CN113840836A - 抗结缔组织生长因子抗体及其应用 - Google Patents

抗结缔组织生长因子抗体及其应用 Download PDF

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CN113840836A
CN113840836A CN202080036744.2A CN202080036744A CN113840836A CN 113840836 A CN113840836 A CN 113840836A CN 202080036744 A CN202080036744 A CN 202080036744A CN 113840836 A CN113840836 A CN 113840836A
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variable region
chain variable
heavy chain
light chain
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CN113840836B (zh
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付雅媛
马晓丽
葛虎
陶维康
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

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Abstract

提供一种包含轻链和重链可变区的抗CTGF抗体及其作为药物的用途，该抗体可用于制备治疗CTGF相关疾病或病症的药物。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080036744.2A 2019-06-04 2020-06-03 抗结缔组织生长因子抗体及其应用 Active CN113840836B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211129173.4A CN115925926A (zh) 2019-06-04 2020-06-03 抗结缔组织生长因子抗体及其应用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019104801694 2019-06-04
CN201910480169 2019-06-04
PCT/CN2020/094136 WO2020244540A1 (zh) 2019-06-04 2020-06-03 抗结缔组织生长因子抗体及其应用

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CN113840836A true CN113840836A (zh) 2021-12-24
CN113840836B CN113840836B (zh) 2022-10-21

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CN202080036744.2A Active CN113840836B (zh) 2019-06-04 2020-06-03 抗结缔组织生长因子抗体及其应用

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US (1) US20220324953A1 (zh)
EP (1) EP3981787A4 (zh)
JP (1) JP2022535810A (zh)
KR (1) KR20220016890A (zh)
CN (2) CN115925926A (zh)
AU (1) AU2020289303A1 (zh)
BR (1) BR112021023669A2 (zh)
CA (1) CA3142092A1 (zh)
MX (1) MX2021014803A (zh)
TW (1) TW202110880A (zh)
WO (1) WO2020244540A1 (zh)
ZA (1) ZA202109744B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115645525A (zh) * 2022-12-14 2023-01-31 北京大学第三医院（北京大学第三临床医学院） Ctgf中和抗体在制备防治绝经后骨关节炎的药物中的应用
WO2024188179A1 (zh) * 2023-03-10 2024-09-19 上海济煜医药科技有限公司 一种靶向ctgf的抗体或其抗原结合片段及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021390125A1 (en) * 2020-12-03 2023-06-22 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising anti-connective tissue growth factor antibody

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104011206A (zh) * 2011-12-22 2014-08-27 安斯泰来制药株式会社 新型抗人ctgf抗体

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5770209A (en) 1991-08-30 1998-06-23 University Of South Florida Acceleration of wound healing using connective tissue growth factor
US5408040A (en) 1991-08-30 1995-04-18 University Of South Florida Connective tissue growth factor(CTGF)
WO1999033878A1 (fr) * 1997-12-25 1999-07-08 Japan Tobacco Inc. Anticorps monoclonal contre le facteur de croissance du tissu conjonctif et ses mises en applications medicales
JP4863548B2 (ja) 1998-09-08 2012-01-25 ヘンリー フォード ヘルス システム 結合組織増殖因子のモジュレーション、調節および抑制による腎障害の検出、予防および治療方法
US7405274B2 (en) * 2003-06-04 2008-07-29 Fibrogen, Inc. Connective tissue growth factor antibodies
DK1715890T3 (da) * 2004-02-11 2008-11-17 Fibrogen Inc CTGF som mål for mikroalbuminuriterapi hos patienter med diabetisk nefropati

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104011206A (zh) * 2011-12-22 2014-08-27 安斯泰来制药株式会社 新型抗人ctgf抗体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115645525A (zh) * 2022-12-14 2023-01-31 北京大学第三医院（北京大学第三临床医学院） Ctgf中和抗体在制备防治绝经后骨关节炎的药物中的应用
WO2024188179A1 (zh) * 2023-03-10 2024-09-19 上海济煜医药科技有限公司 一种靶向ctgf的抗体或其抗原结合片段及其应用

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EP3981787A4 (en) 2022-09-14
WO2020244540A1 (zh) 2020-12-10
CN115925926A (zh) 2023-04-07
US20220324953A1 (en) 2022-10-13
CA3142092A1 (en) 2020-12-10
MX2021014803A (es) 2022-01-18
AU2020289303A1 (en) 2022-01-27
CN113840836B (zh) 2022-10-21
ZA202109744B (en) 2023-05-31
EP3981787A1 (en) 2022-04-13
KR20220016890A (ko) 2022-02-10
TW202110880A (zh) 2021-03-16
BR112021023669A2 (pt) 2022-03-29
JP2022535810A (ja) 2022-08-10

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