CN103815903A - Portable prostate cancer screening and scanning equipment - Google Patents
Portable prostate cancer screening and scanning equipment Download PDFInfo
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- CN103815903A CN103815903A CN201210461408.XA CN201210461408A CN103815903A CN 103815903 A CN103815903 A CN 103815903A CN 201210461408 A CN201210461408 A CN 201210461408A CN 103815903 A CN103815903 A CN 103815903A
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Abstract
The invention discloses portable prostate cancer screening and scanning equipment which comprises a transrectal electrode array device. A data line of the transrectal electrode array device is connected with a computer through a signal amplifier, electric current of a certain intensity and frequency is injected to the prostate and evoked potential signals generated by the injected electric current are detected through the transrectal electrode array device, and the injected electric current and the detected evoked potential signals are analyzed and processed in real time by a computer so as to output a distribution diagram of three-dimensional prostate electrical impedances for screening and scanning of prostate cancers. By the aid of the transrectal electrode array device, controllable electric current injection of prostate tissues is realized, the evoked potential signals, in a prostate area, of the injected electric current are acquired, amplified and inputted into the computer for data processing and analyzing to finally output the distribution diagram of three-dimensional prostate electrical impedances for screening and scanning of prostate cancers, and consequently low cost and rapidness in screening and diagnosis of the prostate cancers are realized.
Description
Technical field
The invention belongs to bio-electrical impedance imaging technical field, relate to one portable carcinoma of prostate screening scanning device cheaply.
Background technology
Carcinoma of prostate is the urinary system malignant tumor of serious harm elderly men health.Its sickness rate becomes ascendant trend in recent years.In American-European countries, carcinoma of prostate is the malignant tumor that sickness rate is the highest, and its mortality rate is only second to pulmonary carcinoma.1992, the white American's carcinoma of prostate sickness rate was about 404.5/10 ten thousand population male, Black people Ke Da 477.2/10 ten thousand population male.China's carcinoma of prostate sickness rate is about 2,41/,100,000 population male, is starkly lower than western countries, but along with the improvement of material life, the prolongation of the average life span, China's carcinoma of prostate sickness rate is obviously in rising trend.
Prostate biopsy biopsy is the main detection means that carcinoma of prostate is finally made a definite diagnosis.Prostate biopsy biopsy is a kind of traumatic inspection, and before examination by centesis, the prostate specific antigen analysis (PSA) of conventionally applying in serum is the means that detect as carcinoma of prostate Preliminary screening.Prostate specific antigen analysis result becomes positive patient further to carry out prostate biopsy biopsy to make a definite diagnosis carcinoma of prostate again.But the false positive rate that prostate specific antigen checks is up to 30%.In other words in the middle of the male that, prostate specific antigen inspection notes abnormalities, there is 1/3 people not have carcinoma of prostate.Cause that prostate specific antigen horizontal abnormality raises a lot of because have, comprising prostate infection, benign prostatic hyperplasia and recent bladder infection etc.Therefore, urology department is badly in need of reliably a kind of clinically, harmless, the means that economic carcinoma of prostate screening detects.
Review of Electrical Impedance Tomography (Electrical Impedance Tomography, EIT) is a new generation's effective not damaged functional imaging technology occurring in the eighties.EIT technology is the electrode array by being disposed at body surface, the tissue that extraction and Human Physiology, pathological state are relevant or the electrical characteristics information of organ.The information that the electrical conductivity of biological tissue contains a large amount of response organizations, organ physiological status and function, electrical impedance tomography technology (EIT) is that the electrical conductivity (or resistivity) presenting in the time that low frequency safe current flows through biological tissue is the noinvasive imaging technique research according to carrying out.EIT technology can reflect the anatomical structure of target object, the more important thing is, is expected to provide functional image result.This is that X-CT, other imaging technique such as ultrasonic cannot be compared.Adopt X ray obtain the X-CT of human body faultage image and adopt the ultrasonic technique of assembling the velocity of sound that organization of human body image is provided, all belong to second filial generation imaging technique, this structural images only has and occurs when disease, and form organic disease, and when the structure of linked groups and organ changes (as formed a certain size tumor), just can provide diagnostic result.It provides clinical diagnosis foundation take the constructive variations of determining generation as doctor.The generation of disease, the functional variation of linked groups and organ, often prior to organic disease, after certain functional compensation phase (or incubation period), develops into organic disease, occurs that tissue and organ structure change.If in incubation period or the functional compensation phase of disease,, before tissue or organ structure variation appearance, detect in time and confirm the functional variation of this tissue and organ, highly beneficial for generaI investigation, prevention and the diagnoses and treatment of relevant disease.
Research shows, the conductivity of tissue and the conductivity of normal structure that canceration occurs in prostata tissue have significant difference.Therefore, if can utilize EIT to obtain the anti-scattergram of three-dimensional resistance of prostata tissue, whether prostata tissue there is canceration so, if had, the position of canceration and size can be by identifying on the three-dimensional distribution map of prostata tissue, thereby realize the effect of carcinoma of prostate initial screening diagnosis.
Summary of the invention
The object of the present invention is to provide a kind of simple, economic, efficient carcinoma of prostate screening scanning device to realize the initial screening diagnosis of carcinoma of prostate.
The present invention realizes like this, a kind of portable carcinoma of prostate screening scanning device, comprise a per rectum electrode array device, by described per rectum electrode array device, prostata tissue being carried out to controlled electric current injects, and gather the bring out electric potential signal of injection current in prostate region simultaneously, after amplifying, signal is input to processing and the analysis of in computer, carrying out data, finally the scattergram for the three-dimensional prostate electrical impedance of the screening scanning of carcinoma of prostate by computer export.
Described per rectum electrode array device comprises the cylindrical shape transrectal probe of a hollow, is evenly laid with 128 electrodes at described transrectal probe outer surface; 128 described electrodes are divided into 8 groups, and every group forms an annular electrode group, and each annular electrode group is made up of 16 equally distributed described electrodes.
Be provided with a semi-cylindrical hill that is used for associated electrodes array and prostatic relative position on the surface of described transrectal probe.
Described transrectal probe diameter is 20mm, and length is 200mm.
Described transrectal probe is that plastic cement is made.
The connection wire of described electrode stretches out by the space of the transrectal probe inside through described.
The present invention carries out controlled electric current by described per rectum electrode array device to prostata tissue and injects, and gather the bring out electric potential signal of injection current in prostate region simultaneously, after amplifying, signal is input to processing and the analysis of in computer, carrying out data, the finally scattergram for the three-dimensional prostate electrical impedance of the screening scanning of carcinoma of prostate by computer export, thereby realized rapidly, carcinoma of prostate is screened, diagnosed, and cost is low.
Accompanying drawing explanation
Fig. 1 is the system construction drawing of the carcinoma of prostate screening scanning device that provides of the embodiment of the present invention;
Fig. 2 is the schematic side view of the per rectum electrode array device that provides of the embodiment of the present invention;
Fig. 3 is the schematic top plan view of the per rectum electrode array device that provides of the embodiment of the present invention;
Fig. 4 is the principle schematic of the bio-electrical impedance imaging that provides of the embodiment of the present invention.
The specific embodiment
Below in conjunction with example, substantive distinguishing features of the present invention and advantage are further described, but the present invention is not limited to listed embodiment.
The present invention is based on human-body biological electrical impedance imaging technology, has merged up-to-date per rectum electrode array designs, and up-to-date electrical impedance imaging algorithm and up-to-date human organ modeling technique design.
The present invention realizes like this, a kind of portable carcinoma of prostate screening scanning device, comprise a per rectum electrode array device, by described per rectum electrode array device, prostata tissue being carried out to controlled electric current injects, and gather the bring out electric potential signal of injection current in prostate region simultaneously, after signal amplifies, be input to processing and the analysis of in computer, carrying out data, finally output is for the scattergram of the three-dimensional prostate electrical impedance of the screening scanning of carcinoma of prostate.
Shown in Figure 1, in the present invention, described per rectum electrode array device 8 is connected with computer by signal amplifier, described signal amplifier is also connected with the ground of a reference electrode while bringing out electric potential signal as per rectum electrode array device 8 record and wears 9, injected the controlled electric current of some strength and frequency to prostata tissue by the pair of electrodes of the per rectum electrode array device 8 described in its plug-in control by described computer, and control bringing out after electric potential signal amplifies by signal amplifier that injection battery that other electrode in described per rectum electrode array device 8 records produces in prostate region and enter computer through data wire, use its built-in specific software program bio-electrical impedance algorithm to carry out real-time data analysis and process to the electric potential signal that brings out of injection current and measurement by described computer, finally export the scattergram of three-dimensional prostate electrical impedance, for the screening scanning of carcinoma of prostate.
Shown in Figure 2, described per rectum electrode array device 8 comprises the cylindrical shape transrectal probe 1 of a hollow, is evenly laid with 128 electrodes 2 at described transrectal probe 1 outer surface; 128 described electrodes are divided into 8 groups, and every group forms an annular electrode group, and each annular electrode group is made up of 16 equally distributed described electrodes.The arrangement of described annular electrode group as shown in Figure 2, begin from the insertion end of described transrectal probe 1, from described outfan 7, be evenly laid in described transrectal probe 1 surface, see the first annular electrode group 4, the four annular electrode groups 5 and the 7th annular electrode group 6.Shown in Figure 3,16 electrodes of each described annular electrode group are uniformly distributed, and form described annular electrode group.
Described outfan 7 connects for the rear described signal amplifier of electrode cable output.Shown in Figure 1 again, wherein, the signal of each annular electrode group collection is inputted respectively an input of described signal amplifier, and described signal amplifier is provided with 8 inputs.
Shown in Figure 2, be provided with a semi-cylindrical hill 3 that is used for associated electrodes array and prostatic relative position on the surface of described transrectal probe 1 near outfan 7.
Described transrectal probe 1 diameter is 20mm, and length is 200mm.
Described transrectal probe 1 is made for plastic cement.
The connection wire of described electrode 2 stretches out by the space of transrectal probe 1 inside through described.
Below, principle of the present invention and work process are described as follows:
When the structure of prostate model, first from the prostatic medical image of patient, construct prostatic geometric model, in patient's the non-existent situation of medical image, can employing system in integrated general prostate model substitute the distinctive model of patient.Current intensity is 1mA electric current by the electrode injection in per rectum electrod-array in prostate and tissue around, and the current potential that injection current produces measures by other electrode pair in per rectum electrod-array.Algorithm by bio-electrical impedance constructs the distribution of electrical impedance in three-dimensional prostate model by the potential data of known injection current parameter and measurement.It is significantly different that the prostata tissue of canceration and the electrical impedance of normal prostata tissue have, because the position of the prostata tissue of canceration and size can distinguish from the anti-scattergram of three-dimensional resistance.
In the present invention, the building method of prostate model used is realized by the proprietary geometric model conformation function of the patient module being stored in described calculating.This functional module can construct the proprietary prostatic geometric model of patient from patient's medical image data (ultrasonic, CT or MR image).In patient's prostate model construction process, first identify the border of prostata tissue on each frame medical image by patient's image data being carried out to medical image segmentation, then applying three-dimensional restructing algorithm prostatic surface model of reconstruct from the border identifying; The volume that the what is called of the prostatic surface model of sealing is got up is exactly the volume-based model of prostatic homogenizing, finally with three-D volumes subdivision algorithm, prostatic volume-based model is carried out to tetrahedron subdivision, thereby generate the required prostatic FEM (finite element) model of three-dimensional of EIT algorithm development.
In the present invention, the distributed in three dimensions of prostate electrical impedance realizes by bio-electrical impedance imaging algorithm.
Shown in Figure 4, when use, first described per rectum electrode array device is arranged in to the surface of organ to be imaged, then, by computer program control, the electric current of some strength and frequency is injected in organ to be imaged by the pair of electrodes in per rectum electrode array device, what injection current produced brings out electric potential signal and can measure by other electrodes of described per rectum electrode array device.Become the algorithm can be from the position of known injection current by being built in bio-electrical impedance in computer, the electric potential signal bringing out when the injection current of intensity and frequency and measurement calculates the distributed in three dimensions of bio-electrical impedance in this organ.
In the present invention, bio-electrical impedance imaging is at last in the additional certain electric current I of organism, and the impedance Ω that carrys out reconstruct organism by recording the information about power V in the organism external world distributes.In the embodiment of the present invention, adopt the injection current of 1mA, by described per rectum electrode array device, the anti-scattergram of prostate three-dimensional resistance of obtaining.Its principle can illustrate by the EIT system of simple 16 electrodes in Fig. 2.
In this system, 16 electrodes are evenly distributed on the border of circular biological tissue.The a pair of electrode that is distributed in biological tissue both sides is used to injection current I, and adjacent electrode pair is used to measure the current potential V that injection current causes.All adjacent electrodes on voltage all measured after, the electrode pair of injection current is transformed to contiguous their electrode pair, and injection current again.Same, adjacent electrode pair is used to measure the current potential that injection current causes.This process just goes in this manner, until obtain all possible voltage pair.For the mode of any injection current, the governing equation of current potential can be written as:
Wherein, σ is the bio-impedance of biological tissue,
be the current potential that injection current causes, ω is the frequency of injection current.The in the situation that of low frequency, governing equation above can be written as following canonical form
The problem that EIT will solve is the problem of a system incentive, i.e. the intensity of injection current and location aware, and the Potential distribution that injection current causes is known, but distribution of impedance the unknown of biological tissue.
Owing to measuring limited (general tens of the electrode number of the Potential distribution that injection current causes, 128 electrode measurement systems in the present invention, are designed), and the impedance parameter huge amount of the biological tissue that generation solves, the problem that generation solves is an ill-conditioning problem.In the present invention, adopt the method for Tikhonov regularization to seek the solution of an optimum approximate solution as the ill-conditioning problem in above-mentioned bio-electrical impedance imaging.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. a portable carcinoma of prostate screening scanning device, it is characterized in that, comprise a per rectum electrode array device, by described per rectum electrode array device, prostata tissue being carried out to controlled electric current injects, and gather the bring out electric potential signal of injection current in prostate region simultaneously, after amplifying, signal is input to processing and the analysis of in computer, carrying out data, finally the scattergram for the three-dimensional prostate electrical impedance of the screening scanning of carcinoma of prostate by computer export.
2. portable carcinoma of prostate screening scanning device according to claim 1, is characterized in that, described per rectum electrode array device comprises the cylindrical shape transrectal probe of a hollow, is evenly laid with 128 electrodes at described transrectal probe outer surface; 128 described electrodes are divided into 8 groups, and every group forms an annular electrode group, and each annular electrode group is made up of 16 equally distributed described electrodes.
3. portable carcinoma of prostate screening scanning device according to claim 2, is characterized in that, is provided with a semi-cylindrical hill that is used for associated electrodes array and prostatic relative position on the surface of described transrectal probe.
4. according to the portable carcinoma of prostate screening scanning device described in claim 2 or 3, it is characterized in that, described transrectal probe diameter is 20mm, and length is 200mm.
5. portable carcinoma of prostate screening scanning device according to claim 4, is characterized in that, described transrectal probe is that plastic cement is made.
6. according to the portable carcinoma of prostate screening scanning device described in claim 2 or 3, it is characterized in that, the connection wire of described electrode stretches out by the space of the transrectal probe inside through described.
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| CN201210461408.XA CN103815903A (en) | 2012-11-16 | 2012-11-16 | Portable prostate cancer screening and scanning equipment |
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| CN201210461408.XA CN103815903A (en) | 2012-11-16 | 2012-11-16 | Portable prostate cancer screening and scanning equipment |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015189727A3 (en) * | 2014-06-11 | 2016-04-07 | Akern S.R.L. | A device for checking the status of integrity of a cavity of a patient |
| CN106037650A (en) * | 2016-06-13 | 2016-10-26 | 河北工业大学 | Hybrid variation bioelectrical impedance imaging method |
| CN110141236A (en) * | 2019-05-22 | 2019-08-20 | 重庆邮电大学 | Frequency for impedance imaging becomes adaptive impedance collection control device and method |
| CN110353680A (en) * | 2019-07-29 | 2019-10-22 | 中国医学科学院生物医学工程研究所 | Transrectal probe, Electrical Impedance Tomography System and method |
| EP3624685A4 (en) * | 2017-05-16 | 2021-03-10 | Beth Israel Deaconess Medical Center, Inc. | Needle impedance electromyography and electrical impedance imaging for enhanced muscle diagnostics |
| RU212641U1 (en) * | 2021-12-22 | 2022-08-01 | Общество с ограниченной ответственностью "Международный Консультативный Диагностический Медицинский центр" (ООО "МКЦД") | DEVICE FOR MEASURING THE ELECTRICAL CONDUCTIVITY OF THE SKIN |
-
2012
- 2012-11-16 CN CN201210461408.XA patent/CN103815903A/en active Pending
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| A BORSIC, ET AL.: "Sensitivity study and optimization of a 3D electric impedance tomography prostate probe", 《PHYSIOL MEAS.》, vol. 30, no. 6, 30 June 2009 (2009-06-30), XP020161071 * |
| JACQUES JOSSINET, ET AL.: "Electrical impedance endotomography", 《PHYS. MED. BIOL.》, vol. 47, 31 December 2002 (2002-12-31) * |
| 刘阳等: "前列腺电特性成像研究现状及展望", 《生物医学工程学杂志》, vol. 29, no. 5, 31 October 2012 (2012-10-31) * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015189727A3 (en) * | 2014-06-11 | 2016-04-07 | Akern S.R.L. | A device for checking the status of integrity of a cavity of a patient |
| CN106037650A (en) * | 2016-06-13 | 2016-10-26 | 河北工业大学 | Hybrid variation bioelectrical impedance imaging method |
| CN106037650B (en) * | 2016-06-13 | 2018-12-28 | 河北工业大学 | A kind of mixing variation biological electrical impedance tomography method |
| EP3624685A4 (en) * | 2017-05-16 | 2021-03-10 | Beth Israel Deaconess Medical Center, Inc. | Needle impedance electromyography and electrical impedance imaging for enhanced muscle diagnostics |
| US11730410B2 (en) | 2017-05-16 | 2023-08-22 | Beth Israel Deaconess Medical Center, Inc. | Needle impedance electromyography and electrical impedance imaging for enhanced muscle diagnostics |
| CN110141236A (en) * | 2019-05-22 | 2019-08-20 | 重庆邮电大学 | Frequency for impedance imaging becomes adaptive impedance collection control device and method |
| CN110141236B (en) * | 2019-05-22 | 2022-11-25 | 重庆邮电大学 | Frequency-varying self-adaptive impedance acquisition control device and method for impedance imaging |
| CN110353680A (en) * | 2019-07-29 | 2019-10-22 | 中国医学科学院生物医学工程研究所 | Transrectal probe, Electrical Impedance Tomography System and method |
| RU212641U1 (en) * | 2021-12-22 | 2022-08-01 | Общество с ограниченной ответственностью "Международный Консультативный Диагностический Медицинский центр" (ООО "МКЦД") | DEVICE FOR MEASURING THE ELECTRICAL CONDUCTIVITY OF THE SKIN |
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Application publication date: 20140528 |