CN205333578U - Liquid chromatogram's pre -column device of deriving - Google Patents
Liquid chromatogram's pre -column device of deriving Download PDFInfo
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- CN205333578U CN205333578U CN201521140295.9U CN201521140295U CN205333578U CN 205333578 U CN205333578 U CN 205333578U CN 201521140295 U CN201521140295 U CN 201521140295U CN 205333578 U CN205333578 U CN 205333578U
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- reative cell
- temperature
- liquid chromatograph
- semiconductor chilling
- column front
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Abstract
The utility model discloses a liquid chromatogram's pre -column device of deriving, include: the liquid phase solution, pump, reaction unit, injector, insulation can chromatographic column, the detector that connect gradually, reaction unit include casing, reacting chamber and accuse temperature unit, and casing interior and one end and pump intercommunication are located to the reacting chamber, and the other end communicates with the injector, just reaction chamber outer wall is equipped with the heat preservation, and accuse temperature unit is including accuse temperature panel and temperature control circuit board, and the reacting chamber bottom face is equipped with a recess that is used for holding accuse temperature panel, and accuse temperature panel is fixed in in the recess and carries out temperature control to the reacting chamber, still includes the spiral guide plate, the spiral guide plate is located inside the reacting chamber. The spiral guide plate is used for reaction liquid intensive mixing. The utility model discloses a temperature and reaction time controlled strong, derive efficient.
Description
Technical field
This utility model relates to chemical derivatization technical field, particularly relates to the column front derivation device of a kind of liquid chromatograph。
Background technology
Derivatization is a kind of to utilize chemical transformation that converting compounds is become the material of similar chemical constitution。In general, the compound of a specific function participates in derivatization reaction, dissolubility, boiling point, fusing point, and state of aggregation or chemical composition can produce deviation。Consequent new chemical property can be used for quantifying or separating。The effect of the derivatization of sample is mainly similar to its chemical constitution the Substance Transformation being difficult to analyze but is prone to the material analyzed, it is simple to quantifies and separates。When detecting material and being not easy detected, as without uv absorption etc., it is possible to process, as plus chromophore etc., generated the material that can be detected。Instrumental Analysis is widely used。In gas chromatogram, applied chemistry derivatization reaction is to increase the volatility of sample or improving detection sensitivity, and the chemical derivatization of high performance liquid chromatography refers to and utilizes certain reagent (being generally called chemically derived reagent or labelled reagent) and sample component to carry out chemical reaction under certain condition, the product of reaction is conducive to chromatograph detection or separates。General chemical derivatization mainly has following purpose: improve the sensitivity of sample detection；Improve the separating degree of sample mixture；It is suitable for doing further Structural Identification, such as mass spectrum, infrared or nuclear magnetic resonance, NMR etc.。Carry out chemically derived reaction and should meet following requirement: reaction condition is required not harsh, and can rapidly, carry out quantitatively；Certain component in sample only generates a kind of derivant, and byproduct of reaction and excessive derivative reagent do not disturb separation and the detection of test sample product；Chemically derived reagent is conveniently easy to get, and versatility is good。
In Liquid Detection, in order to improve the detectability of determinand, the detection of some object needs determinand elder generation derivatization, then makes reactant realize separation on analytical column and detects, the content of indirect reaction thing to be detected。Wherein, column front derivation and post-column derivation two kinds, pre-column derivatization and post-column derivation method are respectively arranged with its pluses and minuses。The advantage of pre-column derivatization is: relatively free to selective response condition；It is absent from the restriction of kinetics；The by-product of derivatization can carry out pretreatment to reduce or to eliminate its interference；Easily allow the carrying out of multistep reaction；More derivatization reagent is had to may select；Do not need complicated instrument and equipment。Shortcoming is: the by-product of formation is likely to chromatographic isolation is caused bigger difficulty；In derivatization process, it is easy to introduce impurity or Interference Peaks, or make sample loss。Having the advantages of of post-column derivation method: forming by-product inessential, product is also without high stability, it is only necessary to the repeatability having had；Analyte can be easily separated under its original form, it is easy to selects existing analysis method。Shortcoming is: need extra equipment, and instrument requirements is higher；Reactor can cause peak stretching, reduces resolution；Excessive reagent is had to interfere。
Utility model content
The purpose of this utility model be to provide a kind of can accurately column front derivation device to the liquid chromatograph that response time, reaction temperature are controlled。
To achieve these goals, the technical scheme that this utility model provides is: provide the column front derivation device of a kind of liquid chromatograph, including: the liquid solution being sequentially connected with, pump, reaction unit, injector, couveuse chromatographic column, detector, described reaction unit includes housing, reative cell and control temperature unit, described reative cell is located in described housing and one end connects with described pump, the other end connects with described injector, and described reacting outdoor wall is provided with heat-insulation layer, described control temperature unit includes temperature control panel and temperature-adjusting circuit plate, and described reative cell bottom face is provided with one for holding the groove of described temperature control panel, described temperature control panel is fixed in described groove and described reative cell is carried out temperature control, also include spiral deflector, described spiral deflector is located at inside described reative cell。
Bottom described reative cell and top is respectively equipped with entrance and the outlet of liquid, and described entrance connects with described pump, and described outlet connects with described injector。
Described temperature control panel includes rectangular-shaped main body sheet material, and described main body sheet material is fixed with some semiconductor chilling plates, and by some described semiconductor chilling plates and the close contact of described reative cell lower surface, and the part of described reative cell lower surface and the close contact of described semiconductor chilling plate is the metallic plate that heat conductivility is good。
In some described semiconductor chilling plates, it is divided into two groups, first group is that the one side heated is in close contact with described reative cell lower surface, and second group is that the one side of refrigeration is in close contact with described reative cell lower surface, and first group of semiconductor chilling plate and second group of spaced laying of semiconductor chilling plate。
It is additionally provided with temperature sensing device in described reative cell。
Also including control unit, described temperature-adjusting circuit plate and described temperature sensing device are all connected with described control unit, the temperature information that described control unit is fed back by described temperature sensing device, and then control the work of described temperature-adjusting circuit plate。
Being additionally provided with air inlet and air outlet on described housing, described air inlet is located at described housing upper surface, and described air outlet is located at described housing lower surface, and described air outlet place is additionally provided with exhaust blower。
It is additionally provided with various way solenoid valve between described liquid solution and described pump, and described various way solenoid valve is electrically connected with described control unit。
Compared with prior art, in the column front derivation device of this utility model liquid chromatograph, including control temperature unit, additionally include spiral deflector, the temperature of derivative solution can be efficiently controlled by described control temperature unit, the liquid in described reative cell is made to form helical flow state by described spiral deflector, it is possible to be effectively improved derivative efficiency。
By description below and in conjunction with accompanying drawing, this utility model will become more fully apparent, and these accompanying drawings are used for explaining embodiment of the present utility model。
Accompanying drawing explanation
Fig. 1 is the column front derivation apparatus structure schematic diagram of this utility model liquid chromatograph。
Fig. 2 is the structural representation of the reaction unit of the column front derivation device of liquid chromatograph as shown in Figure 1。
Fig. 3 is the structural representation of the temperature control panel of the column front derivation device of liquid chromatograph as shown in Figure 1。
Fig. 4 is the circuit theory module map of the temperature control panel of the column front derivation device of liquid chromatograph as shown in Figure 1。
Detailed description of the invention
With reference now to accompanying drawing, describing embodiment of the present utility model, element numbers similar in accompanying drawing represents similar element。As mentioned above, such as Fig. 1, shown in 2, the column front derivation device 100 of the liquid chromatograph that this utility model embodiment provides, including: the liquid solution 1 being sequentially connected with, pump 2, reaction unit 3, injector 4, couveuse chromatographic column 5, detector 6, described reaction unit 3 includes housing 7, reative cell 8 and control temperature unit 9, described reative cell 8 is located in described housing 7 and one end connects with described pump 2, the other end connects with described injector 4, and described reative cell 8 outer wall is provided with heat-insulation layer 10, described control temperature unit 9 includes temperature control panel 91 and temperature-adjusting circuit plate 92, and described reative cell 8 bottom face is provided with one for holding the groove of described temperature control panel 91, described temperature control panel 91 is fixed in described groove and described reative cell 8 is carried out temperature control, also include spiral deflector 11, it is internal that described spiral deflector 11 is located at described reative cell 8。Described heat-insulation layer 10 is asbestos material layer。
In one embodiment, as in figure 2 it is shown, bottom described reative cell 8 and top is respectively equipped with entrance 15 and the outlet 16 of liquid, and described entrance 15 connects with described pump 2, and described outlet 16 connects with described injector 4。By the effect of described spiral deflector 11, the reactant liquor come in from described entrance 15 will helically move upward by motion mode, then flows out from described outlet 16。By described spiral deflector 11, it is possible to make reactant liquor be sufficiently mixed。
In one embodiment, as shown in Figure 3, described temperature control panel 91 includes rectangular-shaped main body sheet material, and described main body sheet material offers six grooves 910, and each groove 910 is fixed with a semiconductor chilling plate 17, and by these six described semiconductor chilling plates 17 and the close contact of described reative cell 8 lower surface, and the part of described reative cell 8 lower surface and the close contact of described semiconductor chilling plate 17 is the metallic plate that heat conductivility is good。
In above-described embodiment, in six described semiconductor chilling plates 17, it is divided into two groups of quantity often organized to be three, first group is that the one side heated is in close contact with described reative cell 8 lower surface, second group is that the one side of refrigeration is in close contact with described reative cell 8 lower surface, and first group of semiconductor chilling plate 17 and second group of spaced laying of semiconductor chilling plate 17。It is thus desirable to when described reative cell 8 is heated, allows first group of semiconductor chilling plate 17 work, and second group of semiconductor chilling plate 17 do not work；When needing described reative cell 8 is freezed, allow second group of semiconductor chilling plate 17 work, and first group of semiconductor chilling plate 17 does not work。
In one embodiment, as in figure 2 it is shown, be additionally provided with temperature sensing device 18 in described reative cell 8。
In above-described embodiment, as shown in Figure 4, also include control unit 19, described temperature-adjusting circuit plate 92 and described temperature sensing device 18 are all connected with described control unit 19, the described control unit 19 temperature information by described temperature sensing device 18 feedback, and then control described temperature-adjusting circuit plate 92 and work, and described temperature-adjusting circuit plate 92 to be located at described housing 7 internal。
In one embodiment, as in figure 2 it is shown, be additionally provided with air inlet 30 and air outlet 31 on described housing 7, described air inlet 30 is located at described housing 7 upper surface, and described air outlet 31 is located at described housing 7 lower surface, and described air outlet 31 place is additionally provided with exhaust blower 32。
In one embodiment, described liquid solution 1 includes several different liquid solution, and connect with described pump 2 commonly through after various way solenoid valve 21, the flow velocity of described liquid solution 1 is by the power decision of described pump 2, additionally can select the electromagnetic valve of controllable flow speed size that the flow velocity of liquid solution is controlled。
Compared with prior art, in conjunction with Fig. 1～4, in the column front derivation device 100 of this utility model liquid chromatograph, described control temperature unit 9 includes temperature control panel 91 and temperature-adjusting circuit plate 92, and described reative cell 8 bottom face is provided with one for holding the groove of described temperature control panel 91, described temperature control panel 91 is fixed in described groove and described reative cell 8 is carried out temperature control, the liquid in described reative cell 8 is made to form helical flow state by described spiral deflector 11, it is possible to be effectively improved derivative efficiency。
Above disclosed it is only preferred embodiment of the present utility model, certainly can not limit the interest field of this utility model, the equivalent variations therefore made according to this utility model claim with this, still belong to the scope that this utility model is contained。
Claims (8)
1. the column front derivation device of a liquid chromatograph, it is characterized in that, including: the liquid solution being sequentially connected with, pump, reaction unit, injector, couveuse chromatographic column, detector, described reaction unit includes housing, reative cell and control temperature unit, described reative cell is located in described housing and one end connects with described pump, the other end connects with described injector, and described reacting outdoor wall is provided with heat-insulation layer, described control temperature unit includes temperature control panel and temperature-adjusting circuit plate, and described reative cell bottom face is provided with one for holding the groove of described temperature control panel, described temperature control panel is fixed in described groove and described reative cell is carried out temperature control, also include spiral deflector, described spiral deflector is located at inside described reative cell。
2. the column front derivation device of liquid chromatograph as claimed in claim 1, it is characterised in that bottom described reative cell and top is respectively equipped with entrance and the outlet of liquid, and described entrance connects with described pump, and described outlet connects with described injector。
3. the column front derivation device of liquid chromatograph as claimed in claim 1, it is characterized in that, described temperature control panel includes rectangular-shaped main body sheet material, and described main body sheet material is fixed with some semiconductor chilling plates, and by some described semiconductor chilling plates and the close contact of described reative cell lower surface, and the part of described reative cell lower surface and the close contact of described semiconductor chilling plate is the metallic plate that heat conductivility is good。
4. the column front derivation device of liquid chromatograph as claimed in claim 3, it is characterized in that, in some described semiconductor chilling plates, it is divided into two groups, first group is that the one side heated is in close contact with described reative cell lower surface, second group is that the one side of refrigeration is in close contact with described reative cell lower surface, and first group of semiconductor chilling plate and second group of spaced laying of semiconductor chilling plate。
5. the column front derivation device of liquid chromatograph as claimed in claim 4, it is characterised in that be additionally provided with temperature sensing device in described reative cell。
6. the column front derivation device of liquid chromatograph as claimed in claim 5, it is characterized in that, also include control unit, described temperature-adjusting circuit plate and described temperature sensing device are all connected with described control unit, the temperature information that described control unit is fed back by described temperature sensing device, and then control the work of described temperature-adjusting circuit plate。
7. the column front derivation device of liquid chromatograph as claimed in claim 1, it is characterized in that, described housing is additionally provided with air inlet and air outlet, and described air inlet is located at described housing upper surface, described air outlet is located at described housing lower surface, and described air outlet place is additionally provided with exhaust blower。
8. the column front derivation device of liquid chromatograph as claimed in claim 6, it is characterised in that be additionally provided with various way solenoid valve between described liquid solution and described pump, and described various way solenoid valve is electrically connected with described control unit。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521140295.9U CN205333578U (en) | 2015-12-31 | 2015-12-31 | Liquid chromatogram's pre -column device of deriving |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201521140295.9U CN205333578U (en) | 2015-12-31 | 2015-12-31 | Liquid chromatogram's pre -column device of deriving |
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| CN205333578U true CN205333578U (en) | 2016-06-22 |
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| CN201521140295.9U Active CN205333578U (en) | 2015-12-31 | 2015-12-31 | Liquid chromatogram's pre -column device of deriving |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105486774A (en) * | 2015-12-31 | 2016-04-13 | 华测检测认证集团股份有限公司 | Liquid chromatogram precolumn derivatization device |
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2015
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105486774A (en) * | 2015-12-31 | 2016-04-13 | 华测检测认证集团股份有限公司 | Liquid chromatogram precolumn derivatization device |
| CN105486774B (en) * | 2015-12-31 | 2019-05-31 | 华测检测认证集团北京有限公司 | The column front derivation device of liquid chromatogram |
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Effective date of registration: 20170605 Address after: 2 121 building, 450001 Indus street, hi tech Industrial Development Zone, Henan, Zhengzhou Patentee after: Henan Hua Testing Technology Co., Ltd. Address before: 518101 Guangdong, Shenzhen Province, Baoan District District, Wei Wei Industrial Park, building C, 70 Patentee before: CENTRE TESTING INTERNATIONAL GROUP CO., LTD. |