CL2019003589A1 - Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer. - Google Patents

Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer.

Info

Publication number
CL2019003589A1
CL2019003589A1 CL2019003589A CL2019003589A CL2019003589A1 CL 2019003589 A1 CL2019003589 A1 CL 2019003589A1 CL 2019003589 A CL2019003589 A CL 2019003589A CL 2019003589 A CL2019003589 A CL 2019003589A CL 2019003589 A1 CL2019003589 A1 CL 2019003589A1
Authority
CL
Chile
Prior art keywords
cancer
same
derivative
treatment
diamine
Prior art date
Application number
CL2019003589A
Other languages
English (en)
Inventor
Gildon Choi
Kwangho Lee
Inji Shin
Chong Hak Chae
Hyeon Jeong Choe
Myoung Eun Jung
Byeong Uk Jeon
Byoung Chul Cho
Chae Won Park
Hwan Kim
Krishna Babu Duggirala
Original Assignee
Korea Res Inst Chemical Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Res Inst Chemical Tech filed Critical Korea Res Inst Chemical Tech
Publication of CL2019003589A1 publication Critical patent/CL2019003589A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN DERIVADO DE N2,N4-DIFENILPIRIMIDIN2,4-DIAMINA, UN MÉTODO PARA PREPARAR EL MISMO Y UNA COMPOSICIÓN FARMACÉUTICA PARA LA PREVENCIÓN O EL TRATAMIENTO DEL CÁNCER, QUE CONTIENE EL MISMO COMO INGREDIENTE ACTIVO. EL DERIVADO MUESTRA UN EFECTO INHIBIDOR DE LA ACTIVIDAD DE EGFR RELATIVAMENTE DÉBIL SOBRE EL EGFR DE TIPO SALVAJE, UNA ALTA CAPACIDAD INHIBITORIA EN LA MUTACIÓN DE EGFR Y UNA ALTA CAPACIDAD INHIBITORIA INCLUSO EN LA MUTACIÓN FLT3 Y FLT3, Y POR LO TANTO, PUEDE USARSE EFICAZMENTE PARA EL TRATAMIENTO DEL CÁNCER CON EGFR MUTACIÓN O CÁNCER CON FLT3 O UNA MUTACIÓN DEL MISMO, Y EL DERIVADO MUESTRA UN EFECTO DE SINERGIA EN EL MOMENTO DE LA ADMINISTRACIÓN COMBINADA Y, POR LO TANTO, PUEDE USARSE EFICAZMENTE PARA EL TRATAMIENTO DE LA ADMINISTRACIÓN COMBINADA.
CL2019003589A 2017-06-13 2019-12-06 Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer. CL2019003589A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170073907 2017-06-13
KR1020170146241A KR20180135781A (ko) 2017-06-13 2017-11-03 N2,n4-디페닐피리미딘-2,4-디아민 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물

Publications (1)

Publication Number Publication Date
CL2019003589A1 true CL2019003589A1 (es) 2020-07-03

Family

ID=70972831

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003589A CL2019003589A1 (es) 2017-06-13 2019-12-06 Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer.

Country Status (19)

Country Link
US (2) US11253516B2 (es)
EP (1) EP3640246B1 (es)
JP (1) JP6945015B2 (es)
KR (2) KR20180135781A (es)
CN (1) CN110740999A (es)
AU (1) AU2018286361B2 (es)
BR (1) BR112019026253A2 (es)
CA (1) CA3066083C (es)
CL (1) CL2019003589A1 (es)
EA (1) EA201992722A1 (es)
ES (1) ES2969701T3 (es)
IL (1) IL271291B2 (es)
JO (1) JOP20190281A1 (es)
MX (1) MX2019014548A (es)
NZ (1) NZ760089A (es)
PL (1) PL3640246T3 (es)
SA (1) SA519410722B1 (es)
WO (1) WO2018230934A1 (es)
ZA (1) ZA201908241B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101992621B1 (ko) 2017-12-07 2019-09-27 주식회사 온코빅스 암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
MX2021011289A (es) 2019-03-22 2021-11-03 Sumitomo Pharma Oncology Inc Composiciones que comprenden moduladores de isoenzima m2 muscular de piruvato cinasa pkm2 y metodos de tratamiento que usan las mismas.
MX2021015543A (es) * 2019-06-20 2022-04-25 Oncobix Co Ltd Derivado de pirimidina que inhibe el crecimiento de celulas cancerosas y uso medicinal del mismo.
EP3986411A4 (en) * 2019-06-20 2023-08-02 Dana-Farber Cancer Institute, Inc. SMALL MOLECULE TYROSINE KINASE SRC INHIBITORS
CA3145864A1 (en) * 2019-07-03 2021-01-07 Sumitomo Dainippon Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof
WO2021125758A1 (ko) * 2019-12-16 2021-06-24 주식회사 온코빅스 신규한 중수소 치환 피리미딘 유도체 및 이를 포함하는 약제학적 조성물
CN113896744B (zh) * 2020-07-06 2024-04-16 成都先导药物开发股份有限公司 一种选择性egfr抑制剂
WO2022055181A1 (ko) * 2020-09-11 2022-03-17 제이투에이치바이오텍 주식회사 Egfr 돌연변이 암의 억제용 화합물 및 이들의 의약 용도
CN112390760B (zh) * 2020-10-15 2022-07-29 北京师范大学 靶向fak的化合物及其制备方法和应用
CN112239422B (zh) * 2020-10-16 2022-07-22 河北化工医药职业技术学院 一种布格替尼中间体、其盐、其制备方法以及布格替尼的制备方法
US20240091226A1 (en) * 2021-01-05 2024-03-21 Sumitomo Pharma Oncology, Inc. Forms and Formulations Of A Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitor
US20240051940A1 (en) * 2021-02-08 2024-02-15 Accutar Biotechnology Inc. Sulfonamides with egfr inhibition activities and their use thereof
WO2022211573A1 (ko) * 2021-04-01 2022-10-06 주식회사 테라펙스 단백질 키나아제 저해 활성을 갖는 피리미딘 유도체 및 이를 포함하는 치료용 약학 조성물
IL310020A (en) * 2021-07-13 2024-03-01 Korea Res Inst Chemical Tech Innovative 2,4-pyrimidine-diamine derivatives, their preparation method and pharmaceutical preparations containing them as an active substance for the prevention and treatment of cancer
TW202404598A (zh) * 2022-04-15 2024-02-01 韓商畢利吉生物科技股份有限公司 用於具有突變之癌症之組合物及治療
WO2024106979A1 (ko) * 2022-11-17 2024-05-23 (주)팜캐드 피페리딘 유도체, 이의 염 및 이를 유효성분으로 포함하는 약학적 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004264382A1 (en) * 2003-08-15 2005-02-24 Irm Llc 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
KR101364277B1 (ko) 2006-12-08 2014-02-21 아이알엠 엘엘씨 단백질 키나제 억제제로서의 화합물
WO2009127642A2 (en) * 2008-04-15 2009-10-22 Cellzome Limited Use of lrrk2 inhibitors for neurodegenerative diseases
EA029131B1 (ru) 2008-05-21 2018-02-28 Ариад Фармасьютикалз, Инк. Фосфорсодержащие производные в качестве ингибиторов киназы
KR102090453B1 (ko) * 2012-03-15 2020-03-19 셀젠 카르 엘엘씨 상피 성장 인자 수용체 키나제 억제제의 염
KR101656382B1 (ko) 2014-02-28 2016-09-09 한국화학연구원 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물
US10058559B2 (en) * 2014-05-15 2018-08-28 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Treatment or prevention of an intestinal disease or disorder
JP6622726B2 (ja) 2014-06-17 2019-12-18 コリア リサーチ インスティチュート オブ ケミカル テクノロジーＫｏｒｅａ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｃｈｅｍｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ ピリミジン‐２，４‐ジアミン誘導体及びそれを有効成分として含有する抗癌用医薬組成物
JP6257782B2 (ja) 2014-08-22 2018-01-10 富士フイルム株式会社 Ｆｌｔ３変異陽性癌を処置するための医薬組成物、変異型ｆｌｔ３阻害剤およびそれらの応用
KR101789934B1 (ko) 2015-07-31 2017-10-26 중앙대학교 산학협력단 상피세포성장인자수용체 변이체를 가진 종양 진단 및 종양 성장 억제 활성을 갖는 신규 화합물 및 이를 포함하는 의학적 용도

Also Published As

Publication number Publication date
JP6945015B2 (ja) 2021-10-06
EA201992722A1 (ru) 2020-04-02
JOP20190281A1 (ar) 2019-12-02
NZ760089A (en) 2022-10-28
AU2018286361A1 (en) 2020-01-16
CA3066083C (en) 2021-11-30
US20200179384A1 (en) 2020-06-11
SA519410722B1 (ar) 2023-03-15
IL271291A (en) 2020-01-30
KR20180135815A (ko) 2018-12-21
EP3640246C0 (en) 2023-11-01
EP3640246A4 (en) 2020-08-05
PL3640246T3 (pl) 2024-04-22
ES2969701T3 (es) 2024-05-22
WO2018230934A1 (ko) 2018-12-20
IL271291B2 (en) 2023-02-01
AU2018286361B2 (en) 2020-11-19
CN110740999A (zh) 2020-01-31
JP2020523360A (ja) 2020-08-06
CA3066083A1 (en) 2018-12-20
IL271291B (en) 2022-10-01
KR102023156B1 (ko) 2019-09-19
EP3640246A1 (en) 2020-04-22
US11253516B2 (en) 2022-02-22
EP3640246B1 (en) 2023-11-01
MX2019014548A (es) 2020-02-07
KR20180135781A (ko) 2018-12-21
ZA201908241B (en) 2021-04-28
BR112019026253A2 (pt) 2020-06-23
US20220249482A1 (en) 2022-08-11

Similar Documents

Publication Publication Date Title
CL2019003589A1 (es) Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer.
ECSP22023220A (es) Derivados de indol mono o disustituidos como inhibidores de la replicación viral del dengue
CO2019008487A2 (es) Compuesto de quinazolina
SV2017005461A (es) Benzamidas sustituidas con 1,3-tiazol-2-ilo
NZ733174A (en) Quinazoline derivatives used to treat hiv
NI201800040A (es) Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue
MX2015016983A (es) Moduladores del transporte nuclear y usos de los mismos.
MX2016012574A (es) Compuestos heteroarilo sustituidos y metodos de uso.
NI201800039A (es) Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue
TW201613919A (en) Inhibitors of Bruton's tyrosine kinase
CO2018009563A2 (es) Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue
AR096892A1 (es) Una combinación farmacéutica para el tratamiento del melanoma
BR112017006299A2 (pt) derivados indol mono- ou dissubstituídos como inibidores da replicação viral da dengue
ECSP16086247A (es) (s)-pirlindole y sus sales farmacéuticamente aceptables para uso en medicina
BR112018002530A2 (pt) combinações e usos e tratamentos destas
PH12016502236A1 (en) (r)-pirlindole and its pharmaceutically acceptable salts for use in medicine
WO2015102850A3 (en) Compositions, devices and methods for treating infections
CL2014003326A1 (es) Formulación antioxidante inyectable de uso intravenoso de ascorbato de sodio - en altas dosis, y n-acetilcisteína como agentes oxidantes, y deferoxamina como agentes quelante de hierro, más excipientes farmacéuticos; método para su administración y uso en prevenir el daño por repertfusión en pacientes con inferto agudo del miocardío, sometidos a angioplastia caronaria primaria; y kit que la contiene.
BR112016029761A8 (pt) composições compreendendo um derivado de ácido quinolona carboxílico e agentes efervescentes, uso das mesmas e forma cristalina do referido derivado
BR112017024356A2 (pt) clonidina e/ou derivados de clonidina para uso na prevenção de lesão na pele resultante de radioterapia