CN205317736U - Sample application system - Google Patents

Sample application system Download PDF

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Publication number
CN205317736U
CN205317736U CN201521085916.8U CN201521085916U CN205317736U CN 205317736 U CN205317736 U CN 205317736U CN 201521085916 U CN201521085916 U CN 201521085916U CN 205317736 U CN205317736 U CN 205317736U
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China
Prior art keywords
sample
sample application
spotting
unit
needle
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CN201521085916.8U
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Chinese (zh)
Inventor
张长春
钱丽娜
刘大鹏
崔健
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Sino Us Huashitong Biomedical Technology Wuhan Co ltd
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Waterstone Pharmaceuticals Wuhan Co Ltd
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Abstract

The utility model discloses a sample application system, this system includes: at least one sample memory cell, sample application unit, positioning unit and dry unit, sample memory cell's exit is provided with quantitative output device, the sample application unit has at least one sample application needle, and gliding connection is on quantitative output device from top to bottom for the sample application needle, and positioning unit is located the below of sample application unit, and positioning unit has fixed station and at least one sample application chi, is equipped with at least a set of locating hole on the sample application chi, and dry unit includes hot -blast main, intake pipe and devices for heating air, and the movably setting of hot -blast main is in sample application chi top, and the corresponding positioning unit's on the hot -blast main sample application 2 has at least one export. From this, adopt this system to carry out synchronous sample application to a plurality of samples simultaneously according to the experiment needs to size through control, adjustment point appearance volume and sample application are ordered realizes quick, effective, the controllable completion of sample application process, and the parameter is tested in the accumulation, and can guarantee experiment operation's high efficiency.

Description

Spotting system
Technical field
This utility model belongs to chromatography analysis field, concrete, and this utility model relates to a kind of spotting system.
Background technology
Planar chromatograph technology mainly includes thin layer chromatography and paper chromatography, the former application is more extensive, belong to the common approach in pharmacy or chemical industry synthesis field, have very quick, convenient for monitoring reaction process, qualitative observation product etc. in real time, and low cost and other advantages. But, spotting methods conventional at present is divided into spot application and band application, is all adopt artificial point sample, sample is separated and is difficult to reach promising result, and point sample can only put an injector every time, and point sample efficiency is very low.
Therefore, current deposition techniques is still further improved.
Utility model content
One of technical problem that this utility model is intended to solve at least to a certain extent in prior art to exist or provide at a kind of useful business and select. For this, a purpose of the present utility model is in that to provide a kind of spotting system, utilize this system can realize multiple sample simultaneously, quantitative point sample, both improved efficiency, turn avoid the absorption error caused by point sample time difference of sample room, thus ensureing experiment effect and efficiency.
Thus, in of utility model, the utility model proposes a kind of spotting system. Embodiment according to utility model, this system includes:
At least one sample storage unit, the exit of described sample storage unit is provided with quantitative output device;
Sample application unit, described sample application unit has at least one spotting needle, and described spotting needle can slide up and down and is connected on described quantitative output device, and described spotting needle is connected with described quantitative output device one_to_one corresponding;
Positioning unit, described positioning unit is positioned at the lower section of described sample application unit, described positioning unit has fixed station and at least one puts sample ruler, described some sample ruler is arranged on above described fixed station, described some sample ruler is provided with hole, least one set location, hole, described location is arranged in described some sample ruler by same apertures size linearly array, and is labeled with aperture scale value on hole, described location;
Drying unit, described drying unit includes warm-air pipe, air inlet pipe and hot air apparatus, one end entrance of described warm-air pipe is connected with described hot air apparatus by described air inlet pipe, described warm-air pipe is movably disposed at above described some sample ruler, and hole, the location place of the described positioning unit of correspondence on described warm-air pipe has at least one outlet.
Thus, spotting system according to this utility model embodiment is by utilizing multiple sample storage unit and multiple spotting needle, realize multiple sample to complete to synchronize point sample within the same time, both improved efficiency, and turn avoid the absorption error caused by point sample time difference of sample room; Simultaneously by arranging hole, location, can the effectively diameter of control point sampling point and point sample spacing, pencil setting-out need not be used on lamellae, be conducive to separation and the discriminating of sample composition, sample adsorption speed can be improved further secondly by arranging drying unit, additionally spotting system of the present utility model can realize automation mechanized operation, and point sample is accurate, standard is unified, operation is very easy.
It addition, the spotting system according to this utility model embodiment can also have following additional technical characteristic:
Optional, described quantitative output device has proportional valve. Thus, it is possible to determine the point sample amount of sample, and the concentration according to different samples, it is set to different some sample values.
Optional, described sample application unit farther includes drive motor, and described drive motor is separately connected with spotting needle each described. Thus, it is possible to realize the automation mechanized operation of sample application unit.
Optional, on described spotting needle, the position at close needle point is inverted cone. Thus, it is possible to avoid spotting needle outer wall infiltration sample, thus both having ensured shape and the size of point of sample, overcome again the sample spot amount that capillarity causes inaccurate.
Optional, described fixed station is further provided with fixing parts. Thus, it is possible to make chromatographic sheet or paper chromatography plate be able to fix on fixed station, it is to avoid move in deposition process.
Optional, described fixed station is further provided with heater block. Thus, it is possible to it is heated by the lower section from chromatographic sheet or paper chromatography plate, thus improving the dry rate of put sample further.
Optional, described some sample ruler one end is provided with rotation and moves parts. Thus, it is possible to the diameter demand according to point of sample, select the some sample ruler with suitable aperture setting hole.
Optional, the diameter in hole, described location is 0.5cm, 1cm, 1.5cm, 2cm.
Optional, described some sample ruler is brocken spectrum sample ruler. Thus, it is simple to observe in deposition process, sample spread condition on thin layer chromatography or paper chromatography.
Optional, the outlet of described warm-air pipe is provided with micro-nozzle. Thus, it is positioned at directly over hole, location by regulating micro-nozzle, makes point of sample on average be heated, it is to avoid sample is dispelled by hot blast.
Additional aspect of the present utility model and advantage will part provide in the following description, and part will become apparent from the description below, or is recognized by practice of the present utility model.
Accompanying drawing explanation
Fig. 1 is the structural representation of the spotting system according to one embodiment of this utility model.
Detailed description of the invention
Being described below in detail embodiment of the present utility model, the example of described embodiment is shown in the drawings, and wherein same or similar label represents same or similar element or has the element of same or like function from start to finish. The embodiment described below with reference to accompanying drawing is illustrative of, it is intended to be used for explaining this utility model, and it is not intended that to restriction of the present utility model.
In description of the present utility model, it will be appreciated that, term " " center ", " longitudinal direction ", " transverse direction ", " length ", " width ", " thickness ", " on ", D score, " front ", " afterwards ", " left side ", " right side ", " vertically ", " level ", " top ", " end ", " interior ", " outward ", " clockwise ", " counterclockwise ", " axially ", " radially ", orientation or the position relationship of the instruction such as " circumference " are based on orientation shown in the drawings or position relationship, it is for only for ease of description this utility model and simplifies description, rather than the device of instruction or hint indication or element must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to restriction of the present utility model.
Additionally, term " first ", " second " are only for descriptive purposes, and it is not intended that indicate or imply relative importance or the implicit quantity indicating indicated technical characteristic.Thus, define " first ", the feature of " second " can express or implicitly include at least one this feature. In description of the present utility model, " multiple " are meant that at least two, for instance two, three etc., unless otherwise expressly limited specifically.
In this utility model, unless otherwise clearly defined and limited, the term such as term " installation ", " being connected ", " connection ", " fixing " should be interpreted broadly, for instance, it is possible to it is fixing connection, it is also possible to be removably connect, or integral; Can be mechanically connected, it is also possible to be electrical connection; Can be joined directly together, it is also possible to be indirectly connected to by intermediary, it is possible to be connection or the interaction relationship of two elements of two element internals, unless otherwise clear and definite restriction. For the ordinary skill in the art, it is possible to understand above-mentioned term concrete meaning in this utility model as the case may be.
In this utility model, unless otherwise clearly defined and limited, fisrt feature second feature " on " or D score can be that the first and second features directly contact, or the first and second features are by intermediary mediate contact. And, fisrt feature second feature " on ", " top " and " above " but fisrt feature directly over second feature or oblique upper, or be merely representative of fisrt feature level height higher than second feature. Fisrt feature second feature " under ", " lower section " and " below " can be fisrt feature immediately below second feature or obliquely downward, or be merely representative of fisrt feature level height less than second feature.
In one side of the present utility model, the utility model proposes a kind of spotting system.
Below with reference to Fig. 1, the spotting system of this utility model embodiment is described in detail:
Embodiment according to utility model, spotting system includes: sample storage unit 100, sample application unit 200, positioning unit 300 and drying unit 400.
According to an embodiment of the present utility model, sample storage unit 100 is at least one, for instance can be multiple, and is suitable to the sample to be identified that storage is different.
According to specific embodiment of the utility model, it is provided with quantitative output device 110 in the exit of each sample storage unit 100, and is suitable to need to arrange different point sample amounts according to point sample, thus realizing the quantitative point sample of system.
According to another specific embodiment of the present utility model, quantitative output device 110 is provided with proportional valve 111. Concentration thus, it is possible to determine the point sample amount of sample, according to different samples, it is possible to be set to different quantitative values.
According to this utility model further embodiment, sample application unit 200 has at least one spotting needle 210, and spotting needle 210 can slide up and down and is connected on quantitative output device 110, and spotting needle 210 is connected with quantitative output device 110 one_to_one corresponding. It should be noted that " spotting needle is connected with quantitative output device one_to_one corresponding " can be understood as spotting needle and quantitative output device number is identical, and a spotting needle is only connected with a quantitative output device.
According to specific embodiment of the utility model, sample application unit 200 farther includes drive motor 220, and drive motor 220 is separately connected with each spotting needle 210. Thus, it is possible to realize moving up and down of spotting needle according to actual needs, thus realizing the automation mechanized operation of sample application unit.
According to another specific embodiment of the present utility model, spotting needle 210 is inverted cone in the position near needle point. Thus, it is possible to avoid spotting needle outer wall infiltration sample, both ensured shape and the size of point of sample, overcome again the sample size that capillarity causes inaccurate.
According to another embodiment of the present utility model, positioning unit 300 is positioned at below sample application unit 200, positioning unit 300 has fixed station 310 and at least one some sample ruler 320, and put sample ruler 320 and be arranged on the top of fixed station 310, point sample ruler 320 is provided with hole 321, least one set location, often same apertures size linearly array is pressed in a sample ruler 320 in hole, group location 321, namely position in hole at each group, there is the hole, location of multiple same apertures, the hole, location of same apertures is linearly arranged in positioning rule, and positions and be labeled with respective aperture scale value on hole.
According to specific embodiment of the utility model, the diameter in hole, location can be 0.5cm, 1cm, 1.5cm, 2cm.
According to further embodiment of the present utility model, fixed station 310 is further provided with fixing parts 311, and is suitable to fixed placement chromatosheet 30 (chromatographic sheet or paper chromatography plate) on fixed station 310. Thus, by making chromatographic sheet or paper chromatography plate be able to fix on fixed station 310, it is to avoid move in deposition process.
According to another embodiment of the present utility model, when adopting chromatographic sheet, chromatographic sheet is covered with silica gel medium, when adopting paper chromatography plate, paper chromatography plate is covered with polyamide medium.
According to another specific embodiment of the present utility model, fixed station 310 surface is further provided with heater block 312, and chromatosheet 30 is arranged on the top of heater block 312. Thus, it is possible to it is heated by the lower section from chromatographic sheet or paper chromatography plate, thus improving the dry rate of put sample further. It should be noted that, the particular type of heater block can be selected by those skilled in the art according to actual needs.
According to another specific embodiment of the present utility model, some sample ruler 320 one end is provided with rotation and moves parts 322, and is suitable to the diameter demand according to point of sample, selects the some sample ruler with suitable aperture setting hole 321.
According to embodiment of the present utility model, put the transparent shape of sample ruler 320. Thus, it is simple to observe in deposition process, sample spread condition on thin layer chromatography or paper chromatography. It should be noted that those skilled in the art can the particular type of selected element sample ruler according to actual needs.
According to another embodiment of the present utility model, drying unit 400 includes warm-air pipe 410, air inlet pipe 420 and hot air apparatus 430, one end entrance of warm-air pipe 410 is connected with outside hot air apparatus 430 by air inlet pipe 420, warm-air pipe 410 is moveable concordant with some sample ruler 320, and it being arranged at above a sample ruler 320, hole, location 321 place of the corresponding positioning unit 300 on warm-air pipe 410 has at least one outlet 411. Such as, being provided with an outlet with the position positioning hole corresponding on positioning unit on warm-air pipe, namely the exit numbers on warm-air pipe is identical with the number in hole, location, and the corresponding outlet in hole, a location.
According to specific embodiment of the utility model, warm-air pipe outlet 411 is provided with micro-nozzle 41. Thus, it is positioned at directly over hole 321, location by regulating micro-nozzle 41, makes point of sample on average be heated, it is to avoid sample is dispelled by hot blast.
According to another embodiment of the present utility model, by arranging multiple sample storage unit, it is possible to when being prevented effectively from prior art only one of which spotting needle, operator need manually change sample and clean spotting needle, also can avoiding the cross-contamination of sample room, impact separates identification result.
According to another embodiment of the present utility model, after multiple samples synchronization point sample completes, it is possible to add cleanout fluid or purified water in sample storage unit, thus can quickly realize the cleaning of multiple spotting needle.
Thus, spotting system according to this utility model embodiment is by utilizing sample storage unit 100 and multiple spotting needle 210, realize multiple sample to complete to synchronize point sample within the same time, both improved efficiency, and turn avoid the absorption error caused by point sample time difference of sample room; And by arranging hole, location, can the effectively diameter of control point sampling point and point sample spacing, pencil setting-out need not be used on lamellae, be conducive to separation and the discriminating of sample composition, sample adsorption speed can be further increased secondly by arranging drying unit 400, additionally spotting system of the present utility model can realize automation mechanized operation, and point sample is accurate, standard is unified, operation is very easy.
Understand in order to convenient, below the method utilizing above-mentioned spotting system to carry out point sample is described in detail. Embodiment according to utility model, this spotting methods includes: sample to be identified is separately added in different described sample storage unit by (1), and utilizes described quantitative output device to arrange the point sample amount of different sample; (2) lamellae is fixed on the fixed station of described positioning unit; (3) the corresponding relative position adjusting described some sample ruler and described spotting needle, makes the center in the corresponding hole, described location of described spotting needle; (4) carry out synchronizing batch point sample; And the sample of absorption on lamellae is carried out rapid draing by described drying unit by (5).
Thus, spotting methods according to this utility model embodiment can need to carry out multiple samples synchronizing point sample according to experiment simultaneously, and by controlling, regulate the size of point sample amount and point of sample, realize quick, effective, controlled the completing of deposition process, accumulation experiment parameter, and can guarantee that the high efficiency of experimental implementation. It should be noted that above-mentioned feature and advantage described by spotting system are equally applicable to this spotting methods, repeat no more herein.
In the description of this specification, specific features, structure, material or feature that the description of reference term " embodiment ", " some embodiments ", " example ", " concrete example " or " some examples " etc. means in conjunction with this embodiment or example describe are contained at least one embodiment of the present utility model or example. In this manual, the schematic representation of above-mentioned term is necessarily directed to identical embodiment or example. And, the specific features of description, structure, material or feature can combine in one or more embodiments in office or example in an appropriate manner. Additionally, when not conflicting, the feature of the different embodiments described in this specification or example and different embodiment or example can be carried out combining and combining by those skilled in the art.
Although above it has been shown and described that embodiment of the present utility model, it is understandable that, above-described embodiment is illustrative of, it is not intended that to restriction of the present utility model, above-described embodiment can be changed in scope of the present utility model, revises, replace and modification by those of ordinary skill in the art.

Claims (9)

1. a spotting system, it is characterised in that including:
At least one sample storage unit, the exit of described sample storage unit is provided with quantitative output device;
Sample application unit, described sample application unit has at least one spotting needle, and described spotting needle can slide up and down and is connected on described quantitative output device, and described spotting needle is connected with described quantitative output device one_to_one corresponding;
Positioning unit, described positioning unit is positioned at the lower section of described sample application unit, described positioning unit has fixed station and at least one puts sample ruler, described some sample ruler is arranged on above described fixed station, described some sample ruler is provided with hole, least one set location, hole, described location is arranged in described some sample ruler by same apertures size linearly array, and is labeled with aperture scale value on hole, described location;
Drying unit, described drying unit includes warm-air pipe, air inlet pipe and hot air apparatus, one end entrance of described warm-air pipe is connected with described hot air apparatus by described air inlet pipe, described warm-air pipe is movably disposed at above described some sample ruler, and hole, the location place of the described positioning unit of correspondence on described warm-air pipe has at least one outlet.
2. spotting system according to claim 1, it is characterised in that on described quantitative output device, there is proportional valve.
3. spotting system according to claim 1 and 2, it is characterised in that described sample application unit farther includes drive motor, and described drive motor is separately connected with spotting needle each described.
4. spotting system according to claim 3, it is characterised in that on described spotting needle, the position at close needle point is inverted cone.
5. spotting system according to claim 4, it is characterised in that be further provided with fixing parts on described fixed station.
6. spotting system according to claim 5, it is characterised in that be further provided with heater block on described fixed station.
7. spotting system according to claim 1, it is characterised in that described some sample ruler one end is provided with rotation and moves parts.
8. spotting system according to claim 7, it is characterised in that described some sample ruler is brocken spectrum sample ruler.
9. spotting system according to claim 1, it is characterised in that the exit of described warm-air pipe is provided with micro-nozzle.
CN201521085916.8U 2015-12-23 2015-12-23 Sample application system Active CN205317736U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106908563A (en) * 2015-12-23 2017-06-30 中美华世通生物医药科技(武汉)有限公司 Spotting system and method
CN110082473A (en) * 2019-05-16 2019-08-02 广州市鹭江远科技有限公司 A kind of spot sample device for aflatoxins detection based on thin layer chromatography

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106908563A (en) * 2015-12-23 2017-06-30 中美华世通生物医药科技(武汉)有限公司 Spotting system and method
CN106908563B (en) * 2015-12-23 2024-01-05 中美华世通生物医药科技(武汉)股份有限公司 Sample application system and method
CN110082473A (en) * 2019-05-16 2019-08-02 广州市鹭江远科技有限公司 A kind of spot sample device for aflatoxins detection based on thin layer chromatography

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Address after: 430075 Guanggu Biological City B3-4, 666 High-tech Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province

Patentee after: Sino US huashitong biomedical technology (Wuhan) Co.,Ltd.

Address before: 430075 Guanggu Biological City B3-4, 666 High-tech Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province

Patentee before: WATERSTONE PHARMACEUTICALS(WUHAN) Co.,Ltd.