BR112017011005A2 - novos indazóis substituídos, métodos para sua produção, preparações farmacêuticas que contêm os novos indazóis substituídos e o uso dos indazóis substituídos para produzir os medicamentos. - Google Patents

novos indazóis substituídos, métodos para sua produção, preparações farmacêuticas que contêm os novos indazóis substituídos e o uso dos indazóis substituídos para produzir os medicamentos.

Info

Publication number
BR112017011005A2
BR112017011005A2 BR112017011005-9A BR112017011005A BR112017011005A2 BR 112017011005 A2 BR112017011005 A2 BR 112017011005A2 BR 112017011005 A BR112017011005 A BR 112017011005A BR 112017011005 A2 BR112017011005 A2 BR 112017011005A2
Authority
BR
Brazil
Prior art keywords
substituted indoles
new substituted
production
drugs
new
Prior art date
Application number
BR112017011005-9A
Other languages
English (en)
Other versions
BR112017011005B1 (pt
Inventor
Bothe Ulrich
Siebeneicher Holger
Schmidt Nicole
Nubbemeyer Reinhard
Bömer Ulf
Günther Judith
Steuber Holger
Lange Martin
Stegmann Christian
Sutter Andreas
Rausch Alexandra
Friedrich Christian
Hauff Peter
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of BR112017011005A2 publication Critical patent/BR112017011005A2/pt
Publication of BR112017011005B1 publication Critical patent/BR112017011005B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

novos indazóis substituídos, métodos para sua produção, preparações farmacêuticas que contêm os novos indazóis substituídos e o uso dos indazóis substituídos para produzir os medicamentos. a presente aplicação está relacionada aos novos indazóis substituídos, aos processos para sua preparação, ao seu uso isoladamente ou em combinações para tratamento e/ou profilaxia de doenças, e ao seu uso para a produção de medicamentos para tratamento e/ou profilaxia de doenças, especialmente para tratamento e/ou profilaxia de endometriose e dor associada à endometriose e outros sintomas associados à endometriose, como dismenorreia, dispareunia, disúria e disquesia, de linforma, artrite reumatoide, espondiloartrite (especialmente espondiloartrite psoriática e doença de bekhterev), lúpus eritematoso, esclerose múltipla, degeneração macular, dpoc, gota, distúrbios hepáticos, resistência à insulina, distúrbios neoplásicos e psoríase.
BR112017011005-9A 2014-11-26 2015-11-25 Indazóis substituídos, processos para sua produção, medicamento e seus usos BR112017011005B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14195032.9 2014-11-26
EP14195032 2014-11-26
PCT/EP2015/077596 WO2016083433A1 (de) 2014-11-26 2015-11-25 Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten sowie deren verwendung zur herstellung von arzneimitteln

Publications (2)

Publication Number Publication Date
BR112017011005A2 true BR112017011005A2 (pt) 2019-05-14
BR112017011005B1 BR112017011005B1 (pt) 2023-03-14

Family

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Family Applications (2)

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BR112017011005-9A BR112017011005B1 (pt) 2014-11-26 2015-11-25 Indazóis substituídos, processos para sua produção, medicamento e seus usos
BR122021002613-0A BR122021002613B1 (pt) 2014-11-26 2015-11-25 Indazóis substituídos, processos para sua produção, medicamento e seus usos

Family Applications After (1)

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BR122021002613-0A BR122021002613B1 (pt) 2014-11-26 2015-11-25 Indazóis substituídos, processos para sua produção, medicamento e seus usos

Country Status (42)

Country Link
US (5) US10308634B2 (pt)
EP (3) EP3224254B1 (pt)
JP (1) JP6496823B2 (pt)
KR (1) KR102083857B1 (pt)
CN (2) CN110305109B (pt)
AR (1) AR102827A1 (pt)
AU (2) AU2015352603B2 (pt)
BR (2) BR112017011005B1 (pt)
CA (1) CA2968614C (pt)
CL (1) CL2017001364A1 (pt)
CO (1) CO2017005374A2 (pt)
CR (1) CR20170220A (pt)
CU (1) CU24448B1 (pt)
CY (1) CY1123815T1 (pt)
DK (2) DK3674298T3 (pt)
DO (1) DOP2017000127A (pt)
EA (1) EA032509B1 (pt)
EC (1) ECSP17032530A (pt)
ES (2) ES2976932T3 (pt)
FI (1) FI3674298T3 (pt)
HR (2) HRP20240414T1 (pt)
HU (2) HUE065938T2 (pt)
IL (3) IL252185B (pt)
JO (1) JO3705B1 (pt)
LT (2) LT3224254T (pt)
MA (1) MA41011B1 (pt)
ME (1) ME03745B (pt)
MX (2) MX2020010623A (pt)
NI (1) NI201700063A (pt)
NZ (1) NZ732126A (pt)
PE (1) PE20171376A1 (pt)
PH (1) PH12017500972A1 (pt)
PL (2) PL3674298T3 (pt)
PT (2) PT3224254T (pt)
RS (2) RS60284B1 (pt)
SG (3) SG11201704092YA (pt)
SI (2) SI3674298T1 (pt)
TN (1) TN2017000226A1 (pt)
TW (2) TWI717061B (pt)
UA (2) UA120948C2 (pt)
UY (1) UY36411A (pt)
WO (1) WO2016083433A1 (pt)

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