CN112472591A

CN112472591A - Medical full-automatic nuclear medicine partial shipment appearance

Info

Publication number: CN112472591A
Application number: CN202011522545.0A
Authority: CN
Inventors: 李晋; 张春利; 李育成
Original assignee: China Nuclear Energy Tianjin Equipment Co ltd
Current assignee: China Nuclear Energy Tianjin Equipment Co ltd
Priority date: 2020-12-22
Filing date: 2020-12-22
Publication date: 2021-03-12

Abstract

The invention discloses a medical full-automatic nuclear medicine split charging instrument which comprises an upper shell, a lower shell, an upper rotary disc, a lower shell inner sleeve and an extraction mechanism, wherein the upper shell is connected with the lower shell through a damping hinge, an observation window and a cover opening handle are arranged on the upper shell, the lower shell is provided with a support, the lower shell inner sleeve is arranged in the lower shell and can support the upper rotary disc in a sliding manner, an upper rotary motor is arranged between the upper rotary disc and the support, and the extraction mechanism is vertically arranged below the upper rotary disc and is fixed at the bottom of the lower shell. The automatic subpackaging machine can complete the automatic subpackaging task safely and accurately, guarantees the sterile and pollution-free state to the maximum extent, can complete the subpackaging work at higher performance and higher speed when subpackaging the medicines, and is suitable for more use scenes and different application requirements.

Description

Medical full-automatic nuclear medicine partial shipment appearance

Technical Field

The invention relates to the field of medical instruments, in particular to an automatic subpackaging device applied to the field of radioactive drug subpackaging.

Background

Related research shows that cancer is a great threat to human health, and the application of molecular imaging technology is becoming more and more extensive in order to combat cancer. The molecular image can carry out physiological and biochemical level imaging on abnormal structures and functions of diseases from a molecular level, so that accurate image information is provided to assist diagnosis and treatment, and the molecular image plays an increasingly important role in early diagnosis, active drug screening, even real-time evaluation of treatment effects and the like of diseases such as coronary heart disease, vasculitis, infection, tumor, diabetic foot and the like. ECT is a kind of molecular image, and can detect the focus earlier by observing the difference of cell activity after injecting radioactive drug into human body, so as to achieve the purpose of early diagnosis and treatment of cancer, and at the same time, it has the characteristics of higher lesion detection rate, better diagnosis specificity, etc. ECT is divided into two categories, SPECT and PET/CT, and the preparation, synthesis and subpackaging of radiopharmaceuticals are required to be completed before the conventional image diagnosis.

The synthesis and the sub-packaging of the medicine are necessary for completing the image diagnosis, and due to the characteristic of continuous decay of the nuclear medicine, in order to ensure that the activity before injection meets the requirement, a nuclear pharmacy often adopts a method for improving the preparation activity to offset the decay amount on the distribution route, so that the nuclear medicine is wasted to a certain extent. On the other hand, the synthesis and the dispensing of the medicines are all performed manually in areas which cannot be covered by the nuclear pharmacy, and the dispensing of the medicines has radioactivity, so that high radiation injury is inevitably caused to hands and bodies of nuclear medicine technicians. Therefore, it is necessary to develop an automatic dispensing device to automatically complete the dispensing of nuclear medicine, thereby reducing the radiation dose to medical personnel and reducing the waste of nuclear medicine.

Simultaneously, the mainstream nuclear medicine partial shipment device in current market adopts two kinds of forms of syringe extraction and peristaltic pump extraction more, and wherein the peristaltic pump extraction mode has the good high characteristics of security of gas tightness, but it often needs a large amount of consumptive materials not convenient for doctor's operation and has the not high shortcoming of precision. The syringe extraction method has the advantages of higher precision and material consumption saving, but the problems of liquid medicine splashing, needle head damage and the like are easy to occur, so that it is particularly important to explore a new split charging method to avoid the defects.

Disclosure of Invention

The invention aims to provide a medical full-automatic nuclear medicine subpackaging instrument aiming at the technical defects in the prior art.

The technical scheme adopted for realizing the purpose of the invention is as follows:

the utility model provides a medical full-automatic nuclear medicine partial shipment appearance, its characterized in that, includes the shell, lower shell, goes up the carousel, shell endotheca and extraction mechanism down, go up through damping hinged joint between shell and the lower shell, upward be provided with the observation window on the shell and uncap the handle, the shell is provided with the support down, the shell endotheca is established and is supported the carousel under inside and slidable of shell down, go up the carousel with the support between be provided with rotating electrical machines, extraction mechanism set up perpendicularly under last carousel and be fixed in shell bottom down.

The extraction mechanism comprises a screw injector clamping groove, a rotary fixer, an extraction clamping groove, an extraction motor, a lifting motor, a lower rotary motor, an extraction frame body and a lifting frame body. The screw injector clamping groove is formed in the extraction frame body, the rotary fixer is rotatably arranged on the screw injector clamping groove, the fixed end of the extraction motor is fixedly connected with the extraction frame body, and the movable end of the extraction motor is fixedly connected with the extraction clamping groove. The drawing clamping groove is slidably arranged in the drawing frame body. The fixed end of the lower rotating motor is fixedly connected with the lifting frame body, and the movable end of the lower rotating motor is fixedly connected with the bottom of the drawing frame body. The fixed end of the lifting motor is fixedly connected with the lower shell, and the movable end of the lifting motor is fixedly connected with the lifting frame body.

The upper rotary disc comprises an interface disc, a shielding barrel and a shielding cover, the interface disc comprises an interface, a filter membrane seat and a filter membrane fixer, the shielding barrel comprises four storage positions, namely a stock solution level, a mixing position, a physiological saline level and a waste solution level, activity detectors are arranged in the stock solution level and the mixing position, and the four storage positions and the horizontal plane form a certain angle and are arranged in the shielding barrel.

The shielding cover is provided with a needle inserting groove corresponding to the shielding barrel, a horizontal platform is arranged on the needle inserting groove, a needle holder and a linear guide rail are arranged above the horizontal platform, and the needle holder can be detachably and slidably arranged on the linear guide rail to assist in inserting needles.

The interface disc is concentrically provided with a plurality of interfaces, each interface comprises a cap taking mechanism and a filter membrane seat, and the filter membrane seat and the filter membrane fixer can fix a gas filter membrane and a liquid filter membrane.

Get cap mechanism include guide way, guide rail, fixed clamp splice, slip guide shaft and small-size electric jar, the fixed clamp splice be fixed in go up the carousel on, small-size electric jar one end with go up the carousel articulated, the other end with the slip clamp splice outside articulated, the slip clamp splice with fixed clamp splice inboard all be stained with flexible chuck, the slip guide shaft through screw the nut with the slip clamp splice is fixed, slip guide shaft slidable ground set up in guide rail.

Compared with the prior art, the invention has the beneficial effects that:

firstly, the invention adopts a split charging method of matching the screw injector and the pipeline to complete the medicine preparation, the needle head of the screw injector is removed by the cap taking mechanism and then is automatically connected into the pipeline, the medicine liquid splashing phenomenon when the needle head is directly inserted into a penicillin bottle is avoided, and meanwhile, the needle head is not separated from the needle cap and is in an aseptic state in the whole split charging process, and the problems of needle head pollution, sharp instrument exposure and the like are avoided. And secondly, each step of the invention is operated by a clean filter membrane, so that the clean states of the penicillin bottle and the screw injector are ensured. Finally, the invention has small volume, low cost and convenient movement, and is more suitable for single-needle quick split charging.

Drawings

FIG. 1 is a general view of a fully automatic nuclear medicine dispensing instrument for medical use;

FIG. 2 is a schematic sectional view showing the internal structure;

FIG. 3 is a schematic view of a shielding cartridge;

FIG. 4 is a schematic view of the needle holder installation;

FIG. 5 is a schematic view of the interface disk;

fig. 6 is a schematic view of the cap removing mechanism.

Detailed Description

The invention is described in further detail below with reference to the figures and specific examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

As shown in fig. 1 and 2, the medical fully automatic nuclear medicine split charging instrument comprises an upper shell 1, a lower shell 2, an upper rotary disc 3, a lower shell inner sleeve 4 and an extraction mechanism 5, wherein the upper shell is connected with the lower shell through a damping hinge 6, the upper shell is provided with an observation window 11 and a cover opening 12 handle, the lower shell is provided with a support 21, the lower shell inner sleeve is arranged in the lower shell and can support the upper rotary disc in a sliding manner, an upper rotary motor 7 is arranged between the upper rotary disc and the support, and the extraction mechanism is vertically arranged below the upper rotary disc and is fixed at the bottom of the lower shell. According to the automatic dispensing machine, the automatic dispensing task of the nuclear medicine is completed through the matching movement of the extracting mechanism and the upper rotating disc, so that the work burden of medical staff is saved. Meanwhile, the cap taking mechanism 10 specially designed by the invention can take down the needle head and the needle cap together, so that the needle head is ensured not to be secondarily polluted and the sharp instrument is exposed in the split charging process, and the combined split charging method of the extraction mechanism and the upper rotary table by matching the relative movement of the extraction mechanism and the upper rotary table with the extraction of the pipeline and the screw injector can provide better safety while ensuring the split charging precision. On the other hand, the constant pressure pipeline design of the invention can balance the air pressure inside and outside the penicillin bottle on the premise of ensuring the cleanliness, and avoid the influence of the air pressure on the subpackaging precision.

Furthermore, the extraction mechanism can be matched with a screw injector to quickly replace an interface and complete extraction and medicine pushing work. As shown in fig. 2, the drawing mechanism includes a screw injector slot 52, a rotary holder 53, a drawing slot 54, a drawing motor 51, a lifting motor 9, a lower rotary motor 8, a drawing frame 55, and a lifting frame 56. Screw socket syringe draw-in groove set up in the extraction support body on, rotatory fixer rotatably set up on the screw socket syringe draw-in groove, extraction motor stiff end with the extraction support body connect fixedly, the expansion end with the extraction draw-in groove connect fixedly, extraction draw-in groove slidable ground set up in the extraction support body, lower rotation motor stiff end with the lifting support body connect fixedly, the expansion end with extraction support body bottom connect fixedly, the lifting motor stiff end with lower shell be connected fixedly, the expansion end with the lifting support body connect fixedly. The screw injector with the shielding sleeve is placed into the extraction clamping groove, the screw injector can be rapidly fixed into the extraction clamping groove through the rotary fixer, the screw injector is fixed and then is tightly covered with the shell, and the automatic subpackaging instrument starts to operate. The extraction support body uses the axle center of screw injector as the center of rotation under the effect of rotating electrical machines down to make the screw injector can accomplish axial rotary motion, the cooperation is got the centre gripping of cap mechanism 10 and the axial motion of elevator motor can be made the syringe needle and the cylinder separation of screw injector, the rotation of last carousel can make the screw injector cylinder switch on other interfaces, the screw injector is carried screw injector push handle end by the extraction draw-in groove and is accomplished extraction and injection etc. and adorn the work after switching on other interfaces.

Preferably, the upper rotary disk of the invention is compatible with a plurality of storage positions and functional interfaces. As shown in fig. 3, 4 and 5, the upper rotating disk 3 includes a mouthpiece 31, a shielding barrel 32 and a shielding cover 33, the mouthpiece includes a mouthpiece 311, a filter membrane holder and a filter membrane holder for clamping and fixing the filter membrane, the shielding barrel includes four storage positions, which are an original liquid level 34, a mixing position 35, a physiological saline level 36 and a waste liquid level 37,

activity detectors

38 and 39 are disposed in the original liquid level and the mixing position, the four storage positions and the horizontal plane are disposed in the shielding barrel at a certain angle, and due to gravity, the liquid in the bottle and the horizontal plane form a certain angle, so that the needle can penetrate into the liquid level to the maximum extent to suck the liquid. The interface disc comprises a plurality of interfaces, the interface 311, the interface 312, the interface 315 and the interface 316 are respectively communicated with a waste liquid level, a physiological saline level and a mixed level original liquid level liquid suction port, and a screw injector with a needle head removed is controlled to automatically connect into each interface to complete the extraction and the liquid pushing of the medicine. The interface 313 is a constant pressure interface, a four-turn-one connecting seat 3131 is connected to the upper part of the constant pressure interface, a clean air filter membrane is connected to the lower part of the four-turn-one connecting seat, and an exhaust port of the waste liquid level, the physiological saline level and the original mixed level is connected to the upper part of the four-turn-one connecting seat. When the liquid volume that xiLin bottle stored in waste liquid level, normal saline level, the former liquid level of mixed position changes, because the effect of negative pressure and malleation can be followed the constant voltage interface and breathed in through clean filter membrane and the effect that the exhaust played the interior constant voltage of bottle, the indirect precision of guaranteeing the extraction is not influenced by pressure and guarantees the sterile condition of the interior liquid of bottle. Interface 314 plays discharge and the effect of absorbing clean air for straining the gas interface, and before the liquid medicine is being absorb to the screw injector, go up the carousel rotation and aim at the screw injector and absorb partial shipment work after a certain amount of air with straining the gas interface again, after extracting a certain amount of volume liquid, because the effect of gravity, liquid is last under, absorb after the completion with the air to the back propelling movement in order to push back the interior raffinate of pipeline and prevent the weeping. The mixing position is used for diluting stock solution, normal saline and the stock solution are respectively mixed into a mixing bottle through the extraction and the liquid pushing of a screw injector, then air is pushed into a liquid sucking port of the mixing position to generate bubbles so that the liquid in the bottle is fully mixed, and a built-in activity detector 39 in the mixing position can detect the liquid radiation dose in the mixing bottle in real time.

As shown in fig. 4, the shielding cover is provided with a needle slot 332 corresponding to the shielding barrel, the needle slot is provided with a horizontal platform 331, a needle holder 334 and a linear guide 333 are arranged above the horizontal platform, the needle holder can be detachably and slidably arranged on the linear guide to assist in inserting needles, the needle holder is correspondingly connected to the linear guide after clamping suction needles and exhaust needles which are communicated with a liquid suction port and an exhaust port pipeline, the needle holder has a certain weight, the suction needles and the exhaust needles penetrate penicillin bottles corresponding to stations through the needle slot under the action of pressure, and the needle tips of the suction needles are tightly attached to the deep ends of the bottoms of the inclined penicillin bottles to ensure that liquid medicine is completely sucked, the operation can be rapidly completed, the needle heads can be smoothly inserted into the penicillin bottles, and the workload of medical personnel can be greatly saved.

Preferably, the invention is provided with a small automatic cap taking mechanism, as shown in fig. 5 and fig. 6, the cap taking mechanism 10 comprises a guide groove 317, a guide rail 318, a fixed clamping block 3191, a sliding clamping block 319, a sliding guide shaft 3193 and a small electric cylinder 310, the fixed clamping block is fixed on the upper rotating disc, one end of the small electric cylinder is hinged with the upper rotating disc, the other end of the small electric cylinder is hinged with the outer side of the sliding clamping block, the telescopic motion of the small electric cylinder can make a movable sliding block slide back and forth along the guide rail to complete the clamping and releasing operation, the inner sides of the sliding clamping block and the fixed clamping block are both adhered with flexible clamping heads 3192, the sliding guide shaft is fixed with the sliding clamping block by screwing a nut 3194, the sliding guide shaft is slidably arranged in the guide rail, the guide groove is an involute guide groove which is gradually reduced counterclockwise, and a screw injector with a needle head and a needle cap enters the guide groove from the left side, go up the carousel clockwise rotation afterwards and make syringe needle and needle cap paste tight fixed clamp splice, slip clamp splice right shift afterwards and press from both sides tight syringe needle and needle cap, the guide way can be fine play the effect of adjustment syringe needle and needle cap position and deviation for should get the screw-socket syringe that cap mechanism can match most specifications well, strengthened the compatibility of equipment to the consumptive material.

Further, the invention provides a safer and more accurate subpackaging method, which comprises the following specific subpackaging procedures: firstly, respectively placing a raw liquid bottle, an empty penicillin bottle, a physiological saline bottle and a waste liquid bottle which are filled with high-concentration nuclear medicine into a raw liquid level, a mixing level, a physiological saline level and a waste liquid level, covering a shielding cover, inserting a needle holder which holds a needle head into each storage position along a linear guide rail, putting a screw injector into the storage positions, fixing the syringe head, and closing an upper cover of the equipment. Then, the upper rotary disc rotates to enable the left end of a guide groove of the cap taking mechanism to be aligned with a screw injector, the screw injector ascends to penetrate through the guide groove under the action of a lifting motor, the upper rotary disc rotates clockwise to enable a needle head and a needle cap to be attached to a fixed clamping block, a sliding block slides to clamp the needle head and the needle cap, the screw injector rotates under the action of a lower rotating motor to enable the needle head and the needle cap to be separated from a needle cylinder, after separation, the upper rotary disc rotates to enable a gas filtering interface to be aligned with the screw injector, after the lifting motor ascends to connect the screw injector and the gas filtering interface, a certain amount of clean air is extracted after the lifting motor ascends to connect the screw injector and the gas filtering interface, the lifting motor descends, the upper rotary disc rotates to enable the screw injector to be aligned with a mixing position to push the extracted raw liquid into the mixing station, then draw a certain amount of normal saline with same process and push the mixing station, produce the bubble through continuously pushing clean air to the mixing station and make liquid medicine and normal saline intensive mixing to the accurate extraction of ration is accomplished to the activity value that the activity detector measured as the benchmark, pushes the air to the mixing station after the extraction is accomplished and discharges back the pipeline liquid. And finally, rotating the upper rotating disc to enable the extracting mechanism to be aligned with the screw injector, and assembling the needle head and the needle cap back to the screw injector under the action of the lifting motor and the lower rotating motor to complete a single subpackaging task. The subpackaging method is different from the traditional subpackaging method that a peristaltic pump is matched with a pipeline to pump the medicine and an injector directly pierces a penicillin bottle to pump the medicine, adopts the subpackaging mode that the injector is matched with the pipeline, and selectively and automatically connects the pipeline to pump the medicine by pulling out the injector with the needle head, avoids the problems that the subpackaging precision is influenced by the pipeline deformation caused by the extrusion of the peristaltic pump and the medicine liquid is splashed caused by the fact that the injector pierces the penicillin bottle, and has the advantages of safety and precision.

In conclusion, the medical full-automatic nuclear medicine subpackaging instrument can safely and accurately complete the automatic subpackaging task by setting good shielding measures and a more reasonable subpackaging method. Meanwhile, the automatic cap taking mechanism can be taken down together with the needle head and the needle cap, so that the needle head is not contacted with the outside in the whole split charging process and keeps a sterile state, the problems of injection safety, sharp instrument exposure and the like are solved, on the other hand, the clean air is contacted with the nuclear medicine in each step of operation by matching with the air filtering interface, the nuclear medicine is ensured not to be polluted, and the sterile and pollution-free state is ensured to the maximum extent. Finally, the performance of the equipment is improved by detailed designs such as the storage position forming a certain angle with the horizontal plane, the involute guide groove, the concentric interface and the like, so that the medicine subpackaging machine can complete subpackaging work at higher performance and higher speed when subpackaging medicines, and is suitable for more use scenes and different application requirements due to the advantages of small size and low cost.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. The utility model provides a medical full-automatic nuclear medicine partial shipment appearance, its characterized in that, includes the shell, lower shell, goes up the carousel, shell endotheca and extraction mechanism down, go up through damping hinged joint between shell and the lower shell, upward be provided with the observation window on the shell and uncap the handle, the shell is provided with the support down, the shell endotheca is established and is supported the carousel under inside and slidable of shell down, go up the carousel with the support between be provided with rotating electrical machines, extraction mechanism set up perpendicularly under last carousel and be fixed in shell bottom down.

2. The medical fully automatic nuclear medicine dispensing instrument according to claim 1, wherein the extracting mechanism comprises a screw injector slot, a rotary fixer, an extracting slot, an extracting motor, a lifting motor, a lower rotary motor, an extracting rack body and a lifting rack body. The screw injector clamping groove is formed in the extraction frame body, and the rotary fixer is rotatably arranged on the screw injector clamping groove. The fixed end of the extraction motor is fixedly connected with the extraction frame body, the movable end of the extraction motor is fixedly connected with the extraction clamping groove, and the extraction clamping groove is slidably arranged in the extraction frame body. The fixed end of the lower rotating motor is fixedly connected with the lifting frame body, and the movable end of the lower rotating motor is fixedly connected with the bottom of the drawing frame body. The fixed end of the lifting motor is fixedly connected with the lower shell, and the movable end of the lifting motor is fixedly connected with the lifting frame body.

3. The medical fully automatic nuclear medicine split charging instrument according to claim 1, wherein the upper rotary plate comprises an interface disc, a shielding barrel and a shielding cover, the interface disc comprises an interface, a filter membrane seat and a filter membrane fixer, the shielding barrel comprises four storage positions, namely a raw liquid level, a mixing position, a physiological saline level and a waste liquid level, activity detectors are arranged in the raw liquid level and the mixing position, and the four storage positions and the horizontal plane form a certain angle and are arranged in the shielding barrel.

4. The shielding cover of claim 3, wherein a pin slot is formed in the shielding cover corresponding to the shielding barrel, a horizontal platform is arranged on the pin slot, a pin holder and a linear guide rail are arranged above the horizontal platform, and the pin holder is detachably and slidably arranged on the linear guide rail to assist in inserting pins.

5. The interface disc of claim 3, wherein a plurality of interfaces are concentrically disposed on the interface disc, the interfaces comprising a cap removal mechanism and a filter membrane holder, the filter membrane holder and the filter membrane holder being capable of holding a gas filter membrane and a liquid filter membrane.

6. The cap taking mechanism as claimed in claim 5, wherein the cap taking mechanism comprises a guide groove, a guide rail, a fixed clamping block, a sliding guide shaft and a small electric cylinder, the fixed clamping block is fixed on the upper rotary table, one end of the small electric cylinder is hinged with the upper rotary table, the other end of the small electric cylinder is hinged with the outer side of the sliding clamping block, flexible chucks are adhered to the inner sides of the sliding clamping block and the fixed clamping block, the sliding guide shaft is fixed with the sliding clamping block through a screwing nut, and the sliding guide shaft is slidably arranged in the guide rail.