY8100186A (en) 1981-12-31
DK139358C (xx) 1979-07-09
GB1492579A (en) 1977-11-23
DD116043A5 (xx) 1975-11-05
NO744456L (xx) 1975-07-14
NL7416237A (nl) 1975-06-20
AU7648374A (en) 1976-06-17
JPS50105700A (xx) 1975-08-20
DK639774A (xx) 1975-08-25
FI59096B (fi) 1981-02-27
JPS5817474B2 (ja) 1983-04-07
SE422798B (sv) 1982-03-29
FI355274A (xx) 1975-06-19
FI59096C (fi) 1981-06-10
PH12927A (en) 1979-10-10
CA1051899A (en) 1979-04-03
FR2254342B1 (xx) 1978-07-21

Similar Documents

Publication Publication Date Title
DE2458164A1 (de) Verfahren zur herstellung von neuen heterocyclischen verbindungen
CH649295A5 (de) Optisch aktive oder razemische brom-e-homo-eburanderivate.
DE1961778A1 (de) Verfahren zur Herstellung von Brenzcatechin-Derivaten
DE2402705A1 (de) Tetrahydrofluorensaeuren
CH649999A5 (de) 10-brom-e-homo-eburnane.
CH645110A5 (de) Racemische oder optisch aktive oxyaminoeburnane sowie verfahren zu ihrer herstellung.
DE68905361T2 (de) Trienische Derivate mit chromenischer Struktur, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen.
CH645623A5 (en) 2-Methyl-3-acetoxy-4,5-bis(halomethyl)pyridines, process for their preparation and process for the preparation of pyridoxin
AT367420B (de) Verfahren zur herstellung neuer vincaminderivate
DE1493323B2 (de) 1-(p-hydroxyphenyl)-2-phenyl-6methoxy- 3,4-dihydronaphthalin, dessen pharmakologisch geeignete salze und verfahren zur herstellung dieser verbindungen
DE2164662A1 (de) Indanderivate und Verfahren zu ihrer Herstellung
DE3026602A1 (de) 14-oxo-15-halogen-e-homoeburnanderivate, verfahren zur herstellung derselben und von 14-oxo-15-hydroxyimino-e-homoeburnanderivaten und die ersteren enthaltende arzneimittel
EP0136662B1 (de) 2,6-Dioxa-Bicyclo-[2,2,2]-octan-7-yl-acetaldehyde
DE1795023C2 (de) Verfahren zur Herstellung von 2-Benzyloxy-2-isopropylmalonsäurediäthylester und dessen Verwendung zur Herstellung von Heterocyclen für die Totalsynthese von Reptidalkaloiden des Mutterkorns
DE2200259C3 (de) 1,2,3,4,6,7,12,12b-E-Octahydroindolo eckige Klammer auf 2,3a eckige Klammer zu chinolizyliden-essigsäureäthylester, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung von (+-)-Ebumamonin
EP0175264B1 (de) Verfahren zur Herstellung von 2-Amino-3-cyano-5-dialkoxymethyl-pyrazinen und Zwischenprodukte für dieses Verfahren
CH596207A5 (en) Vincamine derivs for treating behaviour disorders
AT378190B (de) Verfahren zur herstellung von neuen oximen
DE2613701C2 (xx)
DE1695554B2 (de) Verfahren zur herstellung kondensierter piperazinonderivate
DE4139143A1 (de) Neue benzochinoxaline, ihre herstellung und verwendung
CH526546A (de) Verfahren zur Herstellung neuer 3-Phenylpiperidinderivate
CH529756A (de) Verfahren zur Herstellung neuer 3-Phenylpiperidinderivate
CH602766A5 (en) 10-Alpha-methoxy-di:hydro-beta-ergosine derivs.
DE1947063A1 (de) Verfahren zur Herstellung von Derivaten der Indolylnicotinsaeure,Indolinylnicotinsaeure und der Lysergsaeure

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee