CY1108347T1 - Ενωσεις ιμιδαζολιου για την θεραπεια νευροεκφυλιστικων διαταραχων - Google Patents

Ενωσεις ιμιδαζολιου για την θεραπεια νευροεκφυλιστικων διαταραχων

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Publication number
CY1108347T1
CY1108347T1 CY20081101001T CY081101001T CY1108347T1 CY 1108347 T1 CY1108347 T1 CY 1108347T1 CY 20081101001 T CY20081101001 T CY 20081101001T CY 081101001 T CY081101001 T CY 081101001T CY 1108347 T1 CY1108347 T1 CY 1108347T1
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CY
Cyprus
Prior art keywords
treatment
neurological disorders
imidazoli
unions
compounds
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Application number
CY20081101001T
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English (en)
Inventor
Michael Aaron Brodney
Karen Jean Coffman
Original Assignee
Pfizer Products Incorporated
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Publication date
Application filed by Pfizer Products Incorporated filed Critical Pfizer Products Incorporated
Publication of CY1108347T1 publication Critical patent/CY1108347T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/04—Ortho-condensed systems

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Abstract

Η παρούσα εφεύρεση αφορά ενώσεις του Τύπου (Ι) όπου τα R1, R2, R3, R4, R5, R6, R7 και Α είναι όπως ορίζονται. Ενώσεις του Τύπου (Ι) είναι δραστικές στην αναστολή της παραγωγής του Αβ-πεπτιδίου. Η εφεύρεση επίσης αφορά φαρμακευτικές συνθέσεις και μεθόδους για την θεραπεία ασθενειών και διαταραχών, για παράδειγμα, νευροεκφυλιστικων και/ή νευρολογικών διαταραχών, π.χ., νόσο Alzheimer, σε ένα θηλαστικό, που περιλαμβάνουν ενώσεις του Τύπου (Ι).
CY20081101001T 2004-03-23 2008-09-17 Ενωσεις ιμιδαζολιου για την θεραπεια νευροεκφυλιστικων διαταραχων CY1108347T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55562304P 2004-03-23 2004-03-23
EP05708746A EP1730119B1 (en) 2004-03-23 2005-03-11 Imidazole compounds for the treatment of neurodegenerative disorders

Publications (1)

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CY1108347T1 true CY1108347T1 (el) 2014-02-12

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US (3) US7342118B2 (el)
EP (1) EP1730119B1 (el)
JP (2) JP4054845B2 (el)
KR (1) KR100814599B1 (el)
CN (1) CN1934091B (el)
AP (1) AP2379A (el)
AR (1) AR049875A1 (el)
AT (1) ATE399155T1 (el)
AU (1) AU2005225635B2 (el)
BR (1) BRPI0509069B8 (el)
CA (1) CA2560580C (el)
CR (1) CR8644A (el)
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DE (1) DE602005007717D1 (el)
DK (1) DK1730119T3 (el)
DO (1) DOP2005000040A (el)
EA (1) EA011689B1 (el)
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HK (1) HK1099756A1 (el)
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PA (1) PA8627201A1 (el)
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PL (1) PL1730119T3 (el)
PT (1) PT1730119E (el)
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