CN108535503B - Full-automatic coagulation analyzer and application method thereof - Google Patents
Full-automatic coagulation analyzer and application method thereof Download PDFInfo
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- CN108535503B CN108535503B CN201810762104.4A CN201810762104A CN108535503B CN 108535503 B CN108535503 B CN 108535503B CN 201810762104 A CN201810762104 A CN 201810762104A CN 108535503 B CN108535503 B CN 108535503B
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- 230000015271 coagulation Effects 0.000 title claims abstract description 26
- 238000005345 coagulation Methods 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 22
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 161
- 238000001514 detection method Methods 0.000 claims abstract description 81
- 238000011534 incubation Methods 0.000 claims abstract description 53
- 238000012360 testing method Methods 0.000 claims description 124
- 239000007788 liquid Substances 0.000 claims description 114
- 239000002699 waste material Substances 0.000 claims description 81
- 238000004140 cleaning Methods 0.000 claims description 67
- 238000005406 washing Methods 0.000 claims description 37
- 230000003287 optical effect Effects 0.000 claims description 30
- 239000011324 bead Substances 0.000 claims description 22
- 230000007306 turnover Effects 0.000 claims description 16
- 239000000872 buffer Substances 0.000 claims description 14
- 230000007246 mechanism Effects 0.000 claims description 7
- 239000007853 buffer solution Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 238000010790 dilution Methods 0.000 claims description 4
- 239000012895 dilution Substances 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 230000032258 transport Effects 0.000 claims description 4
- 230000003139 buffering effect Effects 0.000 claims description 3
- 239000003593 chromogenic compound Substances 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 8
- 238000012423 maintenance Methods 0.000 description 6
- 239000003085 diluting agent Substances 0.000 description 4
- 238000005192 partition Methods 0.000 description 4
- 230000001012 protector Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000017525 heat dissipation Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007820 coagulation assay Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a full-automatic coagulation analyzer and a use method thereof, wherein the full-automatic coagulation analyzer comprises a sample position module, a reagent position module, an incubation detection module, a gripper module, a cup feeding module, a needle movement module, a light source module, a pump station module, a consumable module, a power supply module and a cuboid frame body formed by six surfaces of a front surface, a back surface, a left surface, a right surface, a top surface and a bottom surface, a main cavity is arranged in the middle of the frame body, the sample position module, the reagent position module, the incubation detection module, the gripper module and the needle movement module are all positioned in the main cavity, the left surface of the frame body is provided with a left side cavity, the pump station module is positioned in the left side cavity, the right surface of the frame body is provided with a right side cavity, the consumable module and the light source module are positioned in the right side cavity, the cup feeding module is positioned in the right side cavity and communicated in the main cavity, the back surface of the frame body is provided with a back cavity, and the power supply module is positioned in the back cavity, so that full-automatic coagulation analysis is realized through the synergistic effect of the several modules.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a full-automatic coagulation analyzer and a using method thereof.
Background
Currently, in the field of coagulation function tests, there are two types of semi-automatic and full-automatic coagulation analyzers. The semi-automatic coagulation analyzer is generally internally provided with a sample incubation area, a detection area, a display screen area, a printer and other modules. Other samples and reagents need personnel to use a sample adding gun to add a test cup, and the test cup added with the complete sample or the reagent is placed in a corresponding area for incubation and detection by manpower, and the semi-automatic coagulation analyzer mainly has the advantages of low test speed, high labor cost consumption and inapplicability to the requirements of testing a large number of samples and rapidly outputting results.
The existing full-automatic coagulation analyzer is internally provided with independent partitions, and generally mainly comprises a sample position area, a reagent position area, an incubation detection area, a sample needle, a reagent needle sampling and sample adding area, a hand grip cup taking area, a test cup automatic loading area, a pump station area, a power supply control area, an optical path system and other areas, so that the processes of sample automatic sampling, sample adding, detection and result analysis are realized. Because of the advantages of small manual workload, lower labor cost, faster testing speed and the like, the full-automatic coagulation analyzer is widely applied, however, most of the existing full-automatic coagulation analyzers still have complicated internal partitions, so that a plurality of areas of three-dimensional space are frequently crossed, the requirement on software scheduling processing is high, the instrument testing speed is influenced, the instrument operation is easy to fail, the testing result is inaccurate, the maintenance rate is high, the maintenance difficulty is high, the cost is high, the user experience is poor and the like.
Disclosure of Invention
The invention aims to solve the technical problems that: the full-automatic coagulation analyzer and the use method thereof have the advantages of simple internal partition, accurate sample addition, long reagent preservation time, independent and simultaneous non-cross operation of each needle component, each motion component such as a handle and the like, high speed of a unique double-track cup transporting vehicle without clamping cups, constant-temperature heating of an incubation detection area, accurate detection result, high detection efficiency, stable operation, simple operation, convenient maintenance and the like.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
The full-automatic coagulation analyzer comprises a sample position module, a reagent position module, an incubation detection module, a gripper module, a cup feeding module, a needle movement module, a light source module, a pump station module, a consumable module, a power supply module and a cuboid frame main body formed by six surfaces of a front surface, a back surface, a left surface, a right surface, a top surface and a bottom surface, wherein a main cavity is arranged in the middle of the frame main body;
The needle movement module is positioned at the upper part in the main cavity, the sample position module is positioned at the lower left corner in the main cavity, the reagent position module is positioned at the center of the lower part of the main cavity and is positioned at the right side of the sample position module, the incubation detection module is positioned at the lower right corner of the main cavity and is positioned at the right side of the reagent position module, the gripper module is positioned at the middle part of the right side surface in the main cavity and is positioned right above the incubation detection module, the needle movement module is positioned at the upper part in the main cavity, the light source module is positioned at the middle position in the bottom in the right side cavity, the consumable module is positioned right above the light source module, the cup inlet module is positioned at the lower right in the rear side cavity, and the part of the cup inlet module penetrating through the main cavity is positioned at the back surfaces of the reagent position module and the sample position module;
The light source module is connected with the incubation detection module and is used for providing special light for the incubation detection module to detect, the needle movement module collects samples and reagents through the sample position module and the reagent position module respectively, detect in adding the test cup of cup entering module, the pump station module is connected with the needle movement module and is used for cleaning the cleaning waste liquid of the needle movement module and the extraction needle movement module, the pump station module is connected respectively to the power module, the needle movement module, the light source module, the incubation detection module, the cup entering module and the tongs module, be used for providing the power supply of the pump station module, the needle movement module, the light source module, the incubation detection module, the cup entering module and the tongs module, the cup entering module grabs the test cup of cup entering module to the incubation detection module through the tongs module, the consumable module is connected with the cup entering module and is used for providing the test cup for the cup entering module.
Further, the power module comprises a switch power supply, a CAN connector, a control panel, a waste liquid sensor interface, an instrument system switch, a power interface, a protector, a net mouth and a waste liquid interface, wherein the switch power supply is respectively connected with the instrument system switch, the control panel and the CAN connector, the waste liquid sensor interface is connected with the control panel and an external waste liquid sensor, the waste liquid interface is connected with an external waste liquid barrel, the instrument system switch is connected with the power interface, the power interface is connected with an external power supply, the CAN connector is connected with the control panel, the control panel adopts a TMS320C2000 control panel, the control panel is provided with a control display panel, the instrument system switch is connected with the protector, the control panel is connected with the net mouth, and the net mouth is connected with an external PC through a data line.
Further, the sample position module includes sample frame, sample pipe bar code scanner, and be used for judging whether the sample frame is placed the LED pilot lamp that targets in place, sample pipe bar code scanner is located main cavity inboard left surface for scan sample pipe that awaits measuring, and be connected with the control panel through the CAN connector, sample frame bottom is equipped with the business turn over appearance guide rail that is used for business turn over sample frame, business turn over appearance guide rail both sides are equipped with the spacing groove that prevents that the sample frame from empting, business turn over appearance guide rail tail end is equipped with first contact sensor, first contact sensor is connected with the control panel through the CAN connector, the LED pilot lamp is connected with switching power supply and control panel respectively.
Further, reagent position module includes from left to right dilution liquid level, special washing liquid level, buffering reagent position and start reagent position that arrange in proper order, reagent position module bottom is equipped with the business turn over mechanism that is used for reagent position module business turn over, business turn over mechanism is including being used for business turn over gliding first linear slide rail and the support frame that is used for supporting reagent position module, reagent position module below is equipped with the peltier refrigerator, the peltier refrigerator below is equipped with and is used for reagent position module radiating fin and air inlet air flue, the below of fin is equipped with radiator fan, the louvre has been seted up to main cavity bottom, and the louvre is located under the reagent position module, radiator fan is through the louvre heat dissipation of airing exhaust, radiator fan is connected with the control panel through the CAN connector, and be connected with switching power supply.
Further, the needle motion module comprises a sample adding needle, a first reagent needle, a second reagent needle, a sample adding needle servo motor for controlling the sample adding needle, a first reagent needle servo motor for controlling the first reagent needle, and a second reagent needle servo motor for controlling the second reagent needle, wherein a sample adding needle cleaning tank, a first reagent needle cleaning tank and a second reagent needle cleaning tank which correspond to the sample adding needle, are respectively arranged below the sample adding needle, the first reagent needle cleaning tank and the second reagent needle cleaning tank, waste liquid pipelines are arranged below the sample adding needle cleaning tank, the first reagent needle cleaning tank and the second reagent needle cleaning tank, the waste liquid pipelines are connected with the pump station module, the sample adding needle servo motor, the first reagent needle servo motor and the second reagent needle servo motor are respectively connected with a control board through CAN connectors, and the sample adding needle servo motor, the first reagent needle servo motor and the second reagent needle servo motor are respectively connected with a switch power supply.
Further, the incubation detection module comprises an incubation zone, a magnetic bead detection zone, an optical detection zone and a constant temperature heater for heating and preserving heat for the incubation zone, the magnetic bead detection zone and the optical detection zone, the magnetic bead detection zone is provided with a magnetic bead detector for detecting a sample by adopting a solidification method, the optical detection zone is provided with an optical detector for detecting the sample by adopting an immunoturbidimetry method and a chromogenic substrate method, the magnetic bead detector and the optical detector are both connected with a control board through a CAN connector, the optical detector is connected with a light source module, and the light source module provides light of a specific wave band for the optical detector to carry out optical detection.
Further, the tongs module is equipped with magnetic switch including the tongs that adopts pneumatic principle and the waste material box that is used for depositing the waste material, and the waste material box is equipped with second contact sensor, and magnetic switch and second contact sensor all are connected with the control panel through the CAN connector.
Further, the pump station module is including the waste liquid pump that is used for collecting the waste liquid, be used for providing the washing pump of pressure for wasing needle motion module, be used for storing the washing liquid bucket of washing liquid, and be used for splendid attire washing needle motion module's washing liquid buffer bottle, waste liquid pump connection waste liquid pipeline and waste liquid interface, the washing liquid bucket is equipped with the washing liquid storehouse of being convenient for add the washing liquid, the washing liquid storehouse is equipped with the second linear slide rail that is used for washing liquid storehouse to advance out gliding and is used for the handle in push-and-pull washing liquid storehouse, second linear slide rail tail end is equipped with the third contact sensor, washing liquid buffer bottle is equipped with float switch, the waste liquid pump, the washing pump, third contact sensor and float switch all are connected with the control panel through the CAN connector, and waste liquid pump and washing pump all are connected with switching power supply.
Further, the consumable module comprises a cup tray for storing test cups and a rotating central shaft for rotating the cup tray, the cup feeding module comprises a cup belt for pulling out the test cups, a loader for driving the cup belt, guide wheels for limiting the running direction of the cup belt, a cup feeding groove for placing the test cups pulled out by the cup belt, a test cup lane device for dividing the test cups, a cup transporting vehicle for transporting the test cups and a cup transporting rail for transporting the test cups, one end of the cup belt is connected with the lower end face of the cup tray, the other end of the cup belt is connected with the cup feeding groove, the cup feeding groove is connected with the test cup lane device, the test cup lane device is connected with the cup transporting vehicle, the cup transporting vehicle runs on the cup transporting rail, the cup transporting rails are provided with two guide wheels and are respectively positioned on two sides of the lane device, and extend into the main cavity and are positioned on the back faces of the reagent position module and the sample position module.
Further, the using method of the full-automatic coagulation analyzer comprises the following steps:
1) Sample injection: the method comprises the steps that a sample frame is pulled out, a sample to be tested is mounted on the sample frame, a sample injection track is pushed in manually, limiting grooves are formed in two sides of the sample injection track to prevent the sample frame from toppling over, a first contact sensor transmits signals to a control board through a CAN connector, the control board judges that the sample frame is placed in place, a corresponding LED indicator light is turned on, otherwise the LED indicator light is not turned on, and a bar code scanner of a sample tube arranged on one side sequentially scans and stores all sample tubes in the sample frame;
2) Test cup loading and transporting: the loader drives the cup belt, the cup belt drives the test cup to be pulled out of the cup tray and enter the cup inlet groove by the guide wheel, then the test cup is divided into two paths by the test cup lane divider, and the two paths enter the cup transporting vehicle, and the cup transporting vehicle transports the test cup to the sample loading position and the buffer position by the cup transporting rail;
3) Needle loading: the control board controls the sample adding needle servo motor, the first reagent needle servo motor and the second reagent needle servo motor to respectively control the running positions of the sample adding needle, the first reagent needle and the second reagent needle, the sample adding needle samples at a sample position and adds into a test cup, then runs into a sample adding needle cleaning tank to clean, then resets to carry out the next test flow, the first reagent needle adopts buffer solution to add into the test cup, then runs into the first reagent needle cleaning tank to clean, then resets to carry out the next test flow, the second reagent needle adopts starting reagent to add into the test cup, then runs into the second reagent needle cleaning tank to clean, and then resets to carry out the next test flow;
4) Grabbing by a gripper: grabbing the test cup with the sample added in the step 3) to an incubation area by a gripper, incubating for a certain time, and grabbing to a magnetic bead detection area or an optical detection area by the gripper for detection;
5) Test cup treatment: after the test is finished, the test cup is grabbed into the waste box by the grabber, and the waste box is pulled out for processing by the tester.
Compared with the prior art, the invention has the following beneficial effects:
(1) The invention has the advantages of simple internal partition, accurate sample adding, long reagent storage time, independent and mutually non-crossed running of each needle component, each moving component such as a handle and the like, high speed of the unique double-track cup transporting vehicle without clamping a cup, constant-temperature heating of an incubation detection area, accurate detection result, high detection efficiency, stable running, simple operation, convenient maintenance and the like.
(2) According to the invention, the full-automatic operation of the instrument is completed by the connection of the switching power supply, the control panel, the CAN connector, the protector, the instrument system switch, the external PC, the network port and the power interface, which are arranged, together, so that the manual workload is reduced, the labor cost is reduced, and the testing speed is greatly improved.
(3) According to the invention, all the components are connected through the CAN connector, the components are controlled by the control panel respectively, all the components independently operate and do not cross-operate, one of the components is damaged, and CAN be detached and replaced independently, the CAN connector is adopted for connection, so that the disassembly, the replacement and the maintenance are convenient and quick, the maintenance efficiency is improved, and the operation timeliness of equipment is ensured.
(4) The reagent position is provided with the refrigerator, the radiating fins and the radiating inlet and outlet fans, so that the reagent is in a low-temperature favorable storage environment, the effective storage time of the reagent is prolonged, and the activity of the reagent is ensured.
(5) The incubation area is provided with constant-temperature heating, so that the incubation environment of the sample is effectively ensured, the incubation efficiency of the sample is improved, and meanwhile, the accuracy of sample testing is also ensured.
Drawings
FIG. 1 is a schematic diagram of a fully automatic coagulation assay.
Fig. 2 is a schematic diagram of the consumable module and the power module.
FIG. 3 is a schematic diagram of a sample bit block configuration.
Fig. 4 is a schematic diagram of a sample injection module structure.
FIG. 5 is a schematic view of the structure of the cup transporting vehicle and the cup transporting rail.
FIG. 6 is a schematic diagram of a pump station module configuration.
Fig. 7 is a schematic view of the structure of the needle cleaning tank.
FIG. 8 is a schematic diagram of a reagent cartridge.
Fig. 9 is a schematic diagram of a movement module structure.
Fig. 10 is a schematic view of the structure of the incubation module.
Fig. 11 is a schematic diagram of a power module structure.
Wherein, the names corresponding to the reference numerals are:
1-frame body, 2-needle movement module, 21-sample addition needle, 22-first reagent needle, 23-second reagent needle, 24-sample addition needle servo motor, 25-first reagent needle servo motor, 26-second reagent needle servo motor, 27-sample addition needle wash tank, 28-first reagent needle wash tank, 29-second reagent needle wash tank, 3-gripper module, 31-gripper, 32-waste cartridge, 4-incubation detection module, 41-incubation zone, 42-magnetic bead detection zone, 43-optical detection zone, 44-magnetic bead detector, 45-optical detector, 46-constant temperature heater, 5-reagent level module, 51-dilution level, 52-special wash level 53-buffer reagent station, 54-starting reagent station, 55-access mechanism, 56-first linear slide, 57-support rack, 58-air intake duct, 6-cup feeding module, 61-cup tray, 62-cup belt, 63-loader, 64-guide wheel, 66-test cup lane, 67-cup transporting vehicle, 68-cup transporting rail, 69-rotation center shaft, 7-sample position module, 71-sample rack, 72-sample tube barcode scanner, 73-sample access rail, 8-pump station module, 81-waste liquid pump, 82-cleaning pump, 83-cleaning liquid barrel, 84-cleaning liquid buffer bottle, 85-cleaning liquid bin, 86-handle, 87-second linear slide, 89-float switch, 9-power module, 91-switching power supply, 92-CAN connector, 93-control panel, 94-waste liquid interface, 95-instrument system switch, 96-net mouth, 97-insurance ware, 98-power interface, 99-waste liquid sensor interface, 10-light source module, 11-consumable module.
Detailed Description
The invention will be further illustrated by the following description and examples, which include but are not limited to the following examples.
As shown in fig. 1-11: the full-automatic coagulation analyzer comprises a sample position module 7, a reagent position module 5, an incubation detection module 4, a gripper module 3, a cup feeding module 6, a needle movement module 2, a light source module 11, a pump station module 8, a consumable module 10, a power supply module 9 and a cuboid frame body 1 formed by six surfaces of a front surface, a back surface, a left surface, a right surface, a top surface and a bottom surface, wherein a main cavity is arranged in the center of the frame body 1, the sample position module 7, the reagent position module 5, the incubation detection module 4, the gripper module 3 and the needle movement module 2 are all positioned in the main cavity, the left surface of the frame body 1 is provided with a left side cavity, the pump station module 8 is positioned in the left side cavity, the right side surface of the frame body 1 is provided with a right side cavity, the consumable module 10 and the light source module 11 are positioned in the right side cavity and communicated in the main cavity, the back surface of the frame body 1 is provided with a back cavity, and the power supply module 9 is positioned in the back cavity;
The needle movement module 2 is positioned at the upper part in the main cavity, the sample position module 7 is positioned at the lower left corner in the main cavity, the reagent position module 5 is positioned at the lower center of the main cavity and positioned at the right side of the sample position module 7, the incubation detection module 4 is positioned at the lower right corner of the main cavity and positioned at the right side of the reagent position module 5, the gripper module 3 is positioned at the middle part of the right side surface in the main cavity and positioned right above the incubation detection module 4, the needle movement module 2 is positioned at the upper part in the main cavity, the light source module 11 is positioned at the middle position in the bottom in the right side cavity, the consumable module 10 is positioned right above the light source module 11, the cup inlet module 6 is positioned at the lower right corner of the rear side cavity, and the part of the cup inlet module 6 penetrating through the main cavity is positioned at the back surfaces of the reagent position module 5 and the sample position module 7;
The light source module 11 is connected with the incubation detection module 4 and is used for providing special light for the incubation detection module 4 for detection, the needle movement module 2 collects samples and reagents through the sample position module 7 and the reagent position module 5 respectively, the samples and reagents are added into a test cup of the cup feeding module 6 for detection, the pump station module 8 is connected with the needle movement module 2 and is used for cleaning waste liquid of the needle movement module 2 and the extraction needle movement module 2, the power supply module 9 is connected with the pump station module 8, the needle movement module 2, the light source module 11, the incubation detection module 4, the cup feeding module 6 and the gripper module 3 respectively and is used for providing power supply for the pump station module 8, the needle movement module 2, the light source module 11, the incubation detection module 4, the cup feeding module 6 and the gripper module 3, the cup feeding module 6 grabs a test cup of the cup feeding module 6 to the incubation detection module 4 through the gripper module 3, and the consumable module 10 is connected with the cup feeding module 6 and is used for providing a test cup for the cup feeding module 6.
The power module 9 comprises a switch power supply 91, a CAN connector 92, a control panel 93, a waste liquid sensor interface 99, an instrument system switch 95, a power interface 98, a safety device 97, a network port 96 and a waste liquid interface 94, wherein the switch power supply 91 is respectively connected with the instrument system switch 95, the control panel 93 and the CAN connector 92, the waste liquid sensor interface 99 is connected with the control panel 93 and an external waste liquid sensor, the waste liquid interface 94 is connected with the external waste liquid barrel, the external waste liquid barrel is provided with the waste liquid sensor, when the liquid level of the waste liquid barrel reaches the preset liquid level of the waste liquid sensor, signals are fed back to the control panel to give an early warning, then personnel timely treat the waste liquid in the waste liquid barrel, the instrument system switch 95 is connected with the power interface 98, the power interface 98 is connected with the external power supply, the CAN connector 92 is connected with the control panel 93, the control panel 93 adopts a TMS320C2000 control panel, the instrument system switch 95 is connected with the safety device 97, the network port 93 is connected with the network port 96, and the network port 96 is externally connected with a PC through a data line, and the instrument is connected with the control panel 96 through the control panel 93, the CAN connector 92, the safety device 97, the instrument 95, the PC and the external power source interface 98 are matched with the power supply interface to ensure normal running and stable instrument operation.
The sample position module 7 comprises a sample frame 71, a sample tube bar code scanner 72 and LED indicator lamps used for judging whether the sample frame 71 is placed in place, the sample tube bar code scanner 72 is located on the left side face in a main cavity and used for scanning a sample tube to be detected, the sample tube bar code scanner is connected with a control board 93 through a CAN connector 92, sample inlet and outlet guide rails 73 used for entering and exiting the sample frame 71 are arranged at the bottom of the sample frame 71, limit grooves used for preventing the sample frame 71 from toppling are formed in two sides of the sample inlet and outlet guide rails 73, first contact sensors are arranged at the tail ends of the sample inlet and outlet guide rails 73 and are connected with the control board 93 through the CAN connector 92, the LED indicator lamps are respectively connected with a switch power supply 91 and the control board 93, sample tubes to be detected are arranged on the sample frame 71 and manually pushed into sample inlet and outlet tracks, the limit grooves are formed in two sides of the tracks to prevent the sample frame 71 from toppling, signals are transmitted to the control board 93 through the first contact sensors, the control board 93 judges whether the sample frame 71 is placed in place or not through the signals, the corresponding LED indicator lamps are lightened, and in the pushing process of the sample frame 71, the sample tube scanner 72 scans all the sample tubes in the sample frame 71 in sequence, and the sample tubes are connected with the control board by the sample tube bar code scanner, and the bar code meters.
The reagent position module 5 includes the dilution liquid level 51, special washing liquid level 52, buffering reagent position 53 and start reagent position 54 that arrange in proper order from left to right, reagent position module 5 bottom is equipped with the business turn over mechanism 55 that is used for reagent position module 5 business turn over, business turn over mechanism 55 is including being used for business turn over gliding first linear slide rail 56 and being used for supporting reagent position module 5's support frame 57, reagent position module 5 below is equipped with peltier refrigerator, be equipped with the fin and the air inlet air duct 58 that are used for reagent position module 5 radiating below the peltier refrigerator, the radiating fin below is equipped with radiator fan, the louvre has been seted up to main cavity bottom, and the louvre is located under the reagent position module 5, radiator fan is through the louvre heat dissipation of airing exhaust, radiator fan is connected with control panel 93 through CAN connector 92, and be connected with switching power supply 91, peltier refrigerator control temperature is below 16 degrees, because produce more heat when refrigerating, the heat is discharged through the combined action of fin, radiator fan and louvre, ensure that reagent position effect meets performance requirements.
The needle motion module 2 comprises a sample adding needle 21, a first reagent needle 22, a second reagent needle 23, a sample adding needle servo motor 24 for controlling the sample adding needle 21, a first reagent needle servo motor 25 for controlling the first reagent needle 22, and a second reagent needle servo motor 26 for controlling the second reagent needle 23, wherein a sample adding needle cleaning tank 27, a first reagent needle cleaning tank 28 and a second reagent needle cleaning tank 29 corresponding to the sample adding needle 21, the lower parts of the first reagent needle 22 and the second reagent needle 23 are respectively arranged below the sample adding needle 21, the first reagent needle cleaning tank 28 and the second reagent needle cleaning tank 29, a waste liquid pipeline is arranged below the sample adding needle cleaning tank 27, the first reagent needle cleaning tank 28 and the second reagent needle cleaning tank 29, the waste liquid pipeline is connected with a pump station module, the sample adding needle servo motor 24, the first reagent needle servo motor 25 and the second reagent needle servo motor 26 are respectively connected with a control board 93 through CAN connectors, and the sample adding needle servo motor 24, the first reagent servo motor 25 and the second reagent needle servo motor 26 are respectively connected with a switch power supply 91, and the sample adding needle 21 samples and the reagent adding function is started: when an experiment is carried out, the sample adding needle 21 samples at a sample position and then runs to the position of the cup transporting vehicle 67 to add a sample into a test cup, then runs to the sample cleaning tank to clean the needle, if diluent is required to be added, the sample adding needle 21 sucks a certain amount of diluent to the diluent level 51 and injects the diluent into the test cup with the sample, then sucks special cleaning liquid to the special cleaning level 52 to clean the needle in the sample adding needle cleaning tank 27, and then resets to sample the next sample; in some project tests, buffer solution needs to be added, the first reagent needle 22 can take corresponding buffer solution at the buffer reagent position 53 to be injected into a test cup with a sample, then the test cup moves into the first reagent needle cleaning tank 28 to clean the needle, then the test cup resets to carry out the next test flow, corresponding starting reagent needs to be added before the sample is detected, the second reagent needle 23 can move to the starting reagent position 54 to take corresponding starting reagent to be injected into the test cup of the sample to be detected, then the second reagent needle 23 moves to the special cleaning liquid level 52 to absorb special cleaning liquid to carry out needle cleaning in the second reagent needle cleaning tank 29, and then the test cup resets to carry out the next test flow.
The incubation detection module 4 comprises an incubation area 41, a magnetic bead detection area 42, an optical detection area 43 and a constant temperature heater 46 for heating and preserving the incubation area 41, the magnetic bead detection area 42 and the optical detection area 43, the magnetic bead detection area 42 is provided with a magnetic bead detector 44 for detecting a sample by adopting a solidification method, the optical detection area 43 is provided with an optical detector 45 for detecting the sample by adopting an immunonephelometry method and a chromogenic substrate method, the magnetic bead detector 44 and the optical detector 45 are connected with a control board 93 through a CAN connector 92, the optical detector 45 is connected with a light source module 11, the light source module 11 provides light of a specific wave band for the optical detector to carry out optical detection, after a test cup in a cup transporting trolley is added with the sample and a buffer solution, the test cup is grabbed to the incubation area 41 by a gripper 31, after a certain period of incubation time, the gripper 31 grabs the test cup to the magnetic bead detection area 42 or the optical detection area 43 is added with a starting reagent, wherein the incubation area 41, the magnetic bead detection area 42 and the optical detection area 43 are heated by adopting constant temperature, and the temperature is controlled within 37 ℃ to be within 1 ℃.
The gripper module 3 comprises a gripper 31 adopting a pneumatic principle and a waste box 32 for storing waste, the gripper 31 is provided with a magnetic switch, the waste box 32 is provided with a second contact sensor, the magnetic switch and the second contact sensor are connected with the control board 93 through the CAN connector 92, after the test is finished, the gripper 31 grabs the tested test cup into the waste box 32, after the test cup in the waste box 32 is filled, a tester pulls out the fertilizer box, pushes the waste box 32 into the waste box after the test cup is processed, the second contact sensor feeds signals back to the control board, the control board judges whether the waste box 32 is pushed into place or not, the gripper 31 works through the pneumatic principle, and the magnetic switch is arranged on the side edge of the gripper 31 and feeds signals back to the control board, and the control board judges whether the gripper 31 grabs the cup successfully or not, so that the gripper 31 grabs the cup information is ensured to be correct.
The pump station module 8 includes the waste liquid pump 81 that is used for collecting the waste liquid, be used for providing the wash pump 82 of pressure for wash needle motion module 2, be used for storing the washing liquid bucket 83 of washing liquid, and be used for splendid attire washing needle motion module 2's washing liquid buffer bottle 84, waste liquid pump 81 connects waste liquid pipeline and waste liquid interface 94, washing liquid bucket 83 is equipped with the washing liquid storehouse 85 that is convenient for add the washing liquid, washing liquid storehouse 85 is equipped with the second linear slide rail 87 that is used for washing liquid storehouse 85 business turn over gliding and is used for push-pull washing liquid storehouse 85 handle 86, the second linear slide rail 87 tail end is equipped with the third contact sensor, washing liquid buffer bottle 84 is equipped with float switch 89, waste liquid pump 81, wash pump 82, third contact sensor and float switch 89 are all connected with the control panel through CAN connector 92, and waste liquid pump 81 and wash pump 82 all are connected with switch power 91, needle washs through washing liquid pump 82 with the washing liquid in washing liquid bucket 83 to washing liquid buffer bottle 84, float switch 89 that sets up in the buffer bottle, float switch 89 feeds back the signal to the control panel, judge whether the washing liquid quantity is sufficient, take out by washing liquid pump 82 in with the washing liquid, all the washing liquid is set up through the inner wall that the flow path is connected to the waste liquid pump 81 down, all the waste liquid is connected to the waste liquid in the washing liquid through the outer channel, all the outer channel is connected to the waste liquid pump 81.
The consumable module 10 comprises a cup tray 61 for storing test cups and a rotating central shaft 69 for rotating the cup tray 61, the cup feeding module 6 comprises a cup belt 62 for pulling out the test cups, a loader 63 for driving the cup belt 62, guide wheels 64 for limiting the running direction of the cup belt 62, a cup feeding groove for placing the test cups pulled out by the cup belt 62, a test cup lane 66 for dividing the test cups, a cup transporting truck 67 for transporting the test cups and a cup transporting rail 68 for transporting the cup truck 67, one end of the cup belt 62 is connected with the lower end face of the cup tray 61, the other end of the cup belt 62 is connected with a cup transporting groove, the cup feeding groove is connected with the test cup lane 66, the test cup lane 66 is connected with the cup transporting truck 67, the cup transporting truck 67 runs on the cup transporting rail 68, the cup transporting rail 68 is provided with two guide wheels on two sides of the lane, the cup transporting rail 68 extends into a main cavity, and is positioned on the back face of the reagent station module 5 and the sample station module 7, when the test cups are transported, the cup belt 62 is driven by the loader 63, the cup belt 62 is driven by the loader 62 to transport the cup lane 66, the cup transporting rail is stopped by the cup lane 66, the test cups are transported from the cup lane 66 to the cup transporting truck 67 again, the test cups are transported by the cup lane 66, the test cups are transported by the test cup lane and the test cup lane is again conveyed by the test cup lane 53 again, the test cups are transported by the test cup lane and the test cup lane is again, the test cups are conveyed by the test cup lane and the test cups and the test cup lane and the test cup is again to the test cup and the test cup is conveyed by the test cup.
The using method of the full-automatic coagulation analyzer comprises the following steps:
1) Sample injection: the method comprises the steps that a sample frame is pulled out, samples to be tested are mounted on the sample frame, the samples are pushed into a sample feeding track manually, limiting grooves are formed in two sides of the sample feeding track to prevent the sample frame from toppling over, a first contact sensor transmits signals to a control board through a CAN connector, the control board judges that the sample frame is placed in place, a corresponding LED indicator light is lighted, otherwise the LED indicator light is not lighted, and a bar code scanner of a sample tube arranged on one side sequentially scans and stores all sample tubes in the sample frame;
2) Test cup loading and transporting: the loader drives the cup belt, the cup belt drives the test cup to be pulled out of the cup tray and enter the cup inlet groove by the guide wheel, then the test cup is divided into two paths by the test cup lane divider, and the two paths enter the cup transporting vehicle, and the cup transporting vehicle transports the test cup to the sample loading position and the buffer position by the cup transporting rail;
3) Needle loading: the control board controls the sample adding needle servo motor, the first reagent needle servo motor and the second reagent needle servo motor to respectively control the running positions of the sample adding needle, the first reagent needle and the second reagent needle, the sample adding needle samples at a sample position and adds into a test cup, then runs into a sample adding needle cleaning tank to clean, then resets to carry out the next test flow, the first reagent needle adopts buffer solution to add into the test cup, then runs into the first reagent needle cleaning tank to clean, then resets to carry out the next test flow, the second reagent needle adopts starting reagent to add into the test cup, then runs into the second reagent needle cleaning tank to clean, and then resets to carry out the next test flow;
4) Grabbing by a gripper: grabbing the test cup with the sample added in the step 3) to an incubation area by a gripper, incubating for a certain time, and grabbing to a magnetic bead detection area or an optical detection area by the gripper for detection;
5) Test cup treatment: after the test is finished, the test cup is grabbed into the waste box by the grabber, and the waste box is pulled out for processing by the tester.
The above embodiment is only one of the preferred embodiments of the present invention, and should not be used to limit the scope of the present invention, but all the insubstantial modifications or color changes made in the main design concept and spirit of the present invention are still consistent with the present invention, and all the technical problems to be solved are included in the scope of the present invention.
Claims (7)
1. The full-automatic coagulation analyzer is characterized by comprising a sample position module (7), a reagent position module (5), an incubation detection module (4), a gripper module (3), a cup feeding module (6), a needle movement module (2), a light source module (11), a pump station module (8), a consumable module (10), a power supply module (9) and a cuboid frame body (1) formed by six surfaces of a front surface, a back surface, a left side surface, a right side surface, a top surface and a bottom surface, wherein a main cavity is arranged in the center of the frame body (1), the sample position module (7), the reagent position module (5), the incubation detection module (4), the gripper module (3) and the needle movement module (2) are all positioned in the main cavity, the left side surface of the frame body (1) is provided with a left side cavity, the pump station module (8) is positioned in the left side cavity, the right side surface of the frame body (1) is provided with a right side cavity, the consumable module (10) and the light source module (11) are positioned in the right side cavity, and the cup feeding module (6) is positioned in the back cavity (1) and is positioned in the back cavity (9);
The needle movement module (2) is positioned at the upper part in the main cavity, the sample position module (7) is positioned at the lower left corner in the main cavity, the reagent position module (5) is positioned at the central position of the lower part of the main cavity and is positioned at the right side of the sample position module (7), the incubation detection module (4) is positioned at the lower right corner of the main cavity and is positioned at the right side of the reagent position module (5), the gripper module (3) is positioned at the middle part of the right side surface in the main cavity and is positioned right above the incubation detection module (4), the light source module (11) is positioned at the middle position in the bottom in the right side cavity, the consumable module (10) is positioned right above the light source module (11), the cup feeding module (6) is positioned at the lower right side in the rear side cavity of the frame main body (1), and the part of the cup feeding module (6) penetrating through the main cavity is positioned at the reagent position module (5) and the back of the sample position module (7);
The light source module (11) is connected with the incubation detection module (4) and is used for providing special light for the incubation detection module (4) for detection, the needle movement module (2) collects samples and reagents through the sample position module (7) and the reagent position module (5) respectively, the samples and the reagents are added into a test cup of the cup feeding module (6) for detection, the pump station module (8) is connected with the needle movement module (2) and is used for cleaning the needle movement module (2) and extracting cleaning waste liquid of the needle movement module (2), the power supply module (9) is respectively connected with the pump station module (8), the needle movement module (2), the light source module (11), the incubation detection module (4), the cup feeding module (6) and the hand module (3) are used for providing power supply for the pump station module (8), the needle movement module (2), the light source module (11), the incubation detection module (4), the cup feeding module (6) and the hand module (3) to the cup feeding module (6) through the cup feeding module (6) to the cup feeding module (6), for providing the cup feed module (6) with a test cup;
The power module (9) comprises a switch power supply (91), a CAN connector (92), a control panel (93), a waste liquid interface (94), an instrument system switch (95), a network port (96), a safety device (97), a power interface (98) and a waste liquid sensor interface (99), wherein the switch power supply (91) is respectively connected with the instrument system switch (95), the control panel (93) and the CAN connector (92), the waste liquid sensor interface (99) is connected with the control panel (93) and an external waste liquid sensor, the waste liquid interface (94) is connected with an external waste liquid barrel, the instrument system switch (95) is connected with the power interface (98), the power interface (98) is connected with an external power supply, the CAN connector (92) is connected with the control panel (93), the control panel (93) adopts TMS320C2000, the instrument system switch (95) is connected with the safety device (97), the control panel (93) is connected with the network port (96), and the network port (96) is connected through a PC data line;
The sample position module (7) comprises a sample frame (71), a sample tube bar code scanner (72) and an LED indicator lamp used for judging whether the sample frame (71) is placed in place, the sample tube bar code scanner (72) is positioned on the left side surface in the main cavity and used for scanning a sample tube to be detected, the sample tube is connected with the control board (93) through the CAN connector (92), a sample inlet and outlet guide rail (73) used for leading the sample frame (71) to enter and exit is arranged at the bottom of the sample frame (71), limit grooves used for preventing the sample frame (71) from toppling are formed in two sides of the sample inlet and outlet guide rail (73), a first contact sensor is arranged at the tail end of the sample inlet and outlet guide rail (73), the first contact sensor is connected with the control board (93) through the CAN connector (92), and the LED indicator lamp is respectively connected with the switch power supply (91) and the control board (93);
Reagent position module (5) are including from left to right dilution liquid level (51), special washing liquid level (52), buffering reagent position (53) and start reagent position (54) that arrange in proper order, reagent position module (5) bottom is equipped with and is used for business turn over mechanism (55) of reagent position module (5), business turn over mechanism (55) are including being used for business turn over gliding first linear slide rail (56) and being used for supporting support frame (57) of reagent position module (5), reagent position module (5) below is equipped with peltier refrigerator, peltier refrigerator below is equipped with and is used for reagent position module (5) radiating fin and air inlet air duct (58), the below of fin is equipped with radiator fan, the louvre has been seted up to main cavity bottom, just the louvre is located under reagent position module (5), the radiator fan passes through the louvre is used for airing exhaust and is dispelled the heat, radiator fan pass through CAN connector (92) with control panel (93) are connected, and are connected with switch (91).
2. The fully automatic coagulation analyzer according to claim 1, wherein the needle movement module (2) comprises a sample adding needle (21), a first reagent needle (22), a second reagent needle (23), a sample adding needle servo motor (24) for controlling the sample adding needle (21), a first reagent needle servo motor (25) for controlling the first reagent needle (22), and a second reagent needle servo motor (26) for controlling the second reagent needle (23), a sample adding needle cleaning groove (27), a first reagent needle cleaning groove (28) and a second reagent needle cleaning groove (29) corresponding to the sample adding needle cleaning groove are respectively arranged below the sample adding needle (21), the sample adding needle cleaning groove (27), the first reagent needle cleaning groove (28) and the second reagent needle cleaning groove (29), a waste liquid pipeline is arranged below the sample adding needle cleaning groove (28) and the second reagent needle cleaning groove (29), the waste liquid pipeline is connected with the pump station module (8), the sample adding needle servo motor (24), the first reagent needle (22) and the second reagent needle (25) are respectively connected with the sample adding servo control board (93) through the sample adding needle servo motor (25) and the sample adding servo motor (25) respectively And the second reagent needle servo motor (26) is respectively connected with the switch power supply (91).
3. The fully automatic coagulation analyzer according to claim 2, wherein the incubation detection module (4) comprises an incubation zone (41), a magnetic bead detection zone (42), an optical detection zone (43), and a constant temperature heater (46) for heating and maintaining the incubation zone (41), the magnetic bead detection zone (42) and the optical detection zone (43), the magnetic bead detection zone (42) is provided with a magnetic bead detector (44) for detecting a sample by a coagulation method, the optical detection zone (43) is provided with an optical detector (45) for detecting the sample by an immunonephelometry method and a chromogenic substrate method, the magnetic bead detector (44) and the optical detector (45) are both connected with the control board (93) through the CAN connector (92), and the optical detector (45) is connected with the light source module (11), and the light source module (11) provides light of a specific wave band to the optical detector for optical detection.
4. The fully automatic coagulation analyzer as claimed in claim 3, characterized in that the gripper module (3) comprises a gripper (31) employing the pneumatic principle and a waste cartridge (32) for storing waste material, the gripper (31) being provided with a magnetic switch, the waste cartridge (32) being provided with a second contact sensor, both the magnetic switch and the second contact sensor being connected with the control board (93) via the CAN connector (92).
5. The fully automatic coagulation analyzer according to claim 4, wherein the pump station module (8) comprises a waste liquid pump (81) for collecting waste liquid, a cleaning pump (82) for providing pressure for cleaning the needle movement module (2), a cleaning liquid barrel (83) for storing cleaning liquid, and a cleaning liquid buffer bottle (84) for containing cleaning liquid for cleaning the needle movement module (2), the waste liquid pump (81) is connected with the waste liquid pipeline and the waste liquid interface (94), the cleaning liquid barrel (83) is provided with a cleaning liquid bin (85) for adding cleaning liquid, the cleaning liquid bin (85) is provided with a second linear slide rail (87) for sliding in and out of the cleaning liquid bin (85) and a handle (86) for pushing and pulling the cleaning liquid bin (85), the tail end of the second linear slide rail (87) is provided with a third contact sensor, the cleaning liquid buffer bottle (84) is provided with a float switch (89), and the waste liquid pump (81), the third contact sensor and the float switch (89) are connected with the control panel (82) through the CAN switch (92) and the power supply switch (91).
6. The fully automatic coagulation analyzer according to claim 5, wherein the consumable module (10) comprises a cup tray (61) for storing test cups and a rotation center shaft (69) for rotating the cup tray (61), the cup feeding module (6) comprises a cup belt (62) for pulling out the test cups, a loader (63) for driving the cup belt (62), a guide wheel (64) for limiting the running direction of the cup belt (62), a cup feeding groove for placing the test cups pulled out by the cup belt (62), a cup transporting carriage (67) for transporting the test cups, and a cup transporting rail (68) for transporting the test cups, one end of the cup belt (62) is connected with the lower end face of the cup tray (61), the other end of the cup feeding groove is connected with the test cup transporting carriage (66), the test cup transporting carriage (66) is connected with the cup transporting carriage (67), the cup transporting carriage (67) is provided with the reagent cups, and the sample transporting carriage (67) is arranged on the two sides of the sample transporting carriage (67), and the sample transporting carriage (68) is arranged on the two sides of the sample transporting carriage (7).
7. The method of using a fully automatic coagulation analyzer of any one of claims 1-6, comprising the steps of:
1) Sample injection: the method comprises the steps that a sample frame is pulled out, samples to be tested are mounted on the sample frame, the samples are pushed into a sample feeding track manually, limiting grooves are formed in two sides of the sample feeding track to prevent the sample frame from toppling over, a first contact sensor transmits signals to a control board through a CAN connector, the control board judges that the sample frame is placed in place, a corresponding LED indicator light is lighted, otherwise the LED indicator light is not lighted, and a bar code scanner of a sample tube arranged on one side sequentially scans and stores all sample tubes in the sample frame;
2) Test cup loading and transporting: the loader drives the cup belt, the cup belt drives the test cup to be pulled out of the cup tray and enter the cup inlet groove by the guide wheel, then the test cup is divided into two paths by the test cup lane divider, and the two paths enter the cup transporting vehicle, and the cup transporting vehicle transports the test cup to the sample loading position and the buffer position by the cup transporting rail;
3) Needle loading: the control board controls the sample adding needle servo motor, the first reagent needle servo motor and the second reagent needle servo motor to respectively control the running positions of the sample adding needle, the first reagent needle and the second reagent needle, the sample adding needle samples at a sample position and adds into a test cup, then runs into a sample adding needle cleaning tank to clean, then resets to carry out the next test flow, the first reagent needle adopts buffer solution to add into the test cup, then runs into the first reagent needle cleaning tank to clean, then resets to carry out the next test flow, the second reagent needle adopts starting reagent to add into the test cup, then runs into the second reagent needle cleaning tank to clean, and then resets to carry out the next test flow;
4) Grabbing by a gripper: grabbing the test cup with the sample added in the step 3) to an incubation area by a gripper, incubating for a certain time, and grabbing to a magnetic bead detection area or an optical detection area by the gripper for detection;
5) Test cup treatment: after the test is finished, the test cup is grabbed into the waste box by the grabber, and the waste box is pulled out for processing by the tester.
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| CN109239018B (en) * | 2018-10-12 | 2023-10-27 | 武汉纺织大学 | Full-automatic coagulation analysis system |
| CN109283351B (en) * | 2018-11-13 | 2022-03-22 | 北京九强生物技术股份有限公司 | Full-automatic blood coagulation analyzer |
| US11237093B2 (en) * | 2018-12-10 | 2022-02-01 | Bio-Rad Laboratories, Inc. | External fluidics system for flow cytometer |
| CN109596528B (en) * | 2018-12-11 | 2021-12-31 | 迪瑞医疗科技股份有限公司 | Full-automatic coagulation analyzer and analysis method thereof |
| CN109444441B (en) * | 2018-12-19 | 2024-11-05 | 江苏鸿恩医疗器械有限公司 | Full-automatic coagulation analyzer |
| CN112955742B (en) * | 2018-12-26 | 2024-07-05 | 深圳迈瑞生物医疗电子股份有限公司 | Blood sample analysis method and coagulation analyzer |
| WO2020258285A1 (en) * | 2019-06-28 | 2020-12-30 | 深圳迈瑞生物医疗电子股份有限公司 | Hopper structure, cup arranging device, and test cup preparation method |
| CN111458529B (en) * | 2020-05-25 | 2023-01-10 | 北京中勤世帝生物技术有限公司 | Blood coagulation routine test constant speed test method |
| CN111912997A (en) * | 2020-08-25 | 2020-11-10 | 重庆南方数控设备股份有限公司 | Analyzer for full automatic blood coagulation |
| CN112014582B (en) * | 2020-08-31 | 2024-05-03 | 成都艾科斯伦医疗科技有限公司 | Scheduling method of full-automatic coagulation analyzer |
| CN112067834A (en) * | 2020-09-23 | 2020-12-11 | 成都艾科斯伦医疗科技有限公司 | Blood coagulation analyzer with online interface |
| CN113063934A (en) * | 2021-03-10 | 2021-07-02 | 珠海丽珠试剂股份有限公司 | Waste processing mechanism, sample processing apparatus, and sample processing apparatus control method |
| CN113447663B (en) * | 2021-04-22 | 2022-06-24 | 山东大学第二医院 | Multi-method coagulation analyzer |
| CN117092325A (en) * | 2022-05-12 | 2023-11-21 | 深圳市帝迈生物技术有限公司 | Detection device and reagent card for detecting coagulation project |
| CN115128291B (en) * | 2022-08-26 | 2022-12-02 | 普迈德（北京）科技有限公司 | Be suitable for blood coagulation detection device's arm mechanism and blood coagulation detection device |
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| US5646046A (en) * | 1989-12-01 | 1997-07-08 | Akzo Nobel N.V. | Method and instrument for automatically performing analysis relating to thrombosis and hemostasis |
| KR100321508B1 (en) * | 1993-08-16 | 2002-06-24 | 에프.지.엠. 헤르만스 ; 이.에이치. 리링크 | Methods and instruments for automated analysis of thrombosis and congestion |
| CN201045617Y (en) * | 2006-04-21 | 2008-04-09 | 北京赛科希德科技发展有限公司 | Test cup continuous conveyer for full-automatic cruor measurement |
| CN201397337Y (en) * | 2009-05-08 | 2010-02-03 | 北京众驰伟业科技发展有限公司 | Extraction testing cup manipulator for full automatic blood-coagulation measurement |
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