CN201085856Y - Functional image guide radiation therapy integrated machine - Google Patents

Abstract

The utility model discloses a functional-image guide radiotherapy integral instrument, which is composed of a control device and a therapy device. Wherein, the therapy device comprises a rotary frame (1), cone beam imaging devices (6, 9,7,8) arranged on the frame (1), radio-therapeutic devices (5, 6) and a radio-therapeutic bed (13) crossing through the rotary frame (1). The utility model is characterized in that a PET imaging device (4) which is a annular PET detector array is arranged on the rotary frame (1), and the PET imaging device (4) is arranged at one end of the rotary frame (1); the cone beam imaging devices(6, 9, 7,8) and the radio-therapeutic devices (5, 6) are all arranged at the other end of the rotary frame (1). The utility model integrates the PET imaging device onto the radio-therapeutic instrument with the function of CBCT image guiding, integrates the PET image with the CT image obtained in the course of diagnose, and applies the therapy planning system with function of inverse intensity-modulation to plan the therapy of patient and to guide the radiotherapy with functional image.

Description

Function image guided radiation treatment all-in-one

Technical field

This utility model relates to a kind of radiotherapy equipment of field of radiation therapy, is specifically related to be combined with the radiotherapy equipment of the instrument of radiodiagnosis.

Background technology

Radiotherapy is a kind of important means of oncotherapy, conical beam CT (cone beam CT wherein, CBCT) be the imaging device that developed recently gets up based on large area amorphous silicon digital X X-ray detection X plate, it is little to have volume, in light weight, characteristics such as open architecture can be integrated directly on the medical electronic linear accelerator.The accelerator frame rotates a circle and just can obtain and rebuild the interior CT image of a volume range.The CT image that this image and treatment plan are used needs a parameter of regulating by the registration bed that promptly can obtain medical treatment.But the kV-CBCT that adopts kV level X ray still adopts the MV-CBCT of MV level X ray can not reflect truly that weary oxygen of inside tumor and blood supply, propagation, apoptosis and cell cycle regulating, oncogene and antioncogene change, biological informations such as infiltration and transfer characteristic.

Positron computer layer imaging system (PET) is a kind of functional imaging technology, if will just can show that focus reaches the anatomical function image of critical organ on every side, has solved the problems referred to above preferably to PET image and the fusion of CT image.But the PET/CT image is mainly used in the early diagnosis of tumor at present.Owing to diagnose from PET/CT and to formulate radiotherapy treatment planning, arrive radiotherapy again, during long process is arranged, therefore when treatment, enable the PET/CT scanning information when diagnosing, its therapeutic effect is undesirable to be obvious.In addition, because the PET/CT diagnosis is to carry out in different chamber with radiotherapy, patient body position's second positioning error is unavoidable during treatment.

State knows and office on May 16th, 2007 disclosed a kind of " water cooling type RFA employed tumor treatment integrated machine of image guiding " (publication number is: CN1961841A), this all-in-one organically merges radio-frequency ablation technique and ultrasonic image technology, the tissue characteristics of having realized the tracking target tissue changes, and implement the monitoring of radio-frequency (RF) ablation original position inactivation process in view of the above, thereby improved the treatment safety and effectiveness.What but this scheme adopted is the ultrasonic image bootstrap technique, can't obtain real-time biological target area, and its therapeutic effect is still limited.

State know office's Granted publication on June 13rd, 2007 a kind of " robot radiation therapy system " utility model patent (Granted publication number is: CN2910255Y), this patent scheme will have the C shape arm of x-ray source and detector, infrared automatic track and localization instrument and the automatic track and localization instrument of electromagnetism and theratron is integrated in one, the treatment plan of formulating in conjunction with diagnosis such as PET/CT again, its positioning accuracy and therapeutic effect all improve.But, the PET/CT scanning information when the PET/CT image that this patent scheme the time is enabled in treatment remains diagnosis, so the detected real-time dosage of doser will compare with planned value, by manually revising, has the deficiency of above-mentioned known technology unavoidably.

The patent of invention of a kind of " cobalt-60 multi-fault coplane spiral-fault intensity modulated radiation therapy system " (Granted publication number for CN1133473C) that office's Granted publication on January 7th, 2004 has been known by state, the major technique feature of this patent is that a plurality of confocal cobalt-60 radioactive sources are installed on the transverse section of rotating cylinder, to realize the spiral-fault irradiation.But the real-time plan that this patent of invention scheme can't obtain the radiation dose distribution of three-dimensional biological target area comes guided radiation treatment, still is difficult to obtain ideal radiotherapeutic effect.

Summary of the invention

In view of there is above-mentioned deficiency in prior art, technical problem to be solved in the utility model provides a kind of radiotherapy all-in-one that is integrated with PET and CBCT device for image simultaneously, the real-time plan that this all-in-one can obtain the radiation dose distribution of three-dimensional biological target area comes guided radiation treatment, to obtain ideal therapeutic effect.

The solution that the present utility model solves the problems of the technologies described above is:

A kind of function image guided radiation treatment all-in-one, this machine is made up of control device and therapy equipment, wherein said therapy equipment comprises the single-revolution frame, is located at cone beam imaging device (the Cone Beam CT on the frame, CBCT) and radiotherapy apparatus and pass through the radiotherapy bed of rotary rack, it is characterized in that also being provided with on the described rotary rack PET imaging device, this device is a ring-shaped P ET detector array; Described PET imaging device is located at of rotary rack, and described cone beam imaging device and radiotherapy apparatus are located at the other end of rotary rack.

Radiotherapy all-in-one of the present invention, wherein said control device may command rotary rack do gyration, the radiotherapy bed is done lifting, front-rear reciprocation movement or left and right sides translational motion, and any lesions position of patient is carried out PET imaging, cone beam imaging and radiotherapy.

Radiotherapy all-in-one described in the utility model, wherein radiotherapy apparatus is made up of radioactive source and multi-leaf optical grating, and described radioactive source can be a medical electronic linear accelerator, also can be cobalt-60 radioactive source.When adopting medical electronic linear accelerator as radioactive source, then medical electronic linear accelerator is directly installed on the rotary rack; When adopting cobalt-60, then radioactive source is sent to from the lead screen mechanism under the ground of therapeutic room and is installed on the rotary rack by the source transmission mechanism as radioactive source.

This practical described radiotherapy all-in-one is incorporated into the PET imaging device on the theratron with CBCT image guiding function; the registration of the CT image that obtains in PET image and the diagnostic procedure is merged; application possesses the powerful treatment planning systems design of reverse accent patient's treatment plan; generate the suffered treatment parameters such as maximal dose of shape, beam weights, dose volume, dose distribution, critical organ of irradiation field, to protect normal structure to greatest extent.

This practical described radiotherapy all-in-one can be by the registration and the fusion of CT image and PET image; obtain the position of the critical tissue that comprises the tumor target area and need protection, the image of radioactivity sensitive organization, delineate out the biological target area of tumor tissues and the critical tissue that needs protection in view of the above.

This practical described radiotherapy all-in-one can be by introducing advanced function assessment image technology (PET), combine with traditional anatomical image technology (CT), determine image biology of organ-tissue, supply as weary oxygen and blood, propagation, apoptosis and cell cycle regulating, oncogene and antioncogene change, and infiltration and transfer characteristic or the like are delineated out the tumor target area more accurately; According in the tumor-infiltrated situation of function assessment image reflection and the tumor to the difference of radiation-sensitive, give the irradiation of various dose, realize that biological modulated is strong, can increase the dosage of tumor and do not increase even reduce the normal structure exposure dose; Can before treatment, demonstrate simultaneously the function of normal structure, when making a plan, avoid the most responsive or function most important parts of irradiation, reduce whole damage, to obtain the ideal treatment ratio of gains.

Description of drawings

Fig. 1, Fig. 2 and Fig. 3 are a kind of concrete structure sketch map of therapy equipment described in the utility model, and wherein Fig. 1 is vertical facade structures sketch map, and Fig. 2 is the A-A profile of Fig. 1, and Fig. 3 is the B-B profile of Fig. 1;

Fig. 4 carries out the flow chart of radiation therapy method for using function image guided radiation treatment all-in-one described in the utility model.

The specific embodiment

Referring to Fig. 1～3, rotary rack 1 described in the utility model is a cylindrical shape revolving body, and its two is bearing on the support 3 by bearing 2 respectively, drives its rotation by driving device 12; One of described rotary rack 1 is provided with PET imaging device 4, and the same transverse section of other end is provided with cone beam imaging device and radiotherapy apparatus.Wherein, described PET imaging device 4 is a commercially available ring-shaped P ET detector array; Described radiotherapy apparatus is made up of multi-leaf optical grating 5 on the cylindrical shell that is installed in rotary rack 1 from inside to outside successively and medical electronic linear accelerator 6; Described cone beam imaging device is made up of kV-DR digital X radial imaging instrument and MV-DR digital X radial imaging instrument, wherein kV-DR digital X radial imaging instrument is made of X ray bulb 7 on the rotating cylinder that is oppositely arranged on rotary rack 1 and kV-DR detector 8, and described MV-DR digital X radial imaging instrument is made of medical electronic linear accelerator on the rotating cylinder that is oppositely arranged on rotary rack 16 and MV-DR detector 9.

Referring to Fig. 1, the radiotherapy bed of radiotherapy bed 13 described in the utility model for knowing, its bottom is provided with driving device, and this driving device can drive 13 left and right sides translational motions of radiotherapy bed, front-rear reciprocation movement and oscilaltion campaign.Describedly penetrate therapeutic bed 13 three-dimensional motions, cooperate the gyration of rotary rack 1 again, any lesions position of promptly finishing the patient carries out PET imaging, CBCT imaging and radiocurable task.

Referring to Fig. 1 and Fig. 3, the radioactive source that constitutes described radiotherapy apparatus can be above-mentioned medical electronic linear accelerator 6, also can be cobalt-60.Shown in double dot dash line among Fig. 1 and Fig. 3, because the radiation of cobalt-60 is bigger to the harm of human body, cobalt-60 radioactive source 10 with lead screen mechanism can be embedded in the underground of therapeutic room, by radioactive source connecting gear 11 radioactive source is caused on the multi-leaf optical grating 5.

Referring to the rotary rack 1 in the technical scheme shown in Fig. 1～3, therapeutic bed 13 and be located on the rotary rack 1 kV-DR digital X radial imaging instrument, MV-DR digital X radial imaging instrument, radiotherapy apparatus and PET imaging device by a control device centralized Control co-ordination, this control device, those of ordinary skill in the art utilizes the Professional knowledge of being grasped, and has now and transforms slightly on the technical foundation and can obtain.

For being grasped better, the public implements technological means of the present utility model, advantage of understanding this utility model better and being had and the technique effect that can reach, following brief description adopts function image guided radiation treatment all-in-one described in the utility model that the patient is carried out radiocurable method.

After the start, at first determining to treat first still is successive treatment, if treatment first,

1) patient is carried out PET scanning, obtain the PET image of lesions position;

2) call in the patient diagnosis CT scan image and with the PET image co-registration that step 1 is obtained;

3) design treatment plan: calculate patient target area (focus) coordinate, determine biological target area and exposure dose, to realize that biological modulated is strong;

4) position of patient on therapeutic bed is set;

5) carry out the CBCT imaging;

6) the CT scan image that the CBCT image and the step 2 of step 5 are called in compares, and by computational analysis focus centre coordinate whether error is arranged, if there is not error, change next step over to,, then adjust the patient body position if error is arranged, round-off error is determined the target area three-dimensional position;

7) go out beam treatment and carry out the actual target area centre coordinate that the patient is obtained in the kV-DR imaging;

8) the patient target area centre coordinate that calculates in the treatment plan in actual target area centre coordinate in the step 7 and the step 3 is compared, return step 5, do not continue beam treatment to treating end first and gathering the MV-DR image if not change if change;

If follow-up interval procedure,

1) at first want the doctor to determine whether that according to the result of check diagnosis needs carry out functional imaging, if do not need, the step 4 that just enters in the therapeutic process first finishes until treatment, if desired, just calls a preceding treatment plan and MV-DR image;

2) go out according to the MV-DR image calculation before patient's actual radioactive dose during seance, and compare with the prescribed dose of treatment plan, whether once actual radioactive dose has deviation before the judgement, if do not have deviation, the step 4 that just directly enters in the therapeutic process first finishes until treatment, if deviation is arranged, then carry out the PET scanning imagery;

3) input diagnosis CT image carries out registration, fusion;

4) revise treatment plan again, adjust the step 4 that enters after the exposure dose in the therapeutic process first and finish until treatment.

Claims (3)

1. function image guided radiation treatment all-in-one, this machine is made up of control device and therapy equipment, wherein said therapy equipment comprises single-revolution frame (1), be located at the radiotherapy bed (13) that cone beam imaging device (6,9,7,8) on the frame (1) and radiotherapy apparatus (5,6) and pass through rotary rack (1), it is characterized in that also being provided with on the described rotary rack (1) PET imaging device (4), this device is a ring-shaped P ET detector array; Described PET imaging device (4) is located at of rotary rack (1), and described cone beam imaging device (6,9,7,8) and radiotherapy apparatus (5,6) are located at the other end of rotary rack (1).

2. according to the described a kind of function image guided radiation treatment all-in-one of claim, it is characterized in that the radioactive source in the described radiotherapy apparatus is medical electronic linear accelerator (6).

3. according to the described a kind of function image guided radiation treatment all-in-one of claim, it is characterized in that the radioactive source in the described radiotherapy apparatus is cobalt-60 radioactive source (10).

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