CA2190139C - Apparatus for performing diagnostic and therapeutic modalities in the biliary tree - Google Patents
Apparatus for performing diagnostic and therapeutic modalities in the biliary tree Download PDFInfo
- Publication number
- CA2190139C CA2190139C CA002190139A CA2190139A CA2190139C CA 2190139 C CA2190139 C CA 2190139C CA 002190139 A CA002190139 A CA 002190139A CA 2190139 A CA2190139 A CA 2190139A CA 2190139 C CA2190139 C CA 2190139C
- Authority
- CA
- Canada
- Prior art keywords
- lumen
- proximal
- distal
- catheter
- catheter means
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Surgical Instruments (AREA)
Abstract
Catheter apparatus (10) for performing diagnostic and therapeutic modalities in the biliary tree includes a catheter (11) with multi ple lumens. A first lumen (16) is adapted to receive a guidewire and can serve a s a transport lumen for contrast agent. A second lumen ( 17) carries a cutting wire (31) for performing a sphincterotomy. A third lumen ( 20) can be used as an inflation lumen for a distally loc ated balloon. Expansion of the balloon occludes a portion of the biliary tree and allows the catheter to sweep any gallstones through the sphincter of Oddi into the duodenum.
Description
wo 9smz46 2 T 9 ~ ! 3 ~
Descri tion ADTJaT'at'L18 T~O~" PeT'formi n~ 17i agnost~ c and per neutic Mpdalities in the B~~~a~r Tree T
Fi l a~ical e d This invention generally relates to apparatus that is useful in performing diagnostic and therapeutic modalities in the biliary tree and more particularly to apparatus that is adapted for facilitating the diagnosis of gallstones in the bile duct and other portions of the biliary tree and the removal of such gallstones.
Backaround Art Historically the migration of gallstones into an individual's common bile duct was corrected by general surgical procedures. A surgeon would incise the bile duct and remove the gallstones and normally remove the gallbladder. In recent years less invasive treatment modalities have replaced these general surgical procedures and reduced patient trauma, long hospital stays and recovery periods.
For example, United States Letters Patent No.
4,696,668 and United States Letters Patent No. 4,781,677, both to Wilcox, disclose a treatment modality involving the administration of a dissolution agent in the bile duct to essentially dissolve any gallstones. More specifically, a catheter contains several lumens for inflating and deflating each of two balloons, venting bile, and infusing and aspirating the dissolution agent.
Inflating the balloons occludes the bile duct at two spaced sites and creates a sealed spaced that receives the dissolution agent. As the space is sealed from the remaining biliary tree, the dissolution agent finds a t ccess to the gallbladder and any gallstones therein through the cystic duct with the exclusion of bile from the gallbladder fundus. The dissolution agent also will be confined in high concentration around bile duct gallstones. After the gallstones dissolve the balloons are deflated and the catheter can be withdrawn. In this particular approach, the catheter is directed into the biliary tree using a standard duodenoscope that passes through the alimentary tract. Although this and analogous approaches have the potential of minimizing patient trauma, such treatments require extended placement of the duodenoscope in the patient, exhibit low efficacy and introduce a potential for adverse reactions to the dissolution agents.
In an alternative approach, a surgeon directs a surgical extractor into the biliary tree through at least an incision in the bile duct. For example, in United States Letters Patent No. 3,108,593 to Glassman a surgeon incises both the bile duct and duodenum. Then the surgeon directs an extractor through the bile duct incision, biliary tree, sphincter of Oddi and duodenum to exit through the duodenum incision. This extractor includes a series of longitudinally spaced cages for trapping any gallstones in the bile duct and removing them through either of the incisions.
United States Letters Patent No. 4,627,837 to Gonzalo discloses a catheter device with a pair of inflatable balloons at its distal end. This catheter is led through an incision in the bile duct toward the duodenum. After the distal balloon passes through the sphincter of Oddi, both balloons are expanded to anchor the catheter in place. This enables the catheter to be used for irrigating and flushing through other lumens in order to capture any gallstone in the second balloon for removal through the incised bile duct.
In accordance with still another modality as for the treatment of strictures, a surgeon may insert a catheter device through the bile duct or duodenum for the purpose of dilating or enlarging the sphincter of Oddi. For example, United States Letters Patent No. 4,705,041 to Aim discloses a dilator that is directed through an incision in the bile duct and the sphincter of Oddi. An expandable tip dilates the sphincter of Oddi. United States Letters Patent No. 5,035,696 to Rydell discloses an electrosurgical instrument that is directed through the R'O 9S/31?A6 219 013 9 PCTIUS95106457 duodenum and to the sphincter of Oddi for performing a sphincterotomy. This apparatus contains a cutting wire _ . that is heated to cut the sphincter muscle. United States Letters Patent No. 5,024,617 to Karpiel discloses a , similar device that can be directed through a duodenoacope. United States Letters Patent No. 5,152,772 .
to Sewell, Jr. discloses a device for performing a ephincterotomy that is directed through an incision in th e bile duct and includes a knife for cutting the sphincter' 1D muscle.
The use of the duodenoscope and sphincterotomy devices, such as shown in the Rydell and Karpiel patents, enables an internist to diagnose and treat problems in the biliary tree with minimal patient invasion. For example, modalities as described in these patents eliminates the surgery needed for incising the bile duct. Consequently, , these modalities can be performed as outpatient or day surgical procedures. These procedures greatly reduce patient trauma, the length of a hospital stay and recove ry times. For example, if an internist detezmines that gallstones are present in the biliary tree, particularly the common bile duct, the internist can insert a duodenoscope into the duodenum to view the sphincter of Oddi. Then a first catheter can be advanced through the working channel of the duodenoscope with or without a guidewire and directed through the sphincter of Oddi into the biliary tree. Contrast agent injected through the catheter enables fluoroscopy or other imaging procedures to confirm the presence of gallstones within the biliaxy tree. Next the internist exchanges the first catheter for a second catheter for performing a aphincterotomy such as the types disclosed in the above-identified Rydell and Karpiel patents. The second catheter is then exchanged for a third catheter such as shown in the Glasaman patent or some other equivalent retrieval catheter for drawings gallstones through the enlarged sphincter of Oddi.
Thereafter the retrieval catheter is manipulated to release the gallstone into the duodenum. The catheter, any guidewire and the duodenoscope can then be removed to complete the procedure.
This procedure is significantly less traumatic to the patient than other prior art procedures because the only incision occurs during the sphincterotomy. However, this procedure as presently practiced requires three separate catheters and two catheter exchanges. These exchanges are required because the first, second and third catheters function solely to inject contrast agent to perform the sphincterotomy and to dislodge gallstones, respectively.
The time required for performing each catheter exchange can increase patient trauma and increase the duration of the procedure and reduce efficiency. Moreover, each such procedure requires the use of two or three separate catheter devices.
pisc~ osure of rnt.A.,r; r", Therefore, an object of this invention is to provide apparatus for performing both diagnosis and additional therapeutic treatment without requiring a catheter exchange.
Another object of this invention is to provide apparatus for performing diagnosis and treatment in the biliary tree that can reduce patient trauma.
Yet another object of this invention is to provide apparatus that enables the removal of gallstones from the biliary tree by a procedure that reduces the number of required catheters and catheter exchanges.
Still another object of this invention is to provide a single catheter apparatus that can perfoxnt a sphincterotomy and remove gallstones in the common bile duct.
Yet another object of this invention is to provide a single catheter apparatus that can perforni a sphincterotomy and inject contrast material into the.
biliary tree.
Still yet another object of this invention is to provide a single catheter apparatus that can inject contrast agent into biliary tree, performing a W095131246 219 0 ~ 3 9 PCT/US95/06457 sphincterotomy and remove gallstones in the bile duct into the duodenum.
In accordance with one aspect of this invention , apparatus can be used in a treatment modality including an enlargement procedure and another procedure to be performed. This apparatus includes a catheter with proximal and distal ends and proximal and distal portions.
The catheter includes first, second and third generally parallel lumens. The first lumen has a greater diameter ZO than either of the second and third lumens and the lumens each extend between proximal and distal portions of the catheter. The apparatus for performing the enlargement procedure extends through the second lumen for operating distally of the catheter in response to manipulations of an operator at the proximal end of the catheter. The first lumen has a proximal port for enabling access to the first Lumen and the third Lumen has a proximal port and a distal port for enabling the remote control of some other procedure.
In accordance with another aspect of this invention, apparatus is provided for removing objects from the biliary tree. This apparatus includes a catheter that is directed through the working channel of a duodenoscope and the sphincter of Oddi into the biliary tree. The catheter includes first, second and third lumens with the first lumen being larger than either the second or third lumens and the lumens generally extending between proximal and distal portions of the catheter along parallel axes.
Apparatus for cutting the sphincter of Oddi includes a cutting wire extending through the second lumen and externally of the catheter means through a distal port along a length that is coextensive with part of the distal portion of the catheter,. A handle attaches to the catheter at the proximal portion and to the proximal wire portion to control the position and orientation of the cutting wire. An expansible balloon is mounted on the distal portion spaced from the cutting wire and can be inflated through the third lumen in order to move any gallstone in the biliary tree through the enlarged sphincter of Oddi.
In accordance with still another aspect of this invention, the apparatus is provided for directing contrast agent into the biliary tree and performing a sphincterotomy through the working channel of a duodenoscope. This apparatus includes a catheter that is directed through the working channel of the duodenoscope and the sphincter of Oddi into the biliary tree. The catheter includes first, second and third lumens with the first lumen being larger than either the second or third lumens and the lumens generally extending between proximal and distal portions of the catheter along parallel axes. Apparatus for cutting the sphincter of Oddi includes a cutting wire extending through the second lumen and externally of the catheter means through a distal port along a length that is coextensive with part of said distal portion of the catheter. A handle attaches to the catheter into the proximal wire portion to control the position and orientation of the cutting wire.
The proximal port of the third lumen connects to a contrast agent source and the third lumen delivers contrast agent into the biliary tree through a distal port in the distal end of the catheter.
In accordance with a further aspect of this invention, there is provided apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, said apparatus comprising: A. catheter means for being directed through internal passageways in the patient guided by a guidewire previously positioned in the passageways, said catheter means having proximal and distal ends and proximal -6a-and distal portions adjacent to said proximal and distal ends respectively, first, second and third generally parallel lumens adapted for receiving a guidewire therethrough with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, B. enlargement means for performing the enlargement procedure extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, C. operator means at said proximal end attached to said catheter means and said proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means, D. a first lumen proximal port in said proximal portion of said catheter means for enabling access to said first lumen, E. third lumen proximal port at said proximal end of said catheter means for providing access to said third lumen to enable a user to control the other procedure at the distal end of said catheter means through said third lumen and F. a distally facing port at said distal end thereof in said first lumen whereby said first lumen is adapted to receive the pre-positioned guidewire therethrough so that said catheter means is slidable along the guidewire.
In accordance with an even further aspect apparatus for the removal of objects from the biliary tree through the working channel of a duodenoscope, said apparatus comprising: A. catheter means for being directed through the working channel and the sphincter of Oddi into the biliary tree, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively and having first, second and third generally parallel lumens with said first lumen being larger than said second and third lumens, said -6b-lumens extending between said proximal and distal portions, each of said lumens having a proximal port and a distal port at said proximal and distal portions of said catheter means, said distal port of said first lumen being located at said distal end of said catheter means and being adapted for receiving a guidewire therethrough, B. sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through said distal port of said second lumen along a length that is coextensive with a part of said distal portion of said catheter means and handle means attached to said catheter means proximal portion and a proximal portion of said cutting wire exiting said proximal port of said second lumen for positioning said cutting wire, and C. an expansible balloon mounted on the distal portion of said catheter means and coextensive with said distal port of said third lumen thereby to enable inflation of said expansible balloon by the administration of an inflation fluid at said proximal port of said third lumen.
In accordance with a still further aspect apparatus for the diagnosis of objects in the biliary tree by means of a contrast agent delivered from a source, said apparatus being directed through the working channel of a duodenoscope and comprising: A. catheter means for being directed through the working channel and the sphincter of Oddi into the biliary tree, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively and having first, second and third generally parallel lumens with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, each of said lumens having a proximal -6c-port and a distal port at said proximal and distal portions of said catheter means, said distal port of said first lumen being located at said distal end of said catheter means, B. sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through said distal port along a length that is coextensive with a part of said distal portion of said catheter means and handle means attached to said catheter means proximal portion and a proximal portion of said cutting wire exiting said proximal port of said second lumen for operating said cutting wire, and C. means for connecting the proximal port of said third lumen to the contrast agent source, said distal port of said third lumen being located at the distal end of said catheter.
In accordance with yet another aspect apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, of the type comprising: A. catheter means for being directed through internal passageways in the patient guide by a guidewire previously positioned in the passageways, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, and including a first lumen extending between said proximal and distal portions, said first lumen having a distally facing port at said distal end thereof and a proximal port at said proximal portion for enabling access to said first lumen, whereby said first lumen is adapted to receive the pre-positioned guidewire therethrough so that said catheter means is slidable along the guidewire, and B. characterized in that: C. said catheter means further includes second and third lumens disposed generally parallel to said first lumen and -6d-extending between said proximal and distal portions, said first lumen being larger than said second and third lumens, said third lumen having a proximal port at said proximal portion for providing access to said third lumen to enable a user to control the other procedure at said distal end through said third lumen, said third lumen having a radially facing distal port at said distal end whereby fluid introduced at said third lumen proximal port discharges from said third lumen distal port, and D. said apparatus further includes enlargement means for performing the enlargement procedure, extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, and operator means at said proximal end attached to said catheter means and a proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means.
In accordance with a yet further aspect apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, said apparatus comprising: A. catheter means for being directed through internal passageways in the patient said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, first, second and third generally parallel lumens adapted for receiving a guidewire therethrough with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, B. enlargement means for performing the enlargement procedure extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, said enlargement means comprising a cutting wire having a distal end attached to said catheter means at the distal end of -6e-said second lumen, a portion thereof external to said catheter means along a length coextensive with a portion of said distal portion of said catheter means and a proximal end of said cutting wire attached to said operator means, C. operator means at said proximal end attached to said catheter means and said proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means, D, a first lumen proximal port in said proximal portion of said catheter means for enabling access to said first lumen, and E. a third lumen proximal port at said proximal end of said catheter means for providing access to said third lumen to enable a user to control the other procedure at the distal end of said catheter means through said third lumen.
Brief Description of Drawings The appended claims particularly point out and distinctly claim the subject matter of this invention. The various objects, advantages and novel features of this invention will be more fully apparent from a reading of the following detailed description in conjunction with the accompanying drawings in which like reference numerals refer to like parts, and in which:
FIG. 1 is a plan view of one embodiment of apparatus constructed in accordance with this invention;
FIG. 2 is a cross-section taken along lines 2-2 in FIG. 1;
FIG. 3 is a cross-section taken along lines 3-3 in FIG. 2;
W095/31246 219 013 9 PCTIUS95/064i7 FIG. 4 is a cross-section taken along lines 4-4 in FIG. 2;
FIG. 5 depicts the apparatus of FIG. 1 positioned through a duodenoscope for injecting contrast agent into the biliary tree.
FIG. 6 is an enlarged view that depicts the orientation of the apparatus in FIG. 1 for performing a sphincterotomy;
FIG. 7 depicts the apparatus of FIG. 1 positioned through a duodenoscope for dislodging material within the common bile duct;
FIG. 8 is a cross-section of an alternative embodiment of the apparatus as viewed generally along lines 3-3 in FIG. 2.; and FIG. 9 is a cross-section of still another embodiment of this invention taken along lines 3-3 in FIG. 2.
Best Mode for Carrvi,~ n"r rr, rn.>o r FIG. 1 depicts a catheter apparatus 10 that has the capability of injecting a contrast agent into the biliary tree, of performing a sphincterotomy and of dislodging a gallstone into the duodenum. The apparatus 10 includes a catheter 11 which, for purposes of definition in l d , c u es a proximal end portion 12 extending from a proximal end 13 and a distal end 14 with a distal portion 15 extending a short distance from the distal end 14. In a typical application, the catheter will have a working length of 200 cm and the distal end portion 15 will have a length of 6 cm to 9 cm. Normally the distal portion 15 will have a diameter that is smaller than the diameter of the proximal portion to increase the flexibility of the distal portion 15. The reduction in diameter also makes the tip less traumatic and allows the tip portion to reach smaller _ passages while allowing the larger proximal portion to provide necessary hoop strength and rigidity, particularly where the proximal portion 13 is coextensive with the working channel of a duodenoscope. For example, the proximal and distal portions might have diameters wo 9s1311A6 2 I 9 013 9 PCT/U595/06457 _g_ corresponding to 7 Fr and 5.5 Fr catheter sizes (i.e., 0.09" and 0.07" respectively).
As shown particularly in FIG. 2, the catheter 11 has three lumens. A first lumen 16 has a diameter that is greater than either a second lumen 17 or a third lumen 20.
In one particular embodiment the lumen I6 has a diameter of 0.040" in the proximal portion 13 that reduces to about 0.037" in the distal portion 15 to receive a standard 0.035" guidewire. In addition the lumen 16 is offset from the center of the catheter 11.
The lumens 17 and 2~0 are each smaller in diameter than the lumen 16 and are radially offset from the centerline of the catheter, from each other and from the lumen 16. In one particular embodiment the lumens 17 and 20 each have internal diameters of 0.028" in the proximal portions 13 that reduces to about 0.020" in the distal portion 15. As described later, this lumen 20 carries a cutting wire for performing a sphincterotomy and for allowing the infusion of a contrast agent at reasonable 2D rates. The angular spacing between the lumens 17 and 20 is about 45° and the angular spacing between the first lumen 16 and each of the lumens 17 and 20 each is about 157.5°.
In this configuration and with these dimensions the proximal portion 13 readily passes through the working channel of any duodenoscope.
Referring again to FIGS. 1 and 2, each of the lumens 16, 17 and 20 includes an entry port in the proximal portion 13 and an exit port in the distal portion 15.
Generally, and as described in more detail later, the first lumen 16 has an exit port through the distal end 14 while the exit ports for the lumens 17 and 20 can be sited at different locations in the distal portion 15 depending upon a particular application.
In FIG. 1, the entry ports in proximal portion 13 adjacent the proximal end 12 include an entry port 21 that provides access to the lumen 16 and includes an optional Leur lock fitting 22. A proximally positioned entry port 23 provides access to the lumen 17 and includes an _g_ optional Leur lock fitting 24. A proximal entry port 25 for the lumen 20 is located coextensively with a portion -of a handle 26 attached to the proximal end 12.
Referring to the distal end portion 15, the catheter 11 in this particular embodiment carries an expansible balloon 30 proximally of the excursion of a cutting wire 31 externally of the catheter 11. As shown in FIG. 3, the lumen 17 emerges at a distal exit port 32 through the side of the catheter 11 with the interior of the expansible balloon 30. An extension of the lumen 17 beyond the distal port 32 is sealed by known methods of manufacture.
Consequently, fluid forced through the entrance port 23, as by a syringe (not shown) attached to the Leur lock fitting 24, expands the balloon 30 into an occluding I5 orientation as shown in FIG. 3 with an inflated diameter in the range up to 20 mm.
As will also be apparent from viewing FIGS. 3 and 4, the first lumen 16 extends through the catheter 11 and terminates with an exit port 33 in the distal end 14.
Thus the lumen 16 is adapted for receiving a guidewire through the entrance port 21 that will extend through the catheter 11 and exit the distal end 14 and allow the , catheter to slide over that guidewire.
Referring to FIG. 4, a distal end 34 of the cutting wire 31 attaches to a clamp 35 formed at the distal end of the lumen 20. Spaced skived ports 36A and 36B allow an active portion 37 of the cutting wire 31 to emerge from the catheter 11 through the skived aperture 36A, parallel the catheter 11 exteriorly thereof and return into the lumen 20 through the port 36B and a reinforcing sleeve 38.
. The cutting wire 31 then extends through the lumen 2D to the handle 26 shown in FIG. 1 where it emerges as a proximal end portion 40.
The handle 26, as shown in FIG. 1, includes a central member 41 terminating with a thumb ring 42. The central member 41 extends through and slides with respect to a body section 43 having opposed finger rings 44. The central member 41 also attaches to the catheter 11, and is PC1'IUS95106457 therefore an extension of the catheter 11. The member 43 additionally includes an internal connector 45 for clamping the proximal end 40 of the cutting wire 31.
Thus, when the body 43 is at its distal position as shown in FIG. 1, the distal portion of the catheter 15 is in essentially straight line as shown in FIG. 1 with the active portion 37 of the cutting wire 31 being closely adjacent the catheter 11. Retracting the body portion 43, causes the cutting wire 31 to bend the distal end upwardly as shown in FIG. 1 to a position that ie essentially at right angles to the main axis of the catheter, as will be shown later.
The connector block 45 and the cutting wire 31 are generally conductive members that attach through an RF
i5 connector 46 to an RF heating source 47. The use of such RF heating sources 47 for energizing a cutting wire 31 thereby to cut the sphincter muscle is well known in the art and represents one possible sphincterotomy procedure that can be adapted for the apparatus of this invention and is not described further.
With this description of the apparatus structure, it will now be possible to understand its use in a particular application. FIG. 5 discloses, in a partially broken and schematic view, the positioning of a duodenoscope 50 in the duodenum 51 adjacent the sphincter of Oddi 52. A
catheter 11 such as constructed in FIG. 1 passes through the sphincter of Oddi-52 into the common bile duct 53, bypassing the pancreatic duct 54. The distal end 14 does not extend to the gallbladder 55.
Fluoroscopy allows the appropriate positioning by utilizing a series of radio-opaque markers 56 at the distal portion 15 that may include the clamp 35 and the reinforcing sleeve 38 in FIG. 4. The catheter 11 can be positioned with or without the presence of a guidewire 57 in the lumen 16 shown in FIGS. 2, 3 and 4. For purposes of injecting the contrast agent, any guidewire 57 can be withdrawn to allow the contrast agent to be injected through the lumen 16 for purposes of fluoroscopic W095131246 2 ~ 9x139 examination to confirm the presence of one or more gallstones 58. It is also possible during the operation to expand the balloon 30 to occlude the bile duct 53 and block any migration of contrast agent into the duodenum 51 or the pancreatic duct 54.
FIG. 6 is an enlarged view showing the duodenum 51, sphincter of Oddi 52, portions of the pancreatic duct 54 and the common bile duct 53. In FIG. 6 the catheter-11 -has been positioned relative to the duodenoscope 50 through the opening of the sphincter of Oddi 52. The handle 43 in FIG. 1 has been drawn proximally to deflect the distal portion 15 into essentially a right angle configuration such that the cutting wire 31 abuts a portion of the sphincter of Oddi 52. The application of RF heating to the cutting wire 31 then will cut the sphincter of Oddi 52 and enlarge the opening therethrough.
As will be apparent, the sphincterotomy is performed with direct visualization of the sphincter of Oddi through the duodenoscope.
Moreover, as has been observed by others, catheters having guidewire and cutting wire lumens tend to assume a particular angular orientation when the distal portion 15 emerges from the duodenoscope. This orientation is essentially independent of the angular position of the catheter when it is inserted into the duodenoscope. The offset nature of the lumen 20 as shown in FIG. 2, improves the location of the cutting wire 31 as the distal portion 15 passes through the sphincter of Oddi 52. Specifically the angularly offset brings the cutting wire 31 into better alignment with the common bile duct 53 and . displaces the cutting wire from the pancreatic duct 54.
FIG. 7 depicts the catheter after the sphincterotomy and after the catheter li is advanced over the guidewire 57, if used. FIG. 7 also discloses the catheter 11 after the balloon 30 has been moved beyond a gallstone 58 in the bile duct 53. The balloon 30 is expanded so that upon withdrawal of the catheter 11 the balloon 30 will dislodge W0 95/31246 ~ PCT/US95/06457 the gallstones 57 and sweep them through the sphincter of Oddi 52 into the duodenum 51.
As will now be apparent from the description of the particular catheter apparatus 10 shown in FIG. 1 and its use as discussed with respect to FIGS. 5, 6, and 7, the single catheter apparatus of this invention is capable of providing diagnostic contrast agent injection, of performing a sphincterotomy and of dislodging gallstones in the common bile duct or other portions of the biliary tree without having to exchange a catheter. Moreover, positioning and sizing of the lumens enables these functions to be performed with a catheter apparatus that is readily adapted for use in the working channels of standard duodenoscopes. Consequently the gallstones can be removed from the biliary tree without bile duct incisions and accompanying surgical procedures, as duodenoscope can be introduced through the alimentary tract. Consequently the entire procedure is adapted for being performed more rapidly than prior art procedures and with fewer components. The net effect is to reduce patient trauma and the overall time and cost of conducting the procedure.
In FIG. 1 the balloon 30.is located proximally of the cutting wire 31. FIG. 8 discloses an alternative embodiment in which a balloon 60 is located distally of the cutting wire 31. More specifically, the distal end of a lumen I7A, corresponding to the lumen 17 in FIGS. 3 and 4, is sealed. A side facing exit port 61 skived or otherwise formed in the catheter 11 opens into a chamber 62 formed by the balloon 60. A first aealing.portion 63 and a sealing portion 64 of the balloon 60 connect proximally and distally of the aperture 6i respectively and seal the chamber 62.
Introduction of a balloon inflation fluid through the lumen 17A expands the balloon 6D into an occluding orientation corresponding to the orientation of the balloon 30 shown in FIG. 3. Retraction of the catheter 11 with the distal balloon 60 inflated enables withdrawal of WO 95/31246 219 013 9 pCTIUS95106457 a gallstone from the bile duct. This particular embodiment is particularly adapted when it is determined that a gallstone is located high in the biliary tree to minimize the incursion of the distal portion 15 through the biliary tree beyond the gallstone or in any application in which the internist desires to minimize the length of the distal portion 15 that extends beyond the occluding balloon.
FIG. 9 discloses another embodiment. of this invention for enlarging the sphincter of Oddi and performing another procedure, such as injecting a contrast agent into the biliaxy tree, as might be used in the diagnosis and treatment of a stricture in the biliary tree. In this particular embodiment an exit port 65 from the lumen 17B
is located in the distal end 14 of the distal portion 15.
The lumen 16 then can be used for a guidewire and the lumen 178, for injecting the contrast agent directly into the biliary tree while the guidewire remains in place.
The apparatus would then be positioned to perform a sphincterotomy without having to exchange a catheter should the procedure be warranted.
As still another alternative, the internist could utilize a conventional catheter for purposes of injecting the contrast agent to determine the need for gallstone removal. If treatment were indicated, the internist could then utilize apparatus as shown in FIG. 1 with a single exchange over the guidewire that would pass through the lumen 16 as previously described.
Therefore, it will now be apparent that apparatus constructed in accordance with this invention attains the several objects and the advantages of this invention.
More particularly, catheter apparatus constructed in accordance with this invention allows the injecti f . on o a contrast agent, the performance of a sphincterotomy and dislodging gallstones from the common bile duct through the enlarged sphincter of Oddi into the duodenum all without requiring any catheter exchanges. Moreover, this apparatus allows such a procedure.to occur through a duodenoscope to minimize patient trauma. The use of a single catheter with ari elimination of catheter exchanges further reduces the time and costs associated with the use of multiple, single-function catheter devices.
As will be apparent from the foregoing description, many alterations can be made to the specifically disclosed embodiments. Different balloon structures can be used and located at alternative positions. Different cutting wire embodiments and orientations can be used. Thus, although this invention has been disclosed in terms of certain embodiments, it will be apparent that many modifications can be made to the disclosed apparatus Without departing from the invention. Therefore, it is the intent of the appended claims to cover all such variations and modifications as come within the true spirit and scope of this invention.
Descri tion ADTJaT'at'L18 T~O~" PeT'formi n~ 17i agnost~ c and per neutic Mpdalities in the B~~~a~r Tree T
Fi l a~ical e d This invention generally relates to apparatus that is useful in performing diagnostic and therapeutic modalities in the biliary tree and more particularly to apparatus that is adapted for facilitating the diagnosis of gallstones in the bile duct and other portions of the biliary tree and the removal of such gallstones.
Backaround Art Historically the migration of gallstones into an individual's common bile duct was corrected by general surgical procedures. A surgeon would incise the bile duct and remove the gallstones and normally remove the gallbladder. In recent years less invasive treatment modalities have replaced these general surgical procedures and reduced patient trauma, long hospital stays and recovery periods.
For example, United States Letters Patent No.
4,696,668 and United States Letters Patent No. 4,781,677, both to Wilcox, disclose a treatment modality involving the administration of a dissolution agent in the bile duct to essentially dissolve any gallstones. More specifically, a catheter contains several lumens for inflating and deflating each of two balloons, venting bile, and infusing and aspirating the dissolution agent.
Inflating the balloons occludes the bile duct at two spaced sites and creates a sealed spaced that receives the dissolution agent. As the space is sealed from the remaining biliary tree, the dissolution agent finds a t ccess to the gallbladder and any gallstones therein through the cystic duct with the exclusion of bile from the gallbladder fundus. The dissolution agent also will be confined in high concentration around bile duct gallstones. After the gallstones dissolve the balloons are deflated and the catheter can be withdrawn. In this particular approach, the catheter is directed into the biliary tree using a standard duodenoscope that passes through the alimentary tract. Although this and analogous approaches have the potential of minimizing patient trauma, such treatments require extended placement of the duodenoscope in the patient, exhibit low efficacy and introduce a potential for adverse reactions to the dissolution agents.
In an alternative approach, a surgeon directs a surgical extractor into the biliary tree through at least an incision in the bile duct. For example, in United States Letters Patent No. 3,108,593 to Glassman a surgeon incises both the bile duct and duodenum. Then the surgeon directs an extractor through the bile duct incision, biliary tree, sphincter of Oddi and duodenum to exit through the duodenum incision. This extractor includes a series of longitudinally spaced cages for trapping any gallstones in the bile duct and removing them through either of the incisions.
United States Letters Patent No. 4,627,837 to Gonzalo discloses a catheter device with a pair of inflatable balloons at its distal end. This catheter is led through an incision in the bile duct toward the duodenum. After the distal balloon passes through the sphincter of Oddi, both balloons are expanded to anchor the catheter in place. This enables the catheter to be used for irrigating and flushing through other lumens in order to capture any gallstone in the second balloon for removal through the incised bile duct.
In accordance with still another modality as for the treatment of strictures, a surgeon may insert a catheter device through the bile duct or duodenum for the purpose of dilating or enlarging the sphincter of Oddi. For example, United States Letters Patent No. 4,705,041 to Aim discloses a dilator that is directed through an incision in the bile duct and the sphincter of Oddi. An expandable tip dilates the sphincter of Oddi. United States Letters Patent No. 5,035,696 to Rydell discloses an electrosurgical instrument that is directed through the R'O 9S/31?A6 219 013 9 PCTIUS95106457 duodenum and to the sphincter of Oddi for performing a sphincterotomy. This apparatus contains a cutting wire _ . that is heated to cut the sphincter muscle. United States Letters Patent No. 5,024,617 to Karpiel discloses a , similar device that can be directed through a duodenoacope. United States Letters Patent No. 5,152,772 .
to Sewell, Jr. discloses a device for performing a ephincterotomy that is directed through an incision in th e bile duct and includes a knife for cutting the sphincter' 1D muscle.
The use of the duodenoscope and sphincterotomy devices, such as shown in the Rydell and Karpiel patents, enables an internist to diagnose and treat problems in the biliary tree with minimal patient invasion. For example, modalities as described in these patents eliminates the surgery needed for incising the bile duct. Consequently, , these modalities can be performed as outpatient or day surgical procedures. These procedures greatly reduce patient trauma, the length of a hospital stay and recove ry times. For example, if an internist detezmines that gallstones are present in the biliary tree, particularly the common bile duct, the internist can insert a duodenoscope into the duodenum to view the sphincter of Oddi. Then a first catheter can be advanced through the working channel of the duodenoscope with or without a guidewire and directed through the sphincter of Oddi into the biliary tree. Contrast agent injected through the catheter enables fluoroscopy or other imaging procedures to confirm the presence of gallstones within the biliaxy tree. Next the internist exchanges the first catheter for a second catheter for performing a aphincterotomy such as the types disclosed in the above-identified Rydell and Karpiel patents. The second catheter is then exchanged for a third catheter such as shown in the Glasaman patent or some other equivalent retrieval catheter for drawings gallstones through the enlarged sphincter of Oddi.
Thereafter the retrieval catheter is manipulated to release the gallstone into the duodenum. The catheter, any guidewire and the duodenoscope can then be removed to complete the procedure.
This procedure is significantly less traumatic to the patient than other prior art procedures because the only incision occurs during the sphincterotomy. However, this procedure as presently practiced requires three separate catheters and two catheter exchanges. These exchanges are required because the first, second and third catheters function solely to inject contrast agent to perform the sphincterotomy and to dislodge gallstones, respectively.
The time required for performing each catheter exchange can increase patient trauma and increase the duration of the procedure and reduce efficiency. Moreover, each such procedure requires the use of two or three separate catheter devices.
pisc~ osure of rnt.A.,r; r", Therefore, an object of this invention is to provide apparatus for performing both diagnosis and additional therapeutic treatment without requiring a catheter exchange.
Another object of this invention is to provide apparatus for performing diagnosis and treatment in the biliary tree that can reduce patient trauma.
Yet another object of this invention is to provide apparatus that enables the removal of gallstones from the biliary tree by a procedure that reduces the number of required catheters and catheter exchanges.
Still another object of this invention is to provide a single catheter apparatus that can perfoxnt a sphincterotomy and remove gallstones in the common bile duct.
Yet another object of this invention is to provide a single catheter apparatus that can perforni a sphincterotomy and inject contrast material into the.
biliary tree.
Still yet another object of this invention is to provide a single catheter apparatus that can inject contrast agent into biliary tree, performing a W095131246 219 0 ~ 3 9 PCT/US95/06457 sphincterotomy and remove gallstones in the bile duct into the duodenum.
In accordance with one aspect of this invention , apparatus can be used in a treatment modality including an enlargement procedure and another procedure to be performed. This apparatus includes a catheter with proximal and distal ends and proximal and distal portions.
The catheter includes first, second and third generally parallel lumens. The first lumen has a greater diameter ZO than either of the second and third lumens and the lumens each extend between proximal and distal portions of the catheter. The apparatus for performing the enlargement procedure extends through the second lumen for operating distally of the catheter in response to manipulations of an operator at the proximal end of the catheter. The first lumen has a proximal port for enabling access to the first Lumen and the third Lumen has a proximal port and a distal port for enabling the remote control of some other procedure.
In accordance with another aspect of this invention, apparatus is provided for removing objects from the biliary tree. This apparatus includes a catheter that is directed through the working channel of a duodenoscope and the sphincter of Oddi into the biliary tree. The catheter includes first, second and third lumens with the first lumen being larger than either the second or third lumens and the lumens generally extending between proximal and distal portions of the catheter along parallel axes.
Apparatus for cutting the sphincter of Oddi includes a cutting wire extending through the second lumen and externally of the catheter means through a distal port along a length that is coextensive with part of the distal portion of the catheter,. A handle attaches to the catheter at the proximal portion and to the proximal wire portion to control the position and orientation of the cutting wire. An expansible balloon is mounted on the distal portion spaced from the cutting wire and can be inflated through the third lumen in order to move any gallstone in the biliary tree through the enlarged sphincter of Oddi.
In accordance with still another aspect of this invention, the apparatus is provided for directing contrast agent into the biliary tree and performing a sphincterotomy through the working channel of a duodenoscope. This apparatus includes a catheter that is directed through the working channel of the duodenoscope and the sphincter of Oddi into the biliary tree. The catheter includes first, second and third lumens with the first lumen being larger than either the second or third lumens and the lumens generally extending between proximal and distal portions of the catheter along parallel axes. Apparatus for cutting the sphincter of Oddi includes a cutting wire extending through the second lumen and externally of the catheter means through a distal port along a length that is coextensive with part of said distal portion of the catheter. A handle attaches to the catheter into the proximal wire portion to control the position and orientation of the cutting wire.
The proximal port of the third lumen connects to a contrast agent source and the third lumen delivers contrast agent into the biliary tree through a distal port in the distal end of the catheter.
In accordance with a further aspect of this invention, there is provided apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, said apparatus comprising: A. catheter means for being directed through internal passageways in the patient guided by a guidewire previously positioned in the passageways, said catheter means having proximal and distal ends and proximal -6a-and distal portions adjacent to said proximal and distal ends respectively, first, second and third generally parallel lumens adapted for receiving a guidewire therethrough with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, B. enlargement means for performing the enlargement procedure extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, C. operator means at said proximal end attached to said catheter means and said proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means, D. a first lumen proximal port in said proximal portion of said catheter means for enabling access to said first lumen, E. third lumen proximal port at said proximal end of said catheter means for providing access to said third lumen to enable a user to control the other procedure at the distal end of said catheter means through said third lumen and F. a distally facing port at said distal end thereof in said first lumen whereby said first lumen is adapted to receive the pre-positioned guidewire therethrough so that said catheter means is slidable along the guidewire.
In accordance with an even further aspect apparatus for the removal of objects from the biliary tree through the working channel of a duodenoscope, said apparatus comprising: A. catheter means for being directed through the working channel and the sphincter of Oddi into the biliary tree, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively and having first, second and third generally parallel lumens with said first lumen being larger than said second and third lumens, said -6b-lumens extending between said proximal and distal portions, each of said lumens having a proximal port and a distal port at said proximal and distal portions of said catheter means, said distal port of said first lumen being located at said distal end of said catheter means and being adapted for receiving a guidewire therethrough, B. sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through said distal port of said second lumen along a length that is coextensive with a part of said distal portion of said catheter means and handle means attached to said catheter means proximal portion and a proximal portion of said cutting wire exiting said proximal port of said second lumen for positioning said cutting wire, and C. an expansible balloon mounted on the distal portion of said catheter means and coextensive with said distal port of said third lumen thereby to enable inflation of said expansible balloon by the administration of an inflation fluid at said proximal port of said third lumen.
In accordance with a still further aspect apparatus for the diagnosis of objects in the biliary tree by means of a contrast agent delivered from a source, said apparatus being directed through the working channel of a duodenoscope and comprising: A. catheter means for being directed through the working channel and the sphincter of Oddi into the biliary tree, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively and having first, second and third generally parallel lumens with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, each of said lumens having a proximal -6c-port and a distal port at said proximal and distal portions of said catheter means, said distal port of said first lumen being located at said distal end of said catheter means, B. sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through said distal port along a length that is coextensive with a part of said distal portion of said catheter means and handle means attached to said catheter means proximal portion and a proximal portion of said cutting wire exiting said proximal port of said second lumen for operating said cutting wire, and C. means for connecting the proximal port of said third lumen to the contrast agent source, said distal port of said third lumen being located at the distal end of said catheter.
In accordance with yet another aspect apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, of the type comprising: A. catheter means for being directed through internal passageways in the patient guide by a guidewire previously positioned in the passageways, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, and including a first lumen extending between said proximal and distal portions, said first lumen having a distally facing port at said distal end thereof and a proximal port at said proximal portion for enabling access to said first lumen, whereby said first lumen is adapted to receive the pre-positioned guidewire therethrough so that said catheter means is slidable along the guidewire, and B. characterized in that: C. said catheter means further includes second and third lumens disposed generally parallel to said first lumen and -6d-extending between said proximal and distal portions, said first lumen being larger than said second and third lumens, said third lumen having a proximal port at said proximal portion for providing access to said third lumen to enable a user to control the other procedure at said distal end through said third lumen, said third lumen having a radially facing distal port at said distal end whereby fluid introduced at said third lumen proximal port discharges from said third lumen distal port, and D. said apparatus further includes enlargement means for performing the enlargement procedure, extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, and operator means at said proximal end attached to said catheter means and a proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means.
In accordance with a yet further aspect apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, said apparatus comprising: A. catheter means for being directed through internal passageways in the patient said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, first, second and third generally parallel lumens adapted for receiving a guidewire therethrough with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, B. enlargement means for performing the enlargement procedure extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, said enlargement means comprising a cutting wire having a distal end attached to said catheter means at the distal end of -6e-said second lumen, a portion thereof external to said catheter means along a length coextensive with a portion of said distal portion of said catheter means and a proximal end of said cutting wire attached to said operator means, C. operator means at said proximal end attached to said catheter means and said proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means, D, a first lumen proximal port in said proximal portion of said catheter means for enabling access to said first lumen, and E. a third lumen proximal port at said proximal end of said catheter means for providing access to said third lumen to enable a user to control the other procedure at the distal end of said catheter means through said third lumen.
Brief Description of Drawings The appended claims particularly point out and distinctly claim the subject matter of this invention. The various objects, advantages and novel features of this invention will be more fully apparent from a reading of the following detailed description in conjunction with the accompanying drawings in which like reference numerals refer to like parts, and in which:
FIG. 1 is a plan view of one embodiment of apparatus constructed in accordance with this invention;
FIG. 2 is a cross-section taken along lines 2-2 in FIG. 1;
FIG. 3 is a cross-section taken along lines 3-3 in FIG. 2;
W095/31246 219 013 9 PCTIUS95/064i7 FIG. 4 is a cross-section taken along lines 4-4 in FIG. 2;
FIG. 5 depicts the apparatus of FIG. 1 positioned through a duodenoscope for injecting contrast agent into the biliary tree.
FIG. 6 is an enlarged view that depicts the orientation of the apparatus in FIG. 1 for performing a sphincterotomy;
FIG. 7 depicts the apparatus of FIG. 1 positioned through a duodenoscope for dislodging material within the common bile duct;
FIG. 8 is a cross-section of an alternative embodiment of the apparatus as viewed generally along lines 3-3 in FIG. 2.; and FIG. 9 is a cross-section of still another embodiment of this invention taken along lines 3-3 in FIG. 2.
Best Mode for Carrvi,~ n"r rr, rn.>o r FIG. 1 depicts a catheter apparatus 10 that has the capability of injecting a contrast agent into the biliary tree, of performing a sphincterotomy and of dislodging a gallstone into the duodenum. The apparatus 10 includes a catheter 11 which, for purposes of definition in l d , c u es a proximal end portion 12 extending from a proximal end 13 and a distal end 14 with a distal portion 15 extending a short distance from the distal end 14. In a typical application, the catheter will have a working length of 200 cm and the distal end portion 15 will have a length of 6 cm to 9 cm. Normally the distal portion 15 will have a diameter that is smaller than the diameter of the proximal portion to increase the flexibility of the distal portion 15. The reduction in diameter also makes the tip less traumatic and allows the tip portion to reach smaller _ passages while allowing the larger proximal portion to provide necessary hoop strength and rigidity, particularly where the proximal portion 13 is coextensive with the working channel of a duodenoscope. For example, the proximal and distal portions might have diameters wo 9s1311A6 2 I 9 013 9 PCT/U595/06457 _g_ corresponding to 7 Fr and 5.5 Fr catheter sizes (i.e., 0.09" and 0.07" respectively).
As shown particularly in FIG. 2, the catheter 11 has three lumens. A first lumen 16 has a diameter that is greater than either a second lumen 17 or a third lumen 20.
In one particular embodiment the lumen I6 has a diameter of 0.040" in the proximal portion 13 that reduces to about 0.037" in the distal portion 15 to receive a standard 0.035" guidewire. In addition the lumen 16 is offset from the center of the catheter 11.
The lumens 17 and 2~0 are each smaller in diameter than the lumen 16 and are radially offset from the centerline of the catheter, from each other and from the lumen 16. In one particular embodiment the lumens 17 and 20 each have internal diameters of 0.028" in the proximal portions 13 that reduces to about 0.020" in the distal portion 15. As described later, this lumen 20 carries a cutting wire for performing a sphincterotomy and for allowing the infusion of a contrast agent at reasonable 2D rates. The angular spacing between the lumens 17 and 20 is about 45° and the angular spacing between the first lumen 16 and each of the lumens 17 and 20 each is about 157.5°.
In this configuration and with these dimensions the proximal portion 13 readily passes through the working channel of any duodenoscope.
Referring again to FIGS. 1 and 2, each of the lumens 16, 17 and 20 includes an entry port in the proximal portion 13 and an exit port in the distal portion 15.
Generally, and as described in more detail later, the first lumen 16 has an exit port through the distal end 14 while the exit ports for the lumens 17 and 20 can be sited at different locations in the distal portion 15 depending upon a particular application.
In FIG. 1, the entry ports in proximal portion 13 adjacent the proximal end 12 include an entry port 21 that provides access to the lumen 16 and includes an optional Leur lock fitting 22. A proximally positioned entry port 23 provides access to the lumen 17 and includes an _g_ optional Leur lock fitting 24. A proximal entry port 25 for the lumen 20 is located coextensively with a portion -of a handle 26 attached to the proximal end 12.
Referring to the distal end portion 15, the catheter 11 in this particular embodiment carries an expansible balloon 30 proximally of the excursion of a cutting wire 31 externally of the catheter 11. As shown in FIG. 3, the lumen 17 emerges at a distal exit port 32 through the side of the catheter 11 with the interior of the expansible balloon 30. An extension of the lumen 17 beyond the distal port 32 is sealed by known methods of manufacture.
Consequently, fluid forced through the entrance port 23, as by a syringe (not shown) attached to the Leur lock fitting 24, expands the balloon 30 into an occluding I5 orientation as shown in FIG. 3 with an inflated diameter in the range up to 20 mm.
As will also be apparent from viewing FIGS. 3 and 4, the first lumen 16 extends through the catheter 11 and terminates with an exit port 33 in the distal end 14.
Thus the lumen 16 is adapted for receiving a guidewire through the entrance port 21 that will extend through the catheter 11 and exit the distal end 14 and allow the , catheter to slide over that guidewire.
Referring to FIG. 4, a distal end 34 of the cutting wire 31 attaches to a clamp 35 formed at the distal end of the lumen 20. Spaced skived ports 36A and 36B allow an active portion 37 of the cutting wire 31 to emerge from the catheter 11 through the skived aperture 36A, parallel the catheter 11 exteriorly thereof and return into the lumen 20 through the port 36B and a reinforcing sleeve 38.
. The cutting wire 31 then extends through the lumen 2D to the handle 26 shown in FIG. 1 where it emerges as a proximal end portion 40.
The handle 26, as shown in FIG. 1, includes a central member 41 terminating with a thumb ring 42. The central member 41 extends through and slides with respect to a body section 43 having opposed finger rings 44. The central member 41 also attaches to the catheter 11, and is PC1'IUS95106457 therefore an extension of the catheter 11. The member 43 additionally includes an internal connector 45 for clamping the proximal end 40 of the cutting wire 31.
Thus, when the body 43 is at its distal position as shown in FIG. 1, the distal portion of the catheter 15 is in essentially straight line as shown in FIG. 1 with the active portion 37 of the cutting wire 31 being closely adjacent the catheter 11. Retracting the body portion 43, causes the cutting wire 31 to bend the distal end upwardly as shown in FIG. 1 to a position that ie essentially at right angles to the main axis of the catheter, as will be shown later.
The connector block 45 and the cutting wire 31 are generally conductive members that attach through an RF
i5 connector 46 to an RF heating source 47. The use of such RF heating sources 47 for energizing a cutting wire 31 thereby to cut the sphincter muscle is well known in the art and represents one possible sphincterotomy procedure that can be adapted for the apparatus of this invention and is not described further.
With this description of the apparatus structure, it will now be possible to understand its use in a particular application. FIG. 5 discloses, in a partially broken and schematic view, the positioning of a duodenoscope 50 in the duodenum 51 adjacent the sphincter of Oddi 52. A
catheter 11 such as constructed in FIG. 1 passes through the sphincter of Oddi-52 into the common bile duct 53, bypassing the pancreatic duct 54. The distal end 14 does not extend to the gallbladder 55.
Fluoroscopy allows the appropriate positioning by utilizing a series of radio-opaque markers 56 at the distal portion 15 that may include the clamp 35 and the reinforcing sleeve 38 in FIG. 4. The catheter 11 can be positioned with or without the presence of a guidewire 57 in the lumen 16 shown in FIGS. 2, 3 and 4. For purposes of injecting the contrast agent, any guidewire 57 can be withdrawn to allow the contrast agent to be injected through the lumen 16 for purposes of fluoroscopic W095131246 2 ~ 9x139 examination to confirm the presence of one or more gallstones 58. It is also possible during the operation to expand the balloon 30 to occlude the bile duct 53 and block any migration of contrast agent into the duodenum 51 or the pancreatic duct 54.
FIG. 6 is an enlarged view showing the duodenum 51, sphincter of Oddi 52, portions of the pancreatic duct 54 and the common bile duct 53. In FIG. 6 the catheter-11 -has been positioned relative to the duodenoscope 50 through the opening of the sphincter of Oddi 52. The handle 43 in FIG. 1 has been drawn proximally to deflect the distal portion 15 into essentially a right angle configuration such that the cutting wire 31 abuts a portion of the sphincter of Oddi 52. The application of RF heating to the cutting wire 31 then will cut the sphincter of Oddi 52 and enlarge the opening therethrough.
As will be apparent, the sphincterotomy is performed with direct visualization of the sphincter of Oddi through the duodenoscope.
Moreover, as has been observed by others, catheters having guidewire and cutting wire lumens tend to assume a particular angular orientation when the distal portion 15 emerges from the duodenoscope. This orientation is essentially independent of the angular position of the catheter when it is inserted into the duodenoscope. The offset nature of the lumen 20 as shown in FIG. 2, improves the location of the cutting wire 31 as the distal portion 15 passes through the sphincter of Oddi 52. Specifically the angularly offset brings the cutting wire 31 into better alignment with the common bile duct 53 and . displaces the cutting wire from the pancreatic duct 54.
FIG. 7 depicts the catheter after the sphincterotomy and after the catheter li is advanced over the guidewire 57, if used. FIG. 7 also discloses the catheter 11 after the balloon 30 has been moved beyond a gallstone 58 in the bile duct 53. The balloon 30 is expanded so that upon withdrawal of the catheter 11 the balloon 30 will dislodge W0 95/31246 ~ PCT/US95/06457 the gallstones 57 and sweep them through the sphincter of Oddi 52 into the duodenum 51.
As will now be apparent from the description of the particular catheter apparatus 10 shown in FIG. 1 and its use as discussed with respect to FIGS. 5, 6, and 7, the single catheter apparatus of this invention is capable of providing diagnostic contrast agent injection, of performing a sphincterotomy and of dislodging gallstones in the common bile duct or other portions of the biliary tree without having to exchange a catheter. Moreover, positioning and sizing of the lumens enables these functions to be performed with a catheter apparatus that is readily adapted for use in the working channels of standard duodenoscopes. Consequently the gallstones can be removed from the biliary tree without bile duct incisions and accompanying surgical procedures, as duodenoscope can be introduced through the alimentary tract. Consequently the entire procedure is adapted for being performed more rapidly than prior art procedures and with fewer components. The net effect is to reduce patient trauma and the overall time and cost of conducting the procedure.
In FIG. 1 the balloon 30.is located proximally of the cutting wire 31. FIG. 8 discloses an alternative embodiment in which a balloon 60 is located distally of the cutting wire 31. More specifically, the distal end of a lumen I7A, corresponding to the lumen 17 in FIGS. 3 and 4, is sealed. A side facing exit port 61 skived or otherwise formed in the catheter 11 opens into a chamber 62 formed by the balloon 60. A first aealing.portion 63 and a sealing portion 64 of the balloon 60 connect proximally and distally of the aperture 6i respectively and seal the chamber 62.
Introduction of a balloon inflation fluid through the lumen 17A expands the balloon 6D into an occluding orientation corresponding to the orientation of the balloon 30 shown in FIG. 3. Retraction of the catheter 11 with the distal balloon 60 inflated enables withdrawal of WO 95/31246 219 013 9 pCTIUS95106457 a gallstone from the bile duct. This particular embodiment is particularly adapted when it is determined that a gallstone is located high in the biliary tree to minimize the incursion of the distal portion 15 through the biliary tree beyond the gallstone or in any application in which the internist desires to minimize the length of the distal portion 15 that extends beyond the occluding balloon.
FIG. 9 discloses another embodiment. of this invention for enlarging the sphincter of Oddi and performing another procedure, such as injecting a contrast agent into the biliaxy tree, as might be used in the diagnosis and treatment of a stricture in the biliary tree. In this particular embodiment an exit port 65 from the lumen 17B
is located in the distal end 14 of the distal portion 15.
The lumen 16 then can be used for a guidewire and the lumen 178, for injecting the contrast agent directly into the biliary tree while the guidewire remains in place.
The apparatus would then be positioned to perform a sphincterotomy without having to exchange a catheter should the procedure be warranted.
As still another alternative, the internist could utilize a conventional catheter for purposes of injecting the contrast agent to determine the need for gallstone removal. If treatment were indicated, the internist could then utilize apparatus as shown in FIG. 1 with a single exchange over the guidewire that would pass through the lumen 16 as previously described.
Therefore, it will now be apparent that apparatus constructed in accordance with this invention attains the several objects and the advantages of this invention.
More particularly, catheter apparatus constructed in accordance with this invention allows the injecti f . on o a contrast agent, the performance of a sphincterotomy and dislodging gallstones from the common bile duct through the enlarged sphincter of Oddi into the duodenum all without requiring any catheter exchanges. Moreover, this apparatus allows such a procedure.to occur through a duodenoscope to minimize patient trauma. The use of a single catheter with ari elimination of catheter exchanges further reduces the time and costs associated with the use of multiple, single-function catheter devices.
As will be apparent from the foregoing description, many alterations can be made to the specifically disclosed embodiments. Different balloon structures can be used and located at alternative positions. Different cutting wire embodiments and orientations can be used. Thus, although this invention has been disclosed in terms of certain embodiments, it will be apparent that many modifications can be made to the disclosed apparatus Without departing from the invention. Therefore, it is the intent of the appended claims to cover all such variations and modifications as come within the true spirit and scope of this invention.
Claims (32)
1. Apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, said apparatus comprising:
A. catheter means for being directed through internal passageways in the patient guided by a guidewire previously positioned in the passageways, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, first, second and third generally parallel lumens adapted for receiving a guidewire therethrough with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, B. enlargement means for performing the enlargement procedure extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, C. operator means at said proximal end attached to said catheter means and said proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means, D. a first lumen proximal port in said proximal portion of said catheter means for enabling access to said first lumen, E. third lumen proximal port at said proximal end of said catheter means for providing access to said third lumen to enable a user to control the other procedure at the distal end of said catheter means through said third lumen and F. a distally facing port at said distal end thereof in said first lumen whereby said first lumen is adapted to receive the pre-positioned guidewire therethrough so that said catheter means is slidable along the guidewire.
A. catheter means for being directed through internal passageways in the patient guided by a guidewire previously positioned in the passageways, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, first, second and third generally parallel lumens adapted for receiving a guidewire therethrough with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, B. enlargement means for performing the enlargement procedure extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, C. operator means at said proximal end attached to said catheter means and said proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means, D. a first lumen proximal port in said proximal portion of said catheter means for enabling access to said first lumen, E. third lumen proximal port at said proximal end of said catheter means for providing access to said third lumen to enable a user to control the other procedure at the distal end of said catheter means through said third lumen and F. a distally facing port at said distal end thereof in said first lumen whereby said first lumen is adapted to receive the pre-positioned guidewire therethrough so that said catheter means is slidable along the guidewire.
2. Apparatus as recited in claim 1 wherein said catheter means additionally comprises a third lumen distal port at said distal portion thereof spaced proximally of said distal end.
3. Apparatus as recited in claim 2 additionally comprising expansible balloon means for performing the other function, said expansible balloon means being coextensive with said third lumen distal port thereby to be expanded by the introduction of a balloon expansion fluid through said third lumen from said third lumen proximal port.
4. Apparatus as recited in claim 1 wherein said catheter means additionally comprises third lumen distal port at said distal end thereof whereby fluid introduced at said third lumen proximal port discharges from said third lumen distal port.
5. Apparatus as recited in claim 1 wherein said enlargement means comprises a cutting wire having a distal end attached to said catheter means at the distal end of said second lumen, a portion thereof external to said catheter means along a length coextensive with a portion of said distal portion of said catheter means and proximal end of said cutting wire attached to said operator means.
6. Apparatus as recited in claim 5 wherein said cutting wire operates in response to energy from an rf heating source and said operator means includes connector means for connecting said cutting wire to the rf heating source.
7. Apparatus as recited in claim 5 wherein said second lumen extends through said catheter means along an axis that is displaced from the center of said catheter means thereby to offset said cutting wire from the center of said catheter means.
8. Apparatus as recited in claim 7 wherein each of said first and third lumens extends along an axis through said catheter means that is displaced from the center of said catheter means and from the axes of the others of said lumens.
9. Apparatus as recited in claim 5 wherein said catheter means additionally comprises a first lumen distal port at said distal end thereof.
10. Apparatus as recited in claim 9 wherein said catheter means additionally comprises a third lumen distal port at said distal portion thereof spaced proximally of said distal end.
11. Apparatus as recited in claim 10 additionally comprising expansible balloon means for performing the other procedure, said expansible balloon means being located on said catheter means distal portion proximally of said cutting wire and said first lumen distal port exits said catheter means within said expansible balloon means thereby to enable the expansion of said expansible balloon means by the introduction of a balloon expansion fluid through said third lumen from said third lumen proximal port.
12. Apparatus as recited in claim 10 additionally comprising expansible balloon means for performing the other procedure, said expansible balloon means being located on said catheter means distal portion distally of said cutting wire and said first lumen distal port exits said catheter means within said expansible balloon means thereby to enable the expansion of said expansible balloon means by the introduction of a balloon expansion fluid through said third lumen from said third lumen proximal port.
13. Apparatus as recited in claim 9 wherein said catheter means additionally comprises third lumen distal port at said distal end thereof whereby fluid introduced at said third lumen proximal port discharges from said third lumen distal port.
14. Apparatus for the removal of objects from the biliary tree through the working channel of a duodenoscope, said apparatus comprising:
A, catheter means for being directed through the working channel and the sphincter of Oddi into the biliary tree, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively and having first, second and third generally parallel lumens with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, each of said lumens having a proximal port and a distal port at said proximal and distal portions of said catheter means, said distal port of said first lumen being located at said distal end of said catheter means and being adapted for receiving a guidewire therethrough, B. sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through said distal port of said second lumen along a length that is coextensive with a part of said distal portion of said catheter means and handle means attached to said catheter means proximal portion and a proximal portion of said cutting wire exiting said proximal port of said second lumen for positioning said cutting wire, and C. an expansible balloon mounted on the distal portion of said catheter means and coextensive with said distal port of said third lumen thereby to enable inflation of said expansible balloon by the administration of an inflation fluid at said proximal port of said third lumen.
A, catheter means for being directed through the working channel and the sphincter of Oddi into the biliary tree, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively and having first, second and third generally parallel lumens with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, each of said lumens having a proximal port and a distal port at said proximal and distal portions of said catheter means, said distal port of said first lumen being located at said distal end of said catheter means and being adapted for receiving a guidewire therethrough, B. sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through said distal port of said second lumen along a length that is coextensive with a part of said distal portion of said catheter means and handle means attached to said catheter means proximal portion and a proximal portion of said cutting wire exiting said proximal port of said second lumen for positioning said cutting wire, and C. an expansible balloon mounted on the distal portion of said catheter means and coextensive with said distal port of said third lumen thereby to enable inflation of said expansible balloon by the administration of an inflation fluid at said proximal port of said third lumen.
15. Apparatus as recited in claim 14 wherein each of said lumens extends along an axis through said catheter means that is displaced from the center of said catheter means and from the axes of the others of said lumens.
16. Apparatus as recited in claim 15 wherein said expansible balloon and said third lumen exit port are located distally of said cutting wire.
17. Apparatus as recited in claim 15 wherein said expansible balloon and said third lumen exit port are located in said catheter means distal portion proximally of said cutting wire.
18. Apparatus as recited in claim 15 wherein said catheter means has a generally circular cross section and said proximal portion of said catheter means has a greater diameter than said distal portion.
19. Apparatus as recited in claim 15 wherein said distal portion of said catheter means includes a plurality of radio-opaque marker means formed thereon for appearing in diagnostic images and wherein at least one of said marker means is located coextensively with the external portions of said cutting wire.
20. Apparatus as recited in claim 15 wherein said first lumen is adapted for receiving a guidewire and said first lumen proximal port is located distally of said proximal ports of said second and third lumens.
21. Apparatus for the diagnosis of objects in the biliary tree by means of a contrast agent delivered from a source, said apparatus being directed through the working channel of a duodenoscope and comprising:
A. catheter means for being directed through the working channel and the sphincter of Oddi into the biliary tree, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively and having first, second and third generally parallel lumens with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, each of said lumens having a proximal port and a distal port at said proximal and distal portions of said catheter means, said distal port of said first lumen being located at said distal end of said catheter means, B. sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through said distal port along a length that is coextensive with a part of said distal portion of said catheter means and handle means attached to said catheter means proximal portion and a proximal portion of said cutting wire exiting said proximal port of said second lumen for operating said cutting wire, and C. means for connecting the proximal port of said third lumen to the contrast agent source, said distal port of said third lumen being located at the distal end of said catheter.
A. catheter means for being directed through the working channel and the sphincter of Oddi into the biliary tree, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively and having first, second and third generally parallel lumens with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, each of said lumens having a proximal port and a distal port at said proximal and distal portions of said catheter means, said distal port of said first lumen being located at said distal end of said catheter means, B. sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through said distal port along a length that is coextensive with a part of said distal portion of said catheter means and handle means attached to said catheter means proximal portion and a proximal portion of said cutting wire exiting said proximal port of said second lumen for operating said cutting wire, and C. means for connecting the proximal port of said third lumen to the contrast agent source, said distal port of said third lumen being located at the distal end of said catheter.
22. Apparatus as recited in claim 21 wherein each of said lumens extends along an axis through said catheter means that is displaced from the center of said catheter means and from the axes of the others of said lumens.
23. Apparatus as recited in claim 21 wherein said catheter means has a generally circular cross section and said proximal portion of said catheter means has a greater diameter than said distal portion.
24. Apparatus as recited in claim 21 wherein said distal portion of said catheter means includes a plurality of radio-opaque marker means formed thereon for appearing in diagnostic images and wherein at least one of said marker means is located coextensively with the external portions of said cutting wire.
25. Apparatus as recited in claim 21 wherein said first lumen is adapted for receiving a guidewire and said first lumen proximal port is located at distally of said proximal ports of said second and third lumens.
26. Apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, of the type comprising:
A. catheter means for being directed through internal passageways in the patient guide by a guidewire previously positioned in the passageways, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, and including a first lumen extending between said proximal and distal portions, said first lumen having a distally facing port at said distal end thereof and a proximal port at said proximal portion for enabling access to said first lumen, whereby said first lumen is adapted to receive the pre-positioned guidewire therethrough so that said catheter means is slidable along the guidewire, and B. characterized in that:
C. said catheter means further includes second and third lumens disposed generally parallel to said first lumen and extending between said proximal and distal portions, said first lumen being larger than said second and third lumens, said third lumen having a proximal port at said proximal portion for providing access to said third lumen to enable a user to control the other procedure at said distal end through said third lumen, said third lumen having a radially facing distal port at said distal end whereby fluid introduced at said third lumen proximal port discharges from said third lumen distal port, and D. said apparatus further includes enlargement means for performing the enlargement procedure, extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, and operator means at said proximal end attached to said catheter means and a proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means.
A. catheter means for being directed through internal passageways in the patient guide by a guidewire previously positioned in the passageways, said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, and including a first lumen extending between said proximal and distal portions, said first lumen having a distally facing port at said distal end thereof and a proximal port at said proximal portion for enabling access to said first lumen, whereby said first lumen is adapted to receive the pre-positioned guidewire therethrough so that said catheter means is slidable along the guidewire, and B. characterized in that:
C. said catheter means further includes second and third lumens disposed generally parallel to said first lumen and extending between said proximal and distal portions, said first lumen being larger than said second and third lumens, said third lumen having a proximal port at said proximal portion for providing access to said third lumen to enable a user to control the other procedure at said distal end through said third lumen, said third lumen having a radially facing distal port at said distal end whereby fluid introduced at said third lumen proximal port discharges from said third lumen distal port, and D. said apparatus further includes enlargement means for performing the enlargement procedure, extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, and operator means at said proximal end attached to said catheter means and a proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means.
27. Apparatus as recited in claim 26 wherein said enlargement means comprises a cutting wire having a distal end attached to said catheter means at the distal end of said second lumen, a portion thereof external to said catheter means along a length coextensive with a portion of said distal portion of said catheter means, and a proximal end of said cutting wire attached to said operator means.
28. Apparatus as recited in claim 27 wherein said cutting wire operates in response to energy from an rf heating source and said operator means includes connector means for connecting said cutting wire to the rf heating source.
29. Apparatus as recited in claim 27 or 28 wherein said second lumen extends through said catheter means along an axis that is displaced from the center of said catheter means, thereby to offset said cutting wire from the center of said catheter means.
30. Apparatus as recited in claim 26, adapted for the removal of objects from the biliary tree through the working channel of a duodenoscope wherein said catheter means is adapted for being directed through the working channel and the sphincter of Oddi into the biliary tree, wherein said enlargement means includes sphincterotomy means for cutting the sphincter of Oddi, said sphincterotomy means including a cutting wire extending through said second lumen and externally of said catheter means through distal ports of said second lumen in said distal portion of said catheter means along a length that is coextensive with a part of said distal portion of said catheter means, and said operator means includes handle means attached to said catheter means proximal portion, and a proximal portion of said cutting wire exiting said proximal port of said second lumen for positioning said cutting wire.
31. Apparatus as recited in any one of claims 26 to 30 wherein each of said lumens extends along an axis through said catheter means that is displaced from the center of said catheter means and from the axes of the others of said lumens.
32. Apparatus for use in a treatment modality including an enlargement procedure and another procedure to be performed within a patient, said apparatus comprising:
A. catheter means for being directed through internal passageways in the patient said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, first, second and third generally parallel lumens adapted for receiving a guidewire therethrough with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, B. enlargement means for performing the enlargement procedure extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, said enlargement means comprising a cutting wire having a distal end attached to said catheter means at the distal end of said second lumen, a portion thereof external to said catheter means along a length coextensive with a portion of said distal portion of said catheter means and a proximal end of said cutting wire attached to said operator means, C. operator means at said proximal end attached to said catheter means and said proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means, D. a first lumen proximal port in said proximal portion of said catheter means for enabling access to said first lumen, and E. a third lumen proximal port at said proximal end of said catheter means for providing access to said third lumen to enable a user to control the other procedure at the distal end of said catheter means through said third lumen.
A. catheter means for being directed through internal passageways in the patient said catheter means having proximal and distal ends and proximal and distal portions adjacent to said proximal and distal ends respectively, first, second and third generally parallel lumens adapted for receiving a guidewire therethrough with said first lumen being larger than said second and third lumens, said lumens extending between said proximal and distal portions, B. enlargement means for performing the enlargement procedure extending through said second lumen for operating at said distal portion in response to manipulations at said proximal end, said enlargement means comprising a cutting wire having a distal end attached to said catheter means at the distal end of said second lumen, a portion thereof external to said catheter means along a length coextensive with a portion of said distal portion of said catheter means and a proximal end of said cutting wire attached to said operator means, C. operator means at said proximal end attached to said catheter means and said proximal portion of said enlargement means for operating said enlargement means from a point proximal of said catheter means, D. a first lumen proximal port in said proximal portion of said catheter means for enabling access to said first lumen, and E. a third lumen proximal port at said proximal end of said catheter means for providing access to said third lumen to enable a user to control the other procedure at the distal end of said catheter means through said third lumen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/242,168 US5547469A (en) | 1994-05-13 | 1994-05-13 | Apparatus for performing diagnostic and therapeutic modalities in the biliary tree |
| US08/242,168 | 1994-05-13 | ||
| PCT/US1995/006457 WO1995031246A1 (en) | 1994-05-13 | 1995-05-15 | Apparatus for performing diagnostic and therapeutic modalities in the biliary tree |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2190139A1 CA2190139A1 (en) | 1995-11-23 |
| CA2190139C true CA2190139C (en) | 2006-03-14 |
Family
ID=36095705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002190139A Expired - Lifetime CA2190139C (en) | 1994-05-13 | 1995-05-15 | Apparatus for performing diagnostic and therapeutic modalities in the biliary tree |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2190139C (en) |
-
1995
- 1995-05-15 CA CA002190139A patent/CA2190139C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2190139A1 (en) | 1995-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6443924B1 (en) | Apparatus for performing diagnostic and therapeutic modalities in the biliary tree | |
| US6676659B2 (en) | Steerable sphincterotome and methods for cannulation, papillotomy and sphincterotomy | |
| EP1434533B1 (en) | Apparatus for measuring and controlling the exposed length of a tissue cutting device in an endoscopic catheter | |
| AU2002235394B2 (en) | Steerable sphincterotome and methods for cannulation, papillotomy and sphincterotomy | |
| AU2002235394A1 (en) | Steerable sphincterotome and methods for cannulation, papillotomy and sphincterotomy | |
| US7645254B2 (en) | Apparatus for performing diagnostic and therapeutic modalities in the biliary tree | |
| AU2001281264B2 (en) | Steerable sphincterotome and methods for cannulation, papillotomy and sphincterotomy | |
| CA2190139C (en) | Apparatus for performing diagnostic and therapeutic modalities in the biliary tree | |
| AU2001281264A1 (en) | Steerable sphincterotome and methods for cannulation, papillotomy and sphincterotomy | |
| AU2002340044A1 (en) | Method and apparatus for measuring and controlling the exposed length of a tissue cutting device in an endoscopic catheter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20150515 |