CN106234376A - Containing etoxazole and the Pesticidal combination of Amitraz and preparation thereof and application - Google Patents

Containing etoxazole and the Pesticidal combination of Amitraz and preparation thereof and application Download PDF

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Publication number
CN106234376A
CN106234376A CN201610622559.7A CN201610622559A CN106234376A CN 106234376 A CN106234376 A CN 106234376A CN 201610622559 A CN201610622559 A CN 201610622559A CN 106234376 A CN106234376 A CN 106234376A
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China
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etoxazole
amitraz
pesticidal combination
agent
mite
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范坤成
张军
郭世俭
李俊
应小锋
郭近
毛晨蕾
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ZHEJIANG XINNONG CHEMICAL CO Ltd
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ZHEJIANG XINNONG CHEMICAL CO Ltd
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Priority to CN201610622559.7A priority Critical patent/CN106234376A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

nullThe present invention provides a kind of Pesticidal combination comprising etoxazole and Amitraz，Described compositions comprises etoxazole and Amitraz，The weight ratio of etoxazole and Amitraz is 50:1～1:70，The present invention also provides for the preparation of a kind of Pesticidal combination comprising etoxazole and Amitraz，Described preparation formulation is the wettable powder agriculturally allowed、Soluble powder、Water dispersible granules、Aqueous emulsion、Microemulsion、Microcapsule suspending agent、Suspending agent、Suspension emulsion or cream，Instant component is reasonable，Good disinsection effect，And its activity and insecticidal effect are not the simple superposition of each composition activity，Compared with existing unitary agent，In addition to there is significant insecticidal effect，And have significant potentiation，Good to crop safety，Meet the security requirement of pesticidal preparations，The present invention does harm to demodicid mite and has preferable prevention effect plant，Especially the most notable to panonychus citri and Tetranychus urticae prevention effect.

Description

Containing etoxazole and the Pesticidal combination of Amitraz and preparation thereof and application
Technical field
The invention belongs to pesticide field, relate to a kind of Pesticidal combination, particularly to a kind of containing etoxazole and Amitraz Pesticidal combination.
Background technology
Etoxazole is the acaricide of a kind of brand-new tool special construction of SUMITOMO CHEMICAL KCC research and development, English logical By name: etoxazole, chemical molecular formula C21H23F2NO2.Its model of action be suppression demodicid mite ovum embry ogenesis and from children demodicid mite to Becoming the molting process of demodicid mite, effective to ovum and children demodicid mite, to becoming, demodicid mite is invalid.Therefore its optimal preventing and treating time is the evil demodicid mite harm initial stage. This medicament rain fastness is strong, and the lasting period is up to 50 days, and using dosage is low.Environmentally safe, to beneficial insect and benefit demodicid mite non-hazardous or Endanger minimum.To the tetranychid of crop, beginning tetranychid, Panonychus citri, Tetranychus urticae, Cinnabaris leaves such as Citrus, Cotton Gossypii, Fructus Mali pumilae, flowers, vegetables The demodicid mite classes such as demodicid mite have remarkable preventive effect.As the new acaricide of one, it is high that etoxazole in use also exists use cost, resistance wind The risk that danger is gradually increased, effective to ovum and children demodicid mite but invalid to one-tenth demodicid mite defect.
Amitraz (Amitraz) is a kind of broad spectrum activity acaricide, mainly suppresses the activity of monoamine oxidase, MAO, has tactile Kill, refusing to eat, repellent action, also have certain interior suction, fumigation action.Amitraz is used for preventing and treating on the crop such as fruit tree, vegetable multiple Evil demodicid mite is it can also be used to prevent and treat the external acarian of the herding such as cattle, sheep.
Evil demodicid mite occurs from generation to generation the most, and fertility is strong, under suitable temperature and humidity conditions, and evil demodicid mite quantity energy within a short period of time Increase exponentially rapidly, thus easily acaricide is developed immunity to drugs, cause serious harm to crop simultaneously.Such as, the full pawl of mandarin orange Demodicid mite (Panonychus citri McGregor) is the Main Harmful demodicid mite that mandarin orange planting district of current China generally occurs, the generation cycle Short, reproductive capacity is strong, it is easy to develop immunity to drugs pesticide control；And for example, Tetranychus urticae (Tetranychus urticae Koah) be worldwide harmful demodicid mite, be that harm was big in orchard in recent years, Drug resistance by force, the harmful demodicid mite of more difficult preventing and treating；Tetranychid, is commonly called as red Aranea, it has also become one of important pests of harm landscape flower trees, its leaf of main harm plant, stem, flower etc., thorn inhales plant Stem and leaf, the position moisture that makes to be injured reduces, and performance chlorosis bleaches, and leaf surface presents intensive pale fleck, curling jaundice, sternly During weight there is the phenomenons such as yellow leaf, Jiao Ye, leaf roll, fallen leaves and death in plant.Meanwhile, red spider or the vector of virosis.
For preventing and treating the most serious various harmful demodicid mite, countries in the world are all at the acaricide of continuous development of new.Open at acaricide Sending out and in application process, delaying evil demodicid mite Drug resistance or cross resistance is the key factor extending product service life, reasonable employment Acaricide, controls access times and dosage, and the acaricide of different mechanism of action is used alternatingly or uses with and is just particularly important.
Applicant finds through numerous studies, and etoxazole and Amitraz are compounding to preventing and treating Citrus, Herba Marsileae Quadrifoliae fruits and vegetables and Camellia sinensis etc. The demodicid mite classes such as the Panonychus citri of crop, Tetranychus cinnabarinus, Tetranychus urticae have unforeseeable prevention effect, and potentiation is fairly obvious. Finding based on this, applicant completes the present invention.
Summary of the invention
The present invention proposes a kind of containing etoxazole with the Pesticidal combination of Amitraz, and said composition comprises etoxazole and Shuan Jia Amidine.The weight ratio of etoxazole and Amitraz is 50:1～1:70.
Preferably, the weight ratio of etoxazole and Amitraz is 20:1～1:20.
It is furthermore preferred that the weight ratio of etoxazole and Amitraz is 5:1～1:4.
Described compositions also includes pharmaceutical adjunct, it is preferred that by percentage to the quality, the weight of etoxazole and Amitraz it With the 1-90%, more preferably 1-60% accounting for total amount.
Described Pesticidal combination is prepared as the dosage form of preparation and includes wettable powder, soluble powder, water dispersible granules, water Emulsion, microemulsion, microcapsule suspending agent, suspending agent, suspension emulsion and cream.
Described pharmaceutical adjunct selected from wetting agent, dispersant, emulsifying agent, cosurfactant, thickening agent, solvent, cosolvent, Antifreezing agent, preservative, disintegrating agent, stabilizer, film former, one-tenth wafer, pH acid-base modifier, defoamer, coloring agent, filler and water In one or more.
Described wetting agent is selected from EO/PO block polyether, fatty alcohol-polyoxyethylene ether, tallow ethyoxyl ammonium salt, alkylnaphthalene One or more in sulfonate, fatty alcohol polyoxyethylene ether sulfate and acyl group glutamate.
Described dispersant selected from condensation naphthalene sulfonate, phenolsulfonic acid condensation substance sodium salt, methyl naphthalene sulfonate formaldehyde condensate, Sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate, acrylate homopolymer sodium salt, polymeric polycarboxylic acid salt, dioctyl sodium sulfosuccinates One or more in acid sodium-salt, EO/PO block polyether and maleic acid-acrylic acid copolymer sodium salt.
Described emulsifying agent is selected from alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fat Fat polyoxyethylenated alcohol, phenethyl phenol polyethenoxy ether polyethenoxy ether, aliphatic amine polyoxyethylene ether, Oleum Ricini oxirane add Become thing and derivant, polyol fatty acid ester and ethylene oxide adduct thereof, alkylbenzenesulfonate, alkylsulfonate, alkyl Succinate sulfonate, alkyl biphenyl base ether sulfonate, naphthalene sulfonic acid-formaldehyde condensation product, aliphatic alcohol sulfate, alkyl phenol polyoxy second Alkene ether sulphate, aralkyl phenol polyethenoxy ether sulfate, alkylphenol polyoxyethylene phosphate ester, phenethyl phenol polyethenoxy ether Phosphate ester, polyoxyethylene carboxylate phosphate, ethoxylated fatty amines phosphate ester, alkylphosphonic, alkyl phenol polyoxy second Alkene ether formaldehyde condensation products, aralkyl phenol polyethenoxy ether formaldehyde condensation products, xenol polyoxyethylene ether formaldehyde condensation products, polyoxy second Alkene polyoxypropylene block copolymers, alkyl naphthalene sulfonic acid formaldehyde condensation products, phenol formaldehyde condensate sulfonate, alkylphenol polyoxyethylene Formaldehyde condensation products sulfate, contracting methylcellulose and derivant thereof, alkylammonium salt, amino alcohol fatty acid derivatives, polyamines fat Acid derivative, quaternary ammonium salt, tallow ethyoxyl ammonium salt, alkylnaphthalene sulfonate, aminoacid, amine oxide, glycine betaine, fatty alcohol polyoxy One or more in vinyl Ether sulfate and acyl group glutamate；
Described cosurfactant is selected from n-butyl alcohol, isobutanol, n-octyl alcohol；
Described thickening agent is selected from xanthan gum, Magnesiumaluminumsilicate, sodium carboxymethyl cellulose, starch phosphate sodium, octenyl succinic Acid-starch sodium, polyvinyl alcohol.
One or more in dimethylbenzene, turpentine-based vegetable oil, methyl oleate and heavy aromatic solvent oil of described solvent；
Described cosolvent is selected from Ketohexamethylene, DMAC N,N' dimethyl acetamide, N,N-dimethylformamide；
Described antifreezing agent is selected from ethylene glycol, propylene glycol, glycerol, isopropanol, carbamide.
Described film former select polyvinyl alcohol, polyvinyl acetate, polyethylene glycol polymethylacrylic acid glycol ester, Carboxymethyl cellulose, Radix Acaciae senegalis, xanthan gum, starch etc. have the high molecular polymer of caking property and film property.
Cyst material used by described one-tenth wafer is carbamide resin: be to be led to polyhydric alcohol or polyamine by isocyanate-monomer Cross interface polymerization reaction and prepare；Isocyanates includes toluene di-isocyanate(TDI), 4,4-methyl diphenylene diisocyanate, many benzene Quito time methylene polyisocyanates, polyphenyl polymethylene polyisocyanates etc..
Described pH acid-base modifier is selected from citric acid, glacial acetic acid, hydrochloric acid, ammonia, triethylamine, triethanolamine and divinyl three One or more in amine；Institute's expense is to regulate the pH value of final products to be advisable to stability range；
Described disintegrating agent selects sodium chloride, ammonium chloride, ammonium sulfate, sodium sulfate, soluble starch.
Described preservative is selected from Kazon, formaldehyde, phenyl salicylate, sodium benzoate, butyl p-hydroxybenzoate, sorbic acid Potassium.
Described stabilizer is selected from epoxy soybean oil, epoxychloropropane, triphenyl phosphite, glycidyl ether or Ji Wusi Alcohol.
Described defoamer is selected from organic silicon defoamer, polyether antifoam agent.
Described coloring agent is selected from ferrum oxide, titanium oxide, azo dye.
Described filler is selected from Kaolin, kieselguhr, Pulvis Talci, precipitated calcium carbonate, white carbon.
Described water is tap water, deionized water or distilled water.
The Pesticidal combination of the present invention and composite preparation can effectively prevent and treat the mite pest of plant.
Preferably, the demodicid mite class evil in preventing and treating Citrus, Fructus Fragariae Ananssae, Fructus Capsici, Cotton Gossypii, Mulberry, Fructus Mali pumilae, Fructus Solani melongenae, Kidney bean, Semen vignae sinensis and Camellia sinensis Worm, this enumerating has been not offered as any restriction.
Described demodicid mite class insect pest can be in panonychus citri, Tetranychus urticae, Tetranychus cinnabarinus, Citrus blister mite and yellow tea mite Planting or multiple, this enumerating has been not offered as any restriction.
It is furthermore preferred that one or more in preventing and treating panonychus citri, Tetranychus urticae, Tetranychus cinnabarinus and yellow tea mite, this Enumerate and be not offered as any restriction.
Pesticidal combination of the present invention and preparation thereof can be prepared by universal method.Therefore, present invention additionally comprises State the preparation method of Pesticidal combination and preparation thereof.
Pesticidal combination of the present invention and preparation thereof can be with itself concentration form or with dosage form use.
The advantage that insecticidal active compound compositions of the present invention is compared to the prior art the most prominent:
Pesticidal combination Synergistic the most of the present invention is obvious, and its activity and insecticidal effect are not the simple folded of each composition activity Add, be used alone than single dose and significantly improve the prevention effect to insect；
Pesticidal combination the most of the present invention is made up of the active component of different mechanism of action, can the generation of effective delaying drug resistance；
After Pesticidal combination the most of the present invention is compounding, synergistic effect is notable, can reduce dosage, reduces drug cost, subtracts simultaneously The light pesticide pressure to environment；
Pesticidal combination the most of the present invention can significantly improve the toleration of crop, makes medicament higher to the safety of crop.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, present invention specific examples below Illustrate with example.Described embodiment is to preferably explain the present invention rather than the limit to scope System, all based on any amendment made in basic thought of the present invention and principle and variation, broadly fall into what the present invention was claimed Scope.
Dosage form prepares embodiment:
In order to make the purpose of the present invention, technical scheme and advantage clearer, present invention specific examples below Illustrating, described embodiment is to preferably explain the present invention rather than limiting the scope of the invention, all Based on any amendment made in basic thought of the present invention and principle and variation, broadly fall into the scope that the present invention is claimed.With Under the invention will be further described in conjunction with the embodiments, in embodiment, the preparation method of dosage form is conventional method, institute of the present invention " % " that state is mass percent.
One, the preparation of suspending agent
Embodiment 1:40% (10%+30.0%) suspending agent
By 40% reactive compound (10.0% etoxazole and 30.0% Amitraz compositions), fatty alcohol-polyoxyethylene ether 2.0%, alkylnaphthalene sulfonate 3.0%, sodium metnylene bis-naphthalene sulfonate 1.0%, xanthan gum 0.05%, Magnesiumaluminumsilicate 0.6%, the third three Alcohol 2.0%, bigcatkin willow phenyl ester 0.4%, organic silicon defoamer 0.1%, deionized water are mended to 100%, put into high shear homogenized milk Change machine high speed is sheared 20 minutes, then transports in sand mill, and circulation sand milling i.e. obtains suspending agent 1-3 time.Suspending agent contains containing 40% Amount reactive compound.
Embodiment 2:30% (10.0%+20.0%) suspending agent
By 30% reactive compound (10.0% etoxazole and 20.0% Amitraz compositions), EO/PO block polyether 1.0%, alkylnaphthalene sulfonate 1.0%, polymeric polycarboxylic acid salt 4.0%, acrylate homopolymer sodium salt 1.5%, isopropanol 2.0%, organic silicon defoamer 0.1%, sodium benzoate 0.5%, tap water are mended to 100%, put into high shear homogeneous emulsifying machine High speed is sheared 30 minutes, then transports in sand mill, and circulation sand milling i.e. obtains 30% suspending agent 1-3 time.Suspending agent contains containing 30% Amount reactive compound.
Two, microcapsule suspending agent
Embodiment 3:25% (10.0%+15.0%) microcapsule suspending agent
By 25% reactive compound (10.0% etoxazole and 15.0% Amitraz compositions), acyl group glutamate 2.0%, Phenolsulfonic acid condensation substance sodium salt 1.0%, organic silicon defoamer 0.1%, polyphenyl polymethylene polyisocyanates PAPI 3% with Methyl diphenylene diisocyanate MDI 2%, arabic gum (5%) aqueous solution 10%, deionized water 39.46% is sufficiently mixed, Putting into sand milling in sand mill again, sand milling to D90 particle diameter is 3-5 micron.Open stirring (maintaining 700 turns/min), then by sand The suspension of milled is warming up to 60 DEG C, is slowly added triethanolamine 0.04%, maintains stable cyst material solidification temperature 8 Hour, rear addition fatty alcohol polyoxyethylene ether sulfate 2.0%, alkylnaphthalene sulfonate 1.0%, carbamide 2.0%, glycerol 2.0%, Magnesiumaluminumsilicate (2%) aqueous solution 10%, appropriate diluted hydrochloric acid aqueous solution tune pH value to about 6.5, preservative formaldehyde 0.1%, organic silicon defoamer 0.3%, stirs, and i.e. prepares 25% microcapsule suspending agent.Containing 25% content in microcapsule suspending agent Reactive compound.
Three, the preparation of water dispersible granules
Embodiment 4:60% (20.0%+40.0%) water dispersible granules
60% reactive compound (20.0% etoxazole and 40.0% Amitraz compositions), fatty alcohol-polyoxyethylene ether 4.0%, lignosulfonates 3.0%, sodium chloride 15.0%, polyvinyl alcohol 2.0%, Kaolin 16.0% are sufficiently mixed, then lead to Crossing comminution by gas stream, granulating and forming obtains water dispersible granules.Containing 60% content reactive compound in water dispersible granules, product cut size is 80-120 mesh.
Embodiment 5:50% (15.0%+35.0%) water dispersible granules
By 50% reactive compound (15.0% etoxazole and 35.0% Amitraz compositions), EO/PO block polyether 7.0%, fatty alcohol-polyoxyethylene ether 5.0%, sodium sulfate 6.0%, xanthan gum 0.05%, Kaolin 31.95% are sufficiently mixed, and add Enter appropriate tap water mix homogeneously, then put into high shear homogeneous emulsifying machine high speed shearing corase grind and homogenizing, then pump is to sand Sand milling in grinding machine, sand milling is to certain particle diameter, then granulating and forming obtains water dispersible granules.Containing 50% content activation in water dispersible granules Compound, product cut size is 80-120 mesh.
Four, the preparation of wettable powder
By recipe requirements, former medicine, various auxiliary agent and filler etc. are sufficiently mixed in the ratio of formula, through ultrafine crusher powder After broken the most available.
Embodiment 6:40% (20.0%+20.0%) wettable powder
By 40% reactive compound (20.0% etoxazole and 20.0% Amitraz compositions), alkylbenzenesulfonate 4.0%, Sodium lignin sulfonate 5.0%, white carbon 2.0%, Kaolin 49.0% are sufficiently mixed, then by superfine grinding to certain particle diameter, Obtain wettable powder.Containing 40% content reactive compound in wettable powder.
Five, the preparation of soluble powder
Embodiment 7:20% (5.0%+15.0%) soluble powder
20% reactive compound (5.0% etoxazole and 15.0% Amitraz compositions) is mixed, 3% fatty alcohol polyoxy second Alkene ether, 3% alkylnaphthalene sulfonate, 5% white carbon, sodium sulfate are mended to 100% mix homogeneously, then through comminution by gas stream to certain grain Footpath, obtains 20% soluble powder.
Six, aqueous emulsion
Embodiment 8:55% (40.0%+15.0%) aqueous emulsion
By 55% reactive compound (40.0% etoxazole and 15.0% Amitraz compositions), DMAC N,N' dimethyl acetamide 3%, heavy aromatic solvent oil 15%, styrene phenol formaldehyde resin polyoxyethylene ether 4%, fat alcohol alkoxy compound 3%, PO-EO block copolymer 2%, isobutanol 2% is put in high speed shear Mixingemulsificationmachine, i.e. obtains oil phase after high speed shear. In another high speed shear Mixingemulsificationmachine, input isopropanol 3%, xanthan gum 0.3%, deionized water are mended to 100%, and mixing is all I.e. obtain aqueous phase after even, aqueous phase is squeezed into head tank, and under conditions of high speed shear, be added drop-wise in oil phase, then add triethylamine tune Joint pH value is to 4-7 and continues to shear 10-30 minute, obtains aqueous emulsion, and aqueous emulsion contains 55% reactive compound.
Seven, microemulsion
Embodiment 9:25% (20.0%+5.0%) microemulsion
Former medicine is dissolved in a solvent, adds surfactant, be uniformly mixed as oil phase.By water-soluble component and water It is mixed to prepare aqueous phase, then oil phase is added in aqueous phase or aqueous phase is added in oil phase, stirring while adding, prepare microemulsion.Wherein, Reactive compound 25% (etoxazole 20% and Amitraz 5%), Ketohexamethylene 1.5%, N,N-dimethylacetamide 5%, alkyl phenol Polyoxyethylene ether 7%, fatty alcohol-polyoxyethylene ether 4%, ethylene glycol 3%, distilled water is mended to 100%.The process equipment of microemulsion Mainly stir mixing kettle.
Eight, suspension emulsion
Embodiment 10:40% (15.0%+25.0%) suspension emulsion
40% reactive compound (15.0% etoxazole and 25.0% Amitraz compositions) suspension emulsion preparation method: by double first Amidine 50.0%, EO/PO block polyether 2.0%, methyl naphthalene sulfonate formaldehyde condensate 3.0%, acrylate homopolymer sodium salt 1.0%, glycerol 2.0%, xanthan gum 0.3%, potassium sorbate 0.1%, polyether antifoam agent 0.1%, deionized water are mended to 100% It is sufficiently mixed, then puts into high shear homogeneous emulsifying machine high speed shearing corase grind and homogenizing, then pump is to sand milling in sand mill, sand milling To certain particle diameter, after refiltering, i.e. obtain suspending agent.Containing 50.0% Amitraz in suspending agent, D90 particle diameter is 3-5 micron.Again will The 50.0% Amitraz suspending agent of 50.0%, etoxazole 15.0%, turpentine-based vegetable oil 15.0%, fatty alcohol-polyoxyethylene ether 7.0%, glycerol 3.0%, sodium carboxymethyl cellulose 0.3%, polyether antifoam agent 0.1%, deionized water are mended to 100% the most mixed Closing, high speed shear, emulsifying, filtration i.e. prepare suspension emulsion, the suspension emulsion reactive compound containing 40% content.
Nine, cream
Embodiment 11:70% (30%+40.0%) cream
By 70% reactive compound (30.0% etoxazole and 40.0% Amitraz compositions), 5% alkylbenzenesulfonate, 2% fatty alcohol-polyoxyethylene ether, 3% Oleum Ricini ethylene oxide adduct and derivant, 1% epoxy soybean oil, 10%N, N- Dimethyl acetylamide, heavy aromatic solvent oil adds to 100% weight, is sufficiently mixed, and obtains 70% cream after stirring and dissolving is complete.
Indoor biological active determination test
The Application Example of the present invention is the method using indoor biological determination of activity and field control effectiveness test to combine.First By indoor biological determination of activity, the co-toxicity coefficient (CTC) after clear and definite two kinds of medicaments are compounding by a certain percentage, on this basis, Carry out field control effectiveness test again and verify its synergistic effect.Co-toxicity passes judgment on the Sun Pei cloud method that uses: calculate co-toxicity coefficient (CTC), The co-toxicity effect of two kinds of medicaments is passed judgment on CTC value.
The toxicity index of the toxicity index × A of theoretical mixed toxicity index (TTI)=A content (%)+B in mixed × B content (%) in mixed
Co-toxicity coefficient (CTC) if > 120, show there is potentiation；If < 80, it is shown to be antagonism；If >=80, and≤ 120, it is shown to be summation action.
One, etoxazole and the Amitraz mixture indoor virulence to citrus red mite
Test method: activity test is according to the NY/T11547.7-2006 insecticide combination effect criteria for classifying, according to effectively Composition etoxazole (A): Amitraz (B) quality proportioning is 50: 1,30: 1,20: 1,10: 1,5: 1,1: 1,1: 4,1: 10,1: 20,1: 30,1: 50,1: 70 test, measure its common poison that citrus red mite (Panonchus citri Mc Gregor) is become demodicid mite Coefficient.
Result of the test shows: Amitraz is notable with etoxazole mixture preventing and treating citrus red mite synergistic effect.Etoxazole is with double Carbonamidine mixture proportioning is when 50: 1～1: 70, and co-toxicity coefficient is all higher than 120, shows there is notable synergistic effect (being shown in Table 1).
Table 1, etoxazole and the Amitraz mixture indoor virulence to citrus red mite
Two, etoxazole and the Amitraz mixture indoor virulence to Tetranychus urticae
Test method: activity test is according to the NY/T11547.7-2006 insecticide combination effect criteria for classifying, according to effectively Composition etoxazole (A): Amitraz (B) quality proportioning is 50: 1,30: 1,20: 1,10: 1,5: 1,1: 1,1: 4,1: 10,1: 20,1: 30,1: 50,1: 70 test, measure its common poison system that Tetranychus urticae (Tetranychus urticae Koch) is become demodicid mite Number.
Result of the test shows: Amitraz is notable with etoxazole mixture preventing and treating Tetranychus urticae synergistic effect.Etoxazole and Shuan Jia Amidine mixture proportioning is when 50: 1～1: 70, and co-toxicity coefficient is all higher than 120, shows there is notable synergistic effect (being shown in Table 2).
Table 2, etoxazole and the Amitraz mixture indoor virulence to Tetranychus urticae
Field control effectiveness test
Test one:
Application Example 1, embodiment 2, embodiment 3, embodiment 5, embodiment 6 field control panonychus citri.
1, test processes: the embodiment preparation used in this test is all provided with 3 different disposal concentration, and comparison medicament is respectively Single dose 11% etoxazole SC and 20% Amitraz EC, and set clear water blank.Each process repeats for 3 times, each community 3 strain Citrus chachiensis Hort. Tangerine.
2, test method:
Every strain mandarin tree 5 branches of drop labelling before often processing medicine, investigation labelling branch is lived on the Zhang Lao's leaf of top 5 demodicid mite (if including into demodicid mite and demodicid mite) quantity, the residual borer population on 3,7,14 days investigation labelling branches after medicine.
Calculate prevention effect (being shown in Table 3).
Table 3, different agents process panonychus citri field control effect
Test two:
Application Example 1, embodiment 2, embodiment 3, embodiment 5, embodiment 6 field control Fructus Fragariae Ananssae Tetranychus urticae.
1, test processes: the embodiment preparation used in this test is all provided with 2 different disposal concentration, and comparison medicament is respectively Single dose 11% etoxazole SC and 20% Amitraz EC, and set clear water blank.Each process repeats for 3 times, each community 30m2。
2, test method:
The method using fixed point investigation.Each community uses the investigation of diagonal five point taking method, every fixed 2 strains, every strain investigation note Carry new, in, the most each 1 compound leaf (positive and negative investigation) survival demodicid mite (if becoming demodicid mite and demodicid mite) quantity.Before dispenser, carry out demodicid mite mouth radix adjust Looking into, after dispenser, 3,7,14d respectively investigate 1 labelling strain demodicid mite number alive, calculate prevention effect (being shown in Table 4).
Table 4 different agents processes Fructus Fragariae Ananssae Tetranychus urticae field control effect
The data result of table 3 and table 4 shows: etoxazole and Amitraz compositions are to panonychus citri, Fructus Fragariae Ananssae Tetranychus urticae Having obvious potentiation, the prevention effect of compositions is excellent, and prevention effect is all better than single dose kind, has good application It is worth.
Although in the present invention, reactive compound etoxazole and Amitraz are known compound, and the pest control of each component Performance is by those skilled in the art's basic understanding, but compounds desired to realize the present invention by above-mentioned reactive compound More excellent pest control effect, for those skilled in the art's then right and wrong it will be apparent that applicant has paid substantial amounts of wound The property made is worked.

Claims (10)

1. the Pesticidal combination comprising etoxazole and Amitraz, it is characterised in that described compositions comprises etoxazole with double The weight ratio of carbonamidine, etoxazole and Amitraz is 50:1～1:70.
Pesticidal combination the most according to claim 1, it is characterised in that the weight ratio of etoxazole and Amitraz be 20:1～ 1:20.
Pesticidal combination the most according to claim 1, it is characterised in that the weight ratio of etoxazole and Amitraz be 5:1～ 1:4.
Pesticidal combination the most according to claim 1, it is characterised in that also include pharmaceutical adjunct, by percentage to the quality The weight sum of etoxazole and Amitraz accounts for the 1-90% of total composition.
Pesticidal combination the most according to claim 4, it is characterised in that etoxazole and Amitraz by percentage to the quality Weight sum accounts for the 1-60% of total composition.
Pesticidal combination the most according to claim 4, it is characterised in that described pharmaceutical adjunct selected from wetting agent, dispersant, Emulsifying agent, cosurfactant, thickening agent, solvent, cosolvent, antifreezing agent, preservative, disintegrating agent, stabilizer, film former, one-tenth One or more in wafer, pH acid-base modifier, defoamer, coloring agent, filler and water.
Pesticidal combination the most according to claim 1, it is characterised in that described Pesticidal combination is prepared as the dosage form of preparation For wettable powder, soluble powder, water dispersible granules, aqueous emulsion, microemulsion, microcapsule suspending agent, suspending agent, suspension emulsion or breast Oil.
8. the purposes of Pesticidal combination as described in any one of claim 1-7, it is characterised in that for preventing and treating the demodicid mite class evil of plant Worm.
Purposes the most according to claim 8, it is characterised in that described plant is Citrus, Cotton Gossypii, Mulberry, Fructus Mali pumilae, Fructus Fragariae Ananssae, peppery Green pepper, Fructus Solani melongenae, Kidney bean, Semen vignae sinensis and Camellia sinensis.
Purposes the most according to claim 8, it is characterised in that described mite pest is Panonychus citri, Tetranychus urticae, Cinnabaris One or more in tetranychid, Citrus blister mite and yellow tea mite.
CN201610622559.7A 2016-07-29 2016-07-29 Containing etoxazole and the Pesticidal combination of Amitraz and preparation thereof and application Pending CN106234376A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109105369A (en) * 2018-10-19 2019-01-01 佛山市南海东方澳龙制药有限公司 Amitraz milk oil and preparation method thereof
CN112741083A (en) * 2019-10-31 2021-05-04 江苏七洲绿色化工股份有限公司 Trifluralin missible oil

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1102760A (en) * 1993-09-22 1995-05-24 住友化学工业株式会社 Assignment of priority rights
JPH07179308A (en) * 1993-12-21 1995-07-18 Yashima Chem Ind Co Ltd Composite acaricide composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1102760A (en) * 1993-09-22 1995-05-24 住友化学工业株式会社 Assignment of priority rights
JPH07179308A (en) * 1993-12-21 1995-07-18 Yashima Chem Ind Co Ltd Composite acaricide composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109105369A (en) * 2018-10-19 2019-01-01 佛山市南海东方澳龙制药有限公司 Amitraz milk oil and preparation method thereof
CN112741083A (en) * 2019-10-31 2021-05-04 江苏七洲绿色化工股份有限公司 Trifluralin missible oil

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Application publication date: 20161221