BR112017022845A2 - neoepítopos de câncer - Google Patents

neoepítopos de câncer

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Publication number
BR112017022845A2
BR112017022845A2 BR112017022845-9A BR112017022845A BR112017022845A2 BR 112017022845 A2 BR112017022845 A2 BR 112017022845A2 BR 112017022845 A BR112017022845 A BR 112017022845A BR 112017022845 A2 BR112017022845 A2 BR 112017022845A2
Authority
BR
Brazil
Prior art keywords
neoepitopes
therapeutic
cancer
cancer neoepitopes
cellular
Prior art date
Application number
BR112017022845-9A
Other languages
English (en)
Inventor
Nguyen Andrew
Niazi Kayvan
Soon-Shiong Patrick
Rabizadeh Shahrooz
Charles Benz Stephen
Original Assignee
Nantomics, Llc
Nant Holdings Ip, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nantomics, Llc, Nant Holdings Ip, Llc filed Critical Nantomics, Llc
Publication of BR112017022845A2 publication Critical patent/BR112017022845A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P35/00—Antineoplastic agents
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G—PHYSICS
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    • G—PHYSICS
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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Abstract

trata-se de composições e métodos que são dirigidos a neoepítopos de câncer e usos de tais neoepítopos, especialmente para gerar anticorpos sintéticos contra neoepítopos que podem ser, então, empregados na fabricação de um agente terapêutico. os agentes terapêuticos preferenciais irão compreender um anticorpo sintético contra um neoepítopo e, com a máxima preferência, em combinação com um componente celular ou não celular para o uso como um agente terapêutico ou de diagnóstico.
BR112017022845-9A 2015-04-23 2016-04-25 neoepítopos de câncer BR112017022845A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562178956P 2015-04-23 2015-04-23
US62/178,956 2015-04-23
US201562159145P 2015-05-08 2015-05-08
US62/159,145 2015-05-08
PCT/US2016/029244 WO2016172722A1 (en) 2015-04-23 2016-04-25 Cancer neoepitopes

Publications (1)

Publication Number Publication Date
BR112017022845A2 true BR112017022845A2 (pt) 2018-07-17

Family

ID=57144677

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017022845-9A BR112017022845A2 (pt) 2015-04-23 2016-04-25 neoepítopos de câncer

Country Status (11)

Country Link
US (2) US11421016B2 (pt)
EP (1) EP3286361A4 (pt)
JP (2) JP7236216B2 (pt)
CN (1) CN108513593A (pt)
AU (1) AU2016253145B2 (pt)
BR (1) BR112017022845A2 (pt)
CA (3) CA3172686A1 (pt)
IL (1) IL255217B (pt)
MX (1) MX2017013613A (pt)
RU (1) RU2719033C2 (pt)
WO (1) WO2016172722A1 (pt)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970921B1 (en) 2013-03-15 2018-09-19 aTyr Pharma, Inc. Histidyl-trna synthetase-fc conjugates
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
US20160280778A1 (en) 2015-03-27 2016-09-29 Wisconsin Alumni Research Foundation Compositions and methods of use of interleukin-10 peptides and anti-interleukin-10 antibodies
EP3280738A4 (en) 2015-04-08 2019-01-02 Nantomics, LLC Cancer neoepitopes
US11421016B2 (en) 2015-04-23 2022-08-23 Nantomics Llc Cancer neoepitopes
CR20170584A (es) * 2015-05-20 2018-03-20 Massachusetts Gen Hospital Neoantígenos compartidos
GB201513921D0 (en) * 2015-08-05 2015-09-23 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
EP3360886B1 (en) * 2015-10-08 2023-01-25 Oncotherapy Science, Inc. Foxm1-derived peptide, and vaccine including same
JP2018532736A (ja) 2015-10-12 2018-11-08 ナントミクス，エルエルシー チェックポイント阻害物質への感受性を予測するｍｓｉおよびネオエピトープの探索のための系、組成物、および方法
GB201520557D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520559D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520579D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201607535D0 (en) * 2016-04-29 2016-06-15 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
GB201520603D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
CN108701172A (zh) * 2016-02-12 2018-10-23 南托米克斯有限责任公司 高通量识别患者特异性新表位作为癌症免疫疗法的治疗靶点
EP3417289B1 (en) * 2016-02-19 2020-12-23 Nant Holdings IP, LLC Methods of immunogenic modulation
US11318185B2 (en) 2016-03-02 2022-05-03 Toray Industries, Inc. Immunogenic peptides of SCD1 protein
EP3475434A4 (en) * 2016-03-24 2020-07-29 Nantcell, Inc. SEQUENCE ARRANGEMENTS AND SEQUENCES FOR NEOEPITOP REPRESENTATION
WO2017170926A1 (ja) * 2016-03-31 2017-10-05 千寿製薬株式会社 神経保護ペプチド
KR20220163523A (ko) * 2016-03-31 2022-12-09 바이오엔테크 유에스 인크. 신생항원 및 이것의 사용 방법
AU2017286376B2 (en) * 2016-06-16 2024-06-13 SGPTH Life Science AB Comp peptide and antibodies thereto for diagnosing osteoarthritis
CN109789190A (zh) 2016-06-30 2019-05-21 河谷控股Ip有限责任公司 Nant癌症疫苗
GB201615746D0 (en) * 2016-09-15 2016-11-02 Nordic Bioscience As Nidogen-1 Assay
GB201618432D0 (en) 2016-11-01 2016-12-14 Matn Scient Ltd Detection and treatment of demyelinating diseases
EP3323827A1 (en) * 2016-11-21 2018-05-23 Christian-Albrechts-Universität zu Kiel Cationic intrinsically disordered antimicrobial peptides
EP3541931A4 (en) 2016-11-21 2020-11-04 Nant Holdings IP, LLC COMBINED FRACTAL TREATMENT
WO2018094569A1 (zh) * 2016-11-22 2018-05-31 深圳华大基因研究院 多肽及其应用
US20180282402A1 (en) * 2016-11-30 2018-10-04 Atyr Pharma, Inc. Anti-hrs antibodies and combinaton therapies for treating cancers
JP2020504714A (ja) * 2016-12-05 2020-02-13 ニューリタス リミテッド ペプチドｗｋｄｅａｇｋｐｌｖｋを含む組成物
EP3329930A1 (en) * 2016-12-05 2018-06-06 Nuritas Limited Pharmaceuctical compositions
JP7017726B2 (ja) * 2017-01-30 2022-02-09 国立研究開発法人国立循環器病研究センター 血管内皮系細胞に特異的に結合するペプチドの使用、及びペプチド
JP7320796B2 (ja) * 2017-01-30 2023-08-04 国立研究開発法人国立循環器病研究センター 血管内皮系細胞に特異的に結合するペプチドの使用、及びペプチド
RU2019125634A (ru) * 2017-02-06 2021-03-09 Элайз Фарма Сас Соединения, композиции и их применения для улучшения костных расстройств
AU2018219862B2 (en) 2017-02-07 2020-09-17 Nant Holding IP, LLC Maximizing T-cell memory and compositions and methods therefor
US11117930B2 (en) 2017-02-23 2021-09-14 Adrx, Inc. Peptide inhibitors of transcription factor aggregation
SE541618C2 (en) * 2017-02-24 2019-11-12 Biotome Pty Ltd Novel peptides and their use in diagnosis
EP3590957A4 (en) * 2017-03-03 2021-03-31 Hoyu Co., Ltd. ALLERGY ANTIGEN AND ITS EPITOPIC
JP2020514413A (ja) 2017-03-03 2020-05-21 トレオス バイオ ゼットアールティー ペプチドワクチン
CN110621332A (zh) 2017-03-16 2019-12-27 微合成有限公司 用于降低病原体毒力的益生菌分子
WO2018165764A1 (en) * 2017-03-16 2018-09-20 Microsintesis Inc. Compositions and methods involving probiotic molecules
TWI672503B (zh) * 2017-03-31 2019-09-21 行動基因生技股份有限公司 致免疫性之癌症特異抗原決定位的排名系統
AU2018256435A1 (en) 2017-04-20 2019-11-07 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
KR102306403B1 (ko) * 2017-04-24 2021-09-28 난트셀, 인크. 표적화된 네오에피토프 벡터 및 그에 관한 방법 (targeted neoepitope vectors and methods therefor)
WO2018206535A1 (en) * 2017-05-08 2018-11-15 Novozymes A/S Carbohydrate-binding domain and polynucleotides encoding the same
EP3621979A1 (en) 2017-05-09 2020-03-18 VIB vzw Means and methods for treating bacterial infections
WO2018222433A2 (en) * 2017-05-30 2018-12-06 Nant Holdings Ip, Llc Circulating tumor cell enrichment using neoepitopes
JP2020532957A (ja) * 2017-08-10 2020-11-19 グッド ティー セルズ、 インコーポレイテッド 癌治療のためのｔ細胞の活性化方法
EP3681910B1 (en) * 2017-09-12 2023-01-25 Wisconsin Alumni Research Foundation Interleukin-10 receptor-2 peptides, antibodies, compositions, and methods of use thereof
US12098193B2 (en) 2017-10-11 2024-09-24 Institute For Cancer Research Netrin G1 as a biomarker for enhancing tumor treatment efficacy
EP3714896A4 (en) * 2017-11-21 2021-08-04 Miwa, Naofumi MEANS FOR INHIBITING METASTASISATION OF HUMAN CANCER CELLS AND MEANS FOR DETERMINING HUMAN CANCER CELLS
US20200354730A1 (en) * 2017-11-27 2020-11-12 Nantcell, Inc. Improved Yeast Polytope Vaccine Compositions And Methods
WO2019143606A1 (en) 2018-01-17 2019-07-25 Nantbio, Inc. Enhanced immunogenicity for gpi-anchored antigens
DE102018107224A1 (de) 2018-02-21 2019-08-22 Immatics Biotechnologies Gmbh Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten
CN108484733B (zh) * 2018-03-01 2021-06-25 国家纳米科学中心 双亲性靶向穿膜肽及其自组装的纳米探针、载药纳米颗粒
KR20200140291A (ko) * 2018-04-06 2020-12-15 애마 세러퓨틱스 인코포레이티드 치료제의 제어된 방출을 위한 조성물
MX2020010821A (es) * 2018-04-13 2021-01-15 Argenx Iip Bv Anticuerpos contra galectina-10.
US11823773B2 (en) 2018-04-13 2023-11-21 Nant Holdings Ip, Llc Nant cancer vaccine strategies
KR102234027B1 (ko) * 2018-05-09 2021-03-31 서울대학교산학협력단 B형 간염 바이러스 유래 폴리펩티드 및 이의 항바이러스 용도
AU2019269641A1 (en) * 2018-05-17 2020-12-03 Immunome, Inc. CH3 domain epitope tags
EP3807294A1 (en) * 2018-06-13 2021-04-21 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. Peptides having inhibitory activity on muscarinic receptor m3
US10925947B2 (en) 2018-06-29 2021-02-23 Immatics Biotechnologies Gmbh A*03 restricted peptides for use in immunotherapy against cancers and related methods
BR112020024748A2 (pt) 2018-07-11 2021-03-23 Immunity Pharma Ltd. peptídeo isolado, e, composição farmacêutica
EP3820885A4 (en) 2018-07-11 2022-04-20 The Brigham & Women's Hospital, Inc. METHODS AND COMPOSITIONS FOR ADMINISTRATION OF DRUGS ACROSS THE BLOOD-BRAIN BARRIER
US20210252123A1 (en) 2018-07-26 2021-08-19 Frame Pharmaceuticals B.V. ARID1A, CDKN2A, KMT2B, KMT2D, TP53 and PTEN VACCINES FOR CANCER
US12005104B2 (en) 2018-07-26 2024-06-11 Curevac Netherlands B.V. Cancer vaccines for colorectal cancer
US20210213116A1 (en) 2018-07-26 2021-07-15 Frame Pharmaceuticals B.V. Cancer vaccines for kidney cancer
US20210187088A1 (en) 2018-07-26 2021-06-24 Frame Pharmaceuticals B.V. Cancer vaccines for uterine cancer
US20220349010A1 (en) 2018-07-26 2022-11-03 Frame Pharmaceuticals B.V. Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database
EP3827262A1 (en) 2018-07-26 2021-06-02 Frame Pharmaceuticals B.V. Cancer vaccines for breast cancer
TW202019955A (zh) 2018-07-31 2020-06-01 德商英麥提克生物技術股份有限公司 B*07 限制肽和肽組合的抗癌免疫治療和相關方法
MA53543A (fr) 2018-09-04 2021-07-14 Treos Bio Ltd Vaccins peptidiques
TW202024121A (zh) 2018-09-18 2020-07-01 德商英麥提克生物技術股份有限公司 A*01 限制肽和肽組合物在抗癌免疫治療中的用途和相關方法
GB201818576D0 (en) * 2018-11-14 2018-12-26 Io Biotech Aps Arginase 2 polypeptides
JP2022510606A (ja) * 2018-11-21 2022-01-27 エンドメット バイオサイエンシーズ，インク． 子宮内膜症を処置するための組成物および方法
EP3893894A4 (en) * 2018-12-12 2022-11-23 The Regents of University of California MODIFIED NETRIN-1 PEPTIDES AND COMPOSITIONS FOR CARDIOPROTECTION
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
JP7420361B2 (ja) * 2019-02-25 2024-01-23 公立大学法人山陽小野田市立山口東京理科大学 アミロイド線維の形成を抑制するペプチド
CN111533795B (zh) * 2019-03-12 2020-10-30 上海交通大学医学院附属新华医院 Hla-a2限制性膀胱癌肿瘤新抗原肽序列及其应用
US12098175B2 (en) 2019-03-21 2024-09-24 Institute For Research In Biomedicine Peptide inhibitors targeting the CXCL12/HMGB1 interaction and uses thereof
CN113939310A (zh) * 2019-03-30 2022-01-14 百欧恩泰美国公司 用于制备t细胞组合物的组合物和方法及其用途
EP3959233A4 (en) * 2019-04-25 2023-04-19 Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center NETRIN G1 AND NETRIN G1 LIGAND PEPTIDES AND ANTIBODIES AND THEIR USES
EP3763725A1 (en) 2019-07-08 2021-01-13 TCI Co., Ltd. Biomimetic peptides derived from biological source and their uses in retarding aging and improving skin
US20220289866A1 (en) * 2019-07-12 2022-09-15 The Regents Of The University Of California Chemically controlled monoclonal antibody target engagement
CN110534156B (zh) * 2019-09-02 2022-06-17 深圳市新合生物医疗科技有限公司 一种提取免疫治疗新抗原的方法及系统
WO2021043804A1 (en) * 2019-09-02 2021-03-11 Institut Curie Immunotherapy targeting tumor neoantigenic peptides
US20230203095A1 (en) * 2019-11-21 2023-06-29 Shanghai Institute of Pharmaceutical Industry Co., Ltd. Biological peptide for treating lung diseases and application thereof
MX2019014546A (es) * 2019-12-04 2023-01-10 Univ Mexico Nac Autonoma Péptido con actividad anti-cáncer.
IL294608A (en) * 2020-01-10 2022-09-01 Brigham & Womens Hospital Inc Methods and compositions for administering immunotherapy agents across the blood-brain barrier for the treatment of brain cancer
IL272074B1 (en) * 2020-01-15 2024-08-01 Immunity Pharma Ltd Peptide compounds and their use in methods of treating diseases
GB202004974D0 (en) 2020-04-03 2020-05-20 Treos Bio Ltd Coronavirus vaccine
IT202000019708A1 (it) * 2020-08-07 2022-02-07 Ospedale Pediatrico Bambino Gesù Peptidi in grado di legare il recettore enzima di conversione dell'angiotensina 2 (ACE2) e loro usi medici
CN111978375B (zh) * 2020-08-28 2022-10-04 深圳市乐土生物医药有限公司 具有细胞毒性t细胞诱导能力的蛋白质或多肽
WO2022094139A1 (en) * 2020-10-28 2022-05-05 Ohio State Innovation Foundation Peptide inhibitors for the treatment and prevention of coronavirus infections
US11058751B1 (en) 2020-11-20 2021-07-13 Think Therapeutics, Inc. Compositions for optimized RAS peptide vaccines
US11421015B2 (en) 2020-12-07 2022-08-23 Think Therapeutics, Inc. Method of compact peptide vaccines using residue optimization
JP2023551204A (ja) * 2020-11-20 2023-12-07 シンク・セラピューティクス・インコーポレイテッド 最適化ペプチドワクチンの組成物および方法
WO2022120423A1 (en) * 2020-12-08 2022-06-16 James Cook University Peptides and uses thereof
WO2022133074A1 (en) * 2020-12-18 2022-06-23 Bioardis, Llc Muc1 binding molecules and uses thereof
WO2022159341A1 (en) * 2021-01-22 2022-07-28 Syngenta Crop Protection Ag Soybean engineered resistance
US20240083946A1 (en) * 2021-03-10 2024-03-14 The Board Of Regents Of The University Of Oklahoma Self-assembling peptides, nanofibers, and methods of use
CN115605495A (zh) * 2021-03-22 2023-01-13 L 基础有限公司（Kr） 用于预防或治疗癌症的药物组合物
US11464842B1 (en) 2021-04-28 2022-10-11 Think Therapeutics, Inc. Compositions and method for optimized peptide vaccines using residue optimization
CA3227687A1 (en) * 2021-08-06 2023-02-09 Marc Andrew GILLIG Process for producing personalized cancer immunotherapy
CN118852347A (zh) * 2021-09-09 2024-10-29 禾美生物科技(浙江)有限公司 具有抗衰修护功效的功能多肽及其应用
CN118574843A (zh) * 2022-01-21 2024-08-30 T-Knife 股份有限公司 以可检测的亲和力结合特异性肽的抗原识别构建体和对kras具有抗原特异性的t细胞受体以及相应的核酸序列、载体、宿主细胞、药物组合物和试剂盒
AU2023215337A1 (en) * 2022-02-04 2024-09-26 Hbc Immunology Inc. Upregulation of ferritin heavy chain 1 expression
AU2023218551A1 (en) * 2022-02-09 2024-08-01 Teitur Trophics Aps Novel peptides
WO2023161443A1 (en) * 2022-02-25 2023-08-31 Institut Curie PEPTIDES TARGETING THE INTERACTION BETWEEN KINDLIN-1 AND ß-INTEGRIN
AU2023246941A1 (en) * 2022-03-31 2024-10-24 Enterome S.A. Antigenic peptides for prevention and treatment of cancer.
WO2023220688A1 (en) * 2022-05-11 2023-11-16 The Johns Hopkins University Engineering of multifunctional peptides for controlled drug delivery
WO2023244919A1 (en) * 2022-06-16 2023-12-21 Capsida, Inc. Adeno-associated virus compositions having increased brain enrichment and decreased liver enrichment
WO2024030976A2 (en) * 2022-08-03 2024-02-08 Voyager Therapeutics, Inc. Compositions and methods for crossing the blood brain barrier
WO2024076285A1 (en) * 2022-10-05 2024-04-11 Ivarsson Ylva Peptide targeting sars-cov-2 nsp9
CN116813742A (zh) * 2022-11-22 2023-09-29 杭州博茵生物技术有限公司 人gdf-15抗原表位肽、抗原、抗体、试剂盒及应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02007756A (es) * 2000-02-10 2004-09-10 Abbott Lab Anticuerpos que aglutinan interleuqina-18 humana y metodos de fabricacion y uso.
JP2005523888A (ja) 2002-01-03 2005-08-11 ザ スクリプス リサーチ インスティテュート 癌関連エピトープ
US7473532B2 (en) 2003-03-10 2009-01-06 Expression Pathology, Inc. Liquid tissue preparation from histopathologically processed biological samples, tissues and cells
US8207315B2 (en) 2003-08-20 2012-06-26 The Cleveland Clinic Foundation Gene and protein associated with angiogenesis and endothelial cell-specific apoptosis
US7767792B2 (en) 2004-02-20 2010-08-03 Ludwig Institute For Cancer Research Ltd. Antibodies to EGF receptor epitope peptides
NZ553409A (en) 2004-10-12 2010-04-30 Crucell Holland Bv Binding molecules for treatment and detection of acute myeloid leukaemia
WO2007002811A2 (en) * 2005-06-29 2007-01-04 The Wistar Institute Of Anatomy And Biology Methods and compositions for treating melanoma
KR20170123712A (ko) 2006-10-02 2017-11-08 메다렉스, 엘.엘.시. Ｃｘｃｒ4에 결합하는 인간 항체 및 이의 용도
PT2436696T (pt) 2007-01-05 2017-08-21 Univ Zuerich Anticorpo anti-beta-amiloide e usos do mesmo
CN105648056A (zh) 2010-05-14 2016-06-08 综合医院公司 鉴定肿瘤特异性新抗原的组合物和方法
US9646134B2 (en) * 2010-05-25 2017-05-09 The Regents Of The University Of California Bambam: parallel comparative analysis of high-throughput sequencing data
EP3657507A1 (en) * 2010-05-25 2020-05-27 The Regents of The University of California Bambam: parallel comparative analysis of high-throughput sequencing data
JP2013235003A (ja) 2012-05-10 2013-11-21 Fujita Gakuen 細胞におけるｄｎａ損傷の検出方法及びｄｎａ鎖切断応答性細胞表面抗原に対する抗体
CN113967253A (zh) 2012-05-15 2022-01-25 百时美施贵宝公司 通过破坏pd-1/pd-l1信号传输的免疫治疗
AU2013323368B2 (en) * 2012-09-28 2019-03-21 The University Of Connecticut Identification of tumor-protective epitopes for the treatment of cancers
US9492566B2 (en) * 2012-12-13 2016-11-15 Immunomedics, Inc. Antibody-drug conjugates and uses thereof
CA2908434C (en) 2013-04-07 2021-12-28 The Broad Institute, Inc. Compositions and methods for personalized neoplasia vaccines
US20140363454A1 (en) * 2013-06-06 2014-12-11 Igenica Biotherapeutics, Inc. Antibody-Drug Conjugates, Compositions and Methods of Use
AU2014337063A1 (en) 2013-10-18 2016-05-19 Adaptive Biotechnologies Corp. Predicting patient responsiveness to immune checkpoint inhibitors
WO2015095811A2 (en) 2013-12-20 2015-06-25 The Board Institute Inc. Combination therapy with neoantigen vaccine
KR20160102314A (ko) * 2014-01-02 2016-08-29 메모리얼 슬로안-케터링 캔서 센터 면역 치료요법에 대한 암 반응의 결정인자
EP3280738A4 (en) 2015-04-08 2019-01-02 Nantomics, LLC Cancer neoepitopes
US11421016B2 (en) 2015-04-23 2022-08-23 Nantomics Llc Cancer neoepitopes
CN107847596B (zh) * 2015-05-18 2022-05-31 优瑞科生物技术公司 抗ror1抗体

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