CA2776954A1 - Banques combinatoires basees sur le domaine lectine de type c - Google Patents

Banques combinatoires basees sur le domaine lectine de type c Download PDF

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Publication number: CA2776954A1
Authority: CA; Canada
Prior art keywords: loop; amino acid; ctld; library; polypeptide
Prior art date: 2009-10-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2776954A

Other languages

English (en)

Inventor

Martha Wild

Anke Kretz-Rommel

Katherine Bowdish

Mark Renshaw

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bird Rock Bio Inc

Original Assignee

Anaphore Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-09

Filing date

2010-02-10

Publication date

2011-04-14

2009-10-09 Priority claimed from PCT/US2009/060271 external-priority patent/WO2010042890A2/fr

2010-02-10 Application filed by Anaphore Inc filed Critical Anaphore Inc

2011-04-14 Publication of CA2776954A1 publication Critical patent/CA2776954A1/fr

Status Abandoned legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4726—Lectins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Microbiology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Crystallography & Structural Chemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)

CA2776954A 2009-10-09 2010-02-10 Banques combinatoires basees sur le domaine lectine de type c Abandoned CA2776954A1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US12/577,067		2009-10-09
PCT/US2009/060271 WO2010042890A2 (fr)	2008-10-10	2009-10-09	Polypeptides qui se lient à trail-ri et trail-r2
USPCT/US2009/060271		2009-10-09
US12/577,067 US20100105620A1 (en)	2008-10-10	2009-10-09	Polypeptides that bind Trail-R1 and Trail-R2
PCT/US2010/023803 WO2011043834A1 (fr)	2009-10-09	2010-02-10	Banques combinatoires basées sur le domaine lectine de type c

Publications (1)

Publication Number	Publication Date
CA2776954A1 true CA2776954A1 (fr)	2011-04-14

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CA2776954A Abandoned CA2776954A1 (fr)	2009-10-09	2010-02-10	Banques combinatoires basees sur le domaine lectine de type c

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EP (1)	EP2486132A1 (fr)
JP (1)	JP2013507123A (fr)
CN (1)	CN102686727A (fr)
CA (1)	CA2776954A1 (fr)
WO (1)	WO2011043834A1 (fr)

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HUE051267T2 (hu)	2005-12-13	2021-03-01	Harvard College	Sejttranszplantációs állványok
LT2624873T (lt)	2010-10-06	2020-03-10	President And Fellows Of Harvard College	Įšvirkščiami, poras sudarantys hidrogeliai, skirti medžiagų pagrindo ląstelių terapijai
ES2773895T3 (es)	2012-04-16	2020-07-15	Harvard College	Composiciones de sílice mesoporosa para modular las respuestas inmunitarias
US20160039877A1 (en)	2013-03-15	2016-02-11	Shenzhen Hightide Biopharmaceutical, Ltd.	Compositions and methods of using islet neogenesis peptides and analogs thereof
EP3137105A4 (fr)	2014-04-30	2017-12-27	President and Fellows of Harvard College	Dispositifs de vaccin combiné et procédés de destruction de cellules cancéreuses
CA3012602A1 (fr)	2015-01-30	2016-08-04	President And Fellows Of Harvard College	Materiaux peritumoraux et intratumoraux pour traitement anticancereux
CN114099793A (zh)	2015-04-10	2022-03-01	哈佛学院院长等	免疫细胞捕获装置及其制备和使用方法
CN104961833B (zh) *	2015-07-21	2018-08-03	中国科学技术大学	一种人源NKp80-Fc融合蛋白及其制备方法和在肿瘤治疗中的应用
WO2017136837A1 (fr)	2016-02-06	2017-08-10	President And Fellows Of Harvard College	Régénération de la niche hématopoïétique pour reconstituer l'immunité
US10813988B2 (en) *	2016-02-16	2020-10-27	President And Fellows Of Harvard College	Pathogen vaccines and methods of producing and using the same
JP2019522486A (ja)	2016-07-13	2019-08-15	プレジデントアンドフェローズオブハーバードカレッジ	抗原提示細胞模倣足場およびそれを作製および使用するための方法

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DK1341912T3 (da) *	2000-12-13	2009-09-21	Anaphore Inc	Fremgangsmåde til identificering og isolering af bindende polypeptider fra kombinantoriske biblioteker af proteriner med C-type-lectinlignende domæner med scaffold-struktur

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- 2010-02-10 JP JP2012533143A patent/JP2013507123A/ja active Pending
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- 2010-02-10 WO PCT/US2010/023803 patent/WO2011043834A1/fr active Application Filing
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WO2011043834A1 (fr)	2011-04-14
EP2486132A1 (fr)	2012-08-15
JP2013507123A (ja)	2013-03-04
CN102686727A (zh)	2012-09-19

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Publication	Publication Date	Title
US20110086770A1 (en)	2011-04-14	Combinatorial Libraries Based on C-type Lectin-like Domain
CA2776954A1 (fr)	2011-04-14	Banques combinatoires basees sur le domaine lectine de type c
EP1341912B1 (fr)	2009-05-20	Methode pour l'identification et l'isolation des polypeptides de bibliotheques combinatoires de proteines presentant la structure en echafaudage des domaines lectonoides de type c
US20110028403A1 (en)	2011-02-03	HSP70-Based Treatment for Autoimmune Diseases and Cancer
RU2556820C2 (ru)	2015-07-20	Модифицированные убиквитиновые белки со специфической связывающей активностью для экстрадомена "в" фибронектина
JP4907542B2 (ja)	2012-03-28	治療、診断およびクロマトグラフィーに使用するためのタンパク質複合体
EP2284270A2 (fr)	2011-02-16	Procédé d'identification et d'isolation des polypeptides de liaison à partir des bibliothèques combinatoires de protéines dotées d'une structure d'échafaudage des domaines par exemple de la lectine de type C
JP5291279B2 (ja)	2013-09-18	反復モジュールを含む反復タンパク質の集合体
AU2002221568A1 (en)	2002-08-29	Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
WO2012171541A1 (fr)	2012-12-20	Protéines hybrides humaines comportant des interférons et des protéines hétérodimériques modifiées par ubiquitine
KR20150016585A (ko)	2015-02-12	비-천연 컨센서스 알부민 결합 도메인
CA2739663A1 (fr)	2010-05-15	Polypeptides qui se lient a trail-r1 et trail-r2
WO2003091429A1 (fr)	2003-11-06	Polypeptide microbicide et ses utilisations
AU2015305220B2 (en)	2021-01-28	Affinity proteins and uses thereof
AU2010303879A1 (en)	2012-05-24	Combinatorial libraries based on C-type lectin domain
US20110086806A1 (en)	2011-04-14	Polypeptides that Bind IL-23R
EP2486050A1 (fr)	2012-08-15	Polypeptides qui se lient à l'il-23r
EP1225181A1 (fr)	2002-07-24	Expression protéique et résolution structurale au moyen de vecteurs de fusion specifiques
Class et al.	2011	Patent application title: HSP70-Based Treatment for Autoimmune Diseases and Cancer Inventors: Isabelle Caroline Le Poole (Downers Grove, IL, US) Josephus Dirk Nieland (Arhus C, DK) Thor Las Holtet (Ronde, DK) Thor Las Holtet (Ronde, DK)
WO2009102840A1 (fr)	2009-08-20	Msp et leurs domaines en tant que squelettes pour de nouvelles molécules de liaison
CN113811542A (zh)	2021-12-17	包含细胞因子和支架蛋白的融合蛋白