CN101264276A - Oral preparation of 'chaihu dayuan' decoction - Google Patents
Oral preparation of 'chaihu dayuan' decoction Download PDFInfo
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- CN101264276A CN101264276A CNA2008100075360A CN200810007536A CN101264276A CN 101264276 A CN101264276 A CN 101264276A CN A2008100075360 A CNA2008100075360 A CN A2008100075360A CN 200810007536 A CN200810007536 A CN 200810007536A CN 101264276 A CN101264276 A CN 101264276A
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Abstract
The invention relates to an oral preparation, which is characterized in that a mixing extraction (extract or dry powder and volatile oil) of bupleurum, raw orange fruit, magnolia obavata, dried green orange peel, astragalus root, root of the balloonflower, Tsaoko Fruit, betel-nut, lotus petiole and liquorice root; a carrier or an excipient are used as substrate, which can be accepted in pharmacy; the oral preparation is prepared with the extraction and the substrate in ordinary craft; the preparation has wetness and sputum eliminating effect, and treats wet weight, heat siltation and block original membrane disease; the long clinical application of the prescription has the advantages of good therapeutic effect for treating influenza fever patient.
Description
Technical field
The invention belongs to medical technical field, relating to a kind of phlegm-damp that cures mainly hinders in medicine oral formulations of pleurodiaphragmatic in terspace and preparation method thereof, the extract that is particularly related to bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace Chinese medicine Cheng Fang is an active constituents of medicine, and has the oral formulations that malaria, influenza emit the effect of virus.
Background technology
" bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " for initiative in Yu of Qing Dynasty root " reformulating popular Treatise on Febrile Diseases ", always as treatment pestilence from the beginning of or malaria, the side commonly used of evil volt pleurodiaphragmatic in terspace, by Radix Bupleuri, living Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, the Radix Astragali, Radix Platycodonis, Fructus Tsaoko, Semen Arecae, Folium Nelumbinis stalk, Radix Glycyrrhizae Preparata is formed, have the wet expectorant effect of a surname, cure mainly weight in wet base, retardance pleurodiaphragmatic in terspace card in heat.This prescription long-term clinical application shows that retention of heat due to blockage of dampness is played at the place to incubative pathogen, and weight in wet base in heat has better curative effect, and has application widely, finds that also significantly secondary of poison should.
The Chinese crude drug source of being mentioned in the prescription is as follows:
Radix Bupleuri: be the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Reconciling superficies and interior is arranged, dredge the sense liver, the effect of yang invigorating.
Living Fructus Aurantii: be the rutaceae Citrus aurantium Linn. dry green fruit of variety extremely.Regulating the flow of QI to ease the stomach is arranged, the effect of the stagnant relieving distension of row.
Cortex Magnoliae Officinalis: be the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.The algae expectorant of wetting is arranged, and the therapeutic method to keep the adverse QI flowing downwards is removed the effect of hiding from.
Pericarpium Citri Reticulatae Viride: be the dry young fruit of rutaceae orange and variety thereof or the peel of immature fruit.Soothing the liver dispelling the stagnated QI is arranged, the effect that removing food stagnancyization stagnates.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali or Radix Astragali.Invigorating QI to consolidate the body surface resistance is arranged, diuresis poison holding, the effect of evacuation of pus and expelling pus and promoting granulation.
Radix Platycodonis: be the dry root of campanulaceae Platycodon grandiflouorum.Lung qi dispersing is arranged, and sore-throat relieving eliminates the phlegm and the effect of evacuation of pus.
Fructus Tsaoko: be the dry mature fruit of zingiberaceous plant Fructus Tsaoko.The effect of expectorant preventing the attack (or recurrence) of malaria is arranged in the algae hygropyrexia.
Semen Arecae: be the dry mature seed of babassu Semen Arecae.Wind-damp dispelling is arranged, sharp joint and antidotal effect.
Folium Nelumbinis stalk: be the dried leaves of nymphaeaceae plant lotus.Heat-clearing and toxic substances removing and removing food stagnancy analgesic effect are arranged.
Radix Glycyrrhizae Preparata: be the leguminous plant Radix Glycyrrhizae, the dry root and rhizome of expand dried fruits grass or light dried fruits grass.Invigorating the spleen and replenishing QI is arranged, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of relieving spasm to stop pain and coordinating the actions of various ingredients in a prescription.
The bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace in ancient times does not have only decoction, decoct behind the needs purchase decoction pieces and take, carry take all very inconvenient, we quantitatively control by index components and make the modern Chinese medicine oral formulations through studying, and product dosage is accurate, steady quality, conveniently take, be applicable to the big production of commercialization, overcome that the Chinese medicine decoction consumption is big, consumption is inaccurate, carry take inconvenience, can't commercialization etc. shortcoming, the needs that make things convenient for clinical treatment and family to use.
Summary of the invention
The objective of the invention is to preparation method according to modern Chinese medicine, quantitatively control by index components and to make the modern Chinese medicine oral formulations, with bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace be developed to product dosage accurately, steady quality, conveniently take, be applicable to the Chinese patent medicine of the big production of commercialization, make things convenient for clinical treatment and family to use.
The medicine of oral formulations involved in the present invention is by Radix Bupleuri, living Fructus Aurantii, and Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, the Radix Astragali, Radix Platycodonis, Fructus Tsaoko, Semen Arecae, the Folium Nelumbinis stalk, Radix Glycyrrhizae Preparata extract and an amount of pharmaceutic adjuvant form through specific prepared.Adopt following technical scheme to be prepared, can obtain bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace oral formulations involved in the present invention.
Each flavour of a drug and weight fraction (unit is g or kg) are in preparation the present invention prescription:
Radix Bupleuri 1-20 part, living Fructus Aurantii 1-20 part, Cortex Magnoliae Officinalis 1-20 part, Pericarpium Citri Reticulatae Viride 1-20 part, Radix Astragali 1-20 part, Radix Platycodonis 0.5-10 part, Fructus Tsaoko 0.1-10 part, Semen Arecae 1-5 part, 10～60 parts on Folium Nelumbinis stalk, Radix Glycyrrhizae Preparata 0.1-10 part
Each flavour of a drug and weight fraction (unit is g or kg) are in the best optimizing prescriptions of preparation the present invention:
Radix Bupleuri 4-5 part, living Fructus Aurantii 4-5 part, Cortex Magnoliae Officinalis 4-5 part, Pericarpium Citri Reticulatae Viride 4-5 part, Radix Astragali 4-5 part, 3 parts of Radix Platycodoniss, Fructus Tsaoko 1-2 part, Semen Arecae 6 Folium Nelumbinis stalk 5-15 part, Radix Glycyrrhizae Preparata 2-3 part
Substrate: the common medicinal supplementary material in the medicament book in preparation oral administration solid and the liquid preparation;
Proportioning: extract (comprise water extract: extractum or dry powder and volatile oil): substrate=9: 1～1: 9.
The extraction process of bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace mixed extract of the present invention (water extract and volatile oil) is as follows:
(1) each flavor medical material is cleaned, take by weighing each medical material and add 6～20 times of water gagings by best deal and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, and reclaims volatile oil;
(2) aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and concentrating under reduced pressure gets extractum or spray drying, and to get dry powder be water extract;
(3) bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract (water extract and volatile oil) and pharmaceutically acceptable carrier or excipient composition routinely technology make various oral administration solids or liquid preparation, wherein said carrier or excipient pharmaceutically selected according to different dosage forms, and these used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
The extracting method of bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract of the present invention is a lot, has only provided a kind of method here, but is not limited to this kind method.
Medicine of the present invention, wherein dosage form comprises oral solid formulation and oral liquid, wherein oral solid formulation comprises: tablet, hard capsule, liquid type capsule, granule, soft capsule, drop pill, pill, pellet, slow releasing preparation; Oral liquid comprises: oral liquid, syrup, medicated wine; Granule wherein, oral liquid, hard capsule and additive of tablet are selected from starch, sodium bicarbonate, Icing Sugar, lactose, amylum pregelatinisatum, microcrystalline Cellulose, inorganic salts mainly is some inorganic calcium salts, as calcium sulfate, citric acid, calcium hydrogen phosphate and medicinal calcium carbonate, mannitol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hydroxypropyl emthylcellulose, hypromellose, other binding agent, dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, polyethylene compares pyrrolidone, cross-linking sodium carboxymethyl cellulose, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, in polyethylene glycols (Macrogol 2000-6000) and month pure magnesium sulfate of extension and the xylitol one or more; Wherein the adjuvant of soft capsule, liquid type capsule and drop pill is selected from Polyethylene Glycol (Macrogol 200-6000), propylene glycol, Cera Flava, glycerol, ethanol, (polysorbas20,40,60,65,80), spans (span 20,40,60,65,80), soybean oil, Oleum Camelliae, safflower oil, Radix Oenotherae erythrosepalae oil, olive oil, C
5-C
14Triglyceride, in the ethyl oleate one or more, can also dose antioxidant, be selected from alpha-tocopherol, ascorbyl palmitate, Butylated hydroxyanisole (BHA), the dibenzylatiooluene (BHT) one or more.
Pharmaceutical preparation of the present invention, wherein tablet specifically refers to common compressed tablet, coated tablet, coated tablet, Film coated tablets, enteric coated tablet, effervescent tablet, chewable tablet, multilayer tablet, dispersible tablet, Sublingual tablet, buccal tablet.
Pharmaceutical preparation of the present invention wherein can also contain aromatic and antiseptic, and wherein aromatic comprises one or more in Fructus Citri tangerinae essence, flavoring banana essence, strawberry essence, the cream flavour, and antiseptic comprises one or more in parabens, the benzoic acids.
Preparation " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " extract
Prescription: Radix Bupleuri 4-5 part, living Fructus Aurantii 4-5 part, Cortex Magnoliae Officinalis 4-5 part, Pericarpium Citri Reticulatae Viride 4-5 part, Radix Astragali 4-5 part, 3 parts of Radix Platycodoniss, Fructus Tsaoko 1-2 part, Semen Arecae 6, Folium Nelumbinis stalk 5-15 part, Radix Glycyrrhizae Preparata 2-3 part
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and take by weighing each medical material of recipe quantity and add 6～20 times of water gagings and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, collection volatile oil; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and concentrating under reduced pressure gets extractum or spray drying is that dry powder is that water extract is standby.
Preparation " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " oral liquid and syrup
" bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " extract and correctives, antiseptic and water are made oral liquid.Wherein correctives is selected from one or more in sucrose, saccharin sodium, sodium cyclamate, stevioside, aspartoyl aminotoluene acid methyl ester, the Oleum menthae (alcohol); Antiseptic is sorbic acid methyl ester, benzoic acids, you moor in golden class etc. one or more.
The preparation method of oral liquid and syrup is as follows: " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " extract adds water to be adjusted to preparation amount, add correctives, antiseptic mix homogeneously, through technologies such as sterilization, fill, check, packings, promptly get " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " oral liquid and syrup.
Wherein the weight percent content of Jia Ruing is: " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " extract 5-90%, correctives 0.05-5%, antiseptic 0.001-2%, water 10-90%.
Preparation " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " granule, pill, pellet, capsule, tablet
Granule, pill, pellet, capsule, and tablet are made the used adjuvant of concentrated granule or pill or tablet and are comprised diluent, binding agent, lubricant; Diluent is selected from one or more of starch, lactose, dextrin, microcrystalline Cellulose kind; Binding agent comprise water, macromolecular material and alcoholic acid one or more; Lubricant comprises one or more in magnesium stearate, Pulvis Talci, the stearic acid.
Granule, pill, pellet, capsule, and the preparation method of tablet as follows:
With " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " extract and an amount of pharmaceutic adjuvant mixing, adding binding agent etc. is made soft material, makes granule with granulator, and dry, granulate promptly gets granule, or the general pill of making, or makes capsule through capsule filling machine, or makes tablet through tabletting.
Granule, pill, pellet, capsule, and tablet, wherein every gram granule is equivalent to contain the crude drug amount of 0.1-10.0 gram.
Preparation " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " drop pill
The used adjuvant of preparation drop pill comprises substrate, liquid coolant.Substrate comprises one or more of Polyethylene Glycol, polyvidone, octadecanol, cholic acid apoplexy due to endogenous wind; Liquid coolant comprises one or more in water, dimethicone, vegetable oil, the liquid Paraffin.Get the substrate heating and melting, the bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract is mixed wherein, splash in the suitable liquid coolant, drying is made, and wherein every gram drop pill is equivalent to contain the crude drug amount of 0.1-10 gram.
Preparation " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " soft capsule
With " bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace " extract and adjuvant diluent, antioxidant, antiseptic, suspending agent, wherein diluent is selected from one or more in Polyethylene Glycol, propylene glycol, vegetable oil, the mineral oil; Antioxidant is selected from that glycine, vitamin E and derivant thereof, ascorbic acid, pyrosulfurous acid are received, in the potassium metabisulfite one or more; Antiseptic comprises sorbic acid methyl ester, benzoic acids, you moor in golden class etc. one or more; Suspending agent is selected from one or more in chitin, cellulose family, agar, the Cera Flava.
Preparation method is as follows: bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 5-50%, add an amount of diluent, antioxidant, antiseptic, suspending agent mix homogeneously, prepared forms routinely, and wherein every gram soft capsule is equivalent to contain the crude drug amount of 0.1-10 gram.
Specific embodiment
Embodiment one: bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 1 (extractum and volatile oil) preparation method
Prescription: Radix Bupleuri 4.5 grams, living Fructus Aurantii 4.5 grams, Cortex Magnoliae Officinalis 4.5 grams, Pericarpium Citri Reticulatae Viride 4.5 grams, Radix Glycyrrhizae Preparata 2.1 grams, Radix Scutellariae 4.5 grams, Radix Platycodonis 3 grams, Fructus Tsaoko 1.8 grams, Semen Arecae 6 grams, Folium Nelumbinis stalk 10 grams
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and takes by weighing each medical material by recipe quantity, adds 6～15 times of water gagings and soaks 2-10 hour, heat little boiling and extracts 2-3 time, and volatile oil is collected in the extracting solution merging; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and it is the about 12.5g of water extract that concentrating under reduced pressure gets extractum, the about 0.1g of volatile oil.
Embodiment two bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extracts 2 (dry powder and volatile oil) preparation method
Prescription: Radix Bupleuri, living Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, each 5 gram of Radix Scutellariae, Radix Platycodonis 3 grams, Fructus Tsaoko 2 grams, Semen Arecae 6 grams, Folium Nelumbinis stalk 5 grams, Radix Glycyrrhizae Preparata 2 grams
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and takes by weighing each medical material by recipe quantity, adds 8～10 times of water gagings and soaks 2-8 hour, and being heated to boils extracts 2-3 time, and volatile oil is collected in the extracting solution merging; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, concentrating under reduced pressure, and it is the about 10.2g of water extract that spray drying gets dry powder; The about 0.1g of volatile oil.
Embodiment three: bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace oral solid formulation preparation method
(1) preparation bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace granule
Prescription:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 1 10-90%
Starch 5.0-70%
Dextrin 2.0-20%
Xylitol 5.0-20%
Sorbic acid methyl ester 0.001-2.0%
Optimizing prescriptions:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 1 12.6g
Starch 3.0g
Dextrin 5.0g
Xylitol 2.0g
Sorbic acid methyl ester 0.002g
Method for making: prepare bavin bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment one, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and packing is promptly.
(2) preparation bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace tablet:
(1) ordinary tablet prescription:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 5.0-90%
Starch 5.0-50%
Dextrin 2.0-20%
Microcrystalline Cellulose 5.0-20%
Pulvis Talci 0.5-5.0%
Magnesium stearate 0.1-5.0%
Optimizing prescriptions:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10.3g
Starch 6.0g
Dextrin 3.0g
Microcrystalline Cellulose 2.0g
Pulvis Talci 0.2g
Magnesium stearate 0.1g
Method for making: prepare bavin bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and tabletting is promptly.
(2) effervescent tablet is write out a prescription and is prepared as follows:
Prescription: bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10.3
Starch 2.0g
Dextrin 2.0g
Microcrystalline Cellulose 1.0g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Anhydrous citric acid 1.5g
Sodium bicarbonate 2.0g
Lactose 1.5g
Water is an amount of
Method for making: prepare bavin bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and tabletting is promptly.
(3) buccal tablet is write out a prescription and is prepared as follows:
Prescription: bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10.3g
Starch 2.0g
Dextrin 5.0g
Microcrystalline Cellulose 2.0g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Citric acid 0.1g
Aspartame 0.02g
Water is an amount of
Method for making: prepare bavin bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and tabletting is promptly.
(4) coated tablet is write out a prescription and is prepared as follows:
Prescription: bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10.3g
Starch 5.0g
Dextrin 2.0g
Microcrystalline Cellulose 2.0g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Method for making: prepare bavin bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, the an amount of dissolve with ethanol of volatile oil, evenly be sprayed on the granule, cold drying, tabletting is made coating material according to conventional method, with coating machine coating promptly, the difference according to coating material can be bundled into sugar-coat and film-coat.
(3) preparation bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace drop pill
Prescription:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10-70%
Macrogol 4000 20-80%
Polyethylene glycol 6000 20.0-50%
Liquid paraffin is an amount of
Optimizing prescriptions:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10.3g
Macrogol 4000 6.5g
Polyethylene glycol 6000 6.5g
Liquid paraffin is an amount of
Method for making: Macrogol 4000 and the polyethylene glycol 6000 ratio in 1: 1 is added in the lead pan of drop pill machine, in oil bath, be heated to 90-100 ℃, treat whole fusions after, add and to prepare bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 by the method among the embodiment two, be stirred to fusion, be transferred in the reservoir, airtight and the insulation at 80-90 ℃, regulator solution titer valve, splash in 10-15 ℃ the liquid paraffin, fish for the drop pill drop to the greatest extent and wipe liquid Paraffin, put in the Calx cylinder dry, both.
(4) preparation bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace pill
Prescription:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10.3g
Starch 5g
Magnesium stearate 0.1g
Dextrin 3g
Water is an amount of
Method for making: prepare bavin bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and pelleting is promptly.
(5) preparation bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace soft capsule
The content prescription:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10.3g
Vegetable oil 15.0g
Ethylparaben 0.01g
Cera Flava 2.0g
Method for making: prepare the bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment two, add vegetable oil, the Cera Flava of optimizing prescriptions percentage amounts, ethylparaben prepared routinely forms.
(6) preparation bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace capsule
Prescription:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10-95%
Starch 5-55%
Magnesium stearate 0.1-5%
Optimizing prescriptions:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 2 10.3g
Starch 5.0g
Magnesium stearate 0.5g
Method for making: prepare bavin bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, and cold drying, fill are promptly.
Embodiment four: bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace oral liquid preparation method
Prescription: bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 1 5-80%
Sucrose 5.0-50%
Sodium cyclamate 5.0-40%
Sorbic acid methyl ester 0.001-2%
Distilled water 10-90%.
Optimizing prescriptions:
Bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract 1 12.6g
Sucrose 3.0g
Sodium cyclamate 0.5g
Sorbic acid methyl ester 0.002g
Distilled water is settled to 20ml.
Method for making: prepare the bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract by the method among the embodiment one, add each adjuvant of prescription and distilled water, again through the ultrafilter ultrafiltration, the ultrafiltrate fill, sterilization, promptly.
Claims (7)
1, a kind of by 10 flavor Chinese medicines preparations such as Radix Bupleuri cure mainly weight in wet base in bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace drug oral preparation of the former card of thermal resistance stagnant film and preparation method thereof, mixed extract (extractum or dry powder and volatile oil) with Radix Bupleuri, living Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, the Radix Astragali, Radix Platycodonis, Fructus Tsaoko, Semen Arecae, Folium Nelumbinis stalk, Radix Glycyrrhizae Preparata is a raw material, with as the pharmaceutically acceptable carrier of substrate or excipient routinely prepared form, wherein:
1.1 each flavour of a drug and shared percentage by weight (unit is g or kg) are in the prescription:
Radix Bupleuri 1-20 part, living Fructus Aurantii 1-20 part, Cortex Magnoliae Officinalis 1-20 part, Pericarpium Citri Reticulatae Viride 1-20 part, Radix Astragali 1-20 part, Radix Platycodonis 0.5-10 part, Fructus Tsaoko 0.1-10 part, Semen Arecae 1-5 part, Folium Nelumbinis stalk 10-60 part, Radix Glycyrrhizae Preparata 0.1-10 part
In the prescription each flavour of a drug most preferably weight fraction (unit is g or kg) be:
Radix Bupleuri 4-5 part, living Fructus Aurantii 4-5 part, Cortex Magnoliae Officinalis 4-5 part, Pericarpium Citri Reticulatae Viride 4-5 part, Radix Astragali 4-5 part, 3 parts of RADIX PLATYCODI, Fructus Tsaoko 1-2 part, 6 parts of Semen Arecaes, Folium Nelumbinis stalk 5-15 part, Radix Glycyrrhizae Preparata 2-3 part
1.2 substrate: the common medicinal supplementary material in the medicament book in preparation oral administration solid and the liquid preparation;
1.3 proportioning: extract (comprise water extract: extractum or dry powder and volatile oil): substrate=9: 1～1: 9.
2, according to the bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace extract in the claim 1, its preparation technology is as follows:
1.1 each flavor medical material is cleaned, take by weighing each medical material and add 6-20 times of water gaging by best deal and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, and collects volatile oil;
1.2 aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, concentrating under reduced pressure gets extractum or spray drying, and to get dry powder be water extract;
1.3 bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace water extract and volatile oil and carrier pharmaceutically or adjuvant technology are routinely made various oral administration solids or liquid preparation, these wherein used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
3, according to the bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace oral drug preparation among the claim 1-2, wherein dosage form comprises tablet, hard capsule, granule, soft capsule, liquid type capsule, drop pill and oral liquid, wherein:
1.1 granule, tablet, hard capsule and oral liquid liquid preparation substrate are selected from starch, sodium bicarbonate, Icing Sugar, lactose, amylum pregelatinisatum, microcrystalline Cellulose, inorganic salts (mainly is some inorganic calcium salts, as calcium sulfate, citric acid, calcium hydrogen phosphate and medicinal calcium carbonate), mannitol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hydroxypropyl emthylcellulose, hypromellose, other binding agent, dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross linked polyvinyl pyrrolidone, cross-linking sodium carboxymethyl cellulose, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, in polyethylene glycols (Macrogol 2000-6000) and month pure magnesium sulfate of extension and the xylitol one or more.
1.2 the substrate of soft capsule, liquid type capsule and drop pill is selected from Polyethylene Glycol (Macrogol 200-6000), propylene glycol, Cera Flava, Lac, polyoxyethylene monostearate, glycerol, ethanol, (polysorbas20,40,60,65,80), spans (span 20,40,60,65,80), soybean oil, Oleum Camelliae, safflower oil, Radix Oenotherae erythrosepalae oil, olive oil, C
5-C
14Triglyceride, in the ethyl oleate one or more.
4, according to the pharmaceutical preparation among the claim 1-3, wherein tablet specifically refers to common compressed tablet, coated tablet, coated tablet, Film coated tablets, enteric coated tablet, effervescent tablet, chewable tablet, multilayer tablet, dispersible tablet, Sublingual tablet, buccal tablet.
5, according to the pharmaceutical preparation among the claim 1-4, can also dose antioxidant, be selected from alpha-tocopherol, ascorbyl palmitate, Butylated hydroxyanisole (BHA), the dibenzylatiooluene (BHT) one or more.
6, according to the pharmaceutical preparation among the claim 1-5, wherein can also contain aromatic and antiseptic, wherein aromatic comprises one or more in Fructus Citri tangerinae essence, flavoring banana essence, strawberry essence, the cream flavour, and antiseptic comprises one or more in parabens, the benzoic acids.
7, according to the bupleurum decoction for eliminating phelegm-damp in pleuro-diaphragmatic interspace drug oral preparation among the claim 1-6, said preparation cures mainly weight in wet base in the former card of thermal resistance stagnant film, and long-term clinical application shows that treatment influenza fever patient is had better curative effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100075360A CN101264276A (en) | 2008-02-27 | 2008-02-27 | Oral preparation of 'chaihu dayuan' decoction |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100075360A CN101264276A (en) | 2008-02-27 | 2008-02-27 | Oral preparation of 'chaihu dayuan' decoction |
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| CN101264276A true CN101264276A (en) | 2008-09-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008100075360A Pending CN101264276A (en) | 2008-02-27 | 2008-02-27 | Oral preparation of 'chaihu dayuan' decoction |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772751A (en) * | 2012-06-07 | 2012-11-14 | 王晓兵 | Cough-relieving oral liquid for treating pneumonia |
| CN102908573A (en) * | 2012-09-20 | 2013-02-06 | 李承平 | Radix scutellariae and radix bupleuri tablets for clearing heat |
| CN115192680A (en) * | 2022-07-21 | 2022-10-18 | 济宁神农中医药研究所 | Preparation method and efficacy of medicine for treating influenza |
-
2008
- 2008-02-27 CN CNA2008100075360A patent/CN101264276A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772751A (en) * | 2012-06-07 | 2012-11-14 | 王晓兵 | Cough-relieving oral liquid for treating pneumonia |
| CN102908573A (en) * | 2012-09-20 | 2013-02-06 | 李承平 | Radix scutellariae and radix bupleuri tablets for clearing heat |
| CN115192680A (en) * | 2022-07-21 | 2022-10-18 | 济宁神农中医药研究所 | Preparation method and efficacy of medicine for treating influenza |
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Open date: 20080917 |