CN108193342A - For the preparation method of the medicament-carrying nano-fiber covering yarn of medical absorbable suture - Google Patents
For the preparation method of the medicament-carrying nano-fiber covering yarn of medical absorbable suture Download PDFInfo
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- CN108193342A CN108193342A CN201711390475.6A CN201711390475A CN108193342A CN 108193342 A CN108193342 A CN 108193342A CN 201711390475 A CN201711390475 A CN 201711390475A CN 108193342 A CN108193342 A CN 108193342A
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- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/44—Yarns or threads characterised by the purpose for which they are designed
- D02G3/448—Yarns or threads for use in medical applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
- D01D5/0084—Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Textile Engineering (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses the preparation method of the medicament-carrying nano-fiber covering yarn for medical absorbable suture, chitosan, fibroin albumen, polylactic acid hexafluoroisopropanol solution in add in antibacterial anti-inflammatory class drug, be uniformly mixed as spinning precursor liquid；Using degradable operation suture thread as heart yarn；Using the method for electrostatic spinning, the medicament-carrying nano-fiber covering yarn of uniformly continuous is prepared.The present invention prepares the medicament-carrying nano-fiber covering yarn for operation suture thread using method of electrostatic spinning, simple for process, and operation facility, the yarn surface nanofibre of preparation is evenly coated；The covering yarn of preparation is used as operation suture thread, and compared with conventional medical absorbable suture, mechanical strength declines slowly, is conducive to wound healing, and with good antibacterial, hemostasis, antiinflammation, can promote wound healing.
Description
Technical field
The invention belongs to electrostatic spinning technique fields, are related to the medicament-carrying nano-fiber cored for medical absorbable suture
The preparation method of yarn.
Background technology
Existing operation suture thread is roughly divided into nonabsorable and can absorb two kinds：Nonabsorable operation suture thread can be protected
Self-strength is held, but easily invaded, crust by cell in vivo, is taken out stitches and is also be easy to cause secondary injury and bring pain to patient
It is bitter；Medical absorbable suture is mostly that single raw material is prepared, and can not meet the special need of a variety of operative sites in clinic
It asks, and original strength is easily lost in degradation process, be easy to cause the secondary tear of wound.
For the existing issue of absorbable suture, there is scholar to carry out medication coat improvement, the medication coat of improvement to it
Suture can improve mechanical strength, but shortcoming is to be difficult to realize effective drug carrying capacity, and to the releasability control of drug
It makes bad.Therefore, it is necessary to find a kind of new method, while mechanical strength is ensured, medical absorbable suture is solved
Drug carry and release control ability.
There is hemostatic bacteriostatic to sterilize and promote the different physiological roles such as wound healing, and with nontoxic nothing for chitosan
It is harmful, without any side effects and be easily absorbed by organisms with the characteristics such as good histocompatbility, be a kind of excellent medical material
Material.However, during being fabricated to operation suture thread due to chitosan, it is desirable that harsher, step is more complicated, independent spinning
It is relatively difficult；Fibroin albumen is a kind of natural macromolecular material, is not only oozed with good biocompatibility, oxygen and vapor
Permeability, biological degradability etc. can be used as slow releasing carrier of medication, operation suture thread, artificial skin and functional cell culture medium
Deng, but its close structure, biodegradation rate are very slow, limit its application in field of tissue engineering technology；Polylactic acid is a kind of tool
Promising material has good biological degradability, but polylactic acid bioactivity is relatively low, and cell adhesion is more difficult.It is comprehensive
Chitosan, fibroin albumen and polylactic acid are mixed and carry out spinning by the advantages of closing different materials, are formed excellent with cell adhesion
It is good, while the good bio-medical material of degradation property, the drug progress blend spinning for meeting different operative site demands is added in,
While meeting body tissue reparation and require so that the operation suture thread prepared has more superiority.
Electrostatic spinning is a kind of common nanofiber technology of preparing, available for producing medical drug-loading fibre, and with steady
Fixed drug loading and controlled release ability.But its intrinsic relatively low mechanical performance limits its purposes as operation suture thread.
Invention content
The object of the present invention is to provide a kind of preparations of the medicament-carrying nano-fiber covering yarn for medical absorbable suture
Method, it is single to solve function existing for existing medical absorbable suture, the problem of can not realizing drug loading.
The technical solution adopted in the present invention is, for the system of the medicament-carrying nano-fiber covering yarn of medical absorbable suture
Preparation Method is specifically implemented according to the following steps：
Step 1, chitosan, fibroin albumen, polylactic acid added in into dissolving in hexafluoroisopropanol, be uniformly mixed, then added in
Antibacterial anti-inflammatory class drug stirs to being uniformly mixed, obtains spinning precursor liquid；
The degradable operation suture thread for selecting to meet different operative site mechanical requirements is positioned over electrostatic spinning as heart yarn
The reception position of device；
Step 2, the spinning precursor liquid being configured in step 1 is injected in syringe, in room temperature, relative humidity 40%~60%
Under conditions of, metal needle is placed in reception device middle upper part；Syringe needle is adjusted to the distance of reception device, opens micro-injection
Pump, high voltage direct current generator adjust flow velocity and applied voltage, and after jet stability, control heart yarn rotation makes to be mounted in reception dress
The medicament-carrying nano-fiber put is uniformly wrapped on heart yarn outer layer, and then the heart yarn of control cladding medicament-carrying nano-fiber moves horizontally,
It is collected into take-up roll to get to the medicament-carrying nano-fiber covering yarn of uniformly continuous.
The features of the present invention also characterized in that
The mass percentage concentration of spinning precursor liquid is 8%~12% in step 1.
Chitosan in step 1, fibroin albumen, polylactic acid mass ratio be 1:0.5~1.5:0.5~1.5.
Antibacterial anti-inflammatory drugs dosage is the 1%~5% of spinning precursor liquid quality in step 1.
In step 1 antibacterial anti-inflammatory drugs be Diclofenac, it is piroxicam, olsapozine, naproxen, Flurbiprofen, non-
That root, chlorpheniramine, match one or more mixing in pyridine, brufen.
Heart yarn is PGA sutures, one kind in PGLA sutures, PDS sutures, PLA sutures.
Syringe needle internal diameter is 0.5mm~2mm in step 2, and the distance of syringe needle to reception device is 10cm~20cm.
Flow velocity is 0.2mL/h~0.6mL/h in step 2, and applied voltage is 10kV~20kV.
The rotary speed of heart yarn is 200rpm~1000rpm in step 2.
The horizontal movement velocity that the heart yarn of medicament-carrying nano-fiber is coated in step 2 is 10mm/min~15mm/min.
The invention has the advantages that
1. the present invention prepares the medicament-carrying nano-fiber covering yarn for medical absorbable suture, work using method of electrostatic spinning
Skill is simple, operation facility；
2. the present invention receives orientated nano fibers using two sheet metals, the medicament-carrying nano-fiber yarn cladding of preparation is equal
Even, surface layer nanofiber large specific surface area, porosity are high, drug loading is uniform, are conducive to cell homoepitaxial；
3. covering yarn prepared by the present invention is used as operation suture thread, compared with conventional medical absorbable suture, mechanics is strong
Degree declines slowly, is conducive to wound healing；
4. covering yarn prepared by the present invention integrates chitosan, fibroin albumen, polylactic acid three's advantage, and carries antibacterial
Anti-inflammatory drugs compared to common medical absorbable suture, have better antibacterial, hemostasis and anti-inflammatory performance, and can promote wound
Outspoken speed healing.
Description of the drawings
Fig. 1 is electrostatic spinning apparatus structure diagram used by the method for the present invention；
Fig. 2 is medicament-carrying nano-fiber covering yarn scanning electron microscope (SEM) photograph prepared by the present invention.
In figure, 1. micro-injection pumps, 2. syringes, 3. high voltage direct current generators, 4. metal needles, 5. rotary tray motor a, 6.
Turntable a, 7. withdrawal rollers, 8. unwinding motors, 9. heart yarns, 10. nanofibers, 11. sheet metals, 12. earthing or grounding means, 13. turntables
B, 14. winding motors, 15. take-up rolls, 16. rotary tray motor b, 17. master control borads.
Specific embodiment
The present invention is described in detail with reference to the accompanying drawings and detailed description.
The present invention is for the preparation method of the medicament-carrying nano-fiber covering yarn of medical absorbable suture, used electrostatic
Device for spinning, structure is as shown in Figure 1, including master control borad 17, high voltage direct current generator 3, micro-injection pump 1, syringe 2, gold
Belong to syringe needle 4 and reception device.
Frame-type stent is provided on master control borad 17, micro-injection pump 1 and syringe 2 are installed on frame-type stent upper ledge, is noted
2 one end of emitter is connect with micro-injection pump 1, is driven by micro-injection pump 1, and 2 other end of syringe is provided with metal needle 4；
Reception device is provided with below upper ledge；Reception device is located at frame-type internal stent, is connected with 3 cathode of high voltage direct current generator, gold
Belong to syringe needle 6 to be located above reception device, metal needle 4 connects 3 anode of high voltage direct current generator.
4 internal diameter of metal needle is 0.5mm~2mm.
The take-off device of heart yarn unwrapping wire is separately provided at left and right sides of frame-type stent and for coating heart yarn collection
Coiler device.
Take-off device includes turntable a6, withdrawal roller 7 and is respectively used to the turntable that driving disc a6 and withdrawal roller 7 rotate
Motor a5 and unwinding motor 8.Turntable a6 is fixedly installed on the inside of stent.
Coiler device includes turntable b13, take-up roll 15 and is respectively used to what driving disc b13 and take-up roll 15 rotated
Rotary tray motor b16 and winding motor 14.Turntable b13 is fixedly installed on the inside of stent.
Reception device is two sheet metals 11 arranged in parallel, and sheet metal 11 is connect with earthing or grounding means 12, metal foil
Be among piece 11 with certain speed at the uniform velocity by heart yarn 9, the driven by rotary disc heart yarn at the uniform velocity rotation of 11 both sides of sheet metal makes gold
The load medicine orientated nano fibers belonged between thin slice 11 are uniformly wrapped on heart yarn, are finally collected in take-up roll 15.
The side of the medicament-carrying nano-fiber covering yarn for medical absorbable suture is prepared using above-mentioned electrostatic spinning apparatus
Method is specifically implemented according to the following steps：
Step 1, spinning precursor liquid is configured：
By chitosan, fibroin albumen, polylactic acid in mass ratio 1:0.5~1.5:0.5~1.5 is dissolved in hexafluoroisopropanol
Then uniformly mixing adds in the antibacterial anti-inflammatory class drug that mass fraction is 1%~5%, is positioned on magnetic stirring apparatus and at the uniform velocity stirs
Mix the spinning precursor liquid for being uniformly mixed, obtaining that mass percentage concentration is 8%~12%.
Antibacterial anti-inflammatory class drug is Diclofenac, piroxicam, olsapozine, naproxen, Flurbiprofen, phenergan, flutters
You are quick, match one or more mixing in pyridine, brufen.
Step 2, the degradable operation suture thread for selecting to meet different operative site mechanical requirements is positioned over spinning as heart yarn
The reception position of silk device.
Heart yarn is PGA sutures, one kind in PGLA sutures, PDS sutures, PLA sutures.
Step 3, by the spinning precursor liquid being configured in step 1 inject syringe 2 in, room temperature, relative humidity 40%~
Under conditions of 60%, metal needle 4 is placed in reception device middle upper part；Adjust syringe needle to reception device distance be 10cm~
20cm opens micro-injection pump, and adjusting flow velocity is 0.2mL/h~0.6mL/h, opens high voltage direct current generator 3, adjusts outer power up
It presses as 10kV~20kV, after jet stability, starts two turntables, regulation motor rotating speed makes heart yarn with 200rpm~1000rpm
Rotation, makes the orientated nano fibers being mounted between sheet metal 11 be uniformly wrapped on heart yarn outer layer, finally opens unwinding 8 He of motor
Winding motor 14 is made the heart yarn of cladding medicament-carrying nano-fiber be moved horizontally with the speed of 10mm/min~15mm/min, is collected into
In take-up roll, that is, obtain the medicament-carrying nano-fiber covering yarn of uniformly continuous.
Fig. 2 is the medicament-carrying nano-fiber covering yarn scanning electron microscope (SEM) photograph being prepared using the method for the present invention, can be with from figure
Find out, nanofiber can be evenly coated on heart yarn, and covered effect is good.
Embodiment 1
Step 1, chitosan, polylactic acid and fibroin albumen are dissolved in hexafluoroisopropanol and uniformly mixed, add in antibacterial anti-inflammatory
Class drug Diclofenac and piroxicam are positioned on magnetic stirring apparatus and at the uniform velocity stir to being sufficiently mixed, matter is configured at room temperature
Measure the spinning precursor liquid that percentage concentration is 8%.Wherein, the proportioning of chitosan, polylactic acid and fibroin albumen is 1:1:1, anti-microbial type
Drug accounts for 1%, selects PGA sutures as heart yarn.
Step 2, the solution being configured is injected in syringe, under conditions of room temperature and relative humidity are 40%, syringe needle
Internal diameter 0.5mm, the distance of setting syringe needle to reception device is 10cm, opens micro-injection pump, sets flow velocity 0.2mL/h, opens
High voltage direct current generator applies applied voltage 10kV, after jet stability, starts two turntables, sets heart yarn rotating speed 200rpm,
The oriented nanofibers being mounted between sheet metal is made to be uniformly wrapped on heart yarn outer layer, finally open unwinding motor and winding electricity
Machine is made the heart yarn of cladding medicament-carrying nano-fiber be moved horizontally with the speed of 10mm/min, collected in take-up roll, uniformly connected
Continuous orientation medicament-carrying nano-fiber covering yarn.
Embodiment 2
Step 1, chitosan, polylactic acid and fibroin albumen are dissolved in hexafluoroisopropanol and uniformly mixed, add in antibacterial anti-inflammatory
Class drug olsapozine, naproxen are positioned on magnetic stirring apparatus and at the uniform velocity stir to being sufficiently mixed at room temperature, configuration quality hundred
Divide a concentration of 9% spinning precursor liquid.Wherein, the proportioning of chitosan, polylactic acid and fibroin albumen is 1:0.5:1, anti-microbial type medicine
Object accounts for 2%, selects PGLA sutures as heart yarn.
Step 2, the solution being configured is injected in syringe, under conditions of room temperature and relative humidity are 45%, syringe needle
Internal diameter 1mm, the distance of setting syringe needle to reception device is 12cm, opens micro-injection pump, sets flow velocity 0.3mL/h, is opened straight
High pressure generator is flowed, applies applied voltage 12kV, after jet stability, starts two turntables, heart yarn rotating speed 400rpm is set, is made
The oriented nanofibers being mounted between sheet metal are uniformly wrapped on heart yarn outer layer, finally open unwinding motor and winding motor,
The heart yarn of cladding medicament-carrying nano-fiber is made to be moved horizontally with the speed of 11mm/min, is collected in take-up roll, obtains uniformly continuous
Orientation medicament-carrying nano-fiber covering yarn.
Embodiment 3
Step 1, chitosan, polylactic acid and fibroin albumen are dissolved in hexafluoroisopropanol and uniformly mixed, add in antibacterial anti-inflammatory
Class drug Flurbiprofen, phenergan are positioned on magnetic stirring apparatus and at the uniform velocity stir to being sufficiently mixed at room temperature, configuration quality hundred
Divide a concentration of 10% spinning precursor liquid.Wherein, the proportioning of chitosan, polylactic acid and fibroin albumen is 1:1:1.5, anti-microbial type medicine
Object accounts for 3%, selects PDS sutures as heart yarn.
Step 2, the solution being configured is injected in syringe, under conditions of room temperature and relative humidity are 50%, syringe needle
Internal diameter 1.5mm, the distance of setting syringe needle to reception device is 14cm, opens micro-injection pump, sets flow velocity 0.4mL/h, opens
High voltage direct current generator applies applied voltage 14kV, after jet stability, starts two turntables, sets heart yarn rotating speed 600rpm,
The oriented nanofibers being mounted between sheet metal is made to be uniformly wrapped on heart yarn outer layer, finally open unwinding motor and winding electricity
Machine is made the heart yarn of cladding medicament-carrying nano-fiber be moved horizontally with the speed of 12mm/min, collected in take-up roll, uniformly connected
Continuous orientation medicament-carrying nano-fiber covering yarn.
Embodiment 4
Step 1, chitosan, polylactic acid and fibroin albumen are dissolved in hexafluoroisopropanol and uniformly mixed, add in antibacterial anti-inflammatory
Class drug chlorpheniramine, match pyridine, be positioned on magnetic stirring apparatus and at the uniform velocity stirred to being sufficiently mixed at room temperature, configuration quality percentage
A concentration of 11% spinning precursor liquid.Wherein, the proportioning of chitosan, polylactic acid and fibroin albumen is 1:1.5:1.5, anti-microbial type medicine
Object accounts for 4%, selects PLA sutures as heart yarn.
Step 2, the solution being configured is injected in syringe, under conditions of room temperature and relative humidity are 55%, syringe needle
Internal diameter 1.5mm, the distance of setting syringe needle to reception device is 16cm, opens micro-injection pump, sets flow velocity 0.5mL/h, opens
High voltage direct current generator applies applied voltage 16kV, after jet stability, starts two turntables, sets heart yarn rotating speed 800rpm,
The oriented nanofibers being mounted between sheet metal is made to be uniformly wrapped on heart yarn outer layer, finally open unwinding motor and winding electricity
Machine is made the heart yarn of cladding medicament-carrying nano-fiber be moved horizontally with the speed of 14mm/min, collected in take-up roll, uniformly connected
Continuous orientation medicament-carrying nano-fiber covering yarn.
Embodiment 5
Step 1, chitosan, polylactic acid and fibroin albumen are dissolved in hexafluoroisopropanol and uniformly mixed, add in antibacterial anti-inflammatory
Class medicine ibuprofen, is positioned on magnetic stirring apparatus and at the uniform velocity stirs to being sufficiently mixed at room temperature, and configuration quality percentage concentration is
12% spinning precursor liquid.Wherein, the proportioning of chitosan, polylactic acid and fibroin albumen is 1:0.5:0.5, antimicrobial DP finish accounts for
5%, PDS sutures are selected as heart yarn.
Step 2, the solution being configured is injected in syringe, under conditions of room temperature and relative humidity are 60%, syringe needle
Internal diameter 2mm, the distance of setting syringe needle to reception device is 20cm, opens micro-injection pump, sets flow velocity 0.6mL/h, is opened straight
High pressure generator is flowed, applies applied voltage 20kV, after jet stability, starts two turntables, heart yarn rotating speed 1000rpm is set,
The oriented nanofibers being mounted between sheet metal is made to be uniformly wrapped on heart yarn outer layer, finally open unwinding motor and winding electricity
Machine is made the heart yarn of cladding medicament-carrying nano-fiber be moved horizontally with the speed of 15mm/min, collected in take-up roll, uniformly connected
Continuous orientation medicament-carrying nano-fiber covering yarn.
Claims (10)
1. for medical absorbable suture medicament-carrying nano-fiber covering yarn preparation method, which is characterized in that specifically according to
Following steps are implemented：
Step 1, chitosan, fibroin albumen, polylactic acid added in into dissolving in hexafluoroisopropanol, be uniformly mixed, then add in antibacterial
Anti-inflammatory drugs stir to being uniformly mixed, obtain spinning precursor liquid；
The degradable operation suture thread for selecting to meet different operative site mechanical requirements is positioned over electrostatic spinning apparatus as heart yarn
Reception position；
Step 2, the spinning precursor liquid being configured in step 1 is injected in syringe, in the item of room temperature, relative humidity 40%~60%
Under part, metal needle is placed in reception device middle upper part；Adjust syringe needle arrive reception device distance, unlatching micro-injection pump,
High voltage direct current generator adjusts flow velocity and applied voltage, and after jet stability, control heart yarn rotation makes to be mounted in reception device
On medicament-carrying nano-fiber be uniformly wrapped on heart yarn outer layer, then control cladding medicament-carrying nano-fiber heart yarn move horizontally, receive
Collect in take-up roll to get to the medicament-carrying nano-fiber covering yarn of uniformly continuous.
2. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, the mass percentage concentration of spinning precursor liquid is 8%~12% in the step 1.
3. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, the mass ratio of chitosan in the step 1, fibroin albumen, polylactic acid is 1:0.5~1.5:0.5~1.5.
4. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, the dosage of antibacterial anti-inflammatory drugs is the 1%~5% of spinning precursor liquid quality in the step 1.
5. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, antibacterial anti-inflammatory drugs are Diclofenac, piroxicam, olsapozine, naproxen, fluorine ratio in the step 1
Ibuprofen, phenergan, chlorpheniramine, match one or more mixing in pyridine, brufen.
6. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, the heart yarn is PGA sutures, one kind in PGLA sutures, PDS sutures, PLA sutures.
7. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, syringe needle internal diameter is 0.5mm~2mm in the step 2, the distance of syringe needle to reception device is 10cm~20cm.
8. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, flow velocity is 0.2mL/h~0.6mL/h in the step 2, applied voltage is 10kV~20kV.
9. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, the rotary speed of heart yarn is 200rpm~1000rpm in the step 2.
10. the preparation method of the medicament-carrying nano-fiber covering yarn according to claim 1 for medical absorbable suture,
It is characterized in that, the horizontal movement velocity that the heart yarn of medicament-carrying nano-fiber is coated in the step 2 is 10mm/min~15mm/
min。
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711390475.6A CN108193342A (en) | 2017-12-21 | 2017-12-21 | For the preparation method of the medicament-carrying nano-fiber covering yarn of medical absorbable suture |
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| CN201711390475.6A CN108193342A (en) | 2017-12-21 | 2017-12-21 | For the preparation method of the medicament-carrying nano-fiber covering yarn of medical absorbable suture |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111139564A (en) * | 2020-02-28 | 2020-05-12 | 科凯(南通)生命科学有限公司 | Equipment for preparing heart valve suture line |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3847156A (en) * | 1972-07-17 | 1974-11-12 | Sherwood Medical Ind Inc | Suture |
| CN101250763A (en) * | 2008-03-11 | 2008-08-27 | 东华大学 | Long-acting medicine-loading orlon fibre capable of degrading partly, preparation and application thereof |
| CN105648547A (en) * | 2016-03-08 | 2016-06-08 | 西安工程大学 | Nanofiber yarn electrospinning device and preparation method for nanofiber yarns |
| CN106075544A (en) * | 2016-01-26 | 2016-11-09 | 西北工业大学 | A kind of core shell composite construction medicine carrying stitching thread and preparation method thereof |
| CN106334211A (en) * | 2016-10-07 | 2017-01-18 | 常州市鼎日环保科技有限公司 | Method for preparing medical suture material |
-
2017
- 2017-12-21 CN CN201711390475.6A patent/CN108193342A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3847156A (en) * | 1972-07-17 | 1974-11-12 | Sherwood Medical Ind Inc | Suture |
| CN101250763A (en) * | 2008-03-11 | 2008-08-27 | 东华大学 | Long-acting medicine-loading orlon fibre capable of degrading partly, preparation and application thereof |
| CN106075544A (en) * | 2016-01-26 | 2016-11-09 | 西北工业大学 | A kind of core shell composite construction medicine carrying stitching thread and preparation method thereof |
| CN105648547A (en) * | 2016-03-08 | 2016-06-08 | 西安工程大学 | Nanofiber yarn electrospinning device and preparation method for nanofiber yarns |
| CN106334211A (en) * | 2016-10-07 | 2017-01-18 | 常州市鼎日环保科技有限公司 | Method for preparing medical suture material |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111139564A (en) * | 2020-02-28 | 2020-05-12 | 科凯(南通)生命科学有限公司 | Equipment for preparing heart valve suture line |
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