BR112012004817A2 - Processo para identificação e preparação de uma ômega-transaminase (r)-específica - Google Patents

Processo para identificação e preparação de uma ômega-transaminase (r)-específica

Info

Publication number: BR112012004817A2
Authority: BR; Brazil
Prior art keywords: transaminase; identifying; preparing; specific omega; omega
Prior art date: 2009-09-02

Application number

BRBR112012004817-1A

Other languages

English (en)

Inventor

Matthias Hoehne

Uwe Bornscheuer

Karen Robins

Sebastian Schaetzle

Original Assignee

Lonza Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-09-02

Filing date

2010-08-13

Publication date

2015-09-01

2010-08-13 Application filed by Lonza Ag filed Critical Lonza Ag

2015-09-01 Publication of BR112012004817A2 publication Critical patent/BR112012004817A2/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Physics & Mathematics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Analytical Chemistry (AREA)
Medical Informatics (AREA)
Evolutionary Biology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Computational Biology (AREA)
Theoretical Computer Science (AREA)
Spectroscopy & Molecular Physics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

BRBR112012004817-1A 2009-09-02 2010-08-13 Processo para identificação e preparação de uma ômega-transaminase (r)-específica BR112012004817A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP09011271		2009-09-02
EP10005203		2010-05-19
PCT/EP2010/004961 WO2011026556A1 (en)	2009-09-02	2010-08-13	A process for the identification and preparation of a (r)-specific omega-transaminase

Publications (1)

Publication Number	Publication Date
BR112012004817A2 true BR112012004817A2 (pt)	2015-09-01

Family

ID=42733750

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRBR112012004817-1A BR112012004817A2 (pt)	2009-09-02	2010-08-13	Processo para identificação e preparação de uma ômega-transaminase (r)-específica

Country Status (17)

Country	Link
US (1)	US8577622B2 (pt)
EP (3)	EP2473601B1 (pt)
JP (3)	JP5792728B2 (pt)
KR (1)	KR101698435B1 (pt)
CN (3)	CN104480155B (pt)
AU (1)	AU2010291586C1 (pt)
BR (1)	BR112012004817A2 (pt)
CA (1)	CA2772426A1 (pt)
CL (1)	CL2012000590A1 (pt)
EA (1)	EA022764B1 (pt)
ES (2)	ES2599644T3 (pt)
HK (2)	HK1165831A1 (pt)
IL (3)	IL218397A0 (pt)
MX (1)	MX2012002561A (pt)
SG (1)	SG178842A1 (pt)
WO (1)	WO2011026556A1 (pt)
ZA (1)	ZA201200625B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2840000T3 (es)	2009-01-08	2021-07-06	Codexis Inc	Polipéptidos de transaminasa
EP2401366B1 (en)	2009-02-26	2013-12-18	Codexis, Inc.	Transaminase biocatalysts
SG177329A1 (en)	2009-06-22	2012-02-28	Codexis Inc	Transaminase reactions
HUE038434T2 (hu)	2010-06-17	2018-10-29	Codexis Inc	Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez
CN103189519B (zh)	2010-07-14	2018-01-26	DPx控股有限公司	(r)‑选择性胺化
KR101469855B1 (ko) *	2013-03-26	2014-12-09	연세대학교 산학협력단	오메가-트랜스아미나제를 이용한 d-아미노산의 비대칭 생산 방법
US10131926B2 (en) *	2013-11-26	2018-11-20	Asymchem Laboratories (Tianjin) Co., Ltd	Transaminase and uses thereof
CN105018440B (zh) *	2014-04-24	2018-06-05	上海弈柯莱生物医药科技有限公司	一种转氨酶及其在合成西他列汀中间体中的应用
CN105950581B (zh) *	2016-06-21	2019-11-19	浙江科技学院	一种引入二硫键的ω-转氨酶突变体及其应用
CN106754806B (zh) *	2016-12-20	2020-04-14	尚科生物医药（上海）有限公司	一种改进的转氨酶及其在(r)-3-氨基丁醇制备上的应用
EP3558930B1 (en) *	2016-12-23	2021-05-26	Novartis AG	New process for early sacubitril intermediates
CN107384887B (zh) *	2017-07-05	2020-08-21	浙江工业大学	一种氨基转移酶、突变体及其制备西他列汀的应用
CN109234327A (zh) *	2017-07-11	2019-01-18	上海弈柯莱生物医药科技有限公司	一种立体选择性的转氨酶在不对称合成手性胺中的应用
CN107586884B (zh) *	2017-10-25	2020-08-18	东北农业大学	一种用于猫传染性腹膜炎病毒检测的rt-pcr引物组，含有该引物组的试剂盒及其应用
DK3486324T3 (da) *	2017-11-17	2020-09-14	Enzymicals Ag	Fremgangsmåde til fremstilling af aminer fra carbonylforbindelser ved transaminasereaktion under saltudfældning
CN109957554B (zh) *	2017-12-26	2021-05-07	宁波酶赛生物工程有限公司	工程化转氨酶多肽及其应用
CN108866021B (zh) *	2018-05-30	2021-06-08	浙江工业大学	一种转氨酶突变体及在制备西他列汀中间体中的应用
CN109576238A (zh) *	2018-11-12	2019-04-05	太原理工大学	一种重组转氨酶及其在不对称胺化α-羟酮制备手性β-氨基醇中的应用
CN109486784B (zh) *	2018-11-30	2020-06-09	江南大学	一种能催化西他沙星五元环关键中间体的ω-转氨酶突变体
CN112522229B (zh) *	2020-10-26	2021-07-27	浙江工业大学	转氨酶突变体及其在制备西他列汀中间体中的应用
CN112481229B (zh) *	2020-11-25	2022-12-30	华东理工大学	一种ω转氨酶及其突变体、重组质粒、基因工程菌及其应用
CN113881647B (zh) *	2020-12-28	2023-11-17	上海合全药物研发有限公司	转氨酶及其在制备光学纯手性胺中的应用
CN114875005B (zh) *	2021-02-05	2023-11-24	上海交通大学	一种对映选择性翻转的ω-转氨酶突变体的构建及应用
CN114134128B (zh) *	2021-12-07	2023-05-23	浙江科技学院	一种基于祖先序列重建的ω-转氨酶突变体
CN114645030B (zh) *	2022-04-08	2023-11-17	浙江科技学院	一种ω-转氨酶突变体及其在制备西塞卡纳药物中间体的应用
CN118755689A (zh) *	2024-09-06	2024-10-11	长兴制药股份有限公司	一种突变型r-转氨酶及其制备乌布吉泮中间体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58135000A (ja) *	1982-02-02	1983-08-11	Yokogawa Hokushin Electric Corp	グルタミン酸オキサロ酢酸トランスアミナ−ゼおよびグルタミン酸ピルビン酸トランスアミナ−ゼの測定方法および測定装置
US20020132295A1 (en) *	1996-02-09	2002-09-19	Short Jay M.	Enzymes having transaminase and aminotransferase activity and methods of use thereof
EP0987332B1 (en) *	1997-04-23	2009-08-19	Kaneka Corporation	DNA encoding a polypeptide having stereoselective transaminase activity, and transformants comprising said DNA
CA2322605A1 (en) *	1998-03-11	1999-09-16	Celgro	Improvements in the enzymatic synthesis of chiral amines
EP1038953B1 (en)	1999-03-19	2004-09-22	Sumitomo Chemical Company, Limited	Stereoselective transaminase, gene encoding said protein and use thereof
EP1818411A1 (en) *	2006-02-13	2007-08-15	Lonza AG	Process for the preparation of optically active chiral amines
PL2238242T3 (pl) *	2008-01-03	2015-06-30	Basf Enzymes Llc	Transferazy i oksydoreduktazy, kwasy nukleinowe kodujące je oraz sposoby ich wytwarzania i zastosowania
CN101250229B (zh) *	2008-03-05	2012-05-30	天津市血液中心	丙氨酸氨基转移酶单克隆抗体及其用途

2010
- 2010-08-13 EA EA201270350A patent/EA022764B1/ru not_active IP Right Cessation
- 2010-08-13 SG SG2012012068A patent/SG178842A1/en unknown
- 2010-08-13 EP EP10743046.4A patent/EP2473601B1/en not_active Not-in-force
- 2010-08-13 EP EP14190794.9A patent/EP2857505B1/en not_active Not-in-force
- 2010-08-13 CN CN201410652407.2A patent/CN104480155B/zh not_active Expired - Fee Related
- 2010-08-13 AU AU2010291586A patent/AU2010291586C1/en not_active Ceased
- 2010-08-13 ES ES14190794.9T patent/ES2599644T3/es active Active
- 2010-08-13 JP JP2012527213A patent/JP5792728B2/ja not_active Expired - Fee Related
- 2010-08-13 CN CN2013101765720A patent/CN103472093A/zh active Pending
- 2010-08-13 WO PCT/EP2010/004961 patent/WO2011026556A1/en active Application Filing
- 2010-08-13 CA CA2772426A patent/CA2772426A1/en not_active Abandoned
- 2010-08-13 MX MX2012002561A patent/MX2012002561A/es active IP Right Grant
- 2010-08-13 KR KR1020127006836A patent/KR101698435B1/ko active IP Right Grant
- 2010-08-13 ES ES10743046.4T patent/ES2562458T3/es active Active
- 2010-08-13 BR BRBR112012004817-1A patent/BR112012004817A2/pt not_active IP Right Cessation
- 2010-08-13 EP EP14190797.2A patent/EP2862938A3/en not_active Withdrawn
- 2010-08-13 US US13/393,201 patent/US8577622B2/en not_active Expired - Fee Related
- 2010-08-13 CN CN201080039297.2A patent/CN102482650B/zh not_active Expired - Fee Related
2012
- 2012-01-25 ZA ZA2012/00625A patent/ZA201200625B/en unknown
- 2012-02-29 IL IL218397A patent/IL218397A0/en unknown
- 2012-03-02 CL CL2012000590A patent/CL2012000590A1/es unknown
- 2012-07-04 HK HK12106541.7A patent/HK1165831A1/xx not_active IP Right Cessation
2015
- 2015-02-13 JP JP2015025890A patent/JP2015121557A/ja not_active Withdrawn
- 2015-02-13 JP JP2015025891A patent/JP6033900B2/ja not_active Expired - Fee Related
- 2015-02-26 IL IL237444A patent/IL237444A0/en unknown
- 2015-02-26 IL IL237445A patent/IL237445A0/en unknown
- 2015-04-30 HK HK15104185.0A patent/HK1203562A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EA201270350A1 (ru)	2012-07-30
JP2013503610A (ja)	2013-02-04
JP6033900B2 (ja)	2016-11-30
MX2012002561A (es)	2012-04-10
CN103472093A (zh)	2013-12-25
CN104480155A (zh)	2015-04-01
CN102482650B (zh)	2014-12-17
WO2011026556A1 (en)	2011-03-10
EP2473601B1 (en)	2015-12-02
IL237444A0 (en)	2015-04-30
AU2010291586B2 (en)	2015-01-22
EP2862938A2 (en)	2015-04-22
SG178842A1 (en)	2012-04-27
EP2857505B1 (en)	2016-10-19
AU2010291586A1 (en)	2012-03-01
CN104480155B (zh)	2019-03-01
KR20120096465A (ko)	2012-08-30
EA022764B1 (ru)	2016-02-29
HK1165831A1 (en)	2012-10-12
EP2473601A1 (en)	2012-07-11
KR101698435B1 (ko)	2017-01-20
CA2772426A1 (en)	2011-03-10
EP2857505A3 (en)	2015-07-01
HK1203562A1 (en)	2015-10-30
IL218397A0 (en)	2012-04-30
IL237445A0 (en)	2015-04-30
US20120156706A1 (en)	2012-06-21
CL2012000590A1 (es)	2012-08-17
JP5792728B2 (ja)	2015-10-14
ES2599644T3 (es)	2017-02-02
ZA201200625B (en)	2013-05-29
JP2015130865A (ja)	2015-07-23
ES2562458T3 (es)	2016-03-04
US8577622B2 (en)	2013-11-05
JP2015121557A (ja)	2015-07-02
AU2010291586C1 (en)	2015-04-16
EP2862938A3 (en)	2015-07-15
EP2857505A2 (en)	2015-04-08
CN102482650A (zh)	2012-05-30

Legal Events

Date	Code	Title	Description
2017-06-06	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2017-09-19	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Publication	Publication Date	Title
BR112012004817A2 (pt)	2015-09-01	Processo para identificação e preparação de uma ômega-transaminase (r)-específica
BRPI1010766A2 (pt)	2015-09-22	processo para rebaudiosídeo d
BRPI1011702A2 (pt)	2016-03-22	processo para preparação de poliéster insaturado
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BRPI1013219A2 (pt)	2016-03-29	método para o alvejamento-branqueamento enzimático têxtil
BR112013012108A2 (pt)	2017-11-07	processo para a preparação de um poliéster
BRPI1014306A2 (pt)	2016-04-05	processo para preparar um gel reticulado
BRPI1014267A2 (pt)	2016-04-12	processo para a carbonitrificação
BRPI1014911A2 (pt)	2016-07-26	processo para fabricação de resinas carregadas
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BR112012000258A2 (pt)	2016-02-16	processo para preparar uma alquenona.
BRPI0917836A2 (pt)	2015-11-24	processo para preparar uretanos
BRPI0920689A2 (pt)	2015-12-29	processo para produção de cumeno
BRPI0912202A2 (pt)	2015-10-06	processo para a preparação de um painel
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