CN102552035A - Method for preparing pharmaceutic adjuvant and pellet cores via microcrystalline cellulose and starch by aid of physical mixing method - Google Patents
Method for preparing pharmaceutic adjuvant and pellet cores via microcrystalline cellulose and starch by aid of physical mixing method Download PDFInfo
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- CN102552035A CN102552035A CN2012100241615A CN201210024161A CN102552035A CN 102552035 A CN102552035 A CN 102552035A CN 2012100241615 A CN2012100241615 A CN 2012100241615A CN 201210024161 A CN201210024161 A CN 201210024161A CN 102552035 A CN102552035 A CN 102552035A
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Abstract
Disclosed is a method for preparing pharmaceutic adjuvant and pellet cores via microcrystalline cellulose and starch by the aid of a physical mixing method. Steps of the method include: a, preparing a mother core; b, feeding the mother core into a multifunctional fluidized bed dryer to be dried at the temperature of 50 DEG C, and granulating by a sieve with 40 meshes to 60 meshes; c, enlarging the mother core; and d, feeding materials to the multifunctional fluidized bed dryer, setting air inlet temperature of 40 DEG C at first, adjusting the air inlet temperature to 70 DEG C after the temperature of the materials rises to 25 DEG C, cooling the materials after the temperature of the materials rises to 50 DEG C, sieving the materials by the aid of a sieve with 24 meshes to 35 meshes, and then obtaining the pharmaceutic adjuvant and the pellet cores. The method has the advantages that the microcrystalline cellulose is round physically, process is simple, quality is easy to be controlled, adhesive is purified water, other substances are omitted, purification of the cellulose is high, and surface smoothness of the pellet cores under a microscope is high.
Description
Technical field
The present invention relates to a kind of method for preparing medicinal fine pellet core (microcrystalline Cellulose type), relate in particular to a kind of physical mixed method is prepared pharmaceutic adjuvant medicinal fine pellet core (microcrystalline Cellulose type) by microcrystalline Cellulose, starch method.
Background technology
Medicinal fine pellet core (microcrystalline Cellulose type) (Sugar Sphere) is to make by microcrystalline Cellulose physics is round as a ball.Medicinal fine pellet core (microcrystalline Cellulose type) is white or off-white color subcircular granule.
Medicinal fine pellet core is a kind of dosage decentralized; Diameter is generally the spherical or type spheric oral formulations of 0.5-1.5mm; Add controlled slowly releasing adjuncts and can make slow-release micro-pill ball core, wrapping enteric coating is enteric coated micropill ball core, in the capsulae vacuus of can packing into or be pressed into tablet and use; Also can be directly as granule or slow controlled release granule; Slow controlled release granule, the advantage that fine pellet core has in preparation process, pharmacological action is that other dosage forms can't realize, in medicine tabletting and drug coating its advantage of having many other oral formulations to compare of aspect tool such as slow release control particularly: 1. take the back extensive, be evenly distributed in gastrointestinal tract; Big at gastrointestinal surface distributed area, thus bioavailability improved, reduce or eliminate medicine gastrointestinal is stimulated; 2. the fine pellet core agent is in the influence of the gastrointestinal transhipment unable to take food thing conveying rhythm and pace of moving things, gastric emptying; 3. the release rule of slow controlled release micro pill ball core is than the tablet favorable reproducibility, and indivedual fine pellet cores are to the not serious influence of the drug release behavior of total formulation; 4. can the fine pellet core of different rate of releasing drug be dressed up capsule in proportion, to satisfy different needs; 5. the compound capsule of being made up of different fine pellet cores has stability preferably, reduces the interaction between the medicine; 6. fine pellet core is better mobile, helps preparation packing or further molding.
Summary of the invention
The object of the present invention is to provide a kind of physical mixed method to prepare the method for pharmaceutic adjuvant medicinal fine pellet core by microcrystalline Cellulose, starch; With the microcrystalline Cellulose is raw material; With the purified water is adhesive, in omnipotent spheronizator, makes pharmaceutic adjuvant medicinal fine pellet core (microcrystalline Cellulose type).
The present invention realizes like this, it is characterized in that method step is:
A, open multi-functional circular knitting machine, drop into microcrystalline Cellulose 500g, put in the multifunctional rolling circular knitting machine, adjustment rotary speed 450r/min, hydrojet speed 25 r/min, atomizing pressure 1.5bar spray into deionized water, make the powder-stuck balling, process parent nucleus;
B, put into 50 ℃ of oven dry in the multifunctional fluidized bed machine, 40-60 eye mesh screen granulate;
C, dried parent nucleus are put in the multifunctional rolling circular knitting machine again, set rotary speed 450r/min, hydrojet speed 25 r/min, atomizing pressure 1.5bar, spray into deionized water, make parent nucleus become big;
D, material is put into multifunctional fluidized bed machine; Earlier setting EAT is 40 ℃, adjustment EAT to 70 ℃ when treating that temperature of charge rises to 25 ℃, cooling when treating that temperature of charge arrives 50 ℃; Cross 24-35 eye mesh screens, make pharmaceutic adjuvant medicinal fine pellet core (microcrystalline Cellulose type).
Advantage of the present invention is: microcrystalline Cellulose physics is round as a ball, and technology is simple, and quality is controlled easily, and adhesive is a purified water, other material that do not induce one, and cellulose purity is high, and microscopically ball wicking surface smoothness is high.
The specific embodiment
Open multi-functional circular knitting machine, drop into 500g starch microcrystalline cellulose mixt, put in the multifunctional rolling circular knitting machine, adjustment rotary speed 450r/min, hydrojet speed 25 r/min, atomizing pressure 1.2bar.Spray into deionized water, make the powder-stuck balling, process parent nucleus.The parent nucleus of processing is put into 50 ℃ of oven dry in the multifunctional fluidized bed machine.40-60 eye mesh screen granulate.Dried parent nucleus is put in the multifunctional rolling circular knitting machine again, rotary speed 450r/min, hydrojet speed 25 r/min, atomizing pressure 1.2bar.Spray into purified water, make parent nucleus become big.Material after amplifying is put into multifunctional fluidized bed machine, and setting EAT earlier is 40 ℃, adjustment EAT to 70 ℃ when treating that temperature of charge rises to 25 ℃, and 24-35 eye mesh screens are crossed in cooling when treating that temperature of charge arrives 50 ℃.
Claims (1)
1. a physical mixed method prepares the method for pharmaceutic adjuvant medicinal fine pellet core by microcrystalline Cellulose, starch, it is characterized in that method step is:
A, open multi-functional circular knitting machine, drop into microcrystalline Cellulose 500g, put in the multifunctional rolling circular knitting machine, adjustment rotary speed 450r/min, hydrojet speed 25 r/min, atomizing pressure 1.5bar spray into deionized water, make the powder-stuck balling, process parent nucleus;
B, put into 50 ℃ of oven dry in the multifunctional fluidized bed machine, 40-60 eye mesh screen granulate;
C, dried parent nucleus are put in the multifunctional rolling circular knitting machine again, set rotary speed 450r/min, hydrojet speed 25 r/min, atomizing pressure 1.5bar, spray into deionized water, make parent nucleus become big;
D, material is put into multifunctional fluidized bed machine, setting EAT earlier is 40 ℃, adjustment EAT to 70 ℃ when treating that temperature of charge rises to 25 ℃, and 24-35 eye mesh screens are crossed in cooling when treating that temperature of charge arrives 50 ℃, make the pharmaceutic adjuvant medicinal fine pellet core.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100241615A CN102552035A (en) | 2012-02-04 | 2012-02-04 | Method for preparing pharmaceutic adjuvant and pellet cores via microcrystalline cellulose and starch by aid of physical mixing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012100241615A CN102552035A (en) | 2012-02-04 | 2012-02-04 | Method for preparing pharmaceutic adjuvant and pellet cores via microcrystalline cellulose and starch by aid of physical mixing method |
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| CN102552035A true CN102552035A (en) | 2012-07-11 |
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| CN2012100241615A Pending CN102552035A (en) | 2012-02-04 | 2012-02-04 | Method for preparing pharmaceutic adjuvant and pellet cores via microcrystalline cellulose and starch by aid of physical mixing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104548115A (en) * | 2014-12-31 | 2015-04-29 | 深圳市国源医药科技有限公司 | Pharmaceutic adjuvant microcrystalline cellulose pellet core and preparation method thereof |
| CN104607102A (en) * | 2014-12-23 | 2015-05-13 | 江苏金石研磨有限公司 | A manufacturing method of a high-strength small-size mill ball |
| CN104983717A (en) * | 2015-06-04 | 2015-10-21 | 湖北生物医药产业技术研究院有限公司 | Sodium prasterone sulfate sustained-release capsule and preparation method thereof |
| CN105435240A (en) * | 2014-09-29 | 2016-03-30 | 天津尖峰弗兰德医药科技发展有限公司 | Medicinal pellet core and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1579494A (en) * | 2004-01-13 | 2005-02-16 | 贵州益佰制药股份有限公司 | Micropill of traditional Chinese medicine and its preparation method |
| CN102166361A (en) * | 2011-04-19 | 2011-08-31 | 杭州高成生物营养技术有限公司 | Quick-collapsed type pellet core and preparation method thereof |
| CN102319181A (en) * | 2011-09-08 | 2012-01-18 | 广东大华农动物保健品股份有限公司 | Enveloping process for micro-capsule animal medicament |
| CN102327616A (en) * | 2011-09-05 | 2012-01-25 | 安徽山河药用辅料股份有限公司 | Method for preparing medicinal adjuvant medicinal micro-pill pill core from sucrose and starch by physical mixing method |
-
2012
- 2012-02-04 CN CN2012100241615A patent/CN102552035A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579494A (en) * | 2004-01-13 | 2005-02-16 | 贵州益佰制药股份有限公司 | Micropill of traditional Chinese medicine and its preparation method |
| CN102166361A (en) * | 2011-04-19 | 2011-08-31 | 杭州高成生物营养技术有限公司 | Quick-collapsed type pellet core and preparation method thereof |
| CN102327616A (en) * | 2011-09-05 | 2012-01-25 | 安徽山河药用辅料股份有限公司 | Method for preparing medicinal adjuvant medicinal micro-pill pill core from sucrose and starch by physical mixing method |
| CN102319181A (en) * | 2011-09-08 | 2012-01-18 | 广东大华农动物保健品股份有限公司 | Enveloping process for micro-capsule animal medicament |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105435240A (en) * | 2014-09-29 | 2016-03-30 | 天津尖峰弗兰德医药科技发展有限公司 | Medicinal pellet core and preparation method thereof |
| CN104607102A (en) * | 2014-12-23 | 2015-05-13 | 江苏金石研磨有限公司 | A manufacturing method of a high-strength small-size mill ball |
| CN104548115A (en) * | 2014-12-31 | 2015-04-29 | 深圳市国源医药科技有限公司 | Pharmaceutic adjuvant microcrystalline cellulose pellet core and preparation method thereof |
| CN104983717A (en) * | 2015-06-04 | 2015-10-21 | 湖北生物医药产业技术研究院有限公司 | Sodium prasterone sulfate sustained-release capsule and preparation method thereof |
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Application publication date: 20120711 |