BRPI0412153A - métodos para produzir um anticorpo que reage cruzado com produtos de gene kir2dl múltiplos e que neutraliza a atividade inibidora de tais kirs, e para avaliar a toxicidade de um anticorpo, e, anticorpo, fragmento de anticorpo ou um derivado de anticorpo - Google Patents

métodos para produzir um anticorpo que reage cruzado com produtos de gene kir2dl múltiplos e que neutraliza a atividade inibidora de tais kirs, e para avaliar a toxicidade de um anticorpo, e, anticorpo, fragmento de anticorpo ou um derivado de anticorpo

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Publication number
BRPI0412153A
BRPI0412153A BRPI0412153-8A BRPI0412153A BRPI0412153A BR PI0412153 A BRPI0412153 A BR PI0412153A BR PI0412153 A BRPI0412153 A BR PI0412153A BR PI0412153 A BRPI0412153 A BR PI0412153A
Authority
BR
Brazil
Prior art keywords
antibody
methods
kirs
neutralizes
gene products
Prior art date
Application number
BRPI0412153-8A
Other languages
English (en)
Inventor
Alessandro Moretta
Mariella Della Chiesa
Pascale Andre
Laurent Gauthier
Peter Andreas Nicolai Wagtmann
Soren Berg Padkjaer
Original Assignee
Novo Nordisk As
Innate Pharma Sas
Univ Genova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Innate Pharma Sas, Univ Genova filed Critical Novo Nordisk As
Publication of BRPI0412153A publication Critical patent/BRPI0412153A/pt
Publication of BRPI0412153B1 publication Critical patent/BRPI0412153B1/pt
Publication of BRPI0412153B8 publication Critical patent/BRPI0412153B8/pt

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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Abstract

"MéTODOS PARA PRODUZIR UM ANTICORPO QUE REAGE CRUZADO COM PRODUTOS DE GENE KIR2DL MúLTIPLOS E QUE NEUTRALIZA A ATIVIDADE INIBIDORA DE TAIS KIRS, E PARA AVALIAR A TOXICIDADE DE UM ANTICORPO, E, ANTICORPO, FRAGMENTO DE ANTICORPO OU UM DERIVADO DE ANTICORPO". A presente invenção diz respeito a novas composições e métodos para regular uma resposta imune em um paciente. Mais particularmente, a invenção diz respeito a anticorpos específicos que regulam a atividade de células NK e permitem uma potenciação da citotoxicidade de célula NK em pacientes mamíferos. A invenção também diz respeito aos fragmentos e derivados de tais anticorpos, assim como às composições farmacêuticas que compreendem os mesmos e seus usos, particularmente em terapia, para aumentar a atividade ou citotoxicidade de célula NK em pacientes.
BRPI0412153A 2003-07-02 2004-07-01 anticorpo monoclonal e fragmento de ligação a antígeno do anticorpo monoclonal BRPI0412153B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48389403P 2003-07-02 2003-07-02
US60/483,984 2003-07-02
US54547104P 2004-02-19 2004-02-19
US60/545,471 2004-02-19
PCT/DK2004/000470 WO2005003168A2 (en) 2003-07-02 2004-07-01 Methods for the production and cytotoxicity evaluation of kir2dl nk-receptor antibodies

Publications (3)

Publication Number Publication Date
BRPI0412153A true BRPI0412153A (pt) 2006-08-22
BRPI0412153B1 BRPI0412153B1 (pt) 2019-07-30
BRPI0412153B8 BRPI0412153B8 (pt) 2021-05-25

Family

ID=33567703

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0412153A BRPI0412153B8 (pt) 2003-07-02 2004-07-01 anticorpo monoclonal e fragmento de ligação a antígeno do anticorpo monoclonal
BRPI0412138A BRPI0412138B8 (pt) 2003-07-02 2004-07-01 método de selecionar um anticorpo monoclonal, método de selecionar um anticorpo monoclonal ou seu fragmento de ligação em antígeno, método de detectar a presença de células nk, e, método de purificar de uma amostra células nk

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0412138A BRPI0412138B8 (pt) 2003-07-02 2004-07-01 método de selecionar um anticorpo monoclonal, método de selecionar um anticorpo monoclonal ou seu fragmento de ligação em antígeno, método de detectar a presença de células nk, e, método de purificar de uma amostra células nk

Country Status (22)

Country Link
US (2) US9902936B2 (pt)
EP (3) EP1639013B1 (pt)
JP (5) JP4871125B2 (pt)
KR (5) KR101444717B1 (pt)
CN (2) CN103588880B (pt)
AT (1) ATE490984T1 (pt)
AU (2) AU2004253630B2 (pt)
BR (2) BRPI0412153B8 (pt)
CA (2) CA2530272C (pt)
CY (1) CY1113394T1 (pt)
DE (1) DE602004030464D1 (pt)
DK (2) DK1673397T3 (pt)
ES (2) ES2725526T3 (pt)
HK (1) HK1091662A1 (pt)
HR (1) HRP20120845T1 (pt)
IL (3) IL172613A (pt)
MX (1) MXPA05013923A (pt)
NO (4) NO338818B1 (pt)
PL (1) PL1639013T3 (pt)
PT (1) PT1639013E (pt)
RU (2) RU2376315C2 (pt)
WO (2) WO2005003172A2 (pt)

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AU2005238300A1 (en) * 2004-04-30 2005-11-10 Innate Pharma Compositions and methods for treating proliferative disorders such as NK-type LDGL
SI2287195T1 (sl) 2004-07-01 2019-08-30 Novo Nordisk A/S Pan-kir2dl nk-receptor protitelesa in njihova uporaba pri diagnostiki in terapiji
TWI422389B (zh) * 2004-07-01 2014-01-11 Novo Nordisk As 人類抗ｋｉｒ抗體
EP1771471B1 (en) 2004-07-10 2009-09-16 Fox Chase Cancer Center Genetically modified human natural killer cell lines
AU2005302291B2 (en) * 2004-11-02 2011-02-10 The Government Of The United States Of America As Represented By The Secretary Department Of Health & Human Services Compositions and methods for treating hyperproliferative disorders
PT1835937E (pt) 2005-01-06 2012-06-25 Novo Nordisk As Composições e métodos para tratar infeção viral
DK1836225T3 (da) 2005-01-06 2012-02-27 Innate Pharma Sas Kir-bindingagenser og fremgangsmåde til anvendelse deraf
US20090196850A1 (en) * 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
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CN105037549B (zh) * 2007-01-11 2018-09-28 诺和诺德公司 抗-kir抗体、制剂及其应用
WO2010065939A1 (en) 2008-12-05 2010-06-10 Indiana University Research & Technology Corporation Combination therapy to enhace nk cell mediated cytotoxicty
EP2808402A3 (en) * 2008-12-29 2015-03-25 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Methods of predicting responsiveness to interferon treatment
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JP6342325B2 (ja) * 2011-05-25 2018-06-13 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． 炎症性障害の治療のための抗ｋｉｒ抗体
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KR102069394B1 (ko) * 2011-11-23 2020-01-22 에프. 호프만-라 로슈 아게 Ｃｄ40ｌ 발현 포유류 세포 및 그의 용도
CA2881765C (en) * 2012-09-19 2024-02-13 Innate Pharma Kir3dl2 binding agents
EP3263601B1 (en) 2012-10-02 2021-11-24 Bristol-Myers Squibb Company Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer
ES2707057T3 (es) 2013-11-06 2019-04-02 Bristol Myers Squibb Co Combinación de anticuerpos anti-KIR y anti-CS1 para tratar el mieloma múltiple
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