CN106727393A - A kind of sustained release preparations of ibuprofen containing grid internal structure and preparation method thereof - Google Patents
A kind of sustained release preparations of ibuprofen containing grid internal structure and preparation method thereof Download PDFInfo
- Publication number
- CN106727393A CN106727393A CN201611216129.1A CN201611216129A CN106727393A CN 106727393 A CN106727393 A CN 106727393A CN 201611216129 A CN201611216129 A CN 201611216129A CN 106727393 A CN106727393 A CN 106727393A
- Authority
- CN
- China
- Prior art keywords
- internal structure
- sustained release
- parts
- preparation
- grid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of sustained release preparations of ibuprofen containing latticed internal structure and preparation method thereof, the sustained release preparation is made up of following parts by weight raw material：10 25 parts of brufens, 50 70 parts of ethyl celluloses and 15 30 parts of pore-foaming agents, the sustained release preparation is tablet or capsule with grid internal structure.The preparation process of the sustained release preparations of ibuprofen containing latticed internal structure that the present invention is provided includes hot-melt extruded, sets model and 3D printing.By adjusting formulation and internal structure, can optimize and obtain 24h slow-release behaviors.The regulation of drug release behavior is simpler controllable, it is to avoid so that plasticizer, reduces the consumption of release regulator；Same formula, can adjust content of dispersion and release behavior by adjusting internal structure.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of sustained release preparations of ibuprofen and its preparation containing grid internal structure
Method.
Background technology
Brufen is a kind of non-steroidal anti-inflammatory, analgesic-antipyretic, is widely used in the various pain for the treatment of, inflammation and heating.But cloth Lip river
Fragrant biological half-life is short, and orally has gastrointestinal side effect, and clinic often uses sustained release preparation.The ibuprofen slow-release developed at present
Preparation is mainly encapsulated etc. including insoluble matrix agent, erodible matrix agent, sustained release pellet.
Brufen has good thermoplastic potentiality, and it is with good to prepare the miniature matrix tablet of brufen using heat fusing extrusion molding
Good industrial prospect.But brufen poorly water-soluble, hot-melt extruded thing compactness is high, the miniature matrix tablet drug release low degree of gained,
Need to add substantial amounts of pore-foaming agent, directly affect extrudate property, it is difficult to follow-up machine-shaping.
The content of the invention
The present invention provides a kind of sustained release preparations of ibuprofen containing grid internal structure and preparation method thereof.By hot-melt extruded, mould
Type builds and 3D printing, can prepare the tablet and capsule of grid internal structure.Not only greatly reduce the consumption of pore-foaming agent, it is ensured that
The releasing degree of brufen；More can easily adjust that dosage is gentle to release behavior by adjusting internal structure, realize personalization to
Medicine.
The technical proposal for solving the technical problem of the invention is：
A kind of sustained release preparations of ibuprofen containing grid internal structure, is made up of following parts by weight raw material：10-25 parts of brufen,
50-70 parts of ethyl cellulose and 15-30 parts of pore-foaming agent, the sustained release preparation are tablet or capsule with grid internal structure.
Preferably, the viscosity of the ethyl cellulose is 10cp, 20cp and 45cp；The pore-foaming agent is：Sodium alginate,
Polyvinyl alcohol, hydroxypropyl methyl cellulose or xanthans, the viscosity of the hydroxypropyl methyl cellulose is 100cp.
Preferably, the sustained release preparation is made up of following parts by weight raw material：20 parts of brufens, 60 parts of ethyl celluloses
With 20 parts of pore-foaming agents.
It is further preferred that the viscosity of the ethyl cellulose is 10cp.
Preferably, a diameter of 10-14mm of the tablet, a height of 5-9mm；The capsule diameter 5-9mm, a height of 10-
18mm；Grid internal structure is grid-shaped, concentric square, circular concentric, honeycombed, linear, hibert curve, Archimedes
Chord or octagonal star spiral；The filling rate of grid internal structure is 5-40%.
It is further preferred that a diameter of 12mm of the tablet, a height of 7mm；The capsule diameter 7mm, a height of 14mm；Inside grid
Structure can be grid-shaped and honeycombed etc.；The filling rate of grid internal structure is 20%.
Different materials and different type network have a significant effect to product appearance.Hydroxypropyl methyl fiber is respectively adopted
Plain viscosity is that 4000cp and 100cp is pore-foaming agent, is printed under certain condition, and the definition and corner adhesion situation of product are not
Together；Network is the outward appearance of concentric circles, grid and cellular three kinds of typical structures, and compactness extent differs greatly, release in vitro
Behavior is also corresponding different.
Invention also provides the preparation method of the sustained release preparations of ibuprofen containing grid internal structure, including following step
Suddenly：
Main ingredient, slow-release material and pore-foaming agent are well mixed, hot-melt extruded prepares the bar of diameter 1.75mm.It is big that model is set
It is small：Diameter, height, shape, internal structure and filling rate, the Bu Luo containing grid internal structure is printed as using 3D printing by bar
Fragrant sustained release tablets or spansule.The hot-melt extruded condition is：90-110 DEG C of temperature, rotating speed 60-100rpm, incorporation time 10-
20min.The 3D printing parameter is as follows：150-190 DEG C of print temperature, wall thickness 0.2-0.6mm, flow velocity 5-15mm/s.
Preferably, the hot-melt extruded condition is：100 DEG C of temperature, rotating speed 80rpm, incorporation time 15min.The 3D
Print conditions are：Temperature is 170 DEG C, wall thickness 0.4mm, flow velocity 10mm/s.
Hot-melt extruded and the shaping of 3D printing condition on production have a significant effect.Hot-melt extruded temperature is too low, and material can not be complete
Full-fusing mixes；Temperature is too high, and it is uneven that extrusion bar crosses soft drawn silk.3D printing temperature is too low or excessive velocities, it is impossible to printing or
Product local form is unintelligible；The too high influence shaping of temperature and material stability；Speed influences production efficiency slowly excessively.
Beneficial effects of the present invention are：
1st, the sustained release preparation that the present invention is provided has inner mesh structure, and without using plasticizer, pore-foaming agent consumption also subtracts significantly
It is few.Same formula, needs, adjustable integral mould and internal structure for different medications, just can adjust content of dispersion and release behavior, full
The need for sufficient personalized medicine.
2nd, the present invention is provided on the basis of heat fusing extrusion, by modeling and 3D printing, prepares internal structure containing grid
Ibuprofen slow-release tablet and capsule.Not only greatly reduce the consumption of pore-foaming agent, it is ensured that the releasing degree of brufen；Can more lead to
Adjustment internal structure is crossed, easily adjustment dosage is gentle releases behavior, realizes Personalized Drug Administration.The grid frame glue that the present invention is provided
Capsule, compared with grid frame tablet, is not only more conducive to swallow, and one-step shaping, and sustained release pellet filling glue again is first made with conventional
Softgel shell is compared, simple and easy to do, and industrialization prospect is good.
3rd, present invention integration and industrialization degree are high, there is good social value and economic worth.
Brief description of the drawings
Accompanying drawing 1 is brufen slowly release formulation outward appearance prepared by embodiment 1.
Accompanying drawing 2 is brufen slowly release formulation outward appearance prepared by embodiment 3.
Accompanying drawing 3 is the tablets in vitro curve map of embodiment 1, comparative example 1 and the made tablet of comparative example 2.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, the present invention is carried out with reference to embodiments
Further describe.It should be appreciated that specific embodiment described herein is only used to explain the present invention, it is not used to limit this
Invention.
Embodiment 1
20g brufens, 60g ethyl celluloses and 20g sodium alginates are well mixed using high-speed mixer, hot-melt extruded is placed in
In machine, in 100 DEG C, 10rpm mixing 20min, extrusion obtains bar, and bar is placed in 3D printer, 170 DEG C, wall thickness
0.4mm, flow velocity 10%, flow 100% are printed as the mesh flake of diameter 12mm 7mm high, and its shape is shown in accompanying drawing 1.
Embodiment 2
1025 brufens, 50g ethyl celluloses and 25g hydroxypropyl methyl celluloses are well mixed using high-speed mixer, are put
In hot-melt extruded machine, in 110 DEG C, 10rpm mixing 20min, extrusion obtains bar, and bar is placed in 3D printer, 180
DEG C, wall thickness 0.4mm, flow velocity 10%, flow 100% be printed as the mesh flake of diameter 14mm 9mm high.
Embodiment 3
10g brufens, 70g ethyl celluloses and 20g polyvinyl alcohol are well mixed using high-speed mixer, hot-melt extruded is placed in
In machine, in 120 DEG C, 10rpm mixing 20min, extrusion obtains bar, and bar is placed in 3D printer, 180 DEG C, wall thickness
0.4mm, flow velocity 5%, flow 100% are printed as the grid capsule of diameter 7mm 18mm high, and its shape is shown in accompanying drawing 2.
Comparative example 1
20g brufens, 60g ethyl celluloses and 20g sea acid sodium are well mixed using high-speed mixer, hot-melt extruded machine is placed in
In, in 100 DEG C, 10rpm mixing 20min, extrusion obtains bar, and bar is directly cut to cylindrical tablet.
Comparative example 2
20g brufens, 60g ethyl celluloses and 20g sea acid sodium are well mixed using high-speed mixer, hot-melt extruded machine is placed in
In, in 100 DEG C, 10rpm mixing 20min, extrusion obtains bar, and bar is crushed and uniformly mixed with equivalent microcrystalline cellulose,
Direct tablet compressing.
The tablets in vitro behavioral experiment of pharmaceutical preparation：
With 150mL phosphate buffers（pH=7.2）It is dissolution medium, timing sampling 5ml, 0.45 μm of membrane filtration, 263nm is surveyed
Absorbance, concentration is calculated through standard curve, draws tablets in vitro curve, wherein embodiment 1,2 pharmacy of comparative example 1 and comparative example
The tablets in vitro curve of agent is shown in accompanying drawing 3.
By accompanying drawing 3 as can be seen that compared with hot-melt extruded small pieces, the drug release rate and degree of 3D printing piece are carried significantly
It is high；Compared with direct powder compression, 3D printing piece has slow release effect.
In sum, the latticed slow-releasing agent of 3D printing provided by the present invention, the latticed knot being molded by 3D printing
Structure so that medicament has more preferable slow release effect, slow release speed is moderate, and sustained release behavior is simply controllable.
The above, only presently preferred embodiments of the present invention not does any formal limitation to the present invention, it is every according to
According to technical spirit of the invention to any simple modification made for any of the above embodiments, equivalent variations, protection of the invention is each fallen within
Within the scope of.
Claims (8)
1. a kind of sustained release preparations of ibuprofen containing grid internal structure, it is characterised in that the sustained release preparation is by following weight portion
Number raw material is constituted：10-25 parts of brufen, 50-70 parts of ethyl cellulose and 5-40 parts of pore-foaming agent, the sustained release preparation is with net
The tablet or capsule of lattice internal structure.
2. the sustained release preparations of ibuprofen of grid internal structure is contained as claimed in claim 1, it is characterised in that the ethyl cellulose
The viscosity of element is 10cp, 20cp and 45cp；The pore-foaming agent is：Hydroxypropyl methyl cellulose, sodium alginate, polyvinyl alcohol or Huang
Virgin rubber, the viscosity of the hydroxypropyl methyl cellulose is 100cp.
3. the sustained release preparations of ibuprofen of grid internal structure is contained as claimed in claim 1, it is characterised in that the sustained release preparation
It is made up of following parts by weight raw material：20 parts of brufens, 60 parts of ethyl celluloses and 20 parts of release pore-foaming agents.
4. the sustained release preparations of ibuprofen of grid internal structure is contained as claimed in claim 2, it is characterised in that the ethyl cellulose
The viscosity of element is 10cp.
5. the sustained release preparations of ibuprofen containing grid internal structure as claimed in claim 1, it is characterised in that the tablet it is straight
Footpath is 10-14mm, a height of 5-9mm；The capsule diameter 5-9mm, a height of 10-18mm；Grid internal structure be grid-shaped, with one heart
Square, circular concentric, honeycombed, linear, hibert curve, Archimedes's chord or octagonal star spiral；Grid internal structure
Filling rate be 5-40%.
6. the sustained release preparations of ibuprofen containing grid internal structure as claimed in claim 1, it is characterised in that the tablet it is straight
Footpath is 12mm, a height of 7mm；The capsule diameter 7mm, a height of 14mm；Grid internal structure can be grid-shaped and honeycombed etc.；
The filling rate of grid internal structure is 20%.
7. the method for preparing the sustained release preparations of ibuprofen containing grid internal structure described in claim 1, it is characterised in that the system
Preparation Method comprises the following steps：
Main ingredient, slow-release material and pore-foaming agent are well mixed, hot-melt extruded prepares the bar of diameter 1.75mm, it is big that model is set
It is small：Diameter, height, shape, internal structure and filling rate, the Bu Luo containing grid internal structure is printed as using 3D printing by bar
Fragrant sustained release tablets or spansule, the hot-melt extruded condition is：90-110 DEG C of temperature, rotating speed 60-100rpm, incorporation time 10-
20min, the 3D printing parameter is as follows：150-190 DEG C of print temperature, wall thickness 0.2-0.6mm, flow velocity 5-15mm/s.
8. preparation method as claimed in claim 6, it is characterised in that the hot-melt extruded condition is：100 DEG C of temperature, rotating speed
80rpm, incorporation time 15min.The 3D printing condition is：Temperature is 170 DEG C, wall thickness 0.4mm, flow velocity 10mm/s.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611216129.1A CN106727393A (en) | 2016-12-26 | 2016-12-26 | A kind of sustained release preparations of ibuprofen containing grid internal structure and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611216129.1A CN106727393A (en) | 2016-12-26 | 2016-12-26 | A kind of sustained release preparations of ibuprofen containing grid internal structure and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106727393A true CN106727393A (en) | 2017-05-31 |
Family
ID=58925748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611216129.1A Pending CN106727393A (en) | 2016-12-26 | 2016-12-26 | A kind of sustained release preparations of ibuprofen containing grid internal structure and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106727393A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111450070A (en) * | 2020-03-20 | 2020-07-28 | 浙江工业大学 | Extrusion 3D printing coating type sustained release preparation and preparation method thereof |
| CN113925837A (en) * | 2021-09-13 | 2022-01-14 | 四川轻化工大学 | Preparation method of ibuprofen by applying 3D printing technology |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101467989A (en) * | 2007-12-27 | 2009-07-01 | 北京德众万全医药科技有限公司 | Sustained-release pellet containing ibuprofen |
| CN104739773A (en) * | 2013-12-26 | 2015-07-01 | 鲁南贝特制药有限公司 | Dexibuprofen slow release pellet and preparation method thereof |
| CN104786496A (en) * | 2015-04-08 | 2015-07-22 | 金文韬 | Inkjet type hot-melt extrusion full-color 3D (3-dimentional) printer |
| CN105362320A (en) * | 2015-12-02 | 2016-03-02 | 广东药学院 | Method of preparing quick-acting jiuxin orally disintegrating tablet through 3D printing |
| CN105687151A (en) * | 2016-03-22 | 2016-06-22 | 西北工业大学 | Method for preparing tablet medicine on basis of ink-jet 3D printing technology |
| CN106109245A (en) * | 2016-08-16 | 2016-11-16 | 华南农业大学 | Cancer therapy drug that a kind of 3D of employing printing technique prepares and method |
-
2016
- 2016-12-26 CN CN201611216129.1A patent/CN106727393A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101467989A (en) * | 2007-12-27 | 2009-07-01 | 北京德众万全医药科技有限公司 | Sustained-release pellet containing ibuprofen |
| CN104739773A (en) * | 2013-12-26 | 2015-07-01 | 鲁南贝特制药有限公司 | Dexibuprofen slow release pellet and preparation method thereof |
| CN104786496A (en) * | 2015-04-08 | 2015-07-22 | 金文韬 | Inkjet type hot-melt extrusion full-color 3D (3-dimentional) printer |
| CN105362320A (en) * | 2015-12-02 | 2016-03-02 | 广东药学院 | Method of preparing quick-acting jiuxin orally disintegrating tablet through 3D printing |
| CN105687151A (en) * | 2016-03-22 | 2016-06-22 | 西北工业大学 | Method for preparing tablet medicine on basis of ink-jet 3D printing technology |
| CN106109245A (en) * | 2016-08-16 | 2016-11-16 | 华南农业大学 | Cancer therapy drug that a kind of 3D of employing printing technique prepares and method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111450070A (en) * | 2020-03-20 | 2020-07-28 | 浙江工业大学 | Extrusion 3D printing coating type sustained release preparation and preparation method thereof |
| CN111450070B (en) * | 2020-03-20 | 2022-05-03 | 浙江工业大学 | Extrusion 3D printing coating type sustained release preparation and preparation method thereof |
| CN113925837A (en) * | 2021-09-13 | 2022-01-14 | 四川轻化工大学 | Preparation method of ibuprofen by applying 3D printing technology |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Srivastava et al. | Microsponges: a futuristic approach for oral drug delivery | |
| Aguilar-de-Leyva et al. | 3D printed drug delivery systems based on natural products | |
| CN110507637B (en) | Intelligent capsule with gradual controlled release, preparation method and 3D printing system | |
| CN101987091B (en) | Venlafaxine hydrochloride sustained-release pellet capsules | |
| RU2010149992A (en) | METHOD FOR PRODUCING SOLID MEDICINAL FORM, IN PARTICULAR TABLET, FOR PHARMACEUTICAL APPLICATION AND METHOD OF PRODUCING PRECURSOR OF SOLID MEDICINAL FORM, IN PARTICULAR TABLET | |
| Shehata et al. | BÜCHI nano spray dryer B-90: a promising technology for the production of metformin hydrochloride-loaded alginate–gelatin nanoparticles | |
| CN106727393A (en) | A kind of sustained release preparations of ibuprofen containing grid internal structure and preparation method thereof | |
| CN103784396B (en) | Ibuprofen oral micropill xerogel and preparation method thereof | |
| CN105687153A (en) | 3D-printing preparation method for tablet medicines through spraying medicaments on matrix material | |
| CN106109245A (en) | Cancer therapy drug that a kind of 3D of employing printing technique prepares and method | |
| Hosny et al. | Recent trends in assessment of cellulose derivatives in designing novel and nanoparticulate-based drug delivery systems for improvement of oral health | |
| CN111450070A (en) | Extrusion 3D printing coating type sustained release preparation and preparation method thereof | |
| CN102908317A (en) | Macrolide antibiotics enteric-coated pellets and coating solution thereof | |
| CN104474553A (en) | Drug-releasing agent based on beta-sitosterol and preparation method of drug-releasing agent | |
| CN104800184B (en) | The smooth sustained release agent pieces of butanedioic acid furan Luo Qu | |
| Gahlyan et al. | Oral controlled release drug delivery system-a review | |
| CN103565774B (en) | A kind of Glipizide controlled release composition and preparation method thereof | |
| CN102274191A (en) | Coating liquid composition of erythromycin enteric-coated pellet | |
| CN1899287B (en) | Slow release medicinal composition for treating anxiety and its preparing method | |
| CN116942625A (en) | Self-pore sustained release shell and sustained release tablet prepared based on 3D printing and preparation method thereof | |
| CN102283954A (en) | Integrated novel form preparation technology for polyporus umbellatus decoction and production method thereof | |
| CN101513392A (en) | Process for preparing slow and controlled micro pills | |
| CN102319225A (en) | Trimetazidine hydrochloride sustained release tablet and preparation method thereof | |
| CN108968051B (en) | Resveratrol sustained-release preparation and preparation method thereof | |
| CN102283944A (en) | Technology for preparing novel integrated dosage form of lung heat expelling powder and production method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |
|
| RJ01 | Rejection of invention patent application after publication |